compound 1 [PMID: 11425539] [Ligand Id: 6542] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL47394
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  • elastase, neutrophil expressed/Leukocyte elastase in Human [ChEMBL: CHEMBL248] [GtoPdb: 2358] [UniProtKB: P08246]
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  • coagulation factor II, thrombin/Thrombin in Human [ChEMBL: CHEMBL204] [GtoPdb: 2362] [UniProtKB: P00734]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
cathepsin G/Cathepsin G in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4071] [GtoPdb: 2348] [UniProtKB: P08311]
GtoPdb - - 9.4 pIC50 0.39 nM IC50 Bioorg Med Chem Lett (2001) 11: 1691-4 [PMID:11425539]
ChEMBL Compound was evaluated for its inhibitory activity against human cathepsin G B 9.41 pIC50 0.39 nM IC50 Bioorg Med Chem Lett (2001) 11: 1691-1694 [PMID:11425539]
chymase 1/Chymase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4068] [GtoPdb: 2340] [UniProtKB: P23946]
ChEMBL Compound was evaluated for its inhibitory activity against human Serine protease chymase B 8.4 pIC50 4 nM IC50 Bioorg Med Chem Lett (2001) 11: 1691-1694 [PMID:11425539]
chymotrypsin C/Chymotrypsin C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2386] [GtoPdb: 2341] [UniProtKB: Q99895]
ChEMBL Compound was evaluated for its inhibitory activity against bovine pancreatic alpha-chymotrypsin B 9.16 pIC50 0.69 nM IC50 Bioorg Med Chem Lett (2001) 11: 1691-1694 [PMID:11425539]
elastase, neutrophil expressed/Leukocyte elastase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL248] [GtoPdb: 2358] [UniProtKB: P08246]
ChEMBL Compound was evaluated for its inhibitory activity against human neutrophil elastase B 7 pIC50 100 nM IC50 Bioorg Med Chem Lett (2001) 11: 1691-1694 [PMID:11425539]
plasminogen/Plasminogen in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1801] [GtoPdb: 2394] [UniProtKB: P00747]
ChEMBL Compound was evaluated for its inhibitory activity against human plasmin B 5.54 pIC50 2900 nM IC50 Bioorg Med Chem Lett (2001) 11: 1691-1694 [PMID:11425539]
coagulation factor II, thrombin/Thrombin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL204] [GtoPdb: 2362] [UniProtKB: P00734]
ChEMBL Compound was evaluated for its inhibitory activity against human thrombin B 7.14 pIC50 72 nM IC50 Bioorg Med Chem Lett (2001) 11: 1691-1694 [PMID:11425539]
Trypsin I in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3769] [UniProtKB: P00760]
ChEMBL Compound was evaluated for its inhibitory activity against bovine pancreatic trypsin B 7.41 pIC50 39 nM IC50 Bioorg Med Chem Lett (2001) 11: 1691-1694 [PMID:11425539]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]