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Abbreviated name: CD275
Synonyms: B7 homolog 2 | B7-H2 | B7-related protein 1 | B7RP-1 | ICOS-L
Compound class:
Endogenous peptide in human, mouse or rat
Comment: Endogenous ligand for ICOS [1] that is expressed on the surface of antigen presenting cells. Inhibiting the ICOS/ICOSL axis is predicted to provide anti-inflammatory activity applicable for the treatment of autoimmune diseases.
The ICOSL protein contains an immunoglobulin (Ig)-like domain that resembles the antibody variable domain, that has been coined the 'V-set domain'. The genes for all human V-set domain containing proteins are listed in HGNC gene group 590. The anti-ICOSL monoclonal antibody MEDI5872 (AMG557) is being evaluated in Phase 2 clinical trial in patients with primary Sjögren's syndrome (NCT02334306). Phase 1 trials of the same biologic in systemic lupus erythematosus (SLE) and psoriasis were terminated.
Species: Human
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Classification  |
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| Compound class | Endogenous peptide in human, mouse or rat |
| Ligand families/groups | CD molecules (ligands) |
| Synonyms |
| B7 homolog 2 | B7-H2 | B7-related protein 1 | B7RP-1 | ICOS-L |
| Gene/Precursor |
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| Database Links |
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| Ensembl Gene | ENSG00000160223 (Hs) |
| GtoPdb PubChem SID | 340590224 |
| Human Protein Atlas | ENSG00000160223 (Hs) |
| OMIM | 605717 (Hs) |
| UniProtKB | O75144 (Hs) |
