NBI-59159 [Ligand Id: 4626] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1628570 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Excitatory amino acid transporter 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3085] [GtoPdb: 868] [UniProtKB: P43003] | ||||||||
| ChEMBL | Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 1 | B | 6.52 | pIC50 | 300 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 4985-4988 [PMID:16165356] |
| Excitatory amino acid transporter 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4973] [GtoPdb: 869] [UniProtKB: P43004] | ||||||||
| ChEMBL | Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 2 | B | 6.15 | pIC50 | 700 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 4985-4988 [PMID:16165356] |
| Excitatory amino acid transporter 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2721] [GtoPdb: 870] [UniProtKB: P43005] | ||||||||
| ChEMBL | Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 3 | B | 6.38 | pIC50 | 420 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 4985-4988 [PMID:16165356] |
| GtoPdb | - | - | 7.1 | pIC50 | 90 | nM | IC50 | Curr Top Med Chem (2006) 6: 1897-906 [PMID:17017964] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
