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ChEMBL ligand: CHEMBL34241 (Rottlerin) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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chymotrypsinogen B1/Beta-chymotrypsin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4796] [GtoPdb: 3272] [UniProtKB: P17538] | ||||||||
ChEMBL | Inhibitory activity against Chymotrypsinogen from Thermus flavus | B | 4.6 | pIC50 | 25000 | nM | IC50 | J Med Chem (2003) 46: 1478-1483 [PMID:12672248] |
Beta-lactamase in Enterobacter cloacae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2725] [UniProtKB: P05364] | ||||||||
ChEMBL | Inhibition of Enterobacter cloacae beta-lactamase incubated for 10 mins followed by nitrocefin substrate challenge and measured for 5 mins by spectrophotometric analysis | B | 4.02 | pIC50 | 96000 | nM | IC50 | ACS Med Chem Lett (2019) 10: 923-928 [PMID:31223449] |
Beta-lactamase AmpC in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2026] [UniProtKB: P00811] | ||||||||
ChEMBL | Inhibition of 30 nM AmpC beta lactamase | B | 4.12 | pIC50 | 76000 | nM | IC50 | J Med Chem (2006) 49: 7274-7277 [PMID:17149857] |
ChEMBL | Inhibition of 10 nM AmpC beta lactamase | B | 4.68 | pIC50 | 21000 | nM | IC50 | J Med Chem (2006) 49: 7274-7277 [PMID:17149857] |
ChEMBL | Inhibition of 1 nM AmpC beta lactamase | B | 5.74 | pIC50 | 1800 | nM | IC50 | J Med Chem (2006) 49: 7274-7277 [PMID:17149857] |
ChEMBL | Inhibitory activity against Amp C beta-Lactamase | B | 5.92 | pIC50 | 1200 | nM | IC50 | J Med Chem (2003) 46: 4265-4272 [PMID:13678405] |
Malate dehydrogenase in Thermus thermophilus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4255] [UniProtKB: P10584] | ||||||||
ChEMBL | Inhibitory activity against malate dehydrogenase (MDH) from Thermus flavus | B | 6.15 | pIC50 | 700 | nM | IC50 | J Med Chem (2003) 46: 1478-1483 [PMID:12672248] |
MAPK activated protein kinase 2/MAP kinase-activated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2208] [GtoPdb: 2094] [UniProtKB: P49137] | ||||||||
ChEMBL | Inhibition of His-tagged human MAPKAPK2 expressed in Escherichia coli at 10 uM | B | 5.27 | pIC50 | 5400 | nM | IC50 | Biochem J (2000) 351: 95-105 [PMID:10998351] |
MAPK activated protein kinase 5/MAP kinase-activated protein kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3094] [GtoPdb: 2096] [UniProtKB: Q8IW41] | ||||||||
ChEMBL | Inhibition of p38-regulated activated kinase (PRAK) | B | 5.72 | pIC50 | 1900 | nM | IC50 | J Med Chem (2003) 46: 1478-1483 [PMID:12672248] |
ChEMBL | Inhibition of His-tagged human PRAK expressed in Sf9 cells | B | 5.72 | pIC50 | 1900 | nM | IC50 | Biochem J (2000) 351: 95-105 [PMID:10998351] |
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
ChEMBL | Antiplasmodial activity against Plasmodium falciparum Dd2 after 72 hrs by SYBR green assay | F | 5 | pIC50 | 10000 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
ChEMBL | Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by SYBR green assay | F | 5 | pIC50 | 10000 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
ChEMBL | Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay | F | 5.3 | pIC50 | 5011.87 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
ChEMBL | Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay | F | 5.4 | pIC50 | 3981.07 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
ChEMBL | Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay | F | 5.5 | pIC50 | 3162.28 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
ChEMBL | Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay | F | 5.5 | pIC50 | 3162.28 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
ChEMBL | Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay | F | 5.5 | pIC50 | 3162.28 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
protein kinase C delta/Protein kinase C delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2996] [GtoPdb: 1485] [UniProtKB: Q05655] | ||||||||
GtoPdb | - | - | 5.52 | pIC50 | 3020 | nM | IC50 | Biochem Biophys Res Commun (1994) 199: 93-8 [PMID:8123051] |
ChEMBL | Inhibition of Protein kinase C delta (PKCdelta) | B | 5.52 | pIC50 | 3000 | nM | IC50 | J Med Chem (2003) 46: 1478-1483 [PMID:12672248] |
eukaryotic elongation factor 2 kinase/Serine/threonine-protein kinase EEF2K in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5026] [GtoPdb: 2014] [UniProtKB: O00418] | ||||||||
ChEMBL | Inhibition of eEF2K (unknown origin) | B | 5.28 | pIC50 | 5300 | nM | IC50 | Eur J Med Chem (2020) 204: 112505-112505 [PMID:32717479] |
ubiquitin specific peptidase 1/Ubiquitin carboxyl-terminal hydrolase 1/WD repeat-containing protein 48 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3430885] [GtoPdb: 2428] [UniProtKB: O94782, Q8TAF3] | ||||||||
ChEMBL | Inhibition of human USP1/UAF1 complex using Ub-Rho as substrate by qHTS assay | B | 5.1 | pIC50 | 8000 | nM | IC50 | J Med Chem (2016) 59: 9321-9336 [PMID:27362876] |
Kv11.1 in Human [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
GtoPdb | - | - | 6.5 | pEC50 | - | - | - | J Pharmacol Exp Ther (2006) 319: 957-62 [PMID:16928897] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]