ChEMBL ligand: CHEMBL76 (Aralen, Chlorochine, Chloroquine, NSC-187208)
α2A-adrenoceptor/Alpha-2a adrenergic receptor in Human [ChEMBL: CHEMBL1867] [GtoPdb: 25] [UniProtKB: P08913] There should be some charts here, you may need to enable JavaScript!
α2B-adrenoceptor/Alpha-2b adrenergic receptor in Human [ChEMBL: CHEMBL1942] [GtoPdb: 26] [UniProtKB: P18089] There should be some charts here, you may need to enable JavaScript!
α2C-adrenoceptor/Alpha-2c adrenergic receptor in Human [ChEMBL: CHEMBL1916] [GtoPdb: 27] [UniProtKB: P18825] There should be some charts here, you may need to enable JavaScript!
Amyloid-beta A4 protein in Human [ChEMBL: CHEMBL2487] [UniProtKB: P05067] There should be some charts here, you may need to enable JavaScript!
Angiotensin-converting enzyme 2 in Human [ChEMBL: CHEMBL3736] [GtoPdb: 1614] [UniProtKB: Q9BYF1] There should be some charts here, you may need to enable JavaScript!
beta-secretase 1/Beta-secretase 1 in Human [ChEMBL: CHEMBL4822] [GtoPdb: 2330] [UniProtKB: P56817] There should be some charts here, you may need to enable JavaScript!
CXCR4/C-X-C chemokine receptor type 4 in Human [ChEMBL: CHEMBL2107] [GtoPdb: 71] [UniProtKB: P61073] There should be some charts here, you may need to enable JavaScript!
Dihydrofolate reductase in Bovine [ChEMBL: CHEMBL1075051] [UniProtKB: P00376] There should be some charts here, you may need to enable JavaScript!
Falcipain 2 in Plasmodium falciparum [ChEMBL: CHEMBL1697672] [UniProtKB: Q9NAW2] There should be some charts here, you may need to enable JavaScript!
Hemozoin in Plasmodium falciparum [ChEMBL: CHEMBL613898] There should be some charts here, you may need to enable JavaScript!
Kv11.1/HERG in Human [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] There should be some charts here, you may need to enable JavaScript!
Histidine-rich protein in Plasmodium falciparum [ChEMBL: CHEMBL1923] [UniProtKB: P05227] There should be some charts here, you may need to enable JavaScript!
M1 receptor/Muscarinic acetylcholine receptor M1 in Human [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229] There should be some charts here, you may need to enable JavaScript!
M2 receptor/Muscarinic acetylcholine receptor M2 in Human [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172] There should be some charts here, you may need to enable JavaScript!
M3 receptor/Muscarinic acetylcholine receptor M3 in Human [ChEMBL: CHEMBL245] [GtoPdb: 15] [UniProtKB: P20309] There should be some charts here, you may need to enable JavaScript!
M4 receptor/Muscarinic acetylcholine receptor M4 in Human [ChEMBL: CHEMBL1821] [GtoPdb: 16] [UniProtKB: P08173] There should be some charts here, you may need to enable JavaScript!
M5 receptor/Muscarinic acetylcholine receptor M5 in Human [ChEMBL: CHEMBL2035] [GtoPdb: 17] [UniProtKB: P08912] There should be some charts here, you may need to enable JavaScript!
Nuclear receptor related 1/Nuclear receptor subfamily 4 group A member 2 in Human [ChEMBL: CHEMBL5002] [GtoPdb: 630] [UniProtKB: P43354] There should be some charts here, you may need to enable JavaScript!
Plasmodium berghei [ChEMBL: CHEMBL612653] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum K1 [ChEMBL: CHEMBL612856] There should be some charts here, you may need to enable JavaScript!
Plasmodium knowlesi [ChEMBL: CHEMBL613011] There should be some charts here, you may need to enable JavaScript!
Plasmodium malariae [ChEMBL: CHEMBL613257] There should be some charts here, you may need to enable JavaScript!
Plasmodium vivax [ChEMBL: CHEMBL613013] There should be some charts here, you may need to enable JavaScript!
Plasmodium yoelii [ChEMBL: CHEMBL612889] There should be some charts here, you may need to enable JavaScript!
Prion protein in Human [ChEMBL: CHEMBL4869] [UniProtKB: P04156] There should be some charts here, you may need to enable JavaScript!
Quinone reductase 2 in Human [ChEMBL: CHEMBL3959] [UniProtKB: P16083] There should be some charts here, you may need to enable JavaScript!
CoV Replicase polyprotein 1ab/CoV RNA-dependent RNA polymerase/CoV Non-structural protein 15/CoV Non-structural protein 13/Replicase polyprotein 1ab in Severe acute respiratory syndrome coronavirus 2 [ChEMBL: CHEMBL4523582] [GtoPdb: 3125, 3139, 3206, 3261] [UniProtKB: P0DTD1] There should be some charts here, you may need to enable JavaScript!
Riboflavin-binding protein in Chicken [ChEMBL: CHEMBL1944489] [UniProtKB: P02752] There should be some charts here, you may need to enable JavaScript!
mechanistic target of rapamycin kinase/Serine/threonine-protein kinase mTOR in Human [ChEMBL: CHEMBL2842] [GtoPdb: 2109] [UniProtKB: P42345] There should be some charts here, you may need to enable JavaScript!
σ2/Sigma intracellular receptor 2 in Human [ChEMBL: CHEMBL4105907] [GtoPdb: 2553] [UniProtKB: Q5BJF2] There should be some charts here, you may need to enable JavaScript!
sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720] There should be some charts here, you may need to enable JavaScript!
CoV Spike glycoprotein/Spike glycoprotein in Severe acute respiratory syndrome coronavirus 2 [ChEMBL: CHEMBL4662936] [GtoPdb: 3114] [UniProtKB: P0DTC2] There should be some charts here, you may need to enable JavaScript!
MRGPRX1 in Human [GtoPdb: 156] [UniProtKB: Q96LB2] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
α2A-adrenoceptor/Alpha-2a adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1867] [GtoPdb: 25] [UniProtKB: P08913]
ChEMBL	Activity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscine	B	5.36	pKi	4365.16	nM	Ki	A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
α2B-adrenoceptor/Alpha-2b adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1942] [GtoPdb: 26] [UniProtKB: P18089]
ChEMBL	Activity of compound against Alpha 2B (ADRA2B) adrenergic receptor by displacement of [3H]-rauwolscine	B	4.5	pKi	31622.78	nM	Ki	A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
α2C-adrenoceptor/Alpha-2c adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1916] [GtoPdb: 27] [UniProtKB: P18825]
ChEMBL	Activity of compound against Alpha 2C (ADRA2C) adrenergic receptor by displacement of [3H]-rauwolscine	B	5	pKi	10000	nM	Ki	A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
Amyloid-beta A4 protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2487] [UniProtKB: P05067]
ChEMBL	Modulation of human wild-type APP695 expressed in SH-SY5Y cells assessed as inhibition of amyloid beta (1 to 42 residues) production measured after 24 hrs by ELISA	B	4.89	pIC50	12800	nM	IC50	Bioorg Med Chem (2018) 26: 2151-2164 [PMID:29559198]
ChEMBL	Modulation of human wild-type APP695 expressed in SH-SY5Y cells assessed as inhibition of amyloid beta (1 to 40 residues) production measured after 24 hrs	B	5.15	pIC50	7000	nM	IC50	Bioorg Med Chem (2018) 26: 2151-2164 [PMID:29559198]
Angiotensin-converting enzyme 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3736] [GtoPdb: 1614] [UniProtKB: Q9BYF1]
ChEMBL	Inhibition of human recombinant ACE2 at 50 uM using (7Mca-Y-V-A- D -A-P- K(Knp) as a flurogenic substrate measured after 10 mins by fluorescence based analysis	B	5.95	pIC50	1130	nM	IC50	J Med Chem (2020) 63: 12256-12274 [PMID:32539378]
beta-secretase 1/Beta-secretase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4822] [GtoPdb: 2330] [UniProtKB: P56817]
ChEMBL	Inhibition of BACE1 in human SH-SY5Y cells harboring wild type APP695 assessed as reduction in amyloid beta (1 to 42) level after 24 hrs by ELISA method	B	4.9	pIC50	12700	nM	IC50	Eur J Med Chem (2018) 159: 104-125 [PMID:30268822]
ChEMBL	Inhibition of BACE1 in human SH-SY5Y cells harboring wild type APP695 assessed as reduction in amyloid beta (1 to 40) level after 24 hrs by ELISA method	B	5.15	pIC50	7000	nM	IC50	Eur J Med Chem (2018) 159: 104-125 [PMID:30268822]
CXCR4/C-X-C chemokine receptor type 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2107] [GtoPdb: 71] [UniProtKB: P61073]
ChEMBL	Antagonist activity at CXCR4 receptor in human MIA PaCa-2 cells assessed as reduction in forskolin-stimulated inhibition of cAMP production	B	5.19	pEC50	6500	nM	EC50	Eur J Med Chem (2018) 157: 582-598 [PMID:30125720]
Dihydrofolate reductase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075051] [UniProtKB: P00376]
ChEMBL	Inhibition of bovine liver DHFR	B	7.52	pIC50	30.1	nM	IC50	Bioorg Med Chem (2017) 25: 5396-5406 [PMID:28789907]
ChEMBL	Inhibition of bovine liver DHFR pre-incubated 2 mins before dihydrofolic acid substrate addition and measured over 10 mins in presence of NADPH	B	7.52	pIC50	30.1	nM	IC50	Bioorg Med Chem (2017) 25: 4064-4075 [PMID:28634040]
Falcipain 2 in Plasmodium falciparum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1697672] [UniProtKB: Q9NAW2]
ChEMBL	Inhibition of falcipain-2 in chloroquine resistant Plasmodium falciparum RKL9 schizont stage infected in human erythrocytes assessed as reduction in bacterial growth after 24 hrs by Giemsa staining based assay	B	6.7	pIC50	200	nM	IC50	Bioorg Med Chem Lett (2018) 28: 1566-1569 [PMID:29602682]
Hemozoin in Plasmodium falciparum (target type: MACROMOLECULE) [ChEMBL: CHEMBL613898]
ChEMBL	Inhibition of beta-hematin formation assessed as reduction in hemozoin formation incubated for 16 hrs by NP40 detergent-mediated assay	B	4.13	pIC50	74000	nM	IC50	Eur J Med Chem (2019) 180: 121-133 [PMID:31301563]
ChEMBL	Inhibition of beta-hematin	B	4.28	pIC50	53000	nM	IC50	J Med Chem (2016) 59: 6512-6530 [PMID:27299916]
ChEMBL	Inhibition of beta-hematin formation assessed as reduction in hemozoin formation incubated for 5 hrs by NP40 detergent-based assay	B	4.28	pIC50	53000	nM	IC50	Medchemcomm (2019) 10: 450-455 [PMID:31015908]
ChEMBL	Inhibition of beta-hematin in water/NP40/DMSO solution incubated for 5 to 6hrs by detergent-mediated pyridine-ferrichrome method	B	4.5	pIC50	31500	nM	IC50	J Med Chem (2016) 59: 6512-6530 [PMID:27299916]
ChEMBL	Inhibition of Beta-hematin in Plasmodium falciparum NF54 assessed as hemozoin formation after 36 hrs by flow cytometry analysis	B	4.66	pIC50	22000	nM	IC50	J Med Chem (2022) 65: 16695-16715 [PMID:36507890]
ChEMBL	Inhibition of beta-hematin formation assessed as reduction in hemozoin formation incubated for 5 hrs by NP40 detergent-mediated assay	B	4.68	pIC50	21000	nM	IC50	J Med Chem (2020) 63: 13013-13030 [PMID:33103428]
ChEMBL	Inhibition of Beta-hematin assessed as bis-pyridyl-Fe(III)PPIX complex formation incubated for 5 hrs by NP40 detergent-mediated colorimetric assay	B	4.72	pIC50	19000	nM	IC50	J Med Chem (2021) 64: 2739-2761 [PMID:33620219]
ChEMBL	Inhibition of beta hematin formation after 5 hrs by NP40 detergent-based assay	B	4.74	pIC50	18000	nM	IC50	J Med Chem (2019) 62: 1022-1035 [PMID:30562027]
ChEMBL	Inhibition of beta-hematin formation assessed as reduction in hemozoin formation incubated for 20 hrs by NP40 detergent-mediated assay	B	4.77	pIC50	16900	nM	IC50	RSC Med Chem (2020) 11: 85-91 [PMID:33479606]
