ChEMBL ligand: CHEMBL1467 (Allopurinol, Allopurinolum, Aloral, Aluline 100, Aluline 300, BW 56-158, BW-56-158, Caplenal, Cosuric, Hamarin 100, Hamarin 300, Ledopur, Lopurin, NSC-101655, NSC-1390, Suspendol, Takanarumin, Uricto, Xanthomax-100, Xanthomax-300, Zyloprim, Zyloric, Zyloric-300)
CYP3A4/Cytochrome P450 3A4 in Human [ChEMBL: CHEMBL340] [GtoPdb: 1337] [UniProtKB: P08684] There should be some charts here, you may need to enable JavaScript!
Shiga toxin subunit A in Shigella dysenteriae [ChEMBL: CHEMBL3879822] [UniProtKB: Q9FBI2] There should be some charts here, you may need to enable JavaScript!
xanthine dehydrogenase/Xanthine dehydrogenase in Human [ChEMBL: CHEMBL1929] [GtoPdb: 2646] [UniProtKB: P47989] Xanthine dehydrogenase in Bovine [ChEMBL: CHEMBL3649] [UniProtKB: P80457] There should be some charts here, you may need to enable JavaScript!
xanthine dehydrogenase in Human [GtoPdb: 2646] [UniProtKB: P47989] xanthine dehydrogenase/Xanthine dehydrogenase/oxidase in Rat [ChEMBL: CHEMBL1075246] [GtoPdb: 2646] [UniProtKB: P22985] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
CYP3A4/Cytochrome P450 3A4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL340] [GtoPdb: 1337] [UniProtKB: P08684]
ChEMBL	null: A commercially available P450-GLO Assay kit (Promega Corporation, Madison Wis.) is used to screen various compounds for CYP3A4A inhibition activity. CYP3A4A is thought to be one of the primary CYP isoforms responsible for retinoic acid metabolism in the skin. Three benchmark agents, liarozole, climbazole, and ketoconazole, were assessed for CYP3A4 inhibition to confirm that the inhibition activity (the IC50 for CYP3A4 inhibition) measured by the assay corresponds to the activity reported by the published literature. The results show that the substituted azole compounds having the specific structure set forth herein are CYP inhibitors, and thus function as RAMBAs.	B	5	pIC50	>10000	nM	IC50	US-9138393-B2. Cosmetic compositions containing substituted azole and methods for improving the appearance of aging skin (2015)
ChEMBL	In vitro CYP3A4 Inhibition Assay: Cytochrome P450 is a large and diverse group of enzymes that catalyze the oxidation of organic substances. Some members of the CYP family contribute to the elimination of ATRA by catalyzing its 4-hydroxylation in the mammalian liver and skin, including that of humans as well as swine. Applicant evaluated the potential RAMBA activity of several azoles using pig liver microsomes, a rich source of CYP activity, comprising many different CYP 450 isoforms. Therefore, this approach, while a reasonable way to assess CYP inhibitors with broad activities may or may not be the best way to discover RAMBAs with selectivity for the skin, which has a much more narrow complement of CYP expression. As understanding in this area has progressed, a more specific CYP inhibition assay can be used to provide better predictivity of activity in human skin. Nevertheless, this assay may still be used as a general predictor of overall CYP activity.	B	5	pIC50	>10000	nM	IC50	US-9144538-B2. Cosmetic compositions containing substituted azole and methods for alleviating the signs of photoaged skin (2015)
