anagliptin [Ligand Id: 11582] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1929396 (Sk-0403, Anagliptin, SK-0403, CWP-403)
  • fibroblast activation protein alpha/Fibroblast activation protein alpha in Human [ChEMBL: CHEMBL4683] [GtoPdb: 2365] [UniProtKB: Q12884]
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  • dipeptidyl peptidase 4 in Human [GtoPdb: 1612] [UniProtKB: P27487]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
fibroblast activation protein alpha/Fibroblast activation protein alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4683] [GtoPdb: 2365] [UniProtKB: Q12884]
ChEMBL Inhibition of human recombinant FAP expressed in baculovirus-infected Sf9 insect cells using H-Ala-Pro-AFC as substrate after 60 mins by fluorescence assay B 4.14 pIC50 72700 nM IC50 Bioorg. Med. Chem. (2011) 19: 7221-7227 [PMID:22019046]
dipeptidyl peptidase 4 in Human [GtoPdb: 1612] [UniProtKB: P27487]
GtoPdb Inhibition of human recombinant DPP-4 in vitro - 8.42 pIC50 3.8 nM IC50 Bioorg Med Chem (2011) 19: 7221-7 [PMID:22019046]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]