ChEMBL ligand: CHEMBL202721 (TCMDC-125873, ZM-447439)
Aurora kinase B-A in Xenopus laevis [ChEMBL: CHEMBL2176838] [UniProtKB: Q6DE08] There should be some charts here, you may need to enable JavaScript!
cyclin dependent kinase 1/Cyclin-dependent kinase 1 in Human [ChEMBL: CHEMBL308] [GtoPdb: 1961] [UniProtKB: P06493] There should be some charts here, you may need to enable JavaScript!
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533] There should be some charts here, you may need to enable JavaScript!
aurora kinase A/Serine/threonine-protein kinase Aurora-A in Human [ChEMBL: CHEMBL4722] [GtoPdb: 1936] [UniProtKB: O14965] There should be some charts here, you may need to enable JavaScript!
aurora kinase B/Serine/threonine-protein kinase Aurora-B in Human [ChEMBL: CHEMBL2185] [GtoPdb: 1937] [UniProtKB: Q96GD4] There should be some charts here, you may need to enable JavaScript!
polo like kinase 1/Serine/threonine-protein kinase PLK1 in Human [ChEMBL: CHEMBL3024] [GtoPdb: 2168] [UniProtKB: P53350] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Aurora kinase B-A in Xenopus laevis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2176838] [UniProtKB: Q6DE08]
ChEMBL	Inhibition of Xenopus laevis Aurora kinase B/INCEP complex using gamma-[32P]ATP incubated for 1 hr by autoradiography	B	7.35	pIC50	45	nM	IC50	J Med Chem (2012) 55: 7841-7848 [PMID:22920039]
cyclin dependent kinase 1/Cyclin-dependent kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL308] [GtoPdb: 1961] [UniProtKB: P06493]
ChEMBL	Inhibition of in vitro CDK1 kinase activity	B	5	pIC50	>10000	nM	IC50	J Med Chem (2006) 49: 955-970 [PMID:16451062]
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
ChEMBL	Inhibition of EGFR (unknown origin) measured after 40 mins by Kinase Glo luminescence assay	B	6.96	pIC50	110	nM	IC50	Eur J Med Chem (2017) 130: 393-405 [PMID:28279846]
aurora kinase A/Serine/threonine-protein kinase Aurora-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4722] [GtoPdb: 1936] [UniProtKB: O14965]
ChEMBL	Multi-Cycle Kinetic parameter establishment of 8 compounds to gain n=3Completed over 3 identical immbolized CM5 chips	B	6.86	pKd	138.4	nM	Kd	K4DD drug target binding kinetics data
ChEMBL	Multi-Cycle Kinetic parameter establishment of 8 compounds to gain n=3 Completed over 3 identical immbolized CM5 chips	B	7.07	pKd	86.03	nM	Kd	K4DD drug target binding kinetics data
ChEMBL	Inhibition of human Aurora kinase A/TPX2 complex using gamma-[32P]ATP incubated for 1 hr by autoradiography	B	6.44	pIC50	360	nM	IC50	J Med Chem (2012) 55: 7841-7848 [PMID:22920039]
ChEMBL	Inhibition of Aurora-A (unknown origin) using STK substrate 2-biotin by HTRF-KinEASE-STK assay	B	6.86	pIC50	138	nM	IC50	Bioorg Med Chem (2014) 22: 5813-5823 [PMID:25270403]
ChEMBL	Inhibition of aurora A kinase	B	6.96	pIC50	110	nM	IC50	J Med Chem (2009) 52: 2629-2651 [PMID:19320489]
ChEMBL	Inhibition of AURKA (unknown origin)	B	6.96	pIC50	110	nM	IC50	Bioorg Med Chem (2020) 28: 115525-115525 [PMID:32371117]