Shiga toxin subunit A in Shigella dysenteriae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3879822] [UniProtKB: Q9FBI2]
ChEMBL	Inhibition of Shigella dysenteriae type 1 Shiga toxin A subunit in African green monkey Vero cells assessed as inhibition of Stx-induced cytotoxicity pre-treated with compound for 1 hr followed by Stx exposure for 24 hrs by neutral red uptake assay	B	4.62	pIC50	23900	nM	IC50	J Med Chem (2016) 59: 10763-10773 [PMID:27933947]
xanthine dehydrogenase/Xanthine dehydrogenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1929] [GtoPdb: 2646] [UniProtKB: P47989]
ChEMBL	Inhibition of xanthine oxidase (unknown origin)	B	5.14	pKi	7300	nM	Ki	Eur J Med Chem (2014) 84: 206-239 [PMID:25019478]
GtoPdb	-	-	5.15	pKi	7000	nM	Ki	J Med Chem (1996) 39: 2529-35 [PMID:8691450]
ChEMBL	Inhibitory activity against Xanthine Oxidase	B	5.15	pKi	7000	nM	Ki	J Med Chem (1996) 39: 2529-2535 [PMID:8691450]
ChEMBL	Non-competitive inhibition of xanthine oxidase (unknown origin) by Lineweaver-Burk plot analysis	B	5.81	pKi	1550	nM	Ki	Bioorg Med Chem (2016) 24: 226-231 [PMID:26712096]
ChEMBL	Inhibition of xanthine oxidase (unknown origin)	B	6.15	pKi	700	nM	Ki	Eur J Med Chem (2019) 166: 186-196 [PMID:30769179]
ChEMBL	Inhibition of human xanthine oxidase	B	7	pKi	100	nM	Ki	J Nat Prod (2014) 77: 1693-1699 [PMID:25060641]
ChEMBL	Inhibition of xanthine oxidase (unknown origin) using xanthine as substrate preincubated for 15 mins followed by substrate addition by spectrophotometric method	B	4.3	pIC50	50150	nM	IC50	Bioorg Med Chem (2017) 25: 3562-3566 [PMID:28511908]
ChEMBL	Inhibition of Xanthine oxidase	B	4.46	pIC50	34910	nM	IC50	Bioorg Med Chem Lett (2003) 13: 2777-2780 [PMID:12873513]
ChEMBL	Inhibition of xanthine oxidase	B	4.46	pIC50	34910	nM	IC50	J Nat Prod (2005) 68: 1615-1621 [PMID:16309309]
ChEMBL	Inhibition of xanthine oxidase (unknown origin) assessed as reduction in uric acid formation using xanthine as substrate after 30 mins by UV-Vis spectrophotometric assay	B	4.5	pIC50	31620	nM	IC50	Eur J Med Chem (2017) 135: 491-516 [PMID:28478180]
ChEMBL	Inhibition of xanthine oxidase (unknown origin)	B	4.5	pIC50	31620	nM	IC50	Eur J Med Chem (2018) 156: 394-429 [PMID:30015075]
ChEMBL	Inhibition of xanthine oxidase (unknown origin) assessed as reduction in uric acid formation using xanthine as substrate after 4 mins by UV-Vis spectrophotometric assay	B	4.51	pIC50	30700	nM	IC50	Eur J Med Chem (2017) 135: 491-516 [PMID:28478180]
ChEMBL	Inhibition of xanthine oxidase	B	4.61	pIC50	24400	nM	IC50	Eur J Med Chem (2008) 43: 771-780 [PMID:17692432]
ChEMBL	Inhibition of xanthine oxidase (unknown origin) by SAR analysis	B	4.61	pIC50	24300	nM	IC50	Eur J Med Chem (2017) 135: 491-516 [PMID:28478180]
ChEMBL	Inhibition of xanthine oxidase by spectrophotometry	B	4.62	pIC50	24200	nM	IC50	J Nat Prod (1999) 62: 1053-1055 [PMID:10425142]
ChEMBL	Inhibition of xanthine oxidase assessed as formation of formazan at 16 ug/ml after 2 hrs by spectrophotometry	B	4.63	pIC50	23500	nM	IC50	Bioorg Med Chem (2009) 17: 3414-3425 [PMID:19362850]
