ChEMBL ligand: CHEMBL31410 (Corynantheine, Corynanthine)
α1A-adrenoceptor/Alpha-1a adrenergic receptor in Human [ChEMBL: CHEMBL229] [GtoPdb: 22] [UniProtKB: P35348] There should be some charts here, you may need to enable JavaScript!
α1B-adrenoceptor/Alpha-1b adrenergic receptor in Human [ChEMBL: CHEMBL232] [GtoPdb: 23] [UniProtKB: P35368] There should be some charts here, you may need to enable JavaScript!
α1D-adrenoceptor/Alpha-1d adrenergic receptor in Human [ChEMBL: CHEMBL223] [GtoPdb: 24] [UniProtKB: P25100] There should be some charts here, you may need to enable JavaScript!
α2A-adrenoceptor/Alpha-2a adrenergic receptor in Human [ChEMBL: CHEMBL1867] [GtoPdb: 25] [UniProtKB: P08913] There should be some charts here, you may need to enable JavaScript!
α2B-adrenoceptor/Alpha-2b adrenergic receptor in Human [ChEMBL: CHEMBL1942] [GtoPdb: 26] [UniProtKB: P18089] There should be some charts here, you may need to enable JavaScript!
α2C-adrenoceptor/Alpha-2c adrenergic receptor in Human [ChEMBL: CHEMBL1916] [GtoPdb: 27] [UniProtKB: P18825] There should be some charts here, you may need to enable JavaScript!
Cav1.2/Voltage-gated L-type calcium channel alpha-1C subunit in Rat [ChEMBL: CHEMBL3762] [GtoPdb: 529] [UniProtKB: P22002] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
α1A-adrenoceptor/Alpha-1a adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL229] [GtoPdb: 22] [UniProtKB: P35348]
ChEMBL	Inhibition of specific [3H]prazosin binding (0.2 nM) to rat brain membranes alpha-1 adrenergic receptor	B	6.6	pKd	251.19	nM	Kd	J. Med. Chem. (1984) 27: 495-503 [PMID:6142954]
ChEMBL	Inhibition of [3H]prazosin binding to human Alpha-1A adrenergic receptor expressed in CHO cells	B	6.85	pKi	142	nM	Ki	J. Med. Chem. (1995) 38: 3681-3716 [PMID:7562902]
ChEMBL	Binding constant measured against Alpha-1A adrenergic receptor in human prostate; ++:moderately active	B	7.54	pKi	29	nM	Ki	Bioorg. Med. Chem. Lett. (2005) 15: 657-664 [PMID:15664832]
α1B-adrenoceptor/Alpha-1b adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL232] [GtoPdb: 23] [UniProtKB: P35368]
ChEMBL	Inhibition of [3H]prazosin binding to human Alpha-1B adrenergic receptor expressed in CHO cells	B	6.29	pKi	517	nM	Ki	J. Med. Chem. (1995) 38: 3681-3716 [PMID:7562902]
α1D-adrenoceptor/Alpha-1d adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL223] [GtoPdb: 24] [UniProtKB: P25100]
ChEMBL	Inhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cells	B	6.6	pKi	253	nM	Ki	J. Med. Chem. (1995) 38: 3681-3716 [PMID:7562902]
α2A-adrenoceptor/Alpha-2a adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1867] [GtoPdb: 25] [UniProtKB: P08913]
ChEMBL	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor	B	5.91	pKi	1218	nM	Ki	J. Med. Chem. (1995) 38: 3681-3716 [PMID:7562902]
α2B-adrenoceptor/Alpha-2b adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1942] [GtoPdb: 26] [UniProtKB: P18089]
ChEMBL	Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptor	B	6.34	pKi	455	nM	Ki	J. Med. Chem. (1995) 38: 3681-3716 [PMID:7562902]
α2C-adrenoceptor/Alpha-2c adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1916] [GtoPdb: 27] [UniProtKB: P18825]
ChEMBL	Inhibition of [3H]rauwolscine to CHO cells expressing the human Alpha-2C adrenergic receptor	B	6.79	pKi	161	nM	Ki	J. Med. Chem. (1995) 38: 3681-3716 [PMID:7562902]
Cav1.2/Voltage-gated L-type calcium channel alpha-1C subunit in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3762] [GtoPdb: 529] [UniProtKB: P22002]
ChEMBL	Inhibition of [3H]nitrendipine binding to membrane homogenates of rat cardiac muscle.	B	5.9	pKi	1250	nM	Ki	J. Med. Chem. (1995) 38: 3681-3716 [PMID:7562902]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]