Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
ChEMBL ligand: CHEMBL47394 |
---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
---|---|---|---|---|---|---|---|---|
cathepsin G/Cathepsin G in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4071] [GtoPdb: 2348] [UniProtKB: P08311] | ||||||||
GtoPdb | - | - | 9.4 | pIC50 | 0.39 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 1691-4 [PMID:11425539] |
ChEMBL | Compound was evaluated for its inhibitory activity against human cathepsin G | B | 9.41 | pIC50 | 0.39 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 1691-1694 [PMID:11425539] |
chymase 1/Chymase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4068] [GtoPdb: 2340] [UniProtKB: P23946] | ||||||||
ChEMBL | Compound was evaluated for its inhibitory activity against human Serine protease chymase | B | 8.4 | pIC50 | 4 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 1691-1694 [PMID:11425539] |
chymotrypsin C/Chymotrypsin C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2386] [GtoPdb: 2341] [UniProtKB: Q99895] | ||||||||
ChEMBL | Compound was evaluated for its inhibitory activity against bovine pancreatic alpha-chymotrypsin | B | 9.16 | pIC50 | 0.69 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 1691-1694 [PMID:11425539] |
elastase, neutrophil expressed/Leukocyte elastase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL248] [GtoPdb: 2358] [UniProtKB: P08246] | ||||||||
ChEMBL | Compound was evaluated for its inhibitory activity against human neutrophil elastase | B | 7 | pIC50 | 100 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 1691-1694 [PMID:11425539] |
plasminogen/Plasminogen in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1801] [GtoPdb: 2394] [UniProtKB: P00747] | ||||||||
ChEMBL | Compound was evaluated for its inhibitory activity against human plasmin | B | 5.54 | pIC50 | 2900 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 1691-1694 [PMID:11425539] |
coagulation factor II, thrombin/Thrombin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL204] [GtoPdb: 2362] [UniProtKB: P00734] | ||||||||
ChEMBL | Compound was evaluated for its inhibitory activity against human thrombin | B | 7.14 | pIC50 | 72 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 1691-1694 [PMID:11425539] |
Trypsin I in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3769] [UniProtKB: P00760] | ||||||||
ChEMBL | Compound was evaluated for its inhibitory activity against bovine pancreatic trypsin | B | 7.41 | pIC50 | 39 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 1691-1694 [PMID:11425539] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]