ChEMBL	Inhibition of xanthine oxidase assessed as decrease of superoxide generation	B	4.66	pIC50	21800	nM	IC50	Bioorg Med Chem Lett (2008) 18: 5006-5009 [PMID:18722771]
ChEMBL	Inhibition of xanthine oxidase assessed as decrease of uric acid generation	B	4.94	pIC50	11400	nM	IC50	Bioorg Med Chem Lett (2008) 18: 5006-5009 [PMID:18722771]
ChEMBL	Inhibition of xanthine oxidase assessed as uric acid formation by spectrophotometry	B	4.99	pIC50	10340	nM	IC50	Eur J Med Chem (2008) 43: 862-871 [PMID:17706325]
ChEMBL	Inhibition of xanthine oxidase	B	5.01	pIC50	9820	nM	IC50	J Nat Prod (2006) 69: 1089-1091 [PMID:16872152]
ChEMBL	Inhibition of human xanthine oxidase	B	5.11	pIC50	7820	nM	IC50	Bioorg Med Chem (2007) 15: 3450-3456 [PMID:17379526]
ChEMBL	Inhibition of xanthine oxidase	B	5.13	pIC50	7450	nM	IC50	J Nat Prod (2005) 68: 189-193 [PMID:15730241]
ChEMBL	Inhibitory activity against Xanthine Oxidase	B	5.38	pIC50	4200	nM	IC50	J Med Chem (1996) 39: 2529-2535 [PMID:8691450]
ChEMBL	Inhibition of xanthine oxidase using xanthine as substrate at 30 mins by spectrophotometric analysis	B	5.38	pIC50	4190	nM	IC50	Bioorg Med Chem Lett (2012) 22: 7543-7546 [PMID:23122864]
GtoPdb	-	-	5.38	pIC50	4200	nM	IC50	J Med Chem (1996) 39: 2529-35 [PMID:8691450]
ChEMBL	Inhibition of Xanthine oxidase (unknown origin) using xanthine as substrate preincubated for 3 mins followed by substrate addition measured every 15 secs for 7 mins by spectrophotometry	B	5.44	pIC50	3610	nM	IC50	Eur J Med Chem (2016) 124: 637-648 [PMID:27614410]
ChEMBL	Inhibition of xanthine oxidase (unknown origin) at 30 uM using xanthine as substrate preincubated for 5 mins followed by substrate addition measured every min for 10 mins by spectrophotometric method relative to control	B	5.5	pIC50	3170	nM	IC50	Eur J Med Chem (2018) 143: 829-842 [PMID:29223098]
ChEMBL	Inhibition of xanthine oxidase	B	5.52	pIC50	3000	nM	IC50	J Nat Prod (2010) 73: 992-994 [PMID:20384317]
ChEMBL	Inhibition of xanthine oxidase (unknown origin) using xanthine as substrate preincubated for 15 mins followed by substrate addition measured after 30 mins by spectrophotometric analysis	B	5.54	pIC50	2900	nM	IC50	Bioorg Med Chem Lett (2015) 25: 2778-2781 [PMID:26022844]
ChEMBL	Inhibition of Xanthine oxidase (unknown origin) using xanthine as substrate preincubated for 1 to 5 mins followed by substrate addition	B	5.54	pIC50	2900	nM	IC50	Bioorg Med Chem (2018) 26: 1653-1664 [PMID:29472126]
ChEMBL	Inhibition of xanthine oxidase (unknown origin)	B	5.66	pIC50	2200	nM	IC50	Bioorg Med Chem Lett (2020) 30: 126944-126944 [PMID:31924495]
ChEMBL	Inhibition of Xanthine oxidase	B	5.66	pIC50	2200	nM	IC50	Bioorg Med Chem Lett (2007) 17: 2558-2560 [PMID:17346963]
ChEMBL	Inhibtion Assay : Xanthine oxidase inhibition was determined using a standard fluorescence-based assay for xanthine oxidase activity (McHale A, Grimes H, Coughlan M P: Int J Biochem. 10:317-9, 1979) with minor variations. The procedure was internally standardized using allopurinol and DPI as controls for all experiments after determination of their optimal inhibitory concentrations. Experiments on test compounds were performed in triplicate in multi-well plates using 10 concentrations of each compound that ranged over a 3-fold dilution.	B	5.67	pIC50	2130	nM	IC50	US-9428466-B2. Methods for reducing uric acid levels using barbiturate derivatives (2016)
