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|Compound class||Endogenous peptide in human, mouse or rat|
|Ligand families/groups||CD molecules (ligands)|
|B7 homolog 2 | B7-H2 | B7-related protein 1 | B7RP-1 | ICOS-L|
|Endogenous ligand for ICOS that is expressed on the surface of antigen presenting cells. Inhibiting the ICOS/ICOSL axis is predicted to provide anti-inflammatory activity applicable for the treatment of autoimmune diseases.
The ICOSL protein contains an immunoglobulin (Ig)-like domain that resembles the antibody variable domain, that has been coined the 'V-set domain'. The genes for all human V-set domain containing proteins are listed in HGNC gene group 590.
The anti-ICOSL monoclonal antibody MEDI5872 (AMG557) is being evaluated in Phase 2 clinical trial in patients with primary Sjögren's syndrome (NCT02334306). Phase 1 trials of the same biologic in systemic lupus erythematosus (SLE) and psoriasis were terminated.
|GtoPdb PubChem SID||340590224|