ChEMBL ligand: CHEMBL202721 (TCMDC-125873, ZM-447439)
Aurora kinase B-A in Xenopus laevis [ChEMBL: CHEMBL2176838] [UniProtKB: Q6DE08] There should be some charts here, you may need to enable JavaScript!
cyclin dependent kinase 1/Cyclin-dependent kinase 1 in Human [ChEMBL: CHEMBL308] [GtoPdb: 1961] [UniProtKB: P06493] There should be some charts here, you may need to enable JavaScript!
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533] There should be some charts here, you may need to enable JavaScript!
aurora kinase A/Serine/threonine-protein kinase Aurora-A in Human [ChEMBL: CHEMBL4722] [GtoPdb: 1936] [UniProtKB: O14965] There should be some charts here, you may need to enable JavaScript!
aurora kinase B/Serine/threonine-protein kinase Aurora-B in Human [ChEMBL: CHEMBL2185] [GtoPdb: 1937] [UniProtKB: Q96GD4] There should be some charts here, you may need to enable JavaScript!
polo like kinase 1/Serine/threonine-protein kinase PLK1 in Human [ChEMBL: CHEMBL3024] [GtoPdb: 2168] [UniProtKB: P53350] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Aurora kinase B-A in Xenopus laevis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2176838] [UniProtKB: Q6DE08]
ChEMBL	Inhibition of Xenopus laevis Aurora kinase B/INCEP complex using gamma-[32P]ATP incubated for 1 hr by autoradiography	B	7.35	pIC50	45	nM	IC50	J Med Chem (2012) 55: 7841-7848 [PMID:22920039]
cyclin dependent kinase 1/Cyclin-dependent kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL308] [GtoPdb: 1961] [UniProtKB: P06493]
ChEMBL	Inhibition of in vitro CDK1 kinase activity	B	5	pIC50	>10000	nM	IC50	J Med Chem (2006) 49: 955-970 [PMID:16451062]
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
ChEMBL	Inhibition of EGFR (unknown origin) measured after 40 mins by Kinase Glo luminescence assay	B	6.96	pIC50	110	nM	IC50	Eur J Med Chem (2017) 130: 393-405 [PMID:28279846]
aurora kinase A/Serine/threonine-protein kinase Aurora-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4722] [GtoPdb: 1936] [UniProtKB: O14965]
ChEMBL	Multi-Cycle Kinetic parameter establishment of 8 compounds to gain n=3Completed over 3 identical immbolized CM5 chips	B	6.86	pKd	138.4	nM	Kd	K4DD drug target binding kinetics data
ChEMBL	Multi-Cycle Kinetic parameter establishment of 8 compounds to gain n=3 Completed over 3 identical immbolized CM5 chips	B	7.07	pKd	86.03	nM	Kd	K4DD drug target binding kinetics data
ChEMBL	Inhibition of human Aurora kinase A/TPX2 complex using gamma-[32P]ATP incubated for 1 hr by autoradiography	B	6.44	pIC50	360	nM	IC50	J Med Chem (2012) 55: 7841-7848 [PMID:22920039]
ChEMBL	Inhibition of Aurora-A (unknown origin) using STK substrate 2-biotin by HTRF-KinEASE-STK assay	B	6.86	pIC50	138	nM	IC50	Bioorg Med Chem (2014) 22: 5813-5823 [PMID:25270403]
ChEMBL	Inhibition of aurora A kinase	B	6.96	pIC50	110	nM	IC50	J Med Chem (2009) 52: 2629-2651 [PMID:19320489]
ChEMBL	Inhibitory activity against Aurora A	B	6.96	pIC50	110	nM	IC50	Bioorg Med Chem Lett (2006) 16: 1320-1323 [PMID:16337122]
ChEMBL	Inhibition of Aurora A	B	6.96	pIC50	110	nM	IC50	J Med Chem (2006) 49: 4805-4808 [PMID:16884290]