ChEMBL	Inhibition of xanthine oxidase	B	5.7	pIC50	2000	nM	IC50	J Nat Prod (2008) 71: 1027-1031 [PMID:18512985]
ChEMBL	Inhibition of xanthine oxidase (unknown origin) using xanthine as substrate measured at every 1 mins up to 5 mins	B	5.7	pIC50	2000	nM	IC50	Eur J Med Chem (2017) 135: 491-516 [PMID:28478180]
ChEMBL	Inhibition of xanthine oxidase	B	5.7	pIC50	2000	nM	IC50	Bioorg Med Chem (2008) 16: 7270-7276 [PMID:18606546]
ChEMBL	Inhibition of xanthine oxidase activity assessed as uric acid formation pretreated for 15 mins before substrate addition measured after 5 mins	B	5.72	pIC50	1900	nM	IC50	Eur J Med Chem (2011) 46: 1222-1231 [PMID:21345544]
ChEMBL	Inhibition of xanthine oxidase (unknown origin) using xanthine as substrate pretreated for 10 mins followed by substrate addition measured every 2 mins for 6 mins	B	6	pIC50	1000	nM	IC50	J Nat Prod (2017) 80: 2778-2786 [PMID:28972762]
ChEMBL	Inhibition of xanthine oxidase (unknown origin) using xanthine as substrate assessed as inhibition of uric acid formation after 30 mins by spectrophotometric method	B	6.02	pIC50	950	nM	IC50	Eur J Med Chem (2016) 119: 197-217 [PMID:27162124]
ChEMBL	Inhibition of xanthine oxidase assessed as decrease in uric acid production by spectrophotometry	B	6.62	pIC50	240	nM	IC50	J Nat Prod (1998) 61: 71-76 [PMID:9461655]
ChEMBL	Inhibition of xanthine oxidase (unknown origin)	B	6.7	pIC50	200	nM	IC50	Bioorg Med Chem (2016) 24: 578-587 [PMID:26762836]
ChEMBL	Inhibition of XOD	B	6.74	pIC50	180	nM	IC50	J Nat Prod (2009) 72: 1198-1201 [PMID:19476336]
ChEMBL	Inhibition of xanthine oxidase (unknown origin) assessed as reduction in uric acid formation using xanthine as substrate after 10 mins	B	7	pIC50	100	nM	IC50	Eur J Med Chem (2017) 135: 491-516 [PMID:28478180]
ChEMBL	Inhibition of xanthine oxidase (unknown origin) assessed as reduction in uric acid formation preincubated for 5 mins followed by addition of xanthine substrate measured every minute up to 8 mins	B	8.44	pIC50	3.6	nM	IC50	Bioorg Med Chem (2017) 25: 166-174 [PMID:28340987]
Xanthine dehydrogenase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3649] [UniProtKB: P80457]
ChEMBL	Binding affinity to bovine milk xanthine oxidase assessed as reduction in conversion of 4-HPP to 4,6-diHPP by measuring cytochrome c reduction by spectrophotometric assay	B	9.27	pKd	0.54	nM	Kd	Eur J Med Chem (2017) 135: 491-516 [PMID:28478180]
ChEMBL	Mixed-type inhibition of bovine milk xanthine oxidase using hypoxanthine as substrate by Lineweaver-Burk plot analysis	B	5.59	pKi	2600	nM	Ki	J Med Chem (1976) 19: 291-296 [PMID:2778]
ChEMBL	Mixed-type inhibition of bovine milk xanthine oxidase using xanthine as substrate by Lineweaver-Burk plot analysis	B	6	pKi	1000	nM	Ki	J Med Chem (1976) 19: 291-296 [PMID:2778]
ChEMBL	Inhibition of bovine milk xanthine oxidase using xanthine as substrate preincubated for 15 mins followed by substrate addition by spectrophotometric method	B	4.36	pIC50	44000	nM	IC50	Bioorg Med Chem Lett (2016) 26: 2874-2879 [PMID:27133595]
