hydroxyzine [Ligand Id: 7199] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL896 (Atarax, Ataraxoid, Hydroxyzine, Marex, NSC-169188, Orgatrax, Tran-q, Tranquizine, U.c.b-4492)
  • D2 receptor/Dopamine D2 receptor in Human [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
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  • H1 receptor/Histamine H1 receptor in Human [ChEMBL: CHEMBL231] [GtoPdb: 262] [UniProtKB: P35367]
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  • 5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
ChEMBL Binding affinity to D2 receptor (unknown origin) B 6.42 pKi 378 nM Ki Bioorg Med Chem Lett (2018) 28: 2039-2049 [PMID:29730027]
H1 receptor/Histamine H1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL231] [GtoPdb: 262] [UniProtKB: P35367]
ChEMBL Binding affinity to histamine H1 receptor (unknown origin) B 8.7 pKi 2 nM Ki Bioorg Med Chem Lett (2018) 28: 2039-2049 [PMID:29730027]
GtoPdb - - 8.7 pKi 1.99 nM Ki Mol Pharmacol (2002) 61: 391-9 [PMID:11809864]
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223]
ChEMBL Binding affinity to 5-HT2A receptor (unknown origin) B 7.3 pKi 50 nM Ki Bioorg Med Chem Lett (2018) 28: 2039-2049 [PMID:29730027]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]