α-ketoglutaric acid [Ligand Id: 3636] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL1686 (2-Oxoglutarate, 2-Oxopentanedioic Acid, Alpha-Ketoglutarate)
  • egl-9 family hypoxia inducible factor 1/Egl nine homolog 1 in Human [ChEMBL: CHEMBL5697] [GtoPdb: 2833] [UniProtKB: Q9GZT9]
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
  • oxoglutarate receptor in Human [GtoPdb: 162] [UniProtKB: Q96P68]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
egl-9 family hypoxia inducible factor 1/Egl nine homolog 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5697] [GtoPdb: 2833] [UniProtKB: Q9GZT9]
ChEMBL Binding affinity to human PHD2-Mn(II) using 12.5% H2O/87.5% D2O MQC spectrometer operated at 500 MHz at 313K temperature B 5.66 pKd 2200 nM Kd J Med Chem (2010) 53: 867-875 [PMID:20025281]
ChEMBL Binding affinity to human PHD2 catalytic domain (181 to 426) Zn2 expressed in Escherichia coli by 1H-15N HSQC titration assay B 5.7 pKd <2000 nM Kd J Med Chem (2013) 56: 547-555 [PMID:23234607]
ChEMBL Binding affinity to human PHD2-Mn(II) using 100% H2O MQC spectrometer operated at 23 MHz at 313K temperature B 5.77 pKd 1700 nM Kd J Med Chem (2010) 53: 867-875 [PMID:20025281]
ChEMBL Binding affinity to human PHD2-Mn(II) using 12.5% H2O/87.5% D2O MQC spectrometer operated at 500 MHz at 298K temperature in presence of HIF1alpha (556-574) CODD fragment B 6 pKd 1000 nM Kd J Med Chem (2010) 53: 867-875 [PMID:20025281]
ChEMBL Binding affinity to human PHD2-Mn(II) using 12.5% H2O/87.5% D2O MQC spectrometer operated at 500 MHz at 298K temperature B 6.05 pKd 900 nM Kd J Med Chem (2010) 53: 867-875 [PMID:20025281]
ChEMBL Binding affinity to human PHD2 by nondenaturing ESI-MS B 6.05 pKd 900 nM Kd J Med Chem (2010) 53: 867-875 [PMID:20025281]
ChEMBL Binding affinity to human PHD2 catalytic domain (181 to 426) Mn2 expressed in Escherichia coli by 1H-15N HSQC titration assay B 6.05 pKd 900 nM Kd J Med Chem (2013) 56: 547-555 [PMID:23234607]
Olfactory receptor 51E2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523454] [UniProtKB: Q9H255]
ChEMBL Agonist activity at PSGR/OR51E2 (unknown origin) expressed in human Hana3A cells co-transfected with CRE-Luc by luciferase reporter gene assay F 8.26 pEC50 5.5 nM EC50 US-20180116992-A1. Modulators of Prostate-Specific G-Protein Receptor (PSGR/OR51E2) and Methods of Using Same (null)
oxoglutarate receptor in Human [GtoPdb: 162] [UniProtKB: Q96P68]
GtoPdb - - 4.49 pEC50 32000 nM EC50 Nature (2004) 429: 188-93 [PMID:15141213];
J Biomol Screen (2013) 18: 599-609 [PMID:23396314]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]