ChEMBL	Inhibition of Aurora A	B	6.96	pIC50	110	nM	IC50	J Med Chem (2006) 49: 4805-4808 [PMID:16884290]
ChEMBL	Inhibitory activity against Aurora A	B	6.96	pIC50	110	nM	IC50	Bioorg Med Chem Lett (2006) 16: 1320-1323 [PMID:16337122]
ChEMBL	Inhibition of Aurora-A (unknown origin)	B	6.96	pIC50	110	nM	IC50	Bioorg Med Chem (2014) 22: 5813-5823 [PMID:25270403]
ChEMBL	Inhibition of Aurora A kinase (unknown origin)	B	6.96	pIC50	110	nM	IC50	Eur J Med Chem (2017) 140: 1-19 [PMID:28918096]
ChEMBL	Inhibition of human recombinant His6-tagged Aurora A expressed in baculovirus using Biotinyl-Ahx-tetra (LRRWSLG) as substrate incubated for 60 mins by beta scintillation counter	B	6.96	pIC50	110	nM	IC50	Eur J Med Chem (2019) 170: 55-72 [PMID:30878832]
GtoPdb	-	-	7	pIC50	100	nM	IC50	J Cell Biol (2003) 161: 267-80 [PMID:12719470]
ChEMBL	Inhibition of in vitro Aurora-A kinase activity	B	7	pIC50	100	nM	IC50	J Med Chem (2006) 49: 955-970 [PMID:16451062]
aurora kinase B/Serine/threonine-protein kinase Aurora-B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2185] [GtoPdb: 1937] [UniProtKB: Q96GD4]
ChEMBL	Inhibition of Aurora-B (unknown origin) using STK substrate 2-biotin by HTRF-KinEASE-STK assay	B	6.81	pIC50	156	nM	IC50	Bioorg Med Chem (2014) 22: 5813-5823 [PMID:25270403]
ChEMBL	Inhibition of Aurora B (unknown origin) measured after 40 mins by Kinase Glo luminescence assay	B	6.81	pIC50	156	nM	IC50	Eur J Med Chem (2017) 130: 393-405 [PMID:28279846]
ChEMBL	Inhibition of Aurora-B (unknown origin)	B	6.89	pIC50	130	nM	IC50	Bioorg Med Chem (2014) 22: 5813-5823 [PMID:25270403]
ChEMBL	Inhibition of AURKB (unknown origin)	B	6.89	pIC50	130	nM	IC50	Bioorg Med Chem (2020) 28: 115525-115525 [PMID:32371117]
ChEMBL	Inhibition of aurora B kinase	B	6.89	pIC50	130	nM	IC50	J Med Chem (2009) 52: 2629-2651 [PMID:19320489]
ChEMBL	Inhibition of recombinant aurora B (unknown origin)	B	6.89	pIC50	130	nM	IC50	Eur J Med Chem (2017) 140: 1-19 [PMID:28918096]
ChEMBL	Inhibition of human recombinant His6-tagged Aurora B expressed in baculovirus using Biotinyl-Ahx-tetra (LRRWSLG) as substrate incubated for 60 mins by beta scintillation counter	B	6.89	pIC50	130	nM	IC50	Eur J Med Chem (2019) 170: 55-72 [PMID:30878832]
GtoPdb	-	-	7	pIC50	100	nM	IC50	J Cell Biol (2003) 161: 267-80 [PMID:12719470]
ChEMBL	Inhibition of in vitro Aurora-B kinase activity	B	7	pIC50	100	nM	IC50	J Med Chem (2006) 49: 955-970 [PMID:16451062]
ChEMBL	Inhibition of human Aurora kinase B/INCEP complex expressed in Escherichia coli BL21 (DE3) using gamma-[32P]ATP incubated for 1 hr by autoradiography	B	7.29	pIC50	51	nM	IC50	J Med Chem (2012) 55: 7841-7848 [PMID:22920039]
polo like kinase 1/Serine/threonine-protein kinase PLK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3024] [GtoPdb: 2168] [UniProtKB: P53350]
ChEMBL	Inhibition of in vitro Plk1 kinase activity	B	5	pIC50	>10000	nM	IC50	J Med Chem (2006) 49: 955-970 [PMID:16451062]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]