ChEMBL	Inhibition of Beta-hematin in Plasmodium falciparum cells assessed as hemozoin formation after 32 hrs by NP40 detergent-mediated assay	B	4.77	pIC50	16800	nM	IC50	Bioorg Med Chem Lett (2021) 54: 128442-128442 [PMID:34763083]
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL	Inhibition of human ERG expressed in CHO cells	B	5.12	pKi	7500	nM	Ki	ACS Med Chem Lett (2013) 4: 1037-1041 [PMID:24900603]
ChEMBL	Inhibition of human ERG	B	5.6	pIC50	2511.89	nM	IC50	Eur J Med Chem (2011) 46: 618-630 [PMID:21185626]
ChEMBL	Inhibitory concentration against IKr potassium channel	B	5.6	pIC50	2500	nM	IC50	Bioorg Med Chem Lett (2004) 14: 4771-4777 [PMID:15324906]
ChEMBL	Inhibition of human cloned ERG	B	5.6	pIC50	2500	nM	IC50	J Med Chem (2009) 52: 1408-1415 [PMID:19222165]
ChEMBL	Inhibition of human ERG expressed in HEK293 cells assessed as reduction in tail current at membrane potential of +20 mV	B	5.6	pIC50	2500	nM	IC50	Bioorg Med Chem Lett (2015) 25: 1390-1393 [PMID:25746816]
Histidine-rich protein in Plasmodium falciparum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1923] [UniProtKB: P05227]
ChEMBL	Inhibition of 1-monooleoyl glycerol (MOG) induced beta-hematin formation	F	4.12	pIC50	76500	nM	IC50	Bioorg Med Chem Lett (2003) 13: 3783-3787 [PMID:14552779]
ChEMBL	Inhibition of beta-hematin formation in Plasmodium falciparum	F	4.12	pIC50	75000	nM	IC50	Bioorg Med Chem Lett (2001) 11: 2075-2077 [PMID:11514142]
ChEMBL	Inhibition of 1-monooleoyl glycerol induced beta-hematin formation	F	4.22	pIC50	60000	nM	IC50	Bioorg Med Chem Lett (2006) 16: 31-35 [PMID:16263280]
ChEMBL	Inhibition of lipid-induced beta-hematin formation	F	4.33	pIC50	46300	nM	IC50	J Med Chem (2006) 49: 4707-4714 [PMID:16854077]
ChEMBL	Inhibition of beta-hematin formation	F	4.42	pIC50	38000	nM	IC50	J Med Chem (2002) 45: 4975-4983 [PMID:12408708]
ChEMBL	Inhibition of beta-hematin formation after 16 hrs	F	4.81	pIC50	15400	nM	IC50	Antimicrob Agents Chemother (2007) 51: 2842-2847 [PMID:17562796]
ChEMBL	Inhibition of hematin polymerization	F	4.82	pIC50	15000	nM	IC50	J Med Chem (1999) 42: 4630-4639 [PMID:10579825]
ChEMBL	Inhibition of beta-hematin polymerization	B	6.4	pIC50	400	nM	IC50	J Med Chem (2007) 50: 394-398 [PMID:17228883]
ChEMBL	Inhibitory activity against beta-hematin formation	F	7.12	pIC50	76.5	nM	IC50	J Med Chem (2003) 46: 542-557 [PMID:12570376]
M1 receptor/Muscarinic acetylcholine receptor M1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229]
ChEMBL	Activity of compound against Muscarinic acetylcholine receptor M1 (CHRM1) by displacement of 3H-QNB	B	5.04	pKi	9120.11	nM	Ki	A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
M2 receptor/Muscarinic acetylcholine receptor M2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172]
ChEMBL	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	B	5.33	pKi	4677.35	nM	Ki	A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
M3 receptor/Muscarinic acetylcholine receptor M3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL245] [GtoPdb: 15] [UniProtKB: P20309]
ChEMBL	Activity of compound against Muscarinic acetylcholine receptor M3 (CHRM3) by displacement of 3H-QNB	B	5.48	pKi	3311.31	nM	Ki	A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
M4 receptor/Muscarinic acetylcholine receptor M4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1821] [GtoPdb: 16] [UniProtKB: P08173]
ChEMBL	Activity of compound against Muscarinic acetylcholine receptor M4 (CHRM4) by displacement of 3H-QNB	B	5.24	pKi	5754.4	nM	Ki	A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
M5 receptor/Muscarinic acetylcholine receptor M5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2035] [GtoPdb: 17] [UniProtKB: P08912]
ChEMBL	Activity of compound against Muscarinic acetylcholine receptor M5 (CHRM5) by displacement of 3H-QNB	B	4.66	pKi	21877.62	nM	Ki	A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
Nuclear receptor related 1/Nuclear receptor subfamily 4 group A member 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5002] [GtoPdb: 630] [UniProtKB: P43354]
ChEMBL	Agonist activity at Nurr1 ligand binding domain (unknown origin) measured by Gal4-based reporter gene assay	B	4.3	pEC50	50000	nM	EC50	J Med Chem (2022) 65: 9548-9563 [PMID:35797147]
ChEMBL	Agonist activity at Gal4-fused human Nurr1 LBD expressed in HEK293T cells co-expressing firefly luciferase assessed as luciferase activity incubated for 12 to 14 hrs by hybrid reporter gene assay	B	4.33	pEC50	47000	nM	EC50	J Med Chem (2021) 64: 2659-2668 [PMID:33629841]
Plasmodium berghei (target type: ORGANISM) [ChEMBL: CHEMBL612653]
ChEMBL	Antimalarial activity against luciferase-expressing Plasmodium berghei ANKA 676m1cl1 sporozoites infected in human HepG2A16 cells measured after 45 hrs by luciferase-luciferin based reporter gene assay	F	4.5	pIC50	>31262	nM	IC50	J Med Chem (2020) 63: 6179-6202 [PMID:32390431]
ChEMBL	Antimalarial activity against luciferase-expressing Plasmodium berghei ANKA 676m1cl1 sporozoites infected in human HepG2A16 cells measured after 45 hrs by luciferase-luciferin based reporter assay	F	4.5	pIC50	>31262	nM	IC50	J Med Chem (2019) 62: 3475-3502 [PMID:30852885]
ChEMBL	Antiplasmodial activity against Plasmodium berghei liver stage form transfected in human Huh-7 cells assessed as cell viability after 48 hrs by luciferase reporter gene assay	F	4.8	pIC50	15900	nM	IC50	J Med Chem (2013) 56: 556-567 [PMID:23273038]
ChEMBL	Antiplasmodial activity against liver stage of Plasmodium berghei expressing GFP-Luc infected in HuH7 cells incubated at 1 hr prior to infection followed by compound replenisment at 24 hrs post-infection measured after 48 hrs by Alamar blue assay	F	4.82	pIC50	>15000	nM	IC50	Bioorg Med Chem Lett (2013) 23: 610-613 [PMID:23290049]
ChEMBL	Antimalarial activity against exo-erythrocytic form of Plasmodium berghei infected in human HepG2 cells after 48 hrs	F	5	pIC50	>10000	nM	IC50	Eur J Med Chem (2014) 82: 204-213 [PMID:24904967]
ChEMBL	Antimalarial activity against sporozoite stage of Plasmodium berghei yoelii infected in human HepG2 cells	F	5.05	pIC50	9000	nM	IC50	J Med Chem (2016) 59: 264-281 [PMID:26640981]
ChEMBL	Antimalarial activity against schizonts of chloroquine-sensitive Plasmodium berghei ANKA 2.34 after 16 hrs	F	7.22	pIC50	60	nM	IC50	Bioorg Med Chem Lett (2012) 22: 7048-7051 [PMID:23084276]
ChEMBL	Antiplasmodial activity against liver stage Plasmodium berghei ANKA infected in human HepG2 cells measured after 44 hrs	F	8.92	pIC50	>1.2	nM	IC50	Eur J Med Chem (2018) 146: 1-14 [PMID:29360043]
ChEMBL	Antimicrobial activity against Plasmodium berghei sporozoites infected in 12 hrs compound pretreated human HepG2 cells assessed as reduction in viability of exoerythrocytic forms measured after 48 hrs of incubation by luciferase bioluminescence assay	F	5	pEC50	>10000	nM	EC50	J Med Chem (2014) 57: 2773-2788 [PMID:24641010]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Inhibition of hematin polymerization in Plasmodium falciparum	F	4.1	pIC50	80000	nM	IC50	J Med Chem (1998) 41: 4360-4364 [PMID:9784111]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human O positive erythrocyte assessed as reduction in parasitemia after 72 hrs	F	4.19	pIC50	>64000	nM	IC50	Bioorg Med Chem (2014) 22: 5241-5248 [PMID:25199582]
ChEMBL	Gametocytocidal activity against synchronous stage 4 to 5 of transgenic Plasmodium falciparum NF54 gametocyte harboring pfs16 promoter assessed as parasite viability after 72 hrs by MitoTracker Red CMXRos-based assay	F	4.22	pIC50	60000	nM	IC50	J Med Chem (2013) 56: 6200-6215 [PMID:23837878]
ChEMBL	Inhibition of hydrogen peroxide-mediated haem detoxification in Plasmodium falciparum	F	4.43	pIC50	37000	nM	IC50	Bioorg Med Chem Lett (2001) 11: 2075-2077 [PMID:11514142]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human RBC	F	4.49	pIC50	32000	nM	IC50	ACS Med Chem Lett (2013) 4: 1037-1041 [PMID:24900603]
ChEMBL	Antimalarial activity after 72 hrs against chloroquine-sensitive Plasmodium falciparum D6 infected in erythrocytes by LDH assay	F	4.53	pIC50	29700	nM	IC50	Bioorg Med Chem (2009) 17: 741-751 [PMID:19084416]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum	F	4.53	pIC50	29640	nM	IC50	Eur J Med Chem (2019) 166: 206-223 [PMID:30711831]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in erythrocytes after 96 hrs by [3H]hypoxanthine incorporation assay	F	4.68	pIC50	21000	nM	IC50	J Med Chem (2009) 52: 7954-7957 [PMID:19908867]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay	F	4.72	pIC50	19000	nM	IC50	J Med Chem (2009) 52: 7954-7957 [PMID:19908867]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 by lactate dehydrogenase assay	F	4.79	pIC50	16300	nM	IC50	J Nat Prod (2018) 81: 41-48 [PMID:29309141]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7 infected in human O positive erythrocytes assessed as reduction of parasite growth after 24 to 44 hrs by Giemsa staining	F	4.82	pIC50	15000	nM	IC50	Eur J Med Chem (2013) 67: 158-165 [PMID:23851117]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54	F	4.9	pIC50	12500	nM	IC50	Bioorg Med Chem Lett (2014) 24: 5466-5469 [PMID:25455485]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 by LDH assay	F	4.95	pIC50	11300	nM	IC50	Eur J Med Chem (2020) 198: 112330-112330 [PMID:32408064]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K14 infected in human red blood cells after 48 hrs by [3H]hypoxanthine incorporation assay	F	4.96	pIC50	11000	nM	IC50	Eur J Med Chem (2014) 87: 364-371 [PMID:25282260]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 gametocytes (stage 4 & 5)	F	4.97	pIC50	10700	nM	IC50	Antimicrob Agents Chemother (2007) 51: 1463-1472 [PMID:17242150]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 3D7 incubated for 30 hrs followed by addition of [3H]-hypoxanthine and measured after 18 hrs by liquid scintillation counting method	F	5	pIC50	10000	nM	IC50	Eur J Med Chem (2020) 193: 112215-112215 [PMID:32179331]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum Dd2 after 72 hrs by 1536-well format based SYBR green assay	F	5	pIC50	10000	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay	F	5.26	pIC50	5500	nM	IC50	Eur J Med Chem (2013) 60: 497-502 [PMID:23354072]
ChEMBL	In vitro inhibitory activity against Plasmodium falciparum	F	5.52	pIC50	3000	nM	IC50	Bioorg Med Chem Lett (2001) 11: 1851-1854 [PMID:11459645]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by 1536-well format based SYBR green assay	F	5.7	pIC50	2000	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FcB1 assessed as intraerythrocytic growth inhibition	F	5.72	pIC50	1900	nM	IC50	RSC Med Chem (2023) 14: 715-733 [PMID:37122550]
ChEMBL	Antiplasmodial activity against chloroquine and pyrimethamine resistant Plasmodium falciparum K1 assessed as reduction in [3H]-hypoxanthine incorporation incubated for 48 hrs by liquid scintillation counting method	F	5.74	pIC50	1828	nM	IC50	Eur J Med Chem (2017) 140: 595-603 [PMID:28988153]
