L-365260 [Ligand Id: 879] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL289498 |
|---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CCK1 receptor/Cholecystokinin A receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2871] [GtoPdb: 76] [UniProtKB: P30551] | ||||||||
| GtoPdb | - | - | 6.6 | pIC50 | - | - | - | Proc Natl Acad Sci USA (1990) 87: 6728-32 [PMID:1975695] |
| ChEMBL | Displacement of [125 I] CCK-8 from Cholecystokinin type A receptor of rat pancreas | B | 8.09 | pIC50 | 8.1 | nM | IC50 | J Med Chem (1989) 32: 13-16 [PMID:2909725] |
| CCK2 receptor/Cholecystokinin B receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL298] [GtoPdb: 77] [UniProtKB: P32239] | ||||||||
| ChEMBL | Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex | B | 8.15 | pIC50 | 7.1 | nM | IC50 | J Med Chem (1989) 32: 13-16 [PMID:2909725] |
| ChEMBL | Displacement of [125I]-gastrin17 from CCK-B receptor (unknown origin) | B | 8.28 | pIC50 | 5.2 | nM | IC50 | Medchemcomm (2017) 8: 1561-1574 [PMID:30108868] |
| GtoPdb | - | - | 8.4 | pIC50 | 3.98 | nM | IC50 | J Biol Chem (1993) 268: 8164-9 [PMID:7681836] |
| ChEMBL | Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands | B | 8.51 | pIC50 | 3.1 | nM | IC50 | J Med Chem (1989) 32: 13-16 [PMID:2909725] |
| CCK2 receptor/Cholecystokinin B receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3508] [GtoPdb: 77] [UniProtKB: P30553] | ||||||||
| ChEMBL | Displacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting method | B | 8.42 | pIC50 | 3.8 | nM | IC50 | Medchemcomm (2017) 8: 1561-1574 [PMID:30108868] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
