DEBIO 1452 [Ligand Id: 10755] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1652621 (Afn-1252, AFN-1252, API 1252, DEBIO1452, API-1252, DEBIO-1452)
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Enoyl-ACP reductase in S.aureus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1687683] [UniProtKB: Q5TKS5]
ChEMBL Inhibition of Staphylococcus aureus FabI-mediated reduction of enoyl-ACP preincubated for 30 mins measured after 2 hrs by spectrophotometry B 7.54 pIC50 29 nM IC50 Eur. J. Med. Chem. (2014) 84: 382-394 [PMID:25036796]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]