15-deoxy-Δ-12,14-prostaglandin J2 [Ligand Id: 2692] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL482477
  • Peroxisome proliferator-activated receptor-γ/Peroxisome proliferator-activated receptor gamma in Human [ChEMBL: CHEMBL235] [GtoPdb: 595] [UniProtKB: P37231]
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  • TRPA1/Transient receptor potential cation channel subfamily A member 1 in Human [ChEMBL: CHEMBL6007] [GtoPdb: 485] [UniProtKB: O75762]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Peroxisome proliferator-activated receptor-γ/Peroxisome proliferator-activated receptor gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL235] [GtoPdb: 595] [UniProtKB: P37231]
ChEMBL Binding affinity to PPARgamma B 5.7 pKd 2000 nM Kd J. Med. Chem. (2012) 55: 4027-4061 [PMID:22260081]
GtoPdb - - 6.3 pIC50 - - - Proc. Natl. Acad. Sci. U.S.A. (1997) 94: 4318-23 [PMID:9113987];
Cell (1995) 83: 813-9 [PMID:8521498];
Anal. Biochem. (1998) 257: 112-9 [PMID:9514791];
Cell. Signal. (2002) 14: 573-83 [PMID:11955950];
Biochem. Biophys. Res. Commun. (2005) 337: 521-5 [PMID:16198309]
TRPA1/Transient receptor potential cation channel subfamily A member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6007] [GtoPdb: 485] [UniProtKB: O75762]
ChEMBL Activation of TRPA1 channel B 5.25 pEC50 5600 nM EC50 J. Med. Chem. (2010) 53: 5085-5107 [PMID:20356305]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]