[3H]L365260 [Ligand Id: 3477] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL289498
  • CCK1 receptor/Cholecystokinin A receptor in Rat [ChEMBL: CHEMBL2871] [GtoPdb: 76] [UniProtKB: P30551]
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  • CCK2 receptor/Cholecystokinin B receptor in Human [ChEMBL: CHEMBL298] [GtoPdb: 77] [UniProtKB: P32239]
  • CCK2 receptor/Cholecystokinin B receptor in Rat [ChEMBL: CHEMBL3508] [GtoPdb: 77] [UniProtKB: P30553]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
CCK1 receptor/Cholecystokinin A receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2871] [GtoPdb: 76] [UniProtKB: P30551]
ChEMBL Displacement of [125 I] CCK-8 from Cholecystokinin type A receptor of rat pancreas B 8.09 pIC50 8.1 nM IC50 J Med Chem (1989) 32: 13-16 [PMID:2909725]
CCK2 receptor/Cholecystokinin B receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL298] [GtoPdb: 77] [UniProtKB: P32239]
GtoPdb - - 8.5 pKd 2.9 nM Kd Regul Pept (2002) 103: 29-37 [PMID:11738246]
ChEMBL Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex B 8.15 pIC50 7.1 nM IC50 J Med Chem (1989) 32: 13-16 [PMID:2909725]
ChEMBL Displacement of [125I]-gastrin17 from CCK-B receptor (unknown origin) B 8.28 pIC50 5.2 nM IC50 Medchemcomm (2017) 8: 1561-1574 [PMID:30108868]
ChEMBL Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands B 8.51 pIC50 3.1 nM IC50 J Med Chem (1989) 32: 13-16 [PMID:2909725]
CCK2 receptor/Cholecystokinin B receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3508] [GtoPdb: 77] [UniProtKB: P30553]
ChEMBL Displacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting method B 8.42 pIC50 3.8 nM IC50 Medchemcomm (2017) 8: 1561-1574 [PMID:30108868]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]