MUT056399   Click here for help

GtoPdb Ligand ID: 11000

Synonyms: Fab-001 | FAB001 | MUT-056399
PDB Ligand
Compound class: Synthetic organic
Comment: MUT056399 is an inhibitor of bacterial Fabl, the NADH-dependent enoyl reductase from the type II bacterial fatty acid biosynthesis pathway [1].

MUT056399 is commercially available from our sponsors

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 72.55
Molecular weight 293.09
XLogP 2.73
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES CCc1cc(O)c(cc1F)Oc1ccc(cc1F)C(=O)N
Isomeric SMILES CCc1cc(O)c(cc1F)Oc1ccc(cc1F)C(=O)N
InChI InChI=1S/C15H13F2NO3/c1-2-8-6-12(19)14(7-10(8)16)21-13-4-3-9(15(18)20)5-11(13)17/h3-7,19H,2H2,1H3,(H2,18,20)
InChI Key QUHARGDBJJUOEB-UHFFFAOYSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
4-(4-ethyl-5-fluoro-2-hydroxyphenoxy)-3-fluorobenzamide
Synonyms Click here for help
Fab-001 | FAB001 | MUT-056399
Database Links Click here for help
Specialist databases
Antibiotic DB Antibiotic DB Database logo FAB001
Other databases
BindingDB Ligand 50399407
CAS Registry No. 1269055-85-7 (source: ChemIDplus)
ChEMBL Ligand CHEMBL2178284
GtoPdb PubChem SID 405560441
PubChem CID 44208849
RCSB PDB Ligand RQN
Search Google for chemical match using the InChIKey QUHARGDBJJUOEB-UHFFFAOYSA-N
Search Google for chemicals with the same backbone QUHARGDBJJUOEB
UniChem Compound Search for chemical match using the InChIKey QUHARGDBJJUOEB-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey QUHARGDBJJUOEB-UHFFFAOYSA-N

Product suppliers

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MedChemExpress
MUT056399 (links to external site)
Cat. No. HY-18169