ChEMBL	Inhibition of bovine milk xanthine oxidase pre-incubated for 30 mins followed by xanthine addition and measured every 30 secs for 5 mins by spectrophotometry	B	4.71	pIC50	19600	nM	IC50	Bioorg Med Chem Lett (2017) 27: 3602-3606 [PMID:28655421]
ChEMBL	Inhibition of bovine xanthine oxidase using xanthine as substrate measured for 6 mins at 25 degC by spectrophotometry	B	4.95	pIC50	11230	nM	IC50	Eur J Med Chem (2014) 75: 289-296 [PMID:24556143]
ChEMBL	Inhibition of bovine xanthine oxidase assessed as reduction in uric acid formation using xanthine as substrate pretreated for 5 mins followed by substrate addition measured by UV-vis spectrophotometric method	B	4.95	pIC50	11100	nM	IC50	Eur J Med Chem (2017) 131: 14-28 [PMID:28286211]
ChEMBL	Inhibition of bovine milk xanthine oxidase using xanthine as substrate assessed as decrease in uric acid formation preincubated for 5 mins	B	4.95	pIC50	11100	nM	IC50	Bioorg Med Chem Lett (2014) 24: 495-500 [PMID:24388807]
ChEMBL	Inhibition of bovine xanthine oxidase using xanthine as substrate preincubated for 3 mins followed by substrate addition and measured for every 15 secs for 7 mins by spectrophotometric analysis	B	4.97	pIC50	10610	nM	IC50	Eur J Med Chem (2018) 151: 849-860 [PMID:29684895]
ChEMBL	Inhibition of bovine xanthine oxidase assessed as reduction in uric acid levels using xanthine as substrate after 120 mins by spectrophotometry	B	5.01	pIC50	9800	nM	IC50	Bioorg Med Chem Lett (2017) 27: 729-732 [PMID:28131711]
ChEMBL	Inhibition of bovine milk xanthine oxidase using xanthine as substrate preincubated for 5 mins followed by substrate addition by UV-visible spectrophotometry	B	5.06	pIC50	8690	nM	IC50	Medchemcomm (2019) 10: 128-147 [PMID:30931089]
ChEMBL	Inhibition of bovine milk XO assessed as decrease in uric acid formation after 5 mins by UV-spectrophotometric analysis	B	5.07	pIC50	8500	nM	IC50	Bioorg Med Chem (2012) 20: 5649-5657 [PMID:22901670]
ChEMBL	Inhibition of bovine xanthine oxidase assessed as reduction in uric acid formation using xanthine as substrate preincubated for 10 mins followed by substrate addition by UV spectrophotometric method	B	5.07	pIC50	8500	nM	IC50	Eur J Med Chem (2017) 141: 362-372 [PMID:29032030]
ChEMBL	Inhibition of bovine milk xanthine oxidase assessed as reduction in uric acid formation using xanthine as substrate preincubated for 5 mins followed by substrate addition by UV-Vis spectrophotometric assay	B	5.08	pIC50	8310	nM	IC50	Eur J Med Chem (2017) 135: 491-516 [PMID:28478180]
ChEMBL	Inhibition of bovine Xanthine oxidase assessed as decrease in uric acid production preincubated at 293 nM of compound for 5 mins by spectrophotometry	B	5.08	pIC50	8300	nM	IC50	Bioorg Med Chem (2011) 19: 1950-1958 [PMID:21353569]
ChEMBL	Inhibition of bovine milk xanthine oxidase assessed as decrease of uric acid formation preincubated for 5 mins by UV-visible spectrophotometric analysis	B	5.08	pIC50	8300	nM	IC50	Bioorg Med Chem (2011) 19: 5569-5576 [PMID:21862335]