ChEMBL	Displacement of chloroquine from Fe(3+) FPIX-loaded membrane	F	5.75	pIC50	1760	nM	IC50	J Med Chem (2002) 45: 4975-4983 [PMID:12408708]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by 1536-well format based SYBR green assay	F	5.8	pIC50	1600	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by 1536-well format based SYBR green assay	F	5.8	pIC50	1600	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against multidrug-resistant Plasmodium falciparum W2 assessed as intraerythrocytic growth inhibition	F	5.82	pIC50	1500	nM	IC50	RSC Med Chem (2023) 14: 715-733 [PMID:37122550]
ChEMBL	Antiparasitic activity against Plasmodium falciparum W2 incubated for 48 hrs by flow cytometry based analysis	F	5.88	pIC50	1330	nM	IC50	Eur J Med Chem (2020) 193: 112215-112215 [PMID:32179331]
ChEMBL	Antimalarial activity against blood stage chloroquine-resistant Plasmodium falciparum Dd2 assessed as reduction in parasite growth incubated for 72 hrs by SYBR Green dye based fluorescence assay	F	5.89	pIC50	1280	nM	IC50	J Nat Prod (2022) 85: 2454-2460 [PMID:36178104]
ChEMBL	Antimalarial activity against Plasmodium falciparum K1 after 72 hrs by SYBR Green fluorescence assay	F	5.94	pIC50	1160	nM	IC50	ACS Med Chem Lett (2014) 5: 878-883 [PMID:25147607]
ChEMBL	Antimalarial activity against chloroquine resistant Plasmodium falciparum K1 incubated for 72 hrs by SYBR green staining based fluorescence reader method	F	5.95	pIC50	1120	nM	IC50	Eur J Med Chem (2021) 210: 113084-113084 [PMID:33333397]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 assessed as inhibition of parasite growth incubated for 48 hrs by SYBR green 1 dye based fluorescence assay	F	5.95	pIC50	1110	nM	IC50	Eur J Med Chem (2016) 121: 640-648 [PMID:27318984]
ChEMBL	Antimalarial activity against Plasmodium falciparum infected in human O+ erythrocytes after 48 hrs by HRP2-ELISA method	F	5.99	pIC50	1030	nM	IC50	Bioorg Med Chem (2010) 18: 5626-5633 [PMID:20621497]
ChEMBL	Antimicrobial activity against Plasmodium falciparum	F	6	pIC50	1000	nM	IC50	Bioorg Med Chem (2010) 18: 2225-2231 [PMID:20185316]
ChEMBL	Antimalarial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum V1/S assessed as inhibition of parasite growth	F	6	pIC50	>1000	nM	IC50	J Med Chem (2015) 58: 4573-4580 [PMID:25906200]
ChEMBL	Antimalarial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum W2 assessed as inhibition of parasite growth	F	6	pIC50	>1000	nM	IC50	J Med Chem (2015) 58: 4573-4580 [PMID:25906200]
ChEMBL	Antimalarial activity against Plasmodium falciparum V1/S infected in human erythrocytes assessed as reduction in [3H]-hypoxanthine incorporation preincubated for 24 hrs followed by [3H]-hypoxanthine addition measured after 24 hrs by scintillation counting method	F	6	pIC50	>1000	nM	IC50	J Med Chem (2017) 60: 5889-5908 [PMID:28635296]
ChEMBL	Antimalarial activity against chloroquine, pyrimethamine, and mefloquine-resistant Plasmodium falciparum Dd2 infected in human O positive red blood cells assessed as inhibition of [3H]-hypoxanthine uptake after 48 hrs	F	6.01	pIC50	980	nM	IC50	J Nat Prod (2011) 74: 74-78 [PMID:21155593]
ChEMBL	Inhibition of chloroquine uptake from intact parasites	F	6.02	pIC50	950	nM	IC50	J Med Chem (2002) 45: 4975-4983 [PMID:12408708]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human A+ erythrocytes assessed as inhibition of parasite growth after 48 hrs by LDH assay	F	6.03	pIC50	930	nM	IC50	Bioorg Med Chem (2015) 23: 5156-5167 [PMID:25678015]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum K1 as [3H]hypoxanthine uptake	F	6.05	pIC50	900	nM	IC50	Bioorg Med Chem (2009) 17: 1428-1436 [PMID:19196516]
ChEMBL	In vitro inhibitory activity against multidrug-resistant Plasmodium falciparum W2 Indochina	F	6.05	pIC50	900	nM	IC50	J Med Chem (2002) 45: 3195-3209 [PMID:12109904]
ChEMBL	Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum FCM29 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs	F	6.06	pIC50	879	nM	IC50	J Med Chem (2010) 53: 3214-3226 [PMID:20329733]
ChEMBL	Antimalarial activity against chloroquine, pyrimethamine and cycloguanil-resistant Plasmodium falciparum VS1 after 24 hrs	F	6.07	pIC50	860	nM	IC50	Bioorg Med Chem (2007) 15: 5551-5562 [PMID:17548196]
ChEMBL	Antimalarial activity against Plasmodium falciparum K1 assessed as [3H]hypoxanthine incorporation by scintillation counting	F	6.07	pIC50	850	nM	IC50	J Med Chem (2010) 53: 699-714 [PMID:20014857]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 asynchronous cultures infected in human erythrocytes measured after 72 hrs by SYBR Green1 dye based fluorescence assay	F	6.08	pIC50	830	nM	IC50	Medchemcomm (2018) 9: 1232-1238 [PMID:30109012]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 by pLDH assay	F	6.09	pIC50	810	nM	IC50	J Med Chem (2006) 49: 7088-7094 [PMID:17125261]
ChEMBL	Antimalarial activity against multidrug-resistant Plasmodium falciparum K1 by [3H]hypoxanthine uptake	F	6.1	pIC50	800	nM	IC50	Bioorg Med Chem Lett (2008) 18: 5294-5298 [PMID:18774709]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human erythrocytes assessed as inhibition of parasite growth after 24 hrs by [3H]hypoxanthine incorporation assay	F	6.11	pIC50	780	nM	IC50	Eur J Med Chem (2013) 62: 168-176 [PMID:23353738]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 after 48 to 72 hrs by SYBR green-1 assay	F	6.12	pIC50	750	nM	IC50	Bioorg Med Chem Lett (2013) 23: 6167-6171 [PMID:24080459]
ChEMBL	Antimicrobial activity against Plasmodium falciparum W2 after 72 hrs by LDH activity assay	F	6.14	pIC50	720	nM	IC50	Medchemcomm (2013) 4: 1042-1048
ChEMBL	Antiplasmodial activity against Plasmodium falciparum W2 infected in human RBC assessed as parasite growth inhibition measured as LDH activity after 72 hrs by plate reader analysis	F	6.14	pIC50	720	nM	IC50	Eur J Med Chem (2015) 98: 160-169 [PMID:26005918]
ChEMBL	Antiplasmodial activity against drug resistant Plasmodium falciparum Dd2 ring stage cells assessed as reduction parasitemia by Malstat assay	F	6.15	pIC50	710	nM	IC50	Bioorg Med Chem (2012) 20: 5277-5289 [PMID:22858300]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum Dd2 assessed as inhibition of [3H]hypoxanthine incorporation incubated for 24 hrs prior to [3H]hypoxanthine addition measured after 24 hrs by beta scintillation counting	F	6.15	pIC50	710	nM	IC50	ACS Med Chem Lett (2012) 3: 373-377 [PMID:24900481]
ChEMBL	Antimalarial activity against chloroquine, pyrimethamine, proguanil-resistant Plasmodium falciparum infected in human erythrocytes after 48 hrs by flow cytometry	F	6.15	pIC50	700	nM	IC50	Bioorg Med Chem Lett (2009) 19: 5962-5964 [PMID:19748781]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human A+ erythrocytes assessed as inhibition of parasite proliferation after 48 hrs	F	6.15	pIC50	700	nM	IC50	Bioorg Med Chem (2010) 18: 6012-6023 [PMID:20638854]
ChEMBL	Antimalarial activity as reduced parasitaemia after 48 hrs against chloroquine, pyrimethamine and proguanil-resistant Plasmodium falciparum W2 infected in type A+ human erythrocytes by flow cytometry	F	6.15	pIC50	700	nM	IC50	Bioorg Med Chem (2009) 17: 4313-4322 [PMID:19482476]
ChEMBL	Antiplasmodial activity against chloroquinone-resistant Plasmodium falciparum W2	F	6.15	pIC50	700	nM	IC50	Bioorg Med Chem Lett (2008) 18: 396-401 [PMID:17981462]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human erythrocyte after 48 hrs by flow cytometry	F	6.15	pIC50	700	nM	IC50	Eur J Med Chem (2010) 45: 616-622 [PMID:19926173]
ChEMBL	Antiplasmodial activity against multidrug-resistant Plasmodium falciparum W2 infected human erythrocytes after 48 hrs by flow cytometry	F	6.15	pIC50	700	nM	IC50	Eur J Med Chem (2010) 45: 864-869 [PMID:19914747]
ChEMBL	Antiparasitic activity against Plasmodium falciparum W2	F	6.16	pIC50	697.94	nM	IC50	Eur J Med Chem (2019) 181: 111353-111353 [PMID:31525705]
ChEMBL	Antimalarial activity against Plasmodium falciparum Dd2 infected in human erythrocytes assessed as reduction in [3H]-hypoxanthine incorporation preincubated for 24 hrs followed by [3H]-hypoxanthine addition measured after 24 hrs by scintillation counting method	F	6.16	pIC50	690	nM	IC50	J Med Chem (2017) 60: 5889-5908 [PMID:28635296]
ChEMBL	Antimalarial activity after 48 hrs against chloroquine-resistant Plasmodium falciparum K1 by [3H]hypoxanthine uptake	F	6.17	pIC50	682	nM	IC50	Eur J Med Chem (2008) 43: 1903-1910 [PMID:18215443]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human RBCs after 72 hrs by parasite lactate dehydrogenase assay	F	6.17	pIC50	681	nM	IC50	J Med Chem (2012) 55: 10387-10404 [PMID:23145816]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT K14 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter	F	6.18	pIC50	665	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum K1 incubated for 48 hrs	F	6.18	pIC50	660	nM	IC50	Eur J Med Chem (2020) 201: 112327-112327 [PMID:32526552]
ChEMBL	Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum K14 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs	F	6.19	pIC50	648.6	nM	IC50	J Med Chem (2010) 53: 3214-3226 [PMID:20329733]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum FCR3	F	6.19	pIC50	645	nM	IC50	Bioorg Med Chem Lett (2007) 17: 6434-6438 [PMID:17949976]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 assessed as inhibition of parasite LDH activity after 72 hrs by spectrophotometry	F	6.2	pIC50	632	nM	IC50	Eur J Med Chem (2011) 46: 1757-1767 [PMID:21396743]
ChEMBL	Antimicrobial activity against chloroquine-sensitive Plasmodium falciparum W2 by ELISA	F	6.2	pIC50	630.6	nM	IC50	Antimicrob Agents Chemother (2010) 54: 1200-1206 [PMID:20065051]
ChEMBL	Antimalarial activity against chloroquine-resistant/mefloquine-sensitive Plasmodium falciparum W2 by malaria SYBR green 1-based fluorescence (MSF) assay	F	6.2	pIC50	630	nM	IC50	Bioorg Med Chem Lett (2015) 25: 327-332 [PMID:25488841]
ChEMBL	Antimalarial activity against multidrug-resistant Plasmodium falciparum TM93-C1088 infected in human O positive red blood cells assessed as inhibition of [3H]-hypoxanthine uptake after 48 hrs	F	6.21	pIC50	620	nM	IC50	J Nat Prod (2011) 74: 74-78 [PMID:21155593]
ChEMBL	Antimalarial activity against Plasmodium falciparum W2	F	6.21	pIC50	616.94	nM	IC50	J Med Chem (2008) 51: 2261-2266 [PMID:18330976]
ChEMBL	Antiplasmodial activity against chloroquine-, pyrimethamine- and proguanil-resistant Plasmodium falciparum K1 infected in human erythrocytes after 72 hrs by SYBR Green I fluorescence-based method	F	6.22	pIC50	600	nM	IC50	Eur J Med Chem (2014) 83: 26-35 [PMID:24946216]
ChEMBL	Antiplasmodial activity against chloroquine/purimethamine/proguanil-resistant Plasmodium falciparum K1 infected in human A+ erythrocytes assessed as reduction in parasitaemia measured after 72 hrs by SYBR Green I fluorescence-based assay	F	6.22	pIC50	600	nM	IC50	Eur J Med Chem (2016) 119: 34-44 [PMID:27155463]
