Synonyms: 3α,5β-tetrahydroprogesterone | 3α,5β-THP | 3α-hydroxy-5β-pregnan-20-one | Pregnan-3alpha-ol-20-one | pregnanolone
Compound class:
Metabolite
Comment: Eltanolone (pregnanolone) is an endogenous neurosteroid that is derived from progesterone. It is a stereoisomer of 5α-pregnan-3α-ol-20-one (allopregnanolone). Like allopregnanolone it behaves as a positive allosteric modulator of GABAA receptors. It is often formulated as the sulphate salt. Eltanolone induces sedative, anxiolytic, anesthetic, and anticonvulsant effects.
|
|
Classification ![]() |
|
Compound class | Metabolite |
IUPAC Name ![]() |
1-[(3R,5R,8R,9S,10S,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone |
International Nonproprietary Names ![]() |
|
INN number | INN |
6781 | eltanolone |
Synonyms ![]() |
3α,5β-tetrahydroprogesterone | 3α,5β-THP | 3α-hydroxy-5β-pregnan-20-one | Pregnan-3alpha-ol-20-one | pregnanolone |
Database Links ![]() |
|
CAS Registry No. | 128-20-1 (source: WHO INN record) |
DrugBank Ligand | DB12308 |
GtoPdb PubChem SID | 441604906 |
LIPID MAPS | LMST02030175 |
PubChem CID | 31402 |
RCSB PDB Ligand | P9N |
Search Google for chemical match using the InChIKey | AURFZBICLPNKBZ-YZRLXODZSA-N |
Search Google for chemicals with the same backbone | AURFZBICLPNKBZ |
Search PubMed clinical trials | eltanolone |
Search PubMed titles | eltanolone |
Search PubMed titles/abstracts | eltanolone |
UniChem Compound Search for chemical match using the InChIKey | AURFZBICLPNKBZ-YZRLXODZSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | AURFZBICLPNKBZ-YZRLXODZSA-N |