DEBIO 1452 [Ligand Id: 10755] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1652621 (Afn-1252, AFN-1252, API 1252, API-1252, DEBIO-1452, DEBIO1452) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Enoyl-[acyl-carrier-protein] reductase (FabI) in S.aureus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3994] [UniProtKB: Q6GI75] | ||||||||
| ChEMBL | Inhibition of Staphylococcus aureus FabI-mediated reduction of enoyl-ACP preincubated for 30 mins measured after 2 hrs by spectrophotometry | B | 7.54 | pIC50 | 29 | nM | IC50 | Eur J Med Chem (2014) 84: 382-394 [PMID:25036796] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