ChEMBL	Antiplasmodial activity against chloroquine/pyrimethamine/proguanil-resistant Plasmodium falciparum K1 infected in human erythrocytes after 72 hrs by SYBR Green 1 dye based fluorescence spectrophotometric method	F	6.22	pIC50	600	nM	IC50	Eur J Med Chem (2017) 125: 68-86 [PMID:27654395]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FcM29 by [3H]hypoxanthine uptake	F	6.22	pIC50	600	nM	IC50	J Nat Prod (2008) 71: 1189-1192 [PMID:18512987]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum indochina W2 assessed as [3H]-hypoxanthine incorporation by liquid scintillation counting analysis	F	6.23	pIC50	595	nM	IC50	Bioorg Med Chem (2015) 23: 2176-2186 [PMID:25801154]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human red blood cells after 48 hrs by SYBR test	F	6.23	pIC50	590	nM	IC50	Bioorg Med Chem Lett (2016) 26: 1881-1884 [PMID:26988303]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 assessed as parasite growth inhibition and measured after 72 hrs by ELISA	F	6.24	pIC50	580	nM	IC50	J Nat Prod (2022) 85: 1211-1217 [PMID:35512262]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human erythrocytes measured after 72 hrs by malstat reagent based LDH release assay	F	6.24	pIC50	570	nM	IC50	ACS Med Chem Lett (2018) 9: 980-985 [PMID:30344903]
ChEMBL	In vitro inhibitory activity against Plasmodium falciparum NF54-R in blood	F	6.24	pIC50	570	nM	IC50	Bioorg Med Chem Lett (2004) 14: 2773-2776 [PMID:15125930]
ChEMBL	Antimalarial activity against multidrug-resistant Plasmodium falciparum K1 infected human erythrocytes assessed as reduction in parasite viability after 24 hrs by [3H]-hypoxanthine incorporation assay	F	6.24	pIC50	570	nM	IC50	Eur J Med Chem (2016) 124: 896-905 [PMID:27668758]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human A+ erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs by scintillation counting	F	6.25	pIC50	563	nM	IC50	Bioorg Med Chem (2010) 18: 8085-8091 [PMID:20934349]
ChEMBL	Antimalarial activity against Plasmodium falciparum TM90C2B infected in human erythrocytes assessed as reduction in [3H]-hypoxanthine incorporation preincubated for 24 hrs followed by [3H]-hypoxanthine addition measured after 24 hrs by scintillation counting method	F	6.25	pIC50	561	nM	IC50	J Med Chem (2017) 60: 5889-5908 [PMID:28635296]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1	F	6.25	pIC50	560	nM	IC50	Bioorg Med Chem Lett (2004) 14: 3901-3905 [PMID:15225694]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 asexual gametocytes	F	6.25	pIC50	560	nM	IC50	Antimicrob Agents Chemother (2007) 51: 1463-1472 [PMID:17242150]
ChEMBL	Antimalarial activity against Plasmodium falciparum W2 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter	F	6.25	pIC50	556	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL	Antimalarial activity against chloroquine/sulfadoxine-resistant Plasmodium falciparum W2 infected in human A+ erythrocytes assessed as reduction in parasite growth after 72 hrs by HRP2 detection based ELISA	F	6.26	pIC50	550	nM	IC50	Bioorg Med Chem (2016) 24: 4492-4498 [PMID:27485600]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum INDO assessed as growth inhibition by SYBER green 1 dye based fluorescence assay	F	6.26	pIC50	546	nM	IC50	Eur J Med Chem (2021) 224: 113685-113685 [PMID:34303874]
ChEMBL	Antimalarial activity against Plasmodium falciparum INDO	F	6.26	pIC50	546	nM	IC50	Eur J Med Chem (2021) 213: 113193-113193 [PMID:33508479]
ChEMBL	Antimalarial activity against multidrug resistant Plasmodium falciparum Dd2 assessed as parasite growth inhibition incubated for 72 hrs by DAPI staining method	F	6.27	pIC50	543	nM	IC50	J Nat Prod (2023) 86: 557-565 [PMID:36799121]
ChEMBL	Antimalarial activity against Plasmodium falciparum K1 infected in human erythrocytes after 72 hrs by lactate dehydrogenase assay	F	6.27	pIC50	540	nM	IC50	J Nat Prod (2017) 80: 3120-3127 [PMID:29182338]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum PFB Brazil by [3H]hypoxanthine uptake	F	6.27	pIC50	540	nM	IC50	J Nat Prod (2001) 64: 12-16 [PMID:11170658]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2	F	6.27	pIC50	540	nM	IC50	Bioorg Med Chem Lett (2007) 17: 6434-6438 [PMID:17949976]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 after 24 hrs by [G-3H]-hypoxanthine incorporation assay	F	6.27	pIC50	540	nM	IC50	Eur J Med Chem (2017) 139: 22-47 [PMID:28800458]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1	F	6.27	pIC50	540	nM	IC50	Eur J Med Chem (2010) 45: 3245-3264 [PMID:20466465]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum D10	F	6.27	pIC50	540	nM	IC50	Eur J Med Chem (2010) 45: 3245-3264 [PMID:20466465]
ChEMBL	Growth inhibition of chloroquine-resistant Plasmodium falciparum KI	F	6.27	pIC50	540	nM	IC50	Bioorg Med Chem Lett (2001) 11: 2075-2077 [PMID:11514142]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT Bres assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter	F	6.27	pIC50	538	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 by LDH assay	F	6.28	pIC50	530	nM	IC50	Medchemcomm (2013) 4: 724-730
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs	F	6.28	pIC50	527	nM	IC50	J Med Chem (2010) 53: 3214-3226 [PMID:20329733]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT A4 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter	F	6.28	pIC50	525	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 assessed as growth inhibition after 18 hrs by [3H]-hypoxanthine uptake assay	F	6.28	pIC50	525	nM	IC50	J Med Chem (2015) 58: 3411-3431 [PMID:25654185]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum IMT K2 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay	F	6.28	pIC50	523	nM	IC50	J Med Chem (2009) 52: 7954-7957 [PMID:19908867]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT K2 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter	F	6.28	pIC50	523	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Bre1 assessed as inhibition of [3H]hypoxanthine incorporation	F	6.28	pIC50	520	nM	IC50	Bioorg Med Chem (2009) 17: 8032-8039 [PMID:19879150]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum Bre1 by hypoxanthine uptake	F	6.28	pIC50	520	nM	IC50	Bioorg Med Chem (2007) 15: 3278-3289 [PMID:17339112]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human type A-positive red blood cells assessed as parasite lactate dehydrogenase activity after 72 hrs by spectrophotometric analysis	F	6.28	pIC50	520	nM	IC50	J Med Chem (2011) 54: 8526-8540 [PMID:22054038]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2	F	6.28	pIC50	520	nM	IC50	J Nat Prod (2017) 80: 134-140 [PMID:28055207]
ChEMBL	Antiparasitic activity against chloroquine-resistant Plasmodium falciparum K1	F	6.28	pIC50	519.3	nM	IC50	J Med Chem (2008) 51: 1260-1277 [PMID:18260613]
ChEMBL	Antimalarial activity against schizont stage of chloroquine-resistant Plasmodium falciparum W2 infected in erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 48 hrs by scintillation counting analysis	F	6.28	pIC50	519	nM	IC50	Medchemcomm (2011) 2: 430-435
ChEMBL	Antimalarial activity against chloroquine resistant Plasmodium falciparum FcM29 Cameron	F	6.29	pIC50	518	nM	IC50	Eur J Med Chem (2021) 219: 113408-113408 [PMID:33989911]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum FcM29 assessed as inhibition of plasmodial growth	F	6.29	pIC50	518	nM	IC50	J Med Chem (2021) 64: 9786-9874 [PMID:34213340]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum FcM29(CQR)Cameroon incubated for 48 hrs by classical radioactive microdilution method	F	6.29	pIC50	518	nM	IC50	Eur J Med Chem (2020) 188: 111983-111983 [PMID:31911292]
ChEMBL	Antimalarial activity against Plasmodium falciparum FCM29 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter	F	6.29	pIC50	508	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum FCM29 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay	F	6.29	pIC50	508	nM	IC50	J Med Chem (2009) 52: 7954-7957 [PMID:19908867]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human RBC assessed as decrease in parasite viability after 72 hrs by LDH assay	F	6.3	pIC50	503	nM	IC50	Eur J Med Chem (2017) 126: 675-686 [PMID:27936446]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum FCR3 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay	F	6.3	pIC50	501	nM	IC50	J Med Chem (2009) 52: 7954-7957 [PMID:19908867]
ChEMBL	Antimalarial activity against Plasmodium falciparum FCR3 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter	F	6.3	pIC50	501	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL	Antiplasmodial activity against multidrug-resistant Plasmodium falciparum K1 ring stage after 72 hrs by SYBP Green fluorescence-based assay	F	6.3	pIC50	500	nM	IC50	Eur J Med Chem (2012) 55: 315-324 [PMID:22889559]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum FCR3 by hypoxanthine uptake	F	6.3	pIC50	500	nM	IC50	Bioorg Med Chem (2007) 15: 3278-3289 [PMID:17339112]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum W2	F	6.3	pIC50	500	nM	IC50	J Nat Prod (2009) 72: 906-911 [PMID:19344127]
ChEMBL	Antiplasmodial activity against chloroquine-, pyrimethamine-, proguanil-resistant Plasmodium falciparum K1 infected in A-positive human erythrocytes after 72 hrs by SYBR green 1 fluorescence-based method	F	6.3	pIC50	500	nM	IC50	Eur J Med Chem (2012) 54: 75-86 [PMID:22608675]
ChEMBL	Antiplasmodial activity against chloroquine, pyrimethamine, and proguanil-resistant Plasmodium falciparum K1 infected in human A+ erythrocytes after 72 hrs by SYBR Green-I fluorescence-based method	F	6.3	pIC50	500	nM	IC50	Bioorg Med Chem Lett (2011) 21: 6003-6006 [PMID:21852132]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as intraerythrocytic growth inhibition	F	6.3	pIC50	500	nM	IC50	RSC Med Chem (2023) 14: 715-733 [PMID:37122550]
ChEMBL	Antiplasmodial activity against chloroquine, pyrimethamine and proguanil-resistant Plasmodium falciparum K1 infected in human erythrocytes assessed as reduction in Parasitemia incubated for 72 hrs by SYBR Green I fluorescence-based method	F	6.3	pIC50	500	nM	IC50	Eur J Med Chem (2014) 87: 440-453 [PMID:25282267]
ChEMBL	Antiplasmodial activity against multi-drug resistant Plasmodium falciparum K1 infected in human erythrocytes assessed as parasite growth inhibition after 72 hrs by SYBR Green I dye-based fluorescence assay	F	6.3	pIC50	500	nM	IC50	Eur J Med Chem (2015) 95: 16-28 [PMID:25791675]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FCR3/Gambia assessed as inhibition of [3H]hypoxanthine incorporation	F	6.3	pIC50	500	nM	IC50	Bioorg Med Chem (2009) 17: 8032-8039 [PMID:19879150]
ChEMBL	Antimalarial activity against ring stage chloroquine-resistant Plasmodium falciparum INDO infected in human O positive erythrocytes after 48 hrs by SYBR green 1 fluorescence assay	F	6.3	pIC50	500	nM	IC50	J Med Chem (2012) 55: 297-311 [PMID:22098429]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human erythrocytes after 72 hrs by SYBR Green 1 staining based fluorescence assay	F	6.3	pIC50	500	nM	IC50	Eur J Med Chem (2018) 155: 764-771 [PMID:29940466]
