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Molecular properties generated using the CDK
|Compound class||Synthetic organic|
|compound 7b [PMID: 31414801] | SS208|
|SS-208 is reported as an isotype selective inhibitor of histone deacetylase 6 (HDAC6) . It has been developed for potential to treat advanced melanoma. SS-208 has been designed to provide improved HDAC6 selectivity compared to ricolinostat and citarinostat which both exhibit unfavourable levels of HDAC1 inhibition.
Selective pharmacological inhibition or genetic abrogation of HDAC6 modulates immune checkpoint activity by downregulating the expression of PD-L1 via the recruitment and activation of STAT3 . The antitumour activity of SS-208 in vivo is primarily mediated by activation of immune cells and an anti-tumour immune response in the tumour microenvironment.
|GtoPdb PubChem SID||385612249|
|RCSB PDB Ligand||JNN|
|Search Google for chemical match using the InChIKey||JFGOILLZIAIYGA-UHFFFAOYSA-N|
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