compound 2g [PMID: 19309152] [Ligand Id: 5791] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL482768 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| HCA2 receptor/Hydroxycarboxylic acid receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3785] [GtoPdb: 312] [UniProtKB: Q8TDS4] | ||||||||
| ChEMBL | Displacement of [3H]niacin from human GPR109A expressed in CHO cells | B | 7.89 | pIC50 | 13 | nM | IC50 | J Med Chem (2009) 52: 2587-2602 [PMID:19309152] |
| GtoPdb | - | - | 7.89 | pIC50 | 13 | nM | IC50 | J Med Chem (2009) 52: 2587-602 [PMID:19309152] |
| ChEMBL | Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assay | F | 7.19 | pEC50 | 64 | nM | EC50 | J Med Chem (2009) 52: 2587-2602 [PMID:19309152] |
| HCA2 receptor/Hydroxycarboxylic acid receptor 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4731] [GtoPdb: 312] [UniProtKB: Q80Z39] | ||||||||
| ChEMBL | Agonist activity at rat GPR109A expressed by [35S]GTPgammaS binding assay | F | 5.57 | pEC50 | 2700 | nM | EC50 | J Med Chem (2009) 52: 2587-2602 [PMID:19309152] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
