joro toxin [Ligand Id: 4229] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL313747 (Joro Spider Toxin 3)
  • GluN2A/Glutamate [NMDA] receptor subunit epsilon 1 in Rat [ChEMBL: CHEMBL310] [GtoPdb: 456] [UniProtKB: Q00959]
  • This target only has 0 pki data point
1 CHEMBL313747_lig_chart_1 Glutamate [NMDA] receptor subunit epsilon 1 Rat
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  • GluA1/Glutamate receptor ionotropic, AMPA 1 in Human [ChEMBL: CHEMBL2009] [GtoPdb: 444] [UniProtKB: P42261]
  • GluA1/Glutamate receptor ionotropic, AMPA 1 in Rat [ChEMBL: CHEMBL3753] [GtoPdb: 444] [UniProtKB: P19490]
  • This target only has 0 pki data point
2 CHEMBL313747_lig_chart_2 Glutamate receptor ionotropic, AMPA 1 HumanRat
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  • GluA3/Glutamate receptor ionotropic, AMPA 3 in Human [ChEMBL: CHEMBL3595] [GtoPdb: 446] [UniProtKB: P42263]
  • This target only has 0 pki data point
3 CHEMBL313747_lig_chart_3 Glutamate receptor ionotropic, AMPA 3 Human
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  • GluK1/Glutamate receptor ionotropic kainate 1 in Rat [ChEMBL: CHEMBL2919] [GtoPdb: 450] [UniProtKB: P22756]
  • This target only has 0 pki data point
4 CHEMBL313747_lig_chart_4 Glutamate receptor ionotropic kainate 1 Rat
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
GluN2A/Glutamate [NMDA] receptor subunit epsilon 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL310] [GtoPdb: 456] [UniProtKB: Q00959]
ChEMBL Antagonist activity at rat glutamate N1/2A receptor expressed in Xenopus oocytes at membrane potential -60 mV by two-electrode voltage-clamp electrophysiology assay F 5.77 pIC50 1710 nM IC50 J. Med. Chem. (2012) 55: 10297-10301 [PMID:23092360]
GluA1/Glutamate receptor ionotropic, AMPA 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2009] [GtoPdb: 444] [UniProtKB: P42261]
ChEMBL Inhibition of recombinant GluA1 receptor flop isoform expressed in Xenopus oocytes assessed as inhibition of 300 uM kainate-induced current by patch clamp electrophysiological assay B 7.4 pIC50 40 nM IC50 Bioorg. Med. Chem. (2010) 18: 1381-1387 [PMID:20096591]
GluA1/Glutamate receptor ionotropic, AMPA 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3753] [GtoPdb: 444] [UniProtKB: P19490]
ChEMBL Antagonist activity at rat GluA1 receptor expressed in Xenopus oocytes at membrane potential -60 mV by two-electrode voltage-clamp electrophysiology assay F 7.19 pIC50 65 nM IC50 J. Med. Chem. (2012) 55: 10297-10301 [PMID:23092360]
GluA3/Glutamate receptor ionotropic, AMPA 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3595] [GtoPdb: 446] [UniProtKB: P42263]
ChEMBL Inhibition of recombinant GluA3 receptor flop isoform expressed in Xenopus oocytes assessed as inhibition of 300 uM kainate-induced current by patch clamp electrophysiological assay B 7.52 pIC50 30 nM IC50 Bioorg. Med. Chem. (2010) 18: 1381-1387 [PMID:20096591]
GluK1/Glutamate receptor ionotropic kainate 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2919] [GtoPdb: 450] [UniProtKB: P22756]
ChEMBL Antagonist activity at rat GluK1 receptor expressed in Xenopus oocytes at membrane potential -60 mV by two-electrode voltage-clamp electrophysiology assay F 7.72 pIC50 19 nM IC50 J. Med. Chem. (2012) 55: 10297-10301 [PMID:23092360]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]