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Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | - | 858 | 19p13.3 | EEF2 | eukaryotic translation elongation factor 2 | |
| Mouse | - | 858 | 10 C1 | Eef2 | eukaryotic translation elongation factor 2 | |
| Rat | - | 858 | 7q11 | Eef2 | eukaryotic translation elongation factor 2 | |
| Gene and Protein Information Comments | ||||||
| The Antimalarial targets family provides information about P. falciparum eEF2. | ||||||
| Previous and Unofficial Names |
| EEF-2 | polypeptidyl-tRNA translocase |
| Database Links |
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| Alphafold | P13639 (Hs), P58252 (Mm), P05197 (Rn) |
| CATH/Gene3D | 3.30.230.10 |
| ChEMBL Target | CHEMBL1795108 (Hs) |
| Ensembl Gene | ENSG00000167658 (Hs), ENSMUSG00000034994 (Mm), ENSRNOG00000020266 (Rn) |
| Entrez Gene | 1938 (Hs), 13629 (Mm), 29565 (Rn) |
| Human Protein Atlas | ENSG00000167658 (Hs) |
| KEGG Gene | hsa:1938 (Hs), mmu:13629 (Mm), rno:29565 (Rn) |
| OMIM | 130610 (Hs) |
| Pharos | P13639 (Hs) |
| RefSeq Nucleotide | NM_001961 (Hs), NM_007907 (Mm), NM_017245 (Rn) |
| RefSeq Protein | NP_001952 (Hs), NP_031933 (Mm), NP_058941 (Rn) |
| UniProtKB | P13639 (Hs), P58252 (Mm), P05197 (Rn) |
| Wikipedia | EEF2 (Hs) |
| Inhibitor Comments | ||
| Denileukin diftitox is an immunotoxic inhibitor of EEF2 (elongation factor 2). EEF2 is the primary target of the diptheria toxin [2,4] liberated upon intracellular processing of the endocytically internalised drug [3]. Denileukin diftitox inhibits protein synthesis in IL-2 receptor +ve cells (human C91/PL T cells) with an IC50 of 0.01nM [1] but protein synthesis is not inhibited in IL-2 receptor -ve cells in the same study. |
| Immuno Process Associations | ||
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| Clinically-Relevant Mutations and Pathophysiology
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1. Bacha P, Williams DP, Waters C, Williams JM, Murphy JR, Strom TB. (1988) Interleukin 2 receptor-targeted cytotoxicity. Interleukin 2 receptor-mediated action of a diphtheria toxin-related interleukin 2 fusion protein. J Exp Med, 167 (2): 612-22. [PMID:3126255]
2. Deng Q, Barbieri JT. (2008) Molecular mechanisms of the cytotoxicity of ADP-ribosylating toxins. Annu Rev Microbiol, 62: 271-88. [PMID:18785839]
3. Jørgensen R, Merrill AR, Yates SP, Marquez VE, Schwan AL, Boesen T, Andersen GR. (2005) Exotoxin A-eEF2 complex structure indicates ADP ribosylation by ribosome mimicry. Nature, 436 (7053): 979-84. [PMID:16107839]
4. Jørgensen R, Purdy AE, Fieldhouse RJ, Kimber MS, Bartlett DH, Merrill AR. (2008) Cholix toxin, a novel ADP-ribosylating factor from Vibrio cholerae. J Biol Chem, 283 (16): 10671-8. [PMID:18276581]
Ribosomal factors: eukaryotic translation elongation factor 2. Last modified on 11/03/2019. Accessed on 24/01/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2756.