ChEMBL	Inhibition of human recombinant His6-tagged Aurora A expressed in baculovirus using Biotinyl-Ahx-tetra (LRRWSLG) as substrate incubated for 60 mins by beta scintillation counter	B	6.96	pIC50	110	nM	IC50	Eur J Med Chem (2019) 170: 55-72 [PMID:30878832]
ChEMBL	Inhibition of AURKA (unknown origin)	B	6.96	pIC50	110	nM	IC50	Bioorg Med Chem (2020) 28: 115525-115525 [PMID:32371117]
ChEMBL	Inhibition of Aurora-A (unknown origin)	B	6.96	pIC50	110	nM	IC50	Bioorg Med Chem (2014) 22: 5813-5823 [PMID:25270403]
ChEMBL	Inhibition of Aurora A kinase (unknown origin)	B	6.96	pIC50	110	nM	IC50	Eur J Med Chem (2017) 140: 1-19 [PMID:28918096]
GtoPdb	-	-	7	pIC50	100	nM	IC50	J Cell Biol (2003) 161: 267-80 [PMID:12719470]
ChEMBL	Inhibition of in vitro Aurora-A kinase activity	B	7	pIC50	100	nM	IC50	J Med Chem (2006) 49: 955-970 [PMID:16451062]
ChEMBL	Inhibition of human Aurora A kinase	B	7	pIC50	100	nM	IC50	Eur J Med Chem (2021) 211: 113016-113016 [PMID:33243532]
aurora kinase B/Serine/threonine-protein kinase Aurora-B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2185] [GtoPdb: 1937] [UniProtKB: Q96GD4]
ChEMBL	Inhibition of Aurora-B (unknown origin) using STK substrate 2-biotin by HTRF-KinEASE-STK assay	B	6.81	pIC50	156	nM	IC50	Bioorg Med Chem (2014) 22: 5813-5823 [PMID:25270403]
ChEMBL	Inhibition of Aurora B (unknown origin) measured after 40 mins by Kinase Glo luminescence assay	B	6.81	pIC50	156	nM	IC50	Eur J Med Chem (2017) 130: 393-405 [PMID:28279846]
ChEMBL	Inhibition of AURKB (unknown origin)	B	6.89	pIC50	130	nM	IC50	Bioorg Med Chem (2020) 28: 115525-115525 [PMID:32371117]
ChEMBL	Inhibition of human recombinant His6-tagged Aurora B expressed in baculovirus using Biotinyl-Ahx-tetra (LRRWSLG) as substrate incubated for 60 mins by beta scintillation counter	B	6.89	pIC50	130	nM	IC50	Eur J Med Chem (2019) 170: 55-72 [PMID:30878832]
ChEMBL	Inhibition of Aurora-B (unknown origin)	B	6.89	pIC50	130	nM	IC50	Bioorg Med Chem (2014) 22: 5813-5823 [PMID:25270403]
ChEMBL	Inhibition of recombinant aurora B (unknown origin)	B	6.89	pIC50	130	nM	IC50	Eur J Med Chem (2017) 140: 1-19 [PMID:28918096]
ChEMBL	Inhibition of aurora B kinase	B	6.89	pIC50	130	nM	IC50	J Med Chem (2009) 52: 2629-2651 [PMID:19320489]
GtoPdb	-	-	7	pIC50	100	nM	IC50	J Cell Biol (2003) 161: 267-80 [PMID:12719470]
ChEMBL	Inhibition of human Aurora B kinase	B	7	pIC50	100	nM	IC50	Eur J Med Chem (2021) 211: 113016-113016 [PMID:33243532]
ChEMBL	Inhibition of in vitro Aurora-B kinase activity	B	7	pIC50	100	nM	IC50	J Med Chem (2006) 49: 955-970 [PMID:16451062]
ChEMBL	Inhibition of human Aurora kinase B/INCEP complex expressed in Escherichia coli BL21 (DE3) using gamma-[32P]ATP incubated for 1 hr by autoradiography	B	7.29	pIC50	51	nM	IC50	J Med Chem (2012) 55: 7841-7848 [PMID:22920039]
polo like kinase 1/Serine/threonine-protein kinase PLK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3024] [GtoPdb: 2168] [UniProtKB: P53350]
ChEMBL	Inhibition of in vitro Plk1 kinase activity	B	5	pIC50	>10000	nM	IC50	J Med Chem (2006) 49: 955-970 [PMID:16451062]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]