ChEMBL ligand: CHEMBL514800 (Apremilast, CC-10004, CC10004, Otezla)
phosphodiesterase 4B/Phosphodiesterase 4B in Human [ChEMBL: CHEMBL275] [GtoPdb: 1301] [UniProtKB: Q07343] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 4D/Phosphodiesterase 4D in Human [ChEMBL: CHEMBL288] [GtoPdb: 1303] [UniProtKB: Q08499] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 4A in Human [GtoPdb: 1300] [UniProtKB: P27815] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 4C in Human [GtoPdb: 1302] [UniProtKB: Q08493] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
phosphodiesterase 4B/Phosphodiesterase 4B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL275] [GtoPdb: 1301] [UniProtKB: Q07343]
ChEMBL	Inhibition of human PDE4B using [3H]cAMP as substrate incubated for 5 mins followed by substrate addition and measured after 10 mins by scintillation proximity assay	B	7.13	pIC50	74	nM	IC50	Bioorg Med Chem (2016) 24: 5702-5716 [PMID:27713015]
ChEMBL	Inhibition of recombinant human PDE4B2 expressed in African green monkey COS7 cells using cAMP as substrate	B	7.52	pIC50	30	nM	IC50	J Med Chem (2018) 61: 2472-2489 [PMID:29502405]
ChEMBL	Inhibition of PDE4B (unknown origin)	B	7.57	pIC50	27	nM	IC50	Eur J Med Chem (2019) 174: 198-215 [PMID:31035240]
GtoPdb	Potency against recombinant human PDE4B1 and B2 isoforms in a TR-FRET assay.	-	7.57	pIC50	27	nM	IC50	Cell Signal (2014) 26: 2016-29 [PMID:24882690]
phosphodiesterase 4D/Phosphodiesterase 4D in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL288] [GtoPdb: 1303] [UniProtKB: Q08499]
ChEMBL	Inhibition of PDE4D2 (unknown origin)	B	6.27	pIC50	540	nM	IC50	J Med Chem (2020) 63: 3370-3380 [PMID:32115956]
ChEMBL	Inhibition of PDE4D2 (unknown origin)	B	6.3	pIC50	500	nM	IC50	Eur J Med Chem (2022) 242: 114631-114631 [PMID:35985255]
ChEMBL	Inhibition of PDE4D (unknown origin) using cAMP as substrate	B	7.13	pIC50	74	nM	IC50	J Med Chem (2019) 62: 5579-5593 [PMID:31099559]
ChEMBL	Inhibition of human PDE4D catalytic domain (86 to 413 residues) expressed in Escherichia coli BL21 (DE3) cells using [3H]cAMP as substrate measured after 30 mins by scintillation proximity assay	B	7.32	pIC50	47.6	nM	IC50	J Nat Prod (2020) 83: 1229-1237 [PMID:32100544]
GtoPdb	Potency against recombinant human PDE4D2 isoform in a TR-FRET assay.	-	7.48	pIC50	33	nM	IC50	Cell Signal (2014) 26: 2016-29 [PMID:24882690]
ChEMBL	Inhibition of PDE4D (unknown origin)	B	7.48	pIC50	33	nM	IC50	Eur J Med Chem (2019) 174: 198-215 [PMID:31035240]
phosphodiesterase 4A in Human [GtoPdb: 1300] [UniProtKB: P27815]
GtoPdb	Potency against recombinant human PDE4A1A isoform in a TR-FRET assay.	-	7.85	pIC50	14	nM	IC50	Cell Signal (2014) 26: 2016-29 [PMID:24882690]
phosphodiesterase 4C in Human [GtoPdb: 1302] [UniProtKB: Q08493]
GtoPdb	Potency against recombinant human PDE4C1 isoform in a TR-FRET assay.	-	6.93	pIC50	118	nM	IC50	Cell Signal (2014) 26: 2016-29 [PMID:24882690]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]