L-365260 | Ligand Activity Charts | IUPHAR/BPS Guide to PHARMACOLOGY

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L-365260
Ligand Activity Charts

L-365260 [Ligand Id: 879] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL289498
CCK₁ receptor/Cholecystokinin A receptor in Rat [ChEMBL: CHEMBL2871] [GtoPdb: 76] [UniProtKB: P30551] There should be some charts here, you may need to enable JavaScript!
CCK₂ receptor/Cholecystokinin B receptor in Human [ChEMBL: CHEMBL298] [GtoPdb: 77] [UniProtKB: P32239] CCK₂ receptor/Cholecystokinin B receptor in Rat [ChEMBL: CHEMBL3508] [GtoPdb: 77] [UniProtKB: P30553] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
CCK₁ receptor/Cholecystokinin A receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2871] [GtoPdb: 76] [UniProtKB: P30551]
GtoPdb	-	-	6.6	pIC50	-	-	-	Proc Natl Acad Sci USA (1990) 87: 6728-32 [PMID:1975695]
ChEMBL	Displacement of [125 I] CCK-8 from Cholecystokinin type A receptor of rat pancreas	B	8.09	pIC50	8.1	nM	IC50	J Med Chem (1989) 32: 13-16 [PMID:2909725]
CCK₂ receptor/Cholecystokinin B receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL298] [GtoPdb: 77] [UniProtKB: P32239]
ChEMBL	Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex	B	8.15	pIC50	7.1	nM	IC50	J Med Chem (1989) 32: 13-16 [PMID:2909725]
ChEMBL	Displacement of [125I]-gastrin17 from CCK-B receptor (unknown origin)	B	8.28	pIC50	5.2	nM	IC50	Medchemcomm (2017) 8: 1561-1574 [PMID:30108868]
GtoPdb	-	-	8.4	pIC50	3.98	nM	IC50	J Biol Chem (1993) 268: 8164-9 [PMID:7681836]
ChEMBL	Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands	B	8.51	pIC50	3.1	nM	IC50	J Med Chem (1989) 32: 13-16 [PMID:2909725]
CCK₂ receptor/Cholecystokinin B receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3508] [GtoPdb: 77] [UniProtKB: P30553]
ChEMBL	Displacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting method	B	8.42	pIC50	3.8	nM	IC50	Medchemcomm (2017) 8: 1561-1574 [PMID:30108868]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]