L-365260 [Ligand Id: 879] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL289498
  • CCK1 receptor/Cholecystokinin A receptor in Rat [ChEMBL: CHEMBL2871] [GtoPdb: 76] [UniProtKB: P30551]
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  • CCK2 receptor/Cholecystokinin B receptor in Human [ChEMBL: CHEMBL298] [GtoPdb: 77] [UniProtKB: P32239]
  • CCK2 receptor/Cholecystokinin B receptor in Rat [ChEMBL: CHEMBL3508] [GtoPdb: 77] [UniProtKB: P30553]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
CCK1 receptor/Cholecystokinin A receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2871] [GtoPdb: 76] [UniProtKB: P30551]
GtoPdb - - 6.6 pIC50 - - - Proc Natl Acad Sci USA (1990) 87: 6728-32 [PMID:1975695]
ChEMBL Displacement of [125 I] CCK-8 from Cholecystokinin type A receptor of rat pancreas B 8.09 pIC50 8.1 nM IC50 J. Med. Chem. (1989) 32: 13-16 [PMID:2909725]
CCK2 receptor/Cholecystokinin B receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL298] [GtoPdb: 77] [UniProtKB: P32239]
ChEMBL Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex B 8.15 pIC50 7.1 nM IC50 J. Med. Chem. (1989) 32: 13-16 [PMID:2909725]
ChEMBL Displacement of [125I]-gastrin17 from CCK-B receptor (unknown origin) B 8.28 pIC50 5.2 nM IC50 MedChemComm (2017) 8: 1561-1574 [PMID:30108868]
GtoPdb - - 8.4 pIC50 3.98 nM IC50 J Biol Chem (1993) 268: 8164-9 [PMID:7681836]
ChEMBL Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands B 8.51 pIC50 3.1 nM IC50 J. Med. Chem. (1989) 32: 13-16 [PMID:2909725]
CCK2 receptor/Cholecystokinin B receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3508] [GtoPdb: 77] [UniProtKB: P30553]
ChEMBL Displacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting method B 8.42 pIC50 3.8 nM IC50 MedChemComm (2017) 8: 1561-1574 [PMID:30108868]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]