ChEMBL	Inhibition of bovine xanthine oxidase assessed as reduction in uric acid formation using xanthine as substrate preincubated with enzyme for 15 mins followed by substrate addition and measured every 30 secs for 2 mins by spectrophotometric method	B	5.12	pIC50	7590.2	nM	IC50	Eur J Med Chem (2019) 181: 111558-111558 [PMID:31369933]
ChEMBL	Inhibition of bovine xanthine oxidase assessed as reduction in uric acid formation using xanthine as substrate preincubated for 25 mins followed by substrate addition measured at first 2 mins by spectrophotometric analysis	B	5.12	pIC50	7590	nM	IC50	Eur J Med Chem (2020) 190: 112077-112077 [PMID:32014678]
ChEMBL	Inhibition of bovine milk xanthine oxidase using xanthine as substrate incubated for 15 mins followed by substrate addition and measured at 30 sec interval for 2 mins by spectrophotometrically	B	5.12	pIC50	7590	nM	IC50	Eur J Med Chem (2019) 181: 111559-111559 [PMID:31376568]
ChEMBL	Inhibition of bovine xanthine oxidase assessed as reduction in uric acid production using xanthine as substrate preincubated for 10 mins followed by substrate addition by spectrophotometric analysis	B	5.12	pIC50	7560	nM	IC50	Bioorg Med Chem Lett (2017) 27: 3812-3816 [PMID:28693909]
ChEMBL	Inhibition of bovine xanthine oxidase assessed as reduction in uric acid formation preincubated for 5 mins followed by xanthine addition and measured after 20 mins by spectrophotometry	B	5.19	pIC50	6430	nM	IC50	Bioorg Med Chem (2019) 27: 1818-1823 [PMID:30885567]
ChEMBL	Inhibition of bovine xanthine oxidase assessed as uric acid formation using xanthine as substrate after 30 mins by spectrophotometric analysis	B	5.24	pIC50	5700	nM	IC50	Bioorg Med Chem (2012) 20: 2930-2939 [PMID:22483591]
ChEMBL	Inhibition of bovine milk xanthine oxidase assessed as reduction in uric acid formation using xanthine as substrate preincubated for 15 mins followed by substrate addition measured for every 30 sec by spectrophotometric analysis	B	5.26	pIC50	5462	nM	IC50	Bioorg Med Chem (2021) 38: 116117-116117 [PMID:33838610]
ChEMBL	Inhibition of bovine milk xanthine oxidase using xanthine as substrate	B	5.3	pIC50	5000	nM	IC50	J Med Chem (1976) 19: 291-296 [PMID:2778]
ChEMBL	Inhibition of bovine xanthine oxidase-mediated uric acid production after 30 mins by spectrophotometric analysis	B	5.38	pIC50	4200	nM	IC50	Bioorg Med Chem Lett (2013) 23: 834-838 [PMID:23265878]
ChEMBL	Inhibition of cow milk xanthine oxidoreductase using hypoxanthine by spectrophotometry	B	5.38	pIC50	4200	nM	IC50	Eur J Med Chem (2017) 140: 20-30 [PMID:28918097]
ChEMBL	Inhibition of bovine milk xanthine oxidase assessed as reduction in uric acid formation using xanthine as substrate preincubated for 3 hrs followed by substrate addition measured after 1 min by UV spectrophotometric assay	B	5.45	pIC50	3530	nM	IC50	Eur J Med Chem (2017) 135: 491-516 [PMID:28478180]
ChEMBL	Inhibition of bovine xanthine oxidase	B	5.52	pIC50	3000	nM	IC50	J Med Chem (1977) 20: 1189-1193 [PMID:926119]
ChEMBL	Inhibition of bovine milk xanthine oxidase assessed as reduction in uric acid formation using xanthine as substrate preincubated for 3 hrs followed by substrate addition by UV-Vis spectrophotometric assay	B	5.53	pIC50	2930	nM	IC50	Eur J Med Chem (2017) 135: 491-516 [PMID:28478180]
