ChEMBL ligand: CHEMBL1686 (2-Oxoglutarate, 2-Oxopentanedioic Acid, Alpha-Ketoglutarate)
egl-9 family hypoxia inducible factor 1/Egl nine homolog 1 in Human [ChEMBL: CHEMBL5697] [GtoPdb: 2833] [UniProtKB: Q9GZT9] There should be some charts here, you may need to enable JavaScript!
Olfactory receptor 51E2 in Human [ChEMBL: CHEMBL4523454] [UniProtKB: Q9H255] There should be some charts here, you may need to enable JavaScript!
Na+/dicarboxylate cotransporter 3/Solute carrier family 13 member 3 in Human [ChEMBL: CHEMBL3712947] [GtoPdb: 979] [UniProtKB: Q8WWT9] There should be some charts here, you may need to enable JavaScript!
oxoglutarate receptor in Human [GtoPdb: 162] [UniProtKB: Q96P68] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
egl-9 family hypoxia inducible factor 1/Egl nine homolog 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5697] [GtoPdb: 2833] [UniProtKB: Q9GZT9]
ChEMBL	Binding affinity to human PHD2-Mn(II) using 12.5% H2O/87.5% D2O MQC spectrometer operated at 500 MHz at 313K temperature	B	5.66	pKd	2200	nM	Kd	J Med Chem (2010) 53: 867-875 [PMID:20025281]
ChEMBL	Binding affinity to human PHD2 catalytic domain (181 to 426) Zn2 expressed in Escherichia coli by 1H-15N HSQC titration assay	B	5.7	pKd	<2000	nM	Kd	J Med Chem (2013) 56: 547-555 [PMID:23234607]
ChEMBL	Binding affinity to human PHD2-Mn(II) using 100% H2O MQC spectrometer operated at 23 MHz at 313K temperature	B	5.77	pKd	1700	nM	Kd	J Med Chem (2010) 53: 867-875 [PMID:20025281]
ChEMBL	Binding affinity to human PHD2-Mn(II) using 12.5% H2O/87.5% D2O MQC spectrometer operated at 500 MHz at 298K temperature in presence of HIF1alpha (556-574) CODD fragment	B	6	pKd	1000	nM	Kd	J Med Chem (2010) 53: 867-875 [PMID:20025281]
ChEMBL	Binding affinity to human PHD2-Mn(II) using 12.5% H2O/87.5% D2O MQC spectrometer operated at 500 MHz at 298K temperature	B	6.05	pKd	900	nM	Kd	J Med Chem (2010) 53: 867-875 [PMID:20025281]
ChEMBL	Binding affinity to human PHD2 by nondenaturing ESI-MS	B	6.05	pKd	900	nM	Kd	J Med Chem (2010) 53: 867-875 [PMID:20025281]
ChEMBL	Binding affinity to human PHD2 catalytic domain (181 to 426) Mn2 expressed in Escherichia coli by 1H-15N HSQC titration assay	B	6.05	pKd	900	nM	Kd	J Med Chem (2013) 56: 547-555 [PMID:23234607]
Olfactory receptor 51E2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523454] [UniProtKB: Q9H255]
ChEMBL	Agonist activity at PSGR/OR51E2 (unknown origin) expressed in human Hana3A cells co-transfected with CRE-Luc by luciferase reporter gene assay	F	8.26	pEC50	5.5	nM	EC50	US-20180116992-A1. Modulators of Prostate-Specific G-Protein Receptor (PSGR/OR51E2) and Methods of Using Same (2018)
Na+/dicarboxylate cotransporter 3/Solute carrier family 13 member 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3712947] [GtoPdb: 979] [UniProtKB: Q8WWT9]
ChEMBL	Substrate uptake by the Na(+)/Dicarboxylate Cotransporter 3 (NADC3, SLC13A3) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC13A3 cells (PubChem AID: 1794820)	F	4.27	pEC50	54000	nM	EC50	Membrane potential based assay for SLC13A3 using HEK-293 SLC13A3 OE cells
oxoglutarate receptor in Human [GtoPdb: 162] [UniProtKB: Q96P68]
GtoPdb	-	-	4.49	pEC50	32000	nM	EC50	Nature (2004) 429: 188-93 [PMID:15141213]; J Biomol Screen (2013) 18: 599-609 [PMID:23396314]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]