mepacrine   Click here for help

GtoPdb Ligand ID: 10172

Synonyms: Atabrine® | quinacrine
PDB Ligand Immunopharmacology Ligand Antimalarial Ligand
Compound class: Synthetic organic
Comment: Mepacrine is an acridine derivative with antiprotozoal activity. Historically used as an antimalarial drug it is now used off-license as an immunomodulatory agent.

The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 9
Topological polar surface area 37.39
Molecular weight 399.21
XLogP 5.54
No. Lipinski's rules broken 1
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES CCN(CCCC(Nc1c2cc(OC)ccc2nc2c1ccc(c2)Cl)C)CC
Isomeric SMILES CCN(CCCC(Nc1c2cc(OC)ccc2nc2c1ccc(c2)Cl)C)CC
InChI InChI=1S/C23H30ClN3O/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26)
InChI Key GPKJTRJOBQGKQK-UHFFFAOYSA-N
Classification Click here for help
Compound class Synthetic organic
Ligand families/groups Antimalarial ligands
IUPAC Name Click here for help
N'-(6-chloro-2-methoxyacridin-9-yl)-N,N-diethylpentane-1,4-diamine
International Nonproprietary Names Click here for help
INN number INN
396 mepacrine
Synonyms Click here for help
Atabrine® | quinacrine
Database Links Click here for help
Specialist databases
Reactome Drug Reactome logo R-ALL-9695421
Reactome Reaction Reactome logo R-HSA-9695415
Other databases
CAS Registry No. 83-89-6 (source: Scifinder)
ChEBI CHEBI:8711
ChEMBL Ligand CHEMBL7568
DrugBank Ligand DB01103
DrugCentral Ligand 2338
GtoPdb PubChem SID 381118882
PubChem CID 237
RCSB PDB Ligand QUN
Search Google for chemical match using the InChIKey GPKJTRJOBQGKQK-UHFFFAOYSA-N
Search Google for chemicals with the same backbone GPKJTRJOBQGKQK
Search PubMed clinical trials mepacrine
Search PubMed titles mepacrine
Search PubMed titles/abstracts mepacrine
UniChem Compound Search for chemical match using the InChIKey GPKJTRJOBQGKQK-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey GPKJTRJOBQGKQK-UHFFFAOYSA-N
Wikipedia Mepacrine