ChEMBL	Inhibition of bovine milk xanthine oxidase using xanthine as substrate pretreated for 15 mins followed by substrate addition measured after 8 mins	B	5.59	pIC50	2600	nM	IC50	Bioorg Med Chem (2018) 26: 536-542 [PMID:29274704]
ChEMBL	Inhibition of bovine milk xanthine oxidase assessed as reduction in uric acid formation using xanthine as substrate measured for 20 mins by microplate assay	B	5.6	pIC50	2520	nM	IC50	RSC Med Chem (2020) 11: 518-527 [PMID:33479653]
ChEMBL	Inhibition of bovine milk XOR-mediated uric acid formation after 15 mins by spectrophotometer	B	5.64	pIC50	2300	nM	IC50	Bioorg Med Chem Lett (2009) 19: 6225-6229 [PMID:19783139]
ChEMBL	Inhibition of bovine xanthine oxidase using xanthine as substrate preincubated for 10 mins followed by substrate addition measured for 15 mins by spectrophotometric method	B	5.7	pIC50	2000	nM	IC50	Bioorg Med Chem (2017) 25: 2351-2371 [PMID:28302506]
ChEMBL	Inhibition of cow milk xanthine oxidase	B	5.8	pIC50	1600	nM	IC50	J Nat Prod (1989) 52: 210-211 [PMID:2723668]
ChEMBL	Inhibition of bovine milk xanthine oxidase assessed as reduction in uric acid production using xanthine as substrate after 10 mins by HPLC analysis	B	6	pIC50	1000	nM	IC50	J Nat Prod (2019) 82: 205-210 [PMID:30719922]
ChEMBL	Inhibition of bovine milk xanthine oxidase by spectrophotometry	B	6.14	pIC50	730	nM	IC50	Bioorg Med Chem (2011) 19: 211-220 [PMID:21163661]
ChEMBL	In vitro inhibitory concentration against Xanthine oxidase	B	6.59	pIC50	260	nM	IC50	Bioorg Med Chem Lett (2001) 11: 879-882 [PMID:11294382]
ChEMBL	Inhibition of bovine milk xanthine-oxygen reductase using xanthine as substrate by spectrophotometric assay	B	6.59	pIC50	260	nM	IC50	Eur J Med Chem (2017) 135: 491-516 [PMID:28478180]
ChEMBL	Inhibition of bovine milk xanthine oxidase using xanthine as substrate preincubated for 15 mins followed by substrate addition measured after 30 mins by UV-VIS spectrophotometric analysis	B	6.6	pIC50	250	nM	IC50	Eur J Med Chem (2018) 143: 577-582 [PMID:29207340]
xanthine dehydrogenase in Human [GtoPdb: 2646] [UniProtKB: P47989]
GtoPdb	-	-	5.15	pKi	7000	nM	Ki	J Med Chem (1996) 39: 2529-35 [PMID:8691450]
GtoPdb	-	-	5.38	pIC50	4200	nM	IC50	J Med Chem (1996) 39: 2529-35 [PMID:8691450]
xanthine dehydrogenase/Xanthine dehydrogenase/oxidase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075246] [GtoPdb: 2646] [UniProtKB: P22985]
ChEMBL	Inhibition of rat liver xanthine oxidase after 2 hrs by spectrophotometry	B	4.67	pIC50	21200	nM	IC50	J Med Chem (2009) 52: 7732-7752 [PMID:19673490]
ChEMBL	Inhibition of Wistar albino rat xanthine oxidase isolated from liver using xanthine as substrate incubated for 15 mins prior to substrate addition by spectrophotometric analysis	B	5.22	pIC50	6000	nM	IC50	Bioorg Med Chem (2013) 21: 365-372 [PMID:23177727]
ChEMBL	Inhibition of rat liver xanthine oxidase by spectrophotometry	B	6.12	pIC50	753	nM	IC50	Bioorg Med Chem (2011) 19: 211-220 [PMID:21163661]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]