ChEMBL ligand: CHEMBL514800 (Apremilast, CC-10004, CC10004, Otezla)
phosphodiesterase 4B/Phosphodiesterase 4B in Human [ChEMBL: CHEMBL275] [GtoPdb: 1301] [UniProtKB: Q07343] This target only has 0 pki data point 1 CHEMBL514800_lig_chart_1 Phosphodiesterase 4B Human There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 4A in Human [GtoPdb: 1300] [UniProtKB: P27815] This target only has 0 pki data point 2 CHEMBL514800_lig_chart_2 phosphodiesterase 4A Human There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 4C in Human [GtoPdb: 1302] [UniProtKB: Q08493] This target only has 0 pki data point 3 CHEMBL514800_lig_chart_3 phosphodiesterase 4C Human There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 4D in Human [GtoPdb: 1303] [UniProtKB: Q08499] This target only has 0 pki data point 4 CHEMBL514800_lig_chart_4 phosphodiesterase 4D Human There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
phosphodiesterase 4B/Phosphodiesterase 4B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL275] [GtoPdb: 1301] [UniProtKB: Q07343]
ChEMBL	Inhibition of recombinant human PDE4B2 expressed in African green monkey COS7 cells using cAMP as substrate	B	7.52	pIC50	30	nM	IC50	J Med Chem (2018) 61: 2472-2489 [PMID:29502405]
GtoPdb	Potency against recombinant human PDE4B1 and B2 isoforms in a TR-FRET assay.	-	7.57	pIC50	27	nM	IC50	Cell. Signal. (2014) 26: 2016-29 [PMID:24882690]
phosphodiesterase 4A in Human [GtoPdb: 1300] [UniProtKB: P27815]
GtoPdb	Potency against recombinant human PDE4A1A isoform in a TR-FRET assay.	-	7.85	pIC50	14	nM	IC50	Cell. Signal. (2014) 26: 2016-29 [PMID:24882690]
phosphodiesterase 4C in Human [GtoPdb: 1302] [UniProtKB: Q08493]
GtoPdb	Potency against recombinant human PDE4C1 isoform in a TR-FRET assay.	-	6.93	pIC50	118	nM	IC50	Cell. Signal. (2014) 26: 2016-29 [PMID:24882690]
phosphodiesterase 4D in Human [GtoPdb: 1303] [UniProtKB: Q08499]
GtoPdb	Potency against recombinant human PDE4D2 isoform in a TR-FRET assay.	-	7.48	pIC50	33	nM	IC50	Cell. Signal. (2014) 26: 2016-29 [PMID:24882690]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]