5-hydroxyindole [Ligand Id: 2295] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL404923 (5-Hydroxyindole) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| DNA repair protein RAD51 homolog 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2034807] [UniProtKB: Q06609] | ||||||||
| ChEMBL | Binding affinity to RAD51 (unknown origin) by isothermal calorimetry | B | 2.68 | pKd | 2100000 | nM | Kd | Bioorg Med Chem Lett (2015) 25: 2461-2468 [PMID:25971770] |
| Leukotriene A4 hydrolase/Leukotriene A4 hydrolase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4618] [GtoPdb: 1395] [UniProtKB: P09960] | ||||||||
| ChEMBL | Inhibition of hydrolase activity of human recombinant LTA4H expressed in Escherichia coli BL21-AI/pRARE assessed as LTB4 formation by tandem quadrupole mass spectrometry | B | 2.7 | pIC50 | >2000000 | nM | IC50 | J Med Chem (2009) 52: 4694-4715 [PMID:19618939] |
| ChEMBL | Inhibition of peptidase activity of human recombinant LTA4H expressed in Escherichia coli BL21-AI/pRARE | B | 3 | pIC50 | >1000000 | nM | IC50 | J Med Chem (2009) 52: 4694-4715 [PMID:19618939] |
| tyrosinase/Tyrosinase in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5346] [GtoPdb: 2643] [UniProtKB: P11344] | ||||||||
| ChEMBL | Inhibition of catecholase activity of tyrosinase in mouse B16 cells assessed as dopachrome formation | B | 4.17 | pIC50 | 68000 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 4178-4182 [PMID:19524439] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
