ChEMBL ligand: CHEMBL1652621 (Afabicin desphosphono, Afn-1252, AFN-1252, API 1252, API-1252, DEBIO-1452, DEBIO1452)
Enoyl-[acyl-carrier-protein] reductase (FabI) in S.aureus [ChEMBL: CHEMBL3994] [UniProtKB: Q6GI75] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Enoyl-[acyl-carrier-protein] reductase (FabI) in S.aureus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3994] [UniProtKB: Q6GI75]
ChEMBL	Inhibition of Staphylococcus aureus ATCC 29213 FabI in the presence of NADH using crotonyl CoA as substrate by measuring NADH consumption rate	B	5.02	pIC50	9600	nM	IC50	Eur J Med Chem (2020) 208: 112757-112757 [PMID:32883635]
ChEMBL	Inhibition of Staphylococcus aureus FabI-mediated reduction of enoyl-ACP preincubated for 30 mins measured after 2 hrs by spectrophotometry	B	7.54	pIC50	29	nM	IC50	Eur J Med Chem (2014) 84: 382-394 [PMID:25036796]
ChEMBL	Inhibition of Staphylococcus aureus FabI assessed as inhibition of bacterial growth by measuring the NADH consumption rate at 20 mins	B	7.85	pIC50	14	nM	IC50	Eur J Med Chem (2020) 208: 112757-112757 [PMID:32883635]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]