Compound class:
Synthetic organic
Comment: Compound 7r was designed using scaffold hopping and molecular hybridization strategies to identify novel FGFR inhibitors, based on the structures of existing FGFR inhibitors fexagratinib and infigratinib [1]. The X-ray structure of FGFR1 in complex with compound 7n (identical to 7r but without the 2-fluoro side group) has been reported and has RCSB Protein Data Bank ID 4ZSA [1].
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Classification | |
Compound class | Synthetic organic |
IUPAC Name |
4-(4-ethylpiperazin-1-yl)-N-[6-(2-fluoro-3-methoxyphenyl)-1H-indazol-3-yl]benzamide |
Database Links | |
GtoPdb PubChem SID | 252166839 |
PubChem CID | 91827382 |
Search Google for chemical match using the InChIKey | ANMVTYAYYHHSTF-UHFFFAOYSA-N |
Search Google for chemicals with the same backbone | ANMVTYAYYHHSTF |
UniChem Compound Search for chemical match using the InChIKey | ANMVTYAYYHHSTF-UHFFFAOYSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | ANMVTYAYYHHSTF-UHFFFAOYSA-N |