ChEMBL ligand: CHEMBL1206141
ectonucleoside triphosphate diphosphohydrolase 1/Ectonucleoside triphosphate diphosphohydrolase 1 in Human [ChEMBL: CHEMBL5722] [GtoPdb: 2888] [UniProtKB: P49961] ectonucleoside triphosphate diphosphohydrolase 1 in Rat [GtoPdb: 2888] [UniProtKB: P97687] There should be some charts here, you may need to enable JavaScript!
Ectonucleoside triphosphate diphosphohydrolase 3 in Human [ChEMBL: CHEMBL5897] [UniProtKB: O75355] There should be some charts here, you may need to enable JavaScript!
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 in Human [ChEMBL: CHEMBL5925] [UniProtKB: P22413] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
ectonucleoside triphosphate diphosphohydrolase 1/Ectonucleoside triphosphate diphosphohydrolase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5722] [GtoPdb: 2888] [UniProtKB: P49961]
ChEMBL	Competitive inhibition of human CD39 using ATP as substrate preincubated for 3 mins followed by substrate addition and measured after 15 mins by Dixon and Cornish-Bowden plot analysis	B	4.96	pKi	11000	nM	Ki	J Med Chem (2020) 63: 13444-13465 [PMID:32786396]
ectonucleoside triphosphate diphosphohydrolase 1 in Rat [GtoPdb: 2888] [UniProtKB: P97687]
GtoPdb	-	-	4.57	pKi	27000	nM	Ki	J Med Chem (2008) 51: 4518-28 [PMID:18630897]
Ectonucleoside triphosphate diphosphohydrolase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5897] [UniProtKB: O75355]
ChEMBL	Competitive inhibition of human NTPDase3 using ATP as substrate preincubated for 3 mins followed by substrate addition and measured after 15 mins by Dixon and Cornish-Bowden plot analysis	B	4.74	pKi	18000	nM	Ki	J Med Chem (2020) 63: 13444-13465 [PMID:32786396]
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5925] [UniProtKB: P22413]
ChEMBL	Competitive inhibition of human NPP1 transfected in HEK293 cells using p-Nph-5'-TMP as substrate preincubated for 3 mins followed by substrate addition measured after 15 mins by Cornish-Bowden plot analysis	B	4.92	pKi	12000	nM	Ki	Bioorg. Med. Chem. (2016) 24: 3157-3165 [PMID:27265686]
ChEMBL	Competitive-inhibition of recombinant human NPP1 expressed in HEK293 cell membranes using p-Nph-5'-TMP as substrate pretreated for 3 mins followed by substrate addition and measured after 15 mins by HPLC method	B	4.92	pKi	12000	nM	Ki	MedChemComm (2017) 8: 823-840 [PMID:30108800]
ChEMBL	Competitive inhibition of human NPP1 using pnp-TMP as substrate preincubated for 3 mins followed by substrate addition and measured after 15 mins by Dixon and Cornish-Bowden plot analysis	B	4.92	pKi	12000	nM	Ki	J Med Chem (2020) 63: 13444-13465 [PMID:32786396]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]