ChEMBL ligand: CHEMBL963 (14-hydroxydihydromorphinone, 7,8-dihydro-14-hydroxymorphinone, Dihydroxymorphinone, IDS-NO-003, NIH 10323, NSC-19045, Numorphan, Opana, Oximorfona, Oxycodone hydrochloride impurity, oxymorphone-, Oxymorphone, Oxymorphone cii)
δ receptor/Delta opioid receptor in Human [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143] δ receptor/Delta opioid receptor in Mouse [ChEMBL: CHEMBL3222] [GtoPdb: 317] [UniProtKB: P32300] δ receptor/Delta opioid receptor in Rat [ChEMBL: CHEMBL269] [GtoPdb: 317] [UniProtKB: P33533] There should be some charts here, you may need to enable JavaScript!
κ receptor/Kappa opioid receptor in Human [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] κ receptor/Kappa opioid receptor in Rat [ChEMBL: CHEMBL3614] [GtoPdb: 318] [UniProtKB: P34975] Kappa opioid receptor in Guinea pig [ChEMBL: CHEMBL3952] [UniProtKB: P41144] There should be some charts here, you may need to enable JavaScript!
μ receptor/Mu opioid receptor in Human [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] μ receptor/Mu opioid receptor in Mouse [ChEMBL: CHEMBL2858] [GtoPdb: 319] [UniProtKB: P42866] μ receptor/Mu opioid receptor in Rat [ChEMBL: CHEMBL270] [GtoPdb: 319] [UniProtKB: P33535] Mu opioid receptor in Guinea pig [ChEMBL: CHEMBL4354] [UniProtKB: P97266] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143]
ChEMBL	Binding affinity against Opioid receptor delta 1 of guinea pig brain membranes using 1 nM of [3H]DADLE as radioligand	B	6.84	pKi	145	nM	Ki	J Med Chem (1986) 29: 1222-1225 [PMID:2879914]
ChEMBL	Displacement of [3H]-diprenorphine from recombinant human DOR expressed in CHO cell membranes after 60 mins by liquid scintillation counting	B	7.15	pKi	70	nM	Ki	J Med Chem (2017) 60: 9407-9412 [PMID:29053268]
ChEMBL	Inhibitory binding constant in guinea pig brain homogenate was reported at Opioid receptor delta 1 at a a temperature 25 degree Celsius labeled with [3H](D-Ala2-D-Leu5)-enkephalin (0.7 nM)	B	7.3	pKi	50	nM	Ki	J Med Chem (1985) 28: 974-976 [PMID:2409281]
ChEMBL	Inhibition of Opioid receptor delta 1 by displacing 1 nM [3H]DPDPE in guinea pig brain membrane	B	7.35	pIC50	45	nM	IC50	J Med Chem (1992) 35: 4589-4594 [PMID:1335078]
δ receptor/Delta opioid receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3222] [GtoPdb: 317] [UniProtKB: P32300]
ChEMBL	Displacement of [3H]- diprenorphine from delta-receptor expressed in HEK 293 cells	B	6.14	pKi	730	nM	Ki	J Med Chem (2001) 44: 857-862 [PMID:11300867]
ChEMBL	Displacement of [3H]-DPDPE from mouse DOR expressed in HEK293 cells	B	6.14	pKi	724.44	nM	Ki	ACS Med Chem Lett (2012) 3: 640-644 [PMID:23585918]
ChEMBL	Displacement of [3H]- diprenorphine from delta-W284E-receptor expressed in HEK 293 cells	B	6.21	pKi	610	nM	Ki	J Med Chem (2001) 44: 857-862 [PMID:11300867]
δ receptor/Delta opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL269] [GtoPdb: 317] [UniProtKB: P33533]
ChEMBL	Inhibition of [3H][Ile5,6]deltorphin II binding to opioid receptor delta from rat brain membranes	B	7.09	pKi	80.5	nM	Ki	J Med Chem (2005) 48: 3372-3378 [PMID:15857143]
κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145]
ChEMBL	Displacement of [3H]-HS665 from recombinant human KOR expressed in CHO cell membranes after 30 mins by liquid scintillation counting	B	7.6	pKi	25.3	nM	Ki	J Med Chem (2017) 60: 9407-9412 [PMID:29053268]
κ receptor/Kappa opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3614] [GtoPdb: 318] [UniProtKB: P34975]
ChEMBL	Displacement of [3H]diprenorphine from k-Y312A-receptor expressed in HEK 293 cells	B	6.36	pKi	435	nM	Ki	J Med Chem (2001) 44: 857-862 [PMID:11300867]
ChEMBL	Displacement of [3H]diprenorphine from opioid receptor kappa 1 expressed in HEK 293 cells	B	6.68	pKi	208	nM	Ki	J Med Chem (2001) 44: 857-862 [PMID:11300867]
