Synonyms: compound 6i [PMID: 33861086] | CVN-424
Compound class:
Synthetic organic
Comment: CVN424 is a first-in-class, clinical stage, nondopaminergic inverse agonist of GPR6. It is orally bioavailable, and can penetrate the CNS [1,3]. In in vivo Parkinson's disease models, inhibiting GPR6 activity with CVN424 normalises both activity in basal ganglia circuitry and motor behaviour.
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Classification ![]() |
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Compound class | Synthetic organic |
IUPAC Name ![]() |
1-[2-[4-(2,4-difluorophenoxy)piperidin-1-yl]-3-[[(3R)-oxolan-3-yl]amino]-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]ethanone |
Synonyms ![]() |
compound 6i [PMID: 33861086] | CVN-424 |
Database Links ![]() |
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Specialist databases | |
GPCRdb Ligand | CVN424 |
Other databases | |
GtoPdb PubChem SID | 441604886 |
PubChem CID | 137359492 |
Search Google for chemical match using the InChIKey | HSWVJQBEXRKOBZ-QGZVFWFLSA-N |
Search Google for chemicals with the same backbone | HSWVJQBEXRKOBZ |
UniChem Compound Search for chemical match using the InChIKey | HSWVJQBEXRKOBZ-QGZVFWFLSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | HSWVJQBEXRKOBZ-QGZVFWFLSA-N |