ZED1227 [Ligand Id: 12802] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4081588 (Zed-1227, ZED1227) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| transglutaminase 2/Protein-glutamine gamma-glutamyltransferase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2730] [GtoPdb: 3015] [UniProtKB: P21980] | ||||||||
| GtoPdb | - | - | 7.28 | pIC50 | 53 | nM | IC50 | Cells (2022) 11: [PMID:35626704] |
| ChEMBL | Inhibition of human TG2 using glycine methyl ester/Abz-APE as substrate after 5 mins | B | 7.35 | pIC50 | 45 | nM | IC50 | J Med Chem (2017) 60: 554-567 [PMID:28122456] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