ChEMBL	Displacement of [3H]diprenorphine from k-E297A-receptor expressed in HEK 293 cells	B	7.02	pKi	95	nM	Ki	J Med Chem (2001) 44: 857-862 [PMID:11300867]
Kappa opioid receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3952] [UniProtKB: P41144]
ChEMBL	Binding affinity against Opioid receptor kappa 1 of guinea pig brain membranes using 1 nM of (-)-[3H]ethylketazocine as radioligand	B	6.14	pKi	725	nM	Ki	J Med Chem (1986) 29: 1222-1225 [PMID:2879914]
ChEMBL	Inhibitory binding constant in guinea pig brain homogenate was reported at Opioid receptor kappa 1 at temperature 25 degree Celsius labeled with (-)-[3H]immazocine (0.1 nM).	B	6.86	pKi	137	nM	Ki	J Med Chem (1985) 28: 974-976 [PMID:2409281]
ChEMBL	Inhibition of [3H]U-69593 binding to opioid receptor kappa from guinea pig brain membranes	B	7.21	pKi	61.6	nM	Ki	J Med Chem (2005) 48: 3372-3378 [PMID:15857143]
ChEMBL	Displacement of [3H]U69593 from kappa opioid receptor in guinea pig cerebellum homogenate by scintillation counting	B	7.24	pKi	57.6	nM	Ki	Bioorg Med Chem Lett (2011) 21: 4104-4107 [PMID:21641798]
ChEMBL	Inhibition of opioid receptor kappa by displacing 0.5 nM [3H]bremazocine in guinea pig brain membrane	B	6.2	pIC50	630	nM	IC50	J Med Chem (1992) 35: 4589-4594 [PMID:1335078]
μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372]
ChEMBL	Displacement of [3H]-DAMGO from recombinant human MOR expressed in CHO cell membranes after 60 mins by liquid scintillation counting	B	8.75	pKi	1.79	nM	Ki	J Med Chem (2017) 60: 9407-9412 [PMID:29053268]
ChEMBL	Agonist activity at recombinant human MOR expressed in CHO cell membranes after 60 mins by [35S]GTPgammaS binding assay	F	8.11	pEC50	7.8	nM	EC50	J Med Chem (2017) 60: 9407-9412 [PMID:29053268]
μ receptor/Mu opioid receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2858] [GtoPdb: 319] [UniProtKB: P42866]
ChEMBL	Displacement of [3H]-DAMGO from mouse MOR expressed in HEK293 cells	B	8.3	pKi	5.01	nM	Ki	ACS Med Chem Lett (2012) 3: 640-644 [PMID:23585918]
μ receptor/Mu opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL270] [GtoPdb: 319] [UniProtKB: P33535]
ChEMBL	Displacement of [3H]- diprenorphine from mu-K303E-receptor expressed in HEK 293	B	7.58	pKi	26.2	nM	Ki	J Med Chem (2001) 44: 857-862 [PMID:11300867]
ChEMBL	Displacement of [3H]- diprenorphine from mu-W318A-receptor expressed in HEK 293	B	7.64	pKi	23.1	nM	Ki	J Med Chem (2001) 44: 857-862 [PMID:11300867]
ChEMBL	Displacement of [3H]- diprenorphine from mu-receptor expressed in HEK 293 cells	B	7.76	pKi	17.4	nM	Ki	J Med Chem (2001) 44: 857-862 [PMID:11300867]
ChEMBL	Inhibition of [3H]DAMGO binding to opioid receptor mu from rat brain membranes	B	9.01	pKi	0.97	nM	Ki	J Med Chem (2005) 48: 3372-3378 [PMID:15857143]
Mu opioid receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4354] [UniProtKB: P97266]
ChEMBL	Binding affinity against Opioid receptor mu 1 of guinea pig brain membranes using 0.5 nM of [3H]naloxone as radioligand	B	7.82	pKi	15	nM	Ki	J Med Chem (1986) 29: 1222-1225 [PMID:2879914]
ChEMBL	Inhibitory binding constant in guinea pig brain homogenate was reported at mu site at a temperature 25 degree Centigrade labeled with [3H](D-Ala2-MePhe4,Gly-ol5)enkephalin(1 nM)	B	9.11	pKi	0.78	nM	Ki	J Med Chem (1985) 28: 974-976 [PMID:2409281]
ChEMBL	Displacement of [3H]DAMGO from mu opioid receptor in guinea pig forebrain homogenate by scintillation counting	B	9.27	pKi	0.54	nM	Ki	Bioorg Med Chem Lett (2011) 21: 4104-4107 [PMID:21641798]
ChEMBL	Inhibition of opioid receptor mu by displacing 1 nM [3H]DAGO in guinea pig brain membrane	B	8.85	pIC50	1.4	nM	IC50	J Med Chem (1992) 35: 4589-4594 [PMID:1335078]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]