ChEMBL	Antimalarial activity against erythrocytic stage multidrug-resistant Plasmodium falciparum Dd2 after 48 hrs by fluorescence spectrophotometer	F	6.3	pIC50	500	nM	IC50	Bioorg Med Chem (2011) 19: 4562-4573 [PMID:21723734]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 after 48 hrs	F	6.3	pIC50	500	nM	IC50	J Nat Prod (2005) 68: 1297-1299 [PMID:16124784]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 asynchronous cultures infected in human erythrocytes after 72 hrs by SYBR green1 staining based fluorescence assay	F	6.3	pIC50	500	nM	IC50	Eur J Med Chem (2019) 162: 448-454 [PMID:30469040]
ChEMBL	Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum K2 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs	F	6.31	pIC50	493.2	nM	IC50	J Med Chem (2010) 53: 3214-3226 [PMID:20329733]
ChEMBL	Antimalarial activity against Plasmodium falciparum W2	F	6.31	pIC50	491.53	nM	IC50	J Med Chem (2007) 50: 5118-5127 [PMID:17887664]
ChEMBL	Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum W2 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs	F	6.31	pIC50	485.3	nM	IC50	J Med Chem (2010) 53: 3214-3226 [PMID:20329733]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in African green monkey (Cercopithecus aethiops) (Cercopithecus aethiops) Vero cells assessed as parasite LDH activity after 72 hrs	F	6.32	pIC50	484	nM	IC50	Bioorg Med Chem (2009) 17: 7775-7782 [PMID:19833520]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 as LDH activity	F	6.32	pIC50	481.2	nM	IC50	Bioorg Med Chem (2008) 16: 6813-6823 [PMID:18562202]
ChEMBL	Antimalarial activity against Plasmodium falciparum K1 infected in human erythrocytes assessed as reduction in [3H]-hypoxanthine incorporation preincubated for 24 hrs followed by [3H]-hypoxanthine addition measured after 24 hrs by scintillation counting method	F	6.32	pIC50	480	nM	IC50	J Med Chem (2017) 60: 5889-5908 [PMID:28635296]
ChEMBL	Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum FCR3 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs	F	6.32	pIC50	477.5	nM	IC50	J Med Chem (2010) 53: 3214-3226 [PMID:20329733]
ChEMBL	Antimalarial activity against schizont stage of atovaquone-resistant Plasmodium falciparum Tm90C2b infected in erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 48 hrs by scintillation counting analysis	F	6.32	pIC50	475	nM	IC50	Medchemcomm (2011) 2: 430-435
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT K4 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter	F	6.33	pIC50	472	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL	Antiplasmodial activity CQ-resistant Plasmodium falciparum W2 infected in human erythrocytes assessed as inhibition of parasite growth measured after 72 hrs by HRP2-ELISA	F	6.33	pIC50	469.2	nM	IC50	Eur J Med Chem (2022) 228: 113981-113981 [PMID:34782182]
ChEMBL	Antimalarial activity against chloroquine resistant Plasmodium falciparum K1 after 72 hrs by SYBR green 1 dye based fluorescence assay	F	6.33	pIC50	463	nM	IC50	Eur J Med Chem (2017) 135: 382-391 [PMID:28460312]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 after 72 hrs by SYBR Green-I based fluorescence assay	F	6.33	pIC50	>463	nM	IC50	Bioorg Med Chem Lett (2012) 22: 5455-5459 [PMID:22850213]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 incubated for 72 hrs by spectrophotometry based parasite lactate dehydrogenase assay	F	6.34	pIC50	462.02	nM	IC50	ACS Med Chem Lett (2021) 12: 1077-1085 [PMID:34267877]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1	F	6.34	pIC50	460	nM	IC50	J Nat Prod (2017) 80: 134-140 [PMID:28055207]
ChEMBL	Antiplasmodial activity against chloroquine and sulfadoxine-resistant and mefloquine-sensitive Plasmodium falciparum W2 infected in human erythrocytes by anti-HRP2 assay	F	6.34	pIC50	460	nM	IC50	Bioorg Med Chem (2015) 23: 5979-5984 [PMID:26190461]
ChEMBL	Antimalarial activity against ring stage Plasmodium falciparum K1 incubated for 48 hrs by Hoechst 33342 staining based fluorescence based assay	F	6.34	pIC50	457	nM	IC50	Eur J Med Chem (2019) 184: 111755-111755 [PMID:31627059]
ChEMBL	Antimalarial activity against Plasmodium falciparum W2	F	6.34	pIC50	456.2	nM	IC50	J Med Chem (2011) 54: 1157-1169 [PMID:21265542]
ChEMBL	Antimalarial activity against CQ-resistant, MFQ-susceptible Plasmodium falciparum W2 clone Indochina 1 isolate assessed as inhibition of parasite proliferation by MSF assay	F	6.34	pIC50	456.2	nM	IC50	J Med Chem (2014) 57: 4134-4153 [PMID:24742203]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 after 48 hrs by [3H]hypoxanthine incorporation assay	F	6.34	pIC50	456	nM	IC50	J Med Chem (2016) 59: 264-281 [PMID:26640981]
ChEMBL	Antimalarial activity against schizont stage of chloroquine-resistant Plasmodium falciparum W2 infected in erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 96 hrs by scintillation counting analysis	F	6.34	pIC50	455	nM	IC50	Medchemcomm (2011) 2: 430-435
ChEMBL	Antimalarial activity against Plasmodium falciparum W2	F	6.34	pIC50	452.4	nM	IC50	J Med Chem (2006) 49: 4707-4714 [PMID:16854077]
ChEMBL	Antimalarial activity against multidrug-resistant Plasmodium falciparum isolate 208432 infected in human erythrocytes after 48 hrs by flow-cytometry	F	6.35	pIC50	451.4	nM	IC50	J Med Chem (2010) 53: 3552-3557 [PMID:20349996]
ChEMBL	Antiplasmodial activity against chloroquine-resistant erythrocyte stage of Plasmodium falciparum FcM29-Cameroon infected in human RBC assessed as reduction in [3H]hypoxanthine incorporation preincubated for 48 hrs followed by [3H]hypoxanthine addition measured after 24 hrs by liquid scintillation counting method	F	6.35	pIC50	450	nM	IC50	Bioorg Med Chem (2017) 25: 4433-4443 [PMID:28666857]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 after 72 hrs by SYBR Green I-based fluorescence assay	F	6.35	pIC50	443.57	nM	IC50	J Med Chem (2013) 56: 31-45 [PMID:23270565]
ChEMBL	Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum Bres infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs	F	6.35	pIC50	442.6	nM	IC50	J Med Chem (2010) 53: 3214-3226 [PMID:20329733]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human A+ erythrocytes after 72 hrs by parasite LDH assay	F	6.36	pIC50	440.7	nM	IC50	Bioorg Med Chem (2010) 18: 6625-6633 [PMID:20797868]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 by hypoxanthine uptake	F	6.36	pIC50	440	nM	IC50	Bioorg Med Chem (2007) 15: 3278-3289 [PMID:17339112]
ChEMBL	Antiplasmodial activity against synchronized ring stage of chloroquine-resistant Plasmodium falciparum INDO infected in human erythrocytes after 48 hrs by SYBR Green 1 dye based fluorescence assay	F	6.36	pIC50	440	nM	IC50	Eur J Med Chem (2018) 155: 623-638 [PMID:29929118]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 assessed as parasite growth inhibition after 24 hrs by [3H]-hypoxathine incorporation assay	F	6.36	pIC50	440	nM	IC50	ACS Med Chem Lett (2013) 4: 642-646 [PMID:24900724]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human erythrocytes measured after 72 hrs by SYBR green 1 dye based fluorescence assay	F	6.36	pIC50	440	nM	IC50	Eur J Med Chem (2017) 131: 171-184 [PMID:28319782]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 assessed as inhibition of [3H]hypoxanthine incorporation	F	6.36	pIC50	440	nM	IC50	Bioorg Med Chem (2009) 17: 8032-8039 [PMID:19879150]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human RBC assessed as inhibition of parasite growth after 72 hrs by lactate dehydrogenase assay	F	6.36	pIC50	437.62	nM	IC50	Bioorg Med Chem (2012) 20: 5980-5985 [PMID:22901673]
ChEMBL	Antimalarial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum W2 infected in human A-positive erythrocytes assessed as inhibition of [3H]-hypoxanthine incorporation after 48 hrs by semi-automated microdilution technique	F	6.37	pIC50	431	nM	IC50	Eur J Med Chem (2012) 49: 365-378 [PMID:22321992]
ChEMBL	Antiplasmodium activity against multidrug resistant Plasmodium falciparum K1 asexual blood stage forms infected in human erythrocytes assessed as reduction in [3H]-hypoxanthine incorporation incubated for 48 hrs by liquid scintillation counting method	F	6.37	pIC50	431	nM	IC50	Medchemcomm (2019) 10: 450-455 [PMID:31015908]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in type A rhesus-positive human erythrocytes assessed as [3H]hypoxanthine incorporation after 48 hrs by scintillation counting	F	6.37	pIC50	431	nM	IC50	J Med Chem (2012) 55: 3216-3227 [PMID:22380766]
ChEMBL	Antimalarial activity against CQ-resistant Plasmodium falciparum W2 infected in human erythrocytes after 48 hrs by SYBR Green1 dye based fluorescence assay	F	6.37	pIC50	430.6	nM	IC50	ACS Med Chem Lett (2020) 11: 1450-1456 [PMID:32676153]
ChEMBL	Antimalarial malarial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human A positive erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 24 hrs	F	6.37	pIC50	430	nM	IC50	Bioorg Med Chem Lett (2011) 21: 3644-3647 [PMID:21570837]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in RBC assessed as plasmodial LDH activity after 72 hrs	F	6.37	pIC50	430	nM	IC50	Bioorg Med Chem Lett (2013) 23: 112-116 [PMID:23218718]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in red blood cells after 72 hrs by Malstat reagent based LDH assay	F	6.37	pIC50	430	nM	IC50	Eur J Med Chem (2017) 131: 126-140 [PMID:28315598]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 after 48 hrs by LDH release assay	F	6.37	pIC50	422	nM	IC50	Eur J Med Chem (2018) 143: 866-880 [PMID:29223887]
ChEMBL	Antimalarial activity against chloroquine-resistant, mefloquine-susceptible Plasmodium falciparum W2	F	6.38	pIC50	421.59	nM	IC50	J Med Chem (2008) 51: 6216-6219 [PMID:18774792]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in RBC after 72 hrs by LDH release assay	F	6.38	pIC50	421.5	nM	IC50	Eur J Med Chem (2019) 162: 277-289 [PMID:30448417]
ChEMBL	Antimalarial activity against Plasmodium falciparum W2 assessed as plasmodial LDH activity after 72 hrs	F	6.38	pIC50	420	nM	IC50	Eur J Med Chem (2011) 46: 2816-2827 [PMID:21530018]
ChEMBL	Antimalarial activity against asexual blood stage multi drug-resistant Plasmodium falciparum K1 infected in erythrocytes assessed as reduction in parasitemia incubated up to 72 hrs by [3H]hypoxanthine incorporation assay	F	6.38	pIC50	420	nM	IC50	J Med Chem (2021) 64: 5198-5215 [PMID:33844521]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 by LDH release assay	F	6.38	pIC50	420	nM	IC50	Bioorg Med Chem Lett (2010) 20: 322-325 [PMID:19910192]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2	F	6.38	pIC50	420	nM	IC50	Eur J Med Chem (2019) 166: 206-223 [PMID:30711831]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human red blood cells assessed as reduction in parasitic LDH activity by Malstat reagent based spectrophotometric method	F	6.38	pIC50	420	nM	IC50	Eur J Med Chem (2017) 139: 22-47 [PMID:28800458]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1	F	6.38	pIC50	420	nM	IC50	J Nat Prod (2008) 71: 167-174 [PMID:18220356]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 asexual erythrocyte forms after 48 hrs by parasite LDH assay	F	6.38	pIC50	417	nM	IC50	Bioorg Med Chem (2013) 21: 269-277 [PMID:23168082]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 after 72 hrs by parasite lactate dehydrogenase assay	F	6.39	pIC50	412	nM	IC50	Bioorg Med Chem Lett (2012) 22: 5915-5918 [PMID:22884991]
