ARL 67156 [Ligand Id: 9030] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1206141 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| ectonucleoside triphosphate diphosphohydrolase 1/Ectonucleoside triphosphate diphosphohydrolase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5722] [GtoPdb: 2888] [UniProtKB: P49961] | ||||||||
| ChEMBL | Competitive inhibition of human CD39 using ATP as substrate preincubated for 3 mins followed by substrate addition and measured after 15 mins by Dixon and Cornish-Bowden plot analysis | B | 4.96 | pKi | 11000 | nM | Ki | J Med Chem (2020) 63: 13444-13465 [PMID:32786396] |
| ectonucleoside triphosphate diphosphohydrolase 1 in Rat [GtoPdb: 2888] [UniProtKB: P97687] | ||||||||
| GtoPdb | - | - | 4.57 | pKi | 27000 | nM | Ki | J Med Chem (2008) 51: 4518-28 [PMID:18630897] |
| Ectonucleoside triphosphate diphosphohydrolase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5897] [UniProtKB: O75355] | ||||||||
| ChEMBL | Competitive inhibition of human NTPDase3 using ATP as substrate preincubated for 3 mins followed by substrate addition and measured after 15 mins by Dixon and Cornish-Bowden plot analysis | B | 4.74 | pKi | 18000 | nM | Ki | J Med Chem (2020) 63: 13444-13465 [PMID:32786396] |
| Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5925] [UniProtKB: P22413] | ||||||||
| ChEMBL | Competitive inhibition of human NPP1 transfected in HEK293 cells using p-Nph-5'-TMP as substrate preincubated for 3 mins followed by substrate addition measured after 15 mins by Cornish-Bowden plot analysis | B | 4.92 | pKi | 12000 | nM | Ki | Bioorg Med Chem (2016) 24: 3157-3165 [PMID:27265686] |
| ChEMBL | Competitive-inhibition of recombinant human NPP1 expressed in HEK293 cell membranes using p-Nph-5'-TMP as substrate pretreated for 3 mins followed by substrate addition and measured after 15 mins by HPLC method | B | 4.92 | pKi | 12000 | nM | Ki | Medchemcomm (2017) 8: 823-840 [PMID:30108800] |
| ChEMBL | Competitive inhibition of human NPP1 using pnp-TMP as substrate preincubated for 3 mins followed by substrate addition and measured after 15 mins by Dixon and Cornish-Bowden plot analysis | B | 4.92 | pKi | 12000 | nM | Ki | J Med Chem (2020) 63: 13444-13465 [PMID:32786396] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
