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ChEMBL ligand: CHEMBL1201379 (Fluoprostenol, Fluprostenol, ICI-81008) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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EP3 receptor/Prostanoid EP3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3710] [GtoPdb: 342] [UniProtKB: P43115] | ||||||||
GtoPdb | - | - | 6.15 | pKi | 708 | nM | Ki | Biochim Biophys Acta (2000) 1483: 285-93 [PMID:10634944] |
ChEMBL | Agonist activity at human EP3 receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assay | F | 5.47 | pEC50 | 3400 | nM | EC50 | ACS Med Chem Lett (2017) 8: 107-112 [PMID:28105284] |
FP receptor/Prostanoid FP receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1987] [GtoPdb: 344] [UniProtKB: P43088] | ||||||||
GtoPdb | - | - | 8.6 | pKi | - | - | - | Biochim Biophys Acta (2000) 1483: 285-93 [PMID:10634944] |
ChEMBL | Agonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assay | F | 8.44 | pEC50 | 3.6 | nM | EC50 | ACS Med Chem Lett (2017) 8: 107-112 [PMID:28105284] |
FP receptor in Mouse [GtoPdb: 344] [UniProtKB: P43117] | ||||||||
GtoPdb | - | - | 8.4 | pKi | - | - | - | Br J Pharmacol (1997) 122: 217-24 [PMID:9313928] |
TP receptor in Human [GtoPdb: 346] [UniProtKB: P21731] | ||||||||
GtoPdb | - | - | 4.3 | pKi | - | - | - | Biochim Biophys Acta (2000) 1483: 285-93 [PMID:10634944] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]