ChEMBL	Antimalarial activity against Chloroquine-resistant Plasmodium falciparum W2 assessed as parasite growth inhibition after 72 hrs by lactate dehydrogenase assay	F	6.39	pIC50	412	nM	IC50	Medchemcomm (2015) 6: 1173-1177
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FCM29 by SYBR green assay	F	6.39	pIC50	410	nM	IC50	Bioorg Med Chem (2009) 17: 2871-2876 [PMID:19282186]
ChEMBL	Antimalarial activity against Plasmodium falciparum W2 in parasite LDH assay	F	6.39	pIC50	410	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1446-1449 [PMID:18248990]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 after 72 hrs by parasite LDH assay	F	6.39	pIC50	410	nM	IC50	J Nat Prod (2010) 73: 1138-1145 [PMID:20521782]
ChEMBL	Antimalarial activity after 72 hrs against chloroquine-resistant Plasmodium falciparum W2 by Malstat LDH activity	F	6.39	pIC50	410	nM	IC50	Bioorg Med Chem (2009) 17: 5632-5638 [PMID:19574054]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 in erythrocytes after 72 hrs by LDH activity	F	6.39	pIC50	410	nM	IC50	Bioorg Med Chem Lett (2009) 19: 1675-1677 [PMID:19231182]
ChEMBL	Antimalarial activity against chloroquine resistant Plasmodium falciparum W2 infected in human red blood cells assessed as reduction in parasite growth measured after 72 hrs by parasite lactate dehydrogenase assay	F	6.39	pIC50	406	nM	IC50	ACS Med Chem Lett (2021) 12: 1726-1732 [PMID:34795860]
ChEMBL	Antimalarial activity against drug-resistant Plasmodium falciparum W2	F	6.39	pIC50	405	nM	IC50	Antimicrob Agents Chemother (2008) 52: 3467-3477 [PMID:18644969]
ChEMBL	Antimalarial activity against Plasmodium falciparum W2 by hypoxanthine uptake	F	6.39	pIC50	405	nM	IC50	J Med Chem (2008) 51: 3437-3448 [PMID:18494463]
ChEMBL	Antiplasmodial activity against chloroquine, pyrimethamine and proguanil-resistant Plasmodium falciparum W2 infected in human A positive erythrocytes after 72 hrs by SYBR Green I assay	F	6.4	pIC50	400	nM	IC50	Eur J Med Chem (2011) 46: 4184-4191 [PMID:21741131]
ChEMBL	In vitro antimalarial activity for Plasmodium falciparum W2	F	6.4	pIC50	400	nM	IC50	Bioorg Med Chem Lett (2004) 14: 1145-1149 [PMID:14980653]
ChEMBL	Antimalarial activity against CQ-resistant Plasmodium falciparum W2 infected in human type A-positive red blood cells assessed as inhibition of parasite growth incubated for for 72 hrs by spectrophotometry based parasite lactate dehydrogenase assay	F	6.4	pIC50	400	nM	IC50	ACS Med Chem Lett (2019) 10: 590-595 [PMID:30996801]
ChEMBL	Antimalarial activity against chloroquine-resistant/mefloquine-sensitive Plasmodium falciparum W2 ring stage forms infected in human erythrocytes assessed as reduction in parasite growth after 48 hrs by parasite LDH release assay	F	6.4	pIC50	400	nM	IC50	Eur J Med Chem (2018) 145: 191-205 [PMID:29324340]
ChEMBL	Antimalarial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 infected in human O positive red blood cells assessed as inhibition of [3H]-hypoxanthine uptake after 48 hrs	F	6.4	pIC50	400	nM	IC50	J Nat Prod (2011) 74: 74-78 [PMID:21155593]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human RBC assessed as reduction in parasite growth after 72 hrs by LDH assay	F	6.4	pIC50	400	nM	IC50	Bioorg Med Chem (2022) 66: 116830-116830 [PMID:35594648]
ChEMBL	Antimalarial activity against CQ-resistant Plasmodium falciparum K1	F	6.4	pIC50	400	nM	IC50	Eur J Med Chem (2021) 226: 113865-113865 [PMID:34655985]
ChEMBL	Antimalarial activity against Plasmodium falciparum K1 assessed as inhibition of parasite growth by microculture radioisotope technique	F	6.4	pIC50	400	nM	IC50	J Nat Prod (2021) 84: 2775-2785 [PMID:34748348]
ChEMBL	Anti-parasitic activity against CQ-resistant Plasmodium falciparum W2 assessed as growth inhibition by measuring increase in LDH release after 72 hrs by spectrophotometric method	F	6.4	pIC50	400	nM	IC50	J Med Chem (2017) 60: 1959-1970 [PMID:28128956]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum FcM29	F	6.4	pIC50	400	nM	IC50	Antimicrob Agents Chemother (2009) 53: 1100-1106 [PMID:19015354]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 after 72 hr by LDJH assay	F	6.4	pIC50	400	nM	IC50	Med Chem Res (2011) 20: 401-407
ChEMBL	Antimalarial activity against chloroquine-resistant, mefloquine-sensitive Plasmodium falciparum W2 assessed as inhibition of [3H]hypoxanthine uptake	F	6.4	pIC50	397	nM	IC50	Bioorg Med Chem Lett (2011) 21: 786-789 [PMID:21168330]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum Bre1	F	6.4	pIC50	396.2	nM	IC50	Bioorg Med Chem Lett (2007) 17: 6434-6438 [PMID:17949976]
ChEMBL	Antimalarial activity against multidrug-resistant Plasmodium falciparum W2	F	6.4	pIC50	394	nM	IC50	J Med Chem (2006) 49: 4535-4543 [PMID:16854059]
ChEMBL	Antimalarial activity against schizont stage of atovaquone-resistant Plasmodium falciparum Tm90C2b infected in erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 96 hrs by scintillation counting analysis	F	6.41	pIC50	393	nM	IC50	Medchemcomm (2011) 2: 430-435
ChEMBL	Antiplasmodial activity against multidrug-resistant Plasmodium falciparum K1 assessed as inhibition of parasite growth incubated for 3 days by HRP2-ELISA	F	6.41	pIC50	392.1	nM	IC50	Eur J Med Chem (2022) 238: 114408-114408 [PMID:35551033]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2	F	6.41	pIC50	392.09	nM	IC50	J Med Chem (2008) 51: 4388-4391 [PMID:18637666]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in red blood cells after 72 hrs by parasitic LDH assay	F	6.41	pIC50	390	nM	IC50	ACS Med Chem Lett (2012) 3: 555-559 [PMID:24900509]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum 7G8 harboring parental pfcrt allele infected in erythrocytes assessed as [3H]hypoxanthine incorporation	F	6.41	pIC50	389.5	nM	IC50	Antimicrob Agents Chemother (2009) 53: 1362-1366 [PMID:19188388]
ChEMBL	Antimalarial activity against Plasmodium falciparum T9/94 infected in human erythrocytes assessed as reduction in [3H]-hypoxanthine incorporation preincubated for 24 hrs followed by [3H]-hypoxanthine addition measured after 24 hrs by scintillation counting method	F	6.42	pIC50	384	nM	IC50	J Med Chem (2017) 60: 5889-5908 [PMID:28635296]
ChEMBL	Antimalarial activity against Plasmodium falciparum TM90C2A infected in human erythrocytes assessed as reduction in [3H]-hypoxanthine incorporation preincubated for 24 hrs followed by [3H]-hypoxanthine addition measured after 24 hrs by scintillation counting method	F	6.42	pIC50	384	nM	IC50	J Med Chem (2017) 60: 5889-5908 [PMID:28635296]
ChEMBL	Antimalarial activity against Plasmodium falciparum W2 by FACS assay	F	6.42	pIC50	382	nM	IC50	J Med Chem (2010) 53: 3685-3695 [PMID:20361799]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum W2 infected in RBCs by parasitic LDH release assay	F	6.42	pIC50	378.3	nM	IC50	Bioorg Med Chem (2009) 17: 7949-7957 [PMID:19879765]
ChEMBL	Antiplasmodial activity chloroquine-resistant Plasmodium falciparum Dd2 by lactate dehydrogenase assay	F	6.42	pIC50	378	nM	IC50	Bioorg Med Chem Lett (2014) 24: 1214-1217 [PMID:24468411]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum W2 harboring mutations conferring drug-resistance by SYBR-green based assay	F	6.43	pIC50	374.7	nM	IC50	J Med Chem (2014) 57: 6642-6652 [PMID:25007124]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR I method	F	6.43	pIC50	374.66	nM	IC50	J Med Chem (2014) 57: 5702-5713 [PMID:24914738]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 by microculture radioisotope technique	F	6.43	pIC50	370	nM	IC50	J Nat Prod (2015) 78: 2364-2371 [PMID:26398312]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 assessed as inhibition of parasite growth after 72 hrs by parasite LDH release assay	F	6.44	pIC50	367	nM	IC50	Eur J Med Chem (2015) 89: 490-502 [PMID:25462261]
ChEMBL	Antiplasmodial activity against multidrug-resistant Plasmodium falciparum Dd2 assessed as inhibition of parasite growth incubated for 3 days by HRP2-ELISA	F	6.44	pIC50	364.2	nM	IC50	Eur J Med Chem (2022) 238: 114408-114408 [PMID:35551033]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2	F	6.44	pIC50	360	nM	IC50	Bioorg Med Chem Lett (2013) 23: 1507-1510 [PMID:23347684]
ChEMBL	Antiprotozoal activity against chloroquine and pyrimethamine-resistant erythrocytic stage of Plasmodium falciparum K1 assessed as reduction in [3H]hypoxanthine incorporation preincubated for 48 hrs followed by [3H]hypoxanthine addition and measured after 24 hrs by liquid scintillation counting method	F	6.44	pIC50	360	nM	IC50	J Nat Prod (2019) 82: 3150-3164 [PMID:31630523]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 assessed as inhibition of parasite growth after 72 hrs by parasite lactate dehydrogenase assay	F	6.44	pIC50	360	nM	IC50	Bioorg Med Chem (2015) 23: 55-65 [PMID:25497962]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 after 48 hrs	F	6.45	pIC50	354.7	nM	IC50	Eur J Med Chem (2013) 69: 338-347 [PMID:24077524]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human O+ erythrocytes by parasite LDH assay	F	6.45	pIC50	352.3	nM	IC50	Bioorg Med Chem Lett (2010) 20: 1078-1080 [PMID:20034790]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1	F	6.45	pIC50	352.3	nM	IC50	Bioorg Med Chem (2007) 15: 6510-6516 [PMID:17693090]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 infected after 72 hrs by Malaria SYBR Green I-staining based fluorescence assay	F	6.45	pIC50	352.3	nM	IC50	Bioorg Med Chem Lett (2014) 24: 1719-1723 [PMID:24630564]
ChEMBL	Antimalarial activity against Plasmodium falciparum K1	F	6.46	pIC50	350	nM	IC50	Eur J Med Chem (2018) 143: 283-291 [PMID:29197733]
ChEMBL	Growth inhibition against Plasmodium falciparum K1	F	6.46	pIC50	350	nM	IC50	Bioorg Med Chem Lett (2006) 16: 2283-2292 [PMID:16458512]
ChEMBL	Parasite growth in chloroquine-sensitive Plasmodium falciparum K1	F	6.46	pIC50	350	nM	IC50	J Med Chem (1999) 42: 4630-4639 [PMID:10579825]
ChEMBL	Antimalarial activity against Plasmodium falciparum W2	F	6.46	pIC50	349.4	nM	IC50	J Med Chem (2006) 49: 3790-3799 [PMID:16789736]
ChEMBL	Antimalarial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum W2	F	6.46	pIC50	349.35	nM	IC50	Bioorg Med Chem (2008) 16: 7039-7045 [PMID:18550377]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum K1 by SYBR-green based assay	F	6.46	pIC50	347.3	nM	IC50	J Med Chem (2014) 57: 6642-6652 [PMID:25007124]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 after 72 hrs by SYBR I method	F	6.46	pIC50	347.29	nM	IC50	J Med Chem (2014) 57: 5702-5713 [PMID:24914738]
