example 184 [WO2014186035] [Ligand Id: 12668] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4279060 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| indoleamine 2,3-dioxygenase 1/Indoleamine 2,3-dioxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4685] [GtoPdb: 2829] [UniProtKB: P14902] | ||||||||
| ChEMBL | Inhibition of recombinant human N-terminal His-tagged IDO1 (1 to 403 residues) expressed in Escherichia coli assessed as reduction in kynurenine formation using tryptophan as substrate measured by LC/MS/MS analysis | B | 6.7 | pIC50 | <200 | nM | IC50 | US-20160046596-A1. Inhibitors of the kynurenine pathway (null) |
| ChEMBL | Inhibition of IDO1 in IFNgamma-stimulated human HeLa cells assessed as reduction in kynurenine formation using L-tryptophan as substrate measured after 15 mins by UV-vis HPLC analysis | B | 6.7 | pIC50 | <200 | nM | IC50 | US-20160046596-A1. Inhibitors of the kynurenine pathway (null) |
| indoleamine 2,3-dioxygenase 2/Indoleamine 2,3-dioxygenase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3627587] [GtoPdb: 3019] [UniProtKB: Q6ZQW0] | ||||||||
| GtoPdb | Inhibition of recombinant human IDO2 (14-420)-mediated kynurenine formation from tryptophan, detected by LC/MS/MS analysis | - | 6 | pIC50 | <1000 | nM | IC50 | WO2014186035A1. Inhibitors of the kynurenine pathway (2014) |
| ChEMBL | Inhibition of recombinant human C-terminal polyHis-tagged IDO2 (Met14 to Gly420 residues) expressed in Escherichia coli assessed as reduction in kynurenine formation using tryptophan as substrate measured by LC/MS/MS analysis | B | 6 | pIC50 | <1000 | nM | IC50 | US-20160046596-A1. Inhibitors of the kynurenine pathway (null) |
| tryptophan 2,3-dioxygenase/Tryptophan 2,3-dioxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2140] [GtoPdb: 2887] [UniProtKB: P48775] | ||||||||
| ChEMBL | Inhibition of recombinant human TDO2 expressed in CHOK1 cells assessed as reduction in kynurenine formation using L-tryptophan as substrate measured after 2 hrs by LC/MS/MS analysis | B | 6.3 | pIC50 | <500 | nM | IC50 | US-20160046596-A1. Inhibitors of the kynurenine pathway (null) |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
