naratriptan [Ligand Id: 45] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1278 (Naratriptan, Amerge)
  • 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
  • 7.47
1 CHEMBL1278_lig_chart_1 Serotonin 1a (5-HT1a) receptor Human
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  • 5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Human [ChEMBL: CHEMBL1898] [GtoPdb: 2] [UniProtKB: P28222]
  • 8.29
2 CHEMBL1278_lig_chart_2 Serotonin 1b (5-HT1b) receptor Human
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  • 5-HT1D receptor/Serotonin 1d (5-HT1d) receptor in Human [ChEMBL: CHEMBL1983] [GtoPdb: 3] [UniProtKB: P28221]
  • 8.82
3 CHEMBL1278_lig_chart_3 Serotonin 1d (5-HT1d) receptor Human
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  • 5-ht1e receptor in Human [GtoPdb: 4] [UniProtKB: P28566]
  • This target only has 1 pki data point
  • 7.7
4 CHEMBL1278_lig_chart_4 5-ht1e receptor Human
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  • 5-HT1F receptor in Human [GtoPdb: 5] [UniProtKB: P30939]
  • This target only has 1 pki data point
  • 8.2
5 CHEMBL1278_lig_chart_5 5-HT1F receptor Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
ChEMBL In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1A receptor B 7.35 pKi 45 nM Ki J. Med. Chem. (1999) 42: 526-531 [PMID:9986723]
GtoPdb - - 7.6 pKi - - - Naunyn Schmiedebergs Arch Pharmacol (1997) 355: 682-8 [PMID:9205951];
Eur J Pharmacol (1999) 368: 259-68 [PMID:10193663]
5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1898] [GtoPdb: 2] [UniProtKB: P28222]
GtoPdb - - 8.1 pKi - - - Eur J Pharmacol (1999) 368: 259-68 [PMID:10193663]
ChEMBL In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1B receptor B 8.48 pKi 3.3 nM Ki J. Med. Chem. (1999) 42: 526-531 [PMID:9986723]
5-HT1D receptor/Serotonin 1d (5-HT1d) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1983] [GtoPdb: 3] [UniProtKB: P28221]
ChEMBL In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor B 8.64 pKi 2.3 nM Ki J. Med. Chem. (1999) 42: 526-531 [PMID:9986723]
GtoPdb - - 9 pKi - - - Eur J Pharmacol (1999) 368: 259-68 [PMID:10193663];
Naunyn Schmiedebergs Arch Pharmacol (1997) 356: 328-34 [PMID:9303569];
Br J Pharmacol (1995) 114: 993-8 [PMID:7780656]
ChEMBL Ability to inhibit forskolin-stimulated adenylate cyclase in a cell line expressing human 5-hydroxytryptamine 1D receptor F 8.8 pEC50 1.6 nM EC50 J. Med. Chem. (1999) 42: 526-531 [PMID:9986723]
5-ht1e receptor in Human [GtoPdb: 4] [UniProtKB: P28566]
GtoPdb - - 7.7 pKi - - - Eur J Pharmacol (1999) 368: 259-68 [PMID:10193663]
5-HT1F receptor in Human [GtoPdb: 5] [UniProtKB: P30939]
GtoPdb - - 8.2 pKi - - - Naunyn Schmiedebergs Arch Pharmacol (2005) 371: 169-77 [PMID:15900510];
Eur J Pharmacol (1999) 368: 259-68 [PMID:10193663]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]