ivermectin   Click here for help

GtoPdb Ligand ID: 2373

Synonyms: Heartgard® | ivermectin B1a | MK-933 | Sklice® | Soolantra®
Approved drug
ivermectin is an approved drug (FDA (1996), UK (2015))
Compound class: Synthetic organic
Comment: Ivermectin is a broad-spectrum anti-parasitic drug. The approved drug is a mixture of mainly avermectin H2B1a (CAS # 71827-03-7) with some avermectin H2B1b (CAS # 70209-81-3). The avermectins are bacterial marcrolides isolated from Streptomyces avermitilis.

SARS-CoV-2 and COVID-19: There is speculation that ivermectin could be used to treat COVID-19, which is principally founded on in vitro evidence of anti-viral activity, and limited evidence of anti-inflammatory action. The evidence that ivermectin is appropriate to prevent or treat coronavirus infection is not compelling. To date (Jan 2021) there is no persuasive efficacy data available from an adequately sized, appropriately designed and controlled randomised clinical trial.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 14
Hydrogen bond donors 3
Rotatable bonds 8
Topological polar surface area 170.06
Molecular weight 874.51
XLogP 2.84
No. Lipinski's rules broken 1
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Isomeric SMILES CO[C@H]1C[C@H](OC2C(C)/C=C/C=C/3\COC4C3(O)[C@@H](C=C([C@H]4O)C)C(=O)O[C@H]3CC(C/C=C/2\C)O[C@]2(C3)CCC(C(O2)C(CC)C)C)O[C@H](C1O[C@H]1C[C@H](OC)C([C@@H](O1)C)O)C
InChI InChI=1S/C48H74O14/c1-11-25(2)43-28(5)17-18-47(62-43)23-34-20-33(61-47)16-15-27(4)42(26(3)13-12-14-32-24-55-45-40(49)29(6)19-35(46(51)58-34)48(32,45)52)59-39-22-37(54-10)44(31(8)57-39)60-38-21-36(53-9)41(50)30(7)56-38/h12-15,19,25-26,28,30-31,33-45,49-50,52H,11,16-18,20-24H2,1-10H3/b13-12+,27-15+,32-14+/t25?,26?,28?,30-,31-,33?,34-,35-,36-,37-,38-,39-,40+,41?,42?,43?,44?,45?,47+,48?/m0/s1
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA (1996), UK (2015))
WHO Essential Medicine WHO Essential Medicines List (EML) (23rd List, 2023). Access PDF version.
Click to view more information about the WHO Model Lists of Essential Medicines.
IUPAC Name Click here for help
International Nonproprietary Names Click here for help
INN number INN
4828 ivermectin
Synonyms Click here for help
Heartgard® | ivermectin B1a | MK-933 | Sklice® | Soolantra®
Database Links Click here for help
Specialist databases
Antibiotic DB Antibiotic DB Database logo Ivermectin/Colistin
Other databases
CAS Registry No. 70288-86-7 (source: Scifinder)
DrugBank Ligand DB00602
GtoPdb PubChem SID 135650439
PubChem CID 6427057
Search Google for chemical match using the InChIKey AZSNMRSAGSSBNP-ZLRQRZFZSA-N
Search Google for chemicals with the same backbone AZSNMRSAGSSBNP
Search PubMed clinical trials ivermectin
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UniChem Compound Search for chemical match using the InChIKey AZSNMRSAGSSBNP-ZLRQRZFZSA-N
UniChem Connectivity Search for chemical match using the InChIKey AZSNMRSAGSSBNP-ZLRQRZFZSA-N
Wikipedia Ivermectin