ChEMBL	Antimalarial activity against multidrug-resistant Plasmodium falciparum K1 by SYBR green-based assay	F	6.46	pIC50	347	nM	IC50	Bioorg Med Chem Lett (2015) 25: 1100-1103 [PMID:25650255]
ChEMBL	Antiplasmodial activity against multidrug-resistant Plasmodium falciparum K1 by SYBR Green-based method	F	6.46	pIC50	347	nM	IC50	Bioorg Med Chem Lett (2015) 25: 952-955 [PMID:25599834]
ChEMBL	Antiplasmodial activity against multidrug-resistant Plasmodium falciparum K1 infected in human erythrocytes after 48 hrs by [3H]-hypoxanthine incorporation assay	F	6.46	pIC50	344	nM	IC50	Bioorg Med Chem (2015) 23: 5419-5432 [PMID:26264839]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 assessed as [3H]hypoxanthine incorporation after 24 hrs by scintillation counting	F	6.46	pIC50	344	nM	IC50	Bioorg Med Chem Lett (2012) 22: 5046-5050 [PMID:22749280]
ChEMBL	Antiplasmodial activity against erythrocytic stage of multidrug-resistant Plasmodium falciparum Thailand K1 infected in human A positive RBC after 48 hrs by [3H]hypoxanthine incorporation assay	F	6.47	pIC50	340	nM	IC50	ACS Med Chem Lett (2013) 4: 637-641 [PMID:24900723]
ChEMBL	Antiplasmodial activity against erythrocyte form of chloroquine-resistant Plasmodium falciparum Dd2 by parasite lactate dehydrogenase assay	F	6.47	pIC50	340	nM	IC50	Bioorg Med Chem Lett (2013) 23: 318-322 [PMID:23195733]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 after 72 hrs by LDH assay	F	6.47	pIC50	340	nM	IC50	J Nat Prod (2010) 73: 1448-1452 [PMID:20669933]
ChEMBL	Antimalarial activity against Plasmodium falciparum W2 by [3H]hypoxanthine uptake	F	6.47	pIC50	340	nM	IC50	Eur J Med Chem (2009) 44: 3816-3820 [PMID:19403210]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2	F	6.47	pIC50	338	nM	IC50	Bioorg Med Chem Lett (2006) 16: 1854-1858 [PMID:16434194]
ChEMBL	Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum PA infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs	F	6.48	pIC50	330.4	nM	IC50	J Med Chem (2010) 53: 3214-3226 [PMID:20329733]
ChEMBL	Antiplasmodial activity against erythrocytic stage of Plasmodium falciparum K1 after 48 hrs by [3H]-hypoxanthine incorporation assay	F	6.48	pIC50	328	nM	IC50	ACS Med Chem Lett (2013) 4: 538-541 [PMID:24900706]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human erythrocytes assessed as [3H]hypoxanthine incorporation after 48 hrs by betaplate liquid scintillation counting analysis	F	6.49	pIC50	325	nM	IC50	Medchemcomm (2011) 2: 661-665
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 assessed as inhibition of parasite growth after 72 hrs by parasite lactate dehydrogenase assay	F	6.49	pIC50	320	nM	IC50	Bioorg Med Chem (2015) 23: 4681-4687 [PMID:26081764]
ChEMBL	Antimalarial activity against chloroquine,pyrimethamine-resistant Plasmodium falciparum K1 after 24 hrs	F	6.49	pIC50	320	nM	IC50	Bioorg Med Chem (2007) 15: 5551-5562 [PMID:17548196]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by 1536-well format based SYBR green assay	F	6.49	pIC50	320	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1	F	6.49	pIC50	320	nM	IC50	J Nat Prod (2002) 65: 85-88 [PMID:11809075]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human red blood cells after 72 hrs by parasite lactate dehydrogenase assay	F	6.5	pIC50	317.1	nM	IC50	Bioorg Med Chem (2012) 20: 5965-5979 [PMID:22917857]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in red blood cells after 72 hrs by Malstat reagent based LDH assay	F	6.5	pIC50	317	nM	IC50	Eur J Med Chem (2017) 129: 175-185 [PMID:28222317]
ChEMBL	Antiplasmodial activity against chloroquine, pyrimethamine, cycloguanil-resistant Plasmodium falciparum K1 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs	F	6.5	pIC50	316.3	nM	IC50	J Med Chem (2010) 53: 3214-3226 [PMID:20329733]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human type A-positive red blood cells assessed as growth inhibition after 72 hrs by spectrophotometrically	F	6.5	pIC50	316	nM	IC50	Bioorg Med Chem (2014) 22: 5757-5765 [PMID:25311562]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human type A+ erythrocytes after 48 hrs by [3H]-hypoxanthine incorporation assay	F	6.5	pIC50	316	nM	IC50	Eur J Med Chem (2017) 139: 22-47 [PMID:28800458]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 by [3H]hypoxanthine uptake	F	6.5	pIC50	315	nM	IC50	J Med Chem (2008) 51: 3466-3479 [PMID:18512900]
ChEMBL	Antimalarial activity against Plasmodium falciparum W2mef by hypoxanthine uptake assay	F	6.51	pIC50	311	nM	IC50	Bioorg Med Chem Lett (2009) 19: 5452-5457 [PMID:19666223]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in RBC assessed as parasite LDH activity after 72 hrs	F	6.51	pIC50	310	nM	IC50	J Nat Prod (2012) 75: 883-889 [PMID:22530813]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2	F	6.51	pIC50	310	nM	IC50	Bioorg Med Chem Lett (2007) 17: 6101-6106 [PMID:17900897]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 after 72 hrs by lactate dehydrogenase assay	F	6.51	pIC50	310	nM	IC50	Eur J Med Chem (2018) 150: 698-718 [PMID:29571157]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 infected in normal type A human erythrocytes incubated for 72 hrs by spectrophotometry based parasite lactate dehydrogenase assay	F	6.52	pIC50	300	nM	IC50	Bioorg Med Chem Lett (2018) 28: 1287-1291 [PMID:29559277]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FCR-3 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs	F	6.52	pIC50	300	nM	IC50	Bioorg Med Chem Lett (2011) 21: 4498-4502 [PMID:21724395]
ChEMBL	Antimalarial activity against Plasmodium falciparum K1 infected in RBC assessed as growth inhibition after 48 hrs by SYBR Green-I fluorescence assay	F	6.52	pIC50	300	nM	IC50	J Med Chem (2013) 56: 6200-6215 [PMID:23837878]
ChEMBL	Antimalarial activity against Chloroquine resistant blood stage Plasmodium falciparum clone W2	F	6.52	pIC50	300	nM	IC50	Eur J Med Chem (2021) 210: 113084-113084 [PMID:33333397]
ChEMBL	Antiplasmodial activity against multidrug-resistant Plasmodium falciparum K1 infected in human RBC incubated for 18 to 20 hrs by microdilution radioisotope method	F	6.52	pIC50	300	nM	IC50	J Nat Prod (2016) 79: 978-983 [PMID:26928423]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 infected in human erythrocytes after 48 hrs	F	6.52	pIC50	300	nM	IC50	Antimicrob Agents Chemother (2007) 51: 2842-2847 [PMID:17562796]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 infected in human RBC assessed as reduction in parasite growth after 72 hrs by LDH assay	F	6.52	pIC50	300	nM	IC50	Bioorg Med Chem (2022) 66: 116830-116830 [PMID:35594648]
ChEMBL	Antimalarial activity against Plasmodium falciparum K1	F	6.52	pIC50	300	nM	IC50	J Med Chem (1994) 37: 1362-1370 [PMID:8176713]
ChEMBL	Antimalarial activity against chloroquine and mefloquine-resistant Plasmodium falciparum Dd2 after 48 hrs by SYBR Green I assay	F	6.52	pIC50	300	nM	IC50	Bioorg Med Chem Lett (2015) 25: 2112-2116 [PMID:25881827]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human O+erythrocytes after 72 hrs by lactate dehydrogenase assay	F	6.52	pIC50	300	nM	IC50	J Nat Prod (2016) 79: 2865-2872 [PMID:27933893]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 gametocytes (stage 2 & 3)	F	6.52	pIC50	300	nM	IC50	Antimicrob Agents Chemother (2007) 51: 1463-1472 [PMID:17242150]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum 34-1/E	F	6.52	pIC50	299.45	nM	IC50	Antimicrob Agents Chemother (2007) 51: 2265-2267 [PMID:17404003]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum W2	F	6.52	pIC50	299	nM	IC50	Antimicrob Agents Chemother (2009) 53: 1100-1106 [PMID:19015354]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 infected in erythrocytes assessed as [3H]hypoxanthine incorporation	F	6.53	pIC50	293.3	nM	IC50	Antimicrob Agents Chemother (2009) 53: 1362-1366 [PMID:19188388]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 infected in O+ human erythrocytes by [3H]hypoxanthine incorporation assay	F	6.53	pIC50	293	nM	IC50	Antimicrob Agents Chemother (2008) 52: 1454-1461 [PMID:18212103]
ChEMBL	Antiprotozoal activity against erythrocytic stage of chloroquine and pyrimethamine resistant Plasmodium falciparum K1 after 48 hrs by [3H]- hypoxanthine incorporation assay	F	6.54	pIC50	291	nM	IC50	J Nat Prod (2017) 80: 443-458 [PMID:28121440]
ChEMBL	Antiplasmodial activity after 48 hrs against chloroquine-resistant Plasmodium falciparum FcM29-Cameroon by [3H]hypoxanthine uptake	F	6.54	pIC50	291	nM	IC50	Bioorg Med Chem Lett (2007) 17: 6075-6078 [PMID:17904365]
ChEMBL	Antiplasmodial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 assessed as reduction in [3H]-hypoxanthine incorporation pretreated for 48 hrs followed by [3H]-hypoxanthine addition measured after 24 hrs by liquid scintillation counting method	F	6.54	pIC50	291	nM	IC50	J Nat Prod (2018) 81: 918-933 [PMID:29560715]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum 7G8-mdr7G8	F	6.54	pIC50	290.05	nM	IC50	Antimicrob Agents Chemother (2007) 51: 2265-2267 [PMID:17404003]
ChEMBL	Antiplasmodial activity against asynchronous form of Plasmodium falciparum W2 infected in human erythrocytes assessed as parasite growth inhibition after 48 hrs by SYBR green1 staining based flow cytometry	F	6.54	pIC50	290	nM	IC50	Eur J Med Chem (2019) 161: 277-291 [PMID:30366254]
ChEMBL	Antimalarial activity against Plasmodium falciparum W2 in MSF assay	F	6.54	pIC50	290	nM	IC50	Bioorg Med Chem (2008) 16: 1174-1183 [PMID:18023189]
ChEMBL	Antimalarial activity against chloroquine and pyrimethamine-resistant early trophozoite stage of Plasmodium falciparum W2 in human red blood cells assessed as [3H]hypoxanthine uptake after 96 hrs	F	6.54	pIC50	290	nM	IC50	J Med Chem (2013) 56: 2513-2526 [PMID:23448281]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 by Malaria SYBR Green I-nucleic acid staining based fluorescence assay	F	6.54	pIC50	287.89	nM	IC50	Bioorg Med Chem (2014) 22: 5950-5960 [PMID:25284252]
ChEMBL	Antimalarial activity against ring stage Plasmodium falciparum Dd2 infected with human red blood cells incubated for 48 hrs by SYBR Green method	F	6.55	pIC50	285	nM	IC50	Bioorg Med Chem (2015) 23: 1530-1539 [PMID:25725608]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum PA infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay	F	6.55	pIC50	284	nM	IC50	J Med Chem (2009) 52: 7954-7957 [PMID:19908867]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 Indochina by [3H]hypoxanthine uptake	F	6.55	pIC50	284	nM	IC50	J Nat Prod (2001) 64: 12-16 [PMID:11170658]
