cytosporone B [Ligand Id: 5424] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1221517 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Nerve Growth factor IB/Nuclear receptor subfamily 4 group A member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1293229] [GtoPdb: 629] [UniProtKB: P22736] | ||||||||
| ChEMBL | Binding affinity to NuR77-LBD receptor expressed in human BGC823 cells | B | 5.82 | pKd | 1510 | nM | Kd | Nat Chem Biol (2008) 4: 548-556 [PMID:18690216] |
| ChEMBL | Binding affinity to Nur77 receptor expressed in human BGC823 cells | B | 6.13 | pKd | 740 | nM | Kd | Nat Chem Biol (2008) 4: 548-556 [PMID:18690216] |
| ChEMBL | Binding affinity to Nur77 Y453A mutant expressed in human BGC823 cells | B | 6.14 | pKd | 720 | nM | Kd | Nat Chem Biol (2008) 4: 548-556 [PMID:18690216] |
| ChEMBL | Agonist activity at nuclear orphan receptor Nur77 expressed in human BGC823 cells co-transfected with fused GAL4-Nur77 assessed as transactivation after 12 hrs by luciferase reporter gene assay | F | 9.56 | pEC50 | 0.28 | nM | EC50 | Nat Chem Biol (2008) 4: 548-556 [PMID:18690216] |
| ChEMBL | Inhibition of Gal4-fused full length Nur77 in human BGC-823 cells | B | 9.56 | pEC50 | 0.28 | nM | EC50 | J Med Chem (2021) 64: 9592-9638 [PMID:34251209] |
| ChEMBL | Agonist activity at nuclear orphan receptor Nur77 expressed in human BGC823 cells co-transfected with fused GAL4-LBD assessed as transactivation after 12 hrs by luciferase reporter gene assay | F | 9.94 | pEC50 | 0.12 | nM | EC50 | Nat Chem Biol (2008) 4: 548-556 [PMID:18690216] |
| ChEMBL | Inhibition of Gal4-fused Nur77-LBD in human BGC-823 cells | B | 9.94 | pEC50 | 0.12 | nM | EC50 | J Med Chem (2021) 64: 9592-9638 [PMID:34251209] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
