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Synonyms: Heartgard® | ivermectin B1a | MK-933 | Sklice® | Soolantra®
ivermectin is an approved drug (FDA (1996), UK (2015))
Compound class: Synthetic organic
Comment: Ivermectin is a broad-spectrum anti-parasitic drug. The approved drug is a mixture of mainly avermectin H2B1a (CAS # 71827-03-7) with some avermectin H2B1b (CAS # 70209-81-3). The avermectins are bacterial marcrolides isolated from Streptomyces avermitilis.
SARS-CoV-2 and COVID-19: There is speculation that ivermectin could be used to treat COVID-19, which is principally founded on in vitro evidence of anti-viral activity, and limited evidence of anti-inflammatory action. The evidence that ivermectin is appropriate to prevent or treat coronavirus infection is not compelling. To date (Jan 2021) there is no persuasive efficacy data available from an adequately sized, appropriately designed and controlled randomised clinical trial.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|Compound class||Synthetic organic|
|Approved drug?||Yes (FDA (1996), UK (2015))|
|WHO Essential Medicine||WHO Essential Medicines List (EML) (22nd List, 2021). Access PDF version.
Click to view more information about the WHO Model Lists of Essential Medicines.
|International Nonproprietary Names|
|Heartgard® | ivermectin B1a | MK-933 | Sklice® | Soolantra®|
|CAS Registry No.||70288-86-7 (source: Scifinder)|
|GtoPdb PubChem SID||135650439|
|Search Google for chemical match using the InChIKey||AZSNMRSAGSSBNP-ZLRQRZFZSA-N|
|Search Google for chemicals with the same backbone||AZSNMRSAGSSBNP|
|Search PubMed clinical trials||ivermectin|
|Search PubMed titles||ivermectin|
|Search PubMed titles/abstracts||ivermectin|
|UniChem Compound Search for chemical match using the InChIKey||AZSNMRSAGSSBNP-ZLRQRZFZSA-N|
|UniChem Connectivity Search for chemical match using the InChIKey||AZSNMRSAGSSBNP-ZLRQRZFZSA-N|