ChEMBL	Antimalarial activity against Plasmodium falciparum PA assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter	F	6.55	pIC50	284	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2/Indochina by [3H]hypoxanthine uptake	F	6.55	pIC50	284	nM	IC50	J Nat Prod (2002) 65: 1381-1386 [PMID:12398531]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 assessed as [3H]hypoxanthine incorporation	F	6.55	pIC50	283.5	nM	IC50	Antimicrob Agents Chemother (2009) 53: 1320-1324 [PMID:19171802]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human erythrocytes assessed as parasite growth inhibition after 48 hrs by YOYO1 probe-based flow cytometric method	F	6.55	pIC50	282	nM	IC50	Bioorg Med Chem Lett (2017) 27: 1693-1697 [PMID:28318947]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2	F	6.55	pIC50	280	nM	IC50	Bioorg Med Chem Lett (2006) 16: 5384-5388 [PMID:16890433]
ChEMBL	Antiparasitic activity against Plasmodium falciparum K1 amastigotes IEF stage forms incubated for 72 hrs by Alamar Blue staining based fluorometric assay	F	6.55	pIC50	280	nM	IC50	J Nat Prod (2011) 74: 1972-1979 [PMID:21846091]
ChEMBL	Antimalarial activity after 72 hrs against chloroquine-resistant Plasmodium falciparum W2 infected human A+ erythrocytes by Makler LDH reporter assay	F	6.55	pIC50	280	nM	IC50	J Med Chem (2009) 52: 502-513 [PMID:19113955]
ChEMBL	Antiplasmodial activity against multidrug-resistant asexual blood stage Plasmodium falciparum K1 strain assessed as reduction in parasite growth after 72 hrs by NBT reagent based LDH assay	F	6.55	pIC50	280	nM	IC50	J Med Chem (2020) 63: 13013-13030 [PMID:33103428]
ChEMBL	Antimalarial activity against Plasmodium falciparum W2 by parasite lactate dehydrogenase assay	F	6.55	pIC50	280	nM	IC50	Eur J Med Chem (2021) 215: 113227-113227 [PMID:33601312]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 by [3H]hypoxanthine incorporation	F	6.55	pIC50	280	nM	IC50	J Med Chem (2008) 51: 1278-1294 [PMID:18278860]
ChEMBL	Antimalarial activity against multidrug-resistant Plasmodium falciparum TM90-C2B infected in human O positive red blood cells assessed as inhibition of [3H]-hypoxanthine uptake after 48 hrs	F	6.55	pIC50	280	nM	IC50	J Nat Prod (2011) 74: 74-78 [PMID:21155593]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human RBC after 72 hrs by parasite lactate dehydrogenase assay	F	6.55	pIC50	280	nM	IC50	J Med Chem (2012) 55: 6948-6967 [PMID:22783984]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 by [3H]hypoxanthine incorporation	F	6.55	pIC50	280	nM	IC50	J Med Chem (2008) 51: 1333-1343 [PMID:18278859]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2	F	6.55	pIC50	280	nM	IC50	J Med Chem (2007) 50: 595-598 [PMID:17263523]
ChEMBL	Antiprotozoal activity against erythrocytic stages of Plasmodium falciparum K1 by [3H]hypoxanthine incorporation assay	F	6.55	pIC50	280	nM	IC50	Bioorg Med Chem Lett (2013) 23: 452-454 [PMID:23265884]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum schizonts assessed as [3H]hypoxanthine incorporation by liquid scintillation counting	F	6.55	pIC50	280	nM	IC50	J Nat Prod (1997) 60: 1017-1022 [PMID:9358645]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human type A-positive RBC assessed as inhibition of parasite LDH activity after 72 hrs by spectrophotometric analysis	F	6.55	pIC50	280	nM	IC50	J Med Chem (2011) 54: 5949-5953 [PMID:21761935]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 incubated for 48 hrs by parasite lactate dehydrogenase assay	F	6.55	pIC50	279	nM	IC50	J Med Chem (2020) 63: 14470-14501 [PMID:33023291]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum K1 in [3H]hypoxanthine incorporation assay	F	6.56	pIC50	278	nM	IC50	J Med Chem (2008) 51: 909-923 [PMID:18247550]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2	F	6.56	pIC50	276.5	nM	IC50	Antimicrob Agents Chemother (2009) 53: 4339-4344 [PMID:19651905]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 by LDH release assay	F	6.56	pIC50	275	nM	IC50	Eur J Med Chem (2018) 148: 39-53 [PMID:29454189]
ChEMBL	Antiplasmodial activity against chloroquine-resistant asexual erythrocytic stage of Plasmodium falciparum Dd2 assessed as [3H]-hypoxanthine incorporation by lactate dehydrogenase assay	F	6.56	pIC50	274	nM	IC50	Eur J Med Chem (2015) 92: 91-102 [PMID:25544689]
ChEMBL	Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum L1 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs	F	6.56	pIC50	273.5	nM	IC50	J Med Chem (2010) 53: 3214-3226 [PMID:20329733]
ChEMBL	Antiplasmodial activity against multidrug-resistant Plasmodium falciparum K1	F	6.57	pIC50	272	nM	IC50	Bioorg Med Chem Lett (2021) 54: 128442-128442 [PMID:34763083]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 assessed as Plasmodium lactate dehydrogenase release after 48 hrs by colorimetry	F	6.57	pIC50	271	nM	IC50	Antimicrob Agents Chemother (2009) 53: 2212-2214 [PMID:19258270]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum E8B assessed as Plasmodium lactate dehydrogenase release after 48 hrs by colorimetry	F	6.57	pIC50	271	nM	IC50	Antimicrob Agents Chemother (2009) 53: 2212-2214 [PMID:19258270]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1	F	6.57	pIC50	270	nM	IC50	Bioorg Med Chem Lett (2007) 17: 959-963 [PMID:17166718]
ChEMBL	Antimalarial activity against Plasmodium falciparum W2 by [3H]hypoxanthine uptake	F	6.57	pIC50	270	nM	IC50	J Nat Prod (2006) 69: 346-350 [PMID:16562832]
ChEMBL	Inhibition of [3H]hypoxanthine incorporation in Plasmodium falciparum K1	F	6.57	pIC50	270	nM	IC50	J Med Chem (2001) 44: 4443-4452 [PMID:11728189]
ChEMBL	Antiplasmodial activity against chloroquine and pyrimethamine resistant Plasmodium falciparum K1 strain	F	6.57	pIC50	270	nM	IC50	Eur J Med Chem (2021) 210: 112969-112969 [PMID:33148495]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum IMTVo1 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay	F	6.57	pIC50	267	nM	IC50	J Med Chem (2009) 52: 7954-7957 [PMID:19908867]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT Vol assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter	F	6.57	pIC50	267	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL	Inhibition of Plasmodium falciparum K1	F	6.57	pIC50	267	nM	IC50	J Med Chem (2000) 43: 2646-2654 [PMID:10893302]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1	F	6.57	pIC50	266.58	nM	IC50	Antimicrob Agents Chemother (2007) 51: 2265-2267 [PMID:17404003]
ChEMBL	Antimalarial activity against Plasmodium falciparum W2 after 24 hrs by [3H]hypoxanthine uptake	F	6.58	pIC50	266	nM	IC50	J Nat Prod (2002) 65: 614-615 [PMID:11975516]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum FCM29 by [3H]hypoxanthine uptake	F	6.58	pIC50	264	nM	IC50	Bioorg Med Chem (2007) 15: 6018-6026 [PMID:17624792]
ChEMBL	Antiprotozoal activity against Plasmodium falciparum assessed as parasite growth inhibition	F	6.58	pIC50	263	nM	IC50	J Med Chem (2013) 56: 7442-7448 [PMID:23968432]
ChEMBL	Antiprotozoal activity against Chloroquine-resistant Plasmodium falciparum K1 assessed as parasite growth inhibition	F	6.58	pIC50	263	nM	IC50	J Med Chem (2021) 64: 6397-6409 [PMID:33901399]
ChEMBL	Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum Voll infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs	F	6.58	pIC50	262.4	nM	IC50	J Med Chem (2010) 53: 3214-3226 [PMID:20329733]
ChEMBL	Antiparasitic activity against chloroquine-resistant Plasmodium falciparum R1H6/2 pretreated with 0.1 uM phenobarbitone for 48 hrs by [3H]hypoxanthine incorporation assay	F	6.58	pIC50	262	nM	IC50	Antimicrob Agents Chemother (2008) 52: 1438-1445 [PMID:18195056]
ChEMBL	Antimalarial activity after 24 hrs against chloroquine-resistant synchronous Plasmodium falciparum K1 infected human A+ erythrocytes by [3H]hypoxanthine uptake	F	6.59	pIC50	260	nM	IC50	J Med Chem (2009) 52: 502-513 [PMID:19113955]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 by [3H]hypoxanthine incorporation	F	6.59	pIC50	260	nM	IC50	J Med Chem (2008) 51: 1278-1294 [PMID:18278860]
ChEMBL	Antimalarial activity against drug-resistant Plasmodium falciparum Dd2 harboring V259L mutant infected in human erythrocytes after 72 hrs by SYBR green 1-based fluorescence assay	F	6.59	pIC50	260	nM	IC50	J Med Chem (2019) 62: 3475-3502 [PMID:30852885]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum FcM29 infected in human red blood cells after 48 hrs by [3H]-hypoxanthine incorporation assay	F	6.59	pIC50	260	nM	IC50	Eur J Med Chem (2017) 139: 22-47 [PMID:28800458]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1	F	6.59	pIC50	260	nM	IC50	J Med Chem (2007) 50: 595-598 [PMID:17263523]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 by [3H]hypoxanthine incorporation	F	6.59	pIC50	260	nM	IC50	J Med Chem (2008) 51: 1333-1343 [PMID:18278859]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum K1	F	6.59	pIC50	259	nM	IC50	Eur J Med Chem (2010) 45: 5370-5383 [PMID:20850207]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1	F	6.59	pIC50	258	nM	IC50	Bioorg Med Chem Lett (2006) 16: 5384-5388 [PMID:16890433]
ChEMBL	Antimalarial activity against chloroquine-resistant asexual intraerythrocytic stage of Plasmodium falciparum Dd2 assessed as inhibition of parasite growth by lactate dehydrogenase assay	F	6.59	pIC50	257.6	nM	IC50	Eur J Med Chem (2015) 101: 52-62 [PMID:26114811]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 after 48 hrs by LDH reporter assay	F	6.59	pIC50	256	nM	IC50	Bioorg Med Chem (2008) 16: 5254-5265 [PMID:18362073]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1	F	6.59	pIC50	255	nM	IC50	Eur J Med Chem (2019) 161: 101-117 [PMID:30343191]
ChEMBL	In vitro inhibitory concentration against chloroquine-resistant Plasmodium falciparum K1	F	6.59	pIC50	255	nM	IC50	J Med Chem (2002) 45: 1052-1063 [PMID:11855985]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 after 72 hrs by SYBR Green-1 staining-based fluorescence assay	F	6.59	pIC50	255	nM	IC50	Bioorg Med Chem (2014) 22: 3573-3586 [PMID:24906512]
ChEMBL	Antimalarial activity against Plasmodium falciparum K1 assessed as parasite growth inhibition after 72 hrs by MSF assay	F	6.6	pIC50	254.05	nM	IC50	Eur J Med Chem (2013) 62: 693-704 [PMID:23454512]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 incubated for 72 hrs by SYBR Green 1 assay	F	6.6	pIC50	254	nM	IC50	Bioorg Med Chem Lett (2015) 25: 4657-4663 [PMID:26338359]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 after 72 hrs by MSF assay	F	6.6	pIC50	254	nM	IC50	Eur J Med Chem (2013) 66: 69-81 [PMID:23792317]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human erythrocytes after 48 hrs by flow-cytometry	F	6.6	pIC50	252.4	nM	IC50	J Med Chem (2010) 53: 3552-3557 [PMID:20349996]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum Dd2 after 72 hrs by SYBR I method	F	6.6	pIC50	251.34	nM	IC50	J Med Chem (2014) 57: 5702-5713 [PMID:24914738]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum Dd2 harboring mutations conferring drug-resistance by SYBR-green based assay	F	6.6	pIC50	251.3	nM	IC50	J Med Chem (2014) 57: 6642-6652 [PMID:25007124]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7	F	6.6	pIC50	250	nM	IC50	Bioorg Med Chem Lett (2007) 17: 4733-4736 [PMID:17644333]
ChEMBL	Antimalarial activity against Plasmