Synonyms: GSK286
Compound class:
Synthetic organic
Comment: GSK2556286 is a substituted 4-aryloxypiperidine identified from a screen of compounds that inhibit intracellular growth of Mycobacterium tuberculosis in human macrophage-like differentiated monocytes (THP-1 cell line) [2]. It has a novel cholesterol-dependent mechanism of action, with recent studies establishing it as an agonist of mycobacterial Rv1625c, a membrane-bound adenylyl cyclase [1-2]. GSK2556286 is under clinical development as a potential treatment for tuberculosis (TB).
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Classification | |
Compound class | Synthetic organic |
IUPAC Name |
6-[[4-(2,3-dimethylphenoxy)piperidin-1-yl]methyl]-1H-pyrimidine-2,4-dione |
Synonyms |
GSK286 |
Database Links | |
Specialist databases | |
Antibiotic DB | GSK2556286, GSK286 |
Other databases | |
CAS Registry No. | 1210456-20-4 (source: Scifinder) |
ChEMBL Ligand | CHEMBL4650308 |
GtoPdb PubChem SID | 491299860 |
PubChem CID | 45833762 |
Search Google for chemical match using the InChIKey | AZOFJHATIPDIER-UHFFFAOYSA-N |
Search Google for chemicals with the same backbone | AZOFJHATIPDIER |
UniChem Compound Search for chemical match using the InChIKey | AZOFJHATIPDIER-UHFFFAOYSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | AZOFJHATIPDIER-UHFFFAOYSA-N |