VU0361737 [Ligand Id: 3956] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL562551 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| mGlu4 receptor/Metabotropic glutamate receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2736] [GtoPdb: 292] [UniProtKB: Q14833] | ||||||||
| ChEMBL | Displacement of [3H]N-(4-chloro-3-methoxyphenyl)picolinamide from human mGlu4 receptor expressed in CHO cell membranes incubated for 30 mins by liquid scintillation counting method | B | 8.29 | pIC50 | 5.13 | nM | IC50 | Bioorg Med Chem Lett (2015) 25: 3956-3960 [PMID:26231155] |
| ChEMBL | Displacement of [3H]N-(4-chloro-3-methoxyphenyl)picolinamide from human mGlu4 receptor expressed in CHO cell membranes incubated for 30 mins by liquid scintillation counting method | B | 8.29 | pIC50 | 5.1 | nM | IC50 | Bioorg Med Chem Lett (2015) 25: 3956-3960 [PMID:26231155] |
| GtoPdb | - | - | 6.6 | pEC50 | 240 | nM | EC50 | J Med Chem (2009) 52: 4115-8 [PMID:19469556] |
| ChEMBL | Activity at human mGluR4 receptor expressed in CHO cells assessed as effect on calcium mobilization | F | 6.62 | pEC50 | 240 | nM | EC50 | J Med Chem (2009) 52: 4115-4118 [PMID:19469556] |
| ChEMBL | Positive allosteric modulation of human mGlu4 receptor expressed in BHK cells assessed as potentiation of glutamate-induced calcium mobilization after 1 hr by FLIPR assay | F | 6.62 | pEC50 | 240 | nM | EC50 | J Med Chem (2011) 54: 5070-5081 [PMID:21688779] |
| mGlu4 receptor/Metabotropic glutamate receptor 4 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2787] [GtoPdb: 292] [UniProtKB: P31423] | ||||||||
| ChEMBL | Displacement of [3H]ML128 from rat mGlu4 receptor expressed in CHO cells after 30 mins by liquid scintillation counting analysis | B | 7.89 | pIC50 | 12.88 | nM | IC50 | J Med Chem (2014) 57: 9130-9138 [PMID:25330258] |
| ChEMBL | Displacement of [3H]ML128 from rat mGlu4 receptor expressed in CHO cells after 30 mins by liquid scintillation counting analysis | B | 7.89 | pIC50 | 12.8 | nM | IC50 | J Med Chem (2014) 57: 9130-9138 [PMID:25330258] |
| ChEMBL | Activity at rat mGluR4 receptor expressed in HEK293 cells assessed as effect on thallium flux | B | 6.96 | pEC50 | 110 | nM | EC50 | J Med Chem (2009) 52: 4115-4118 [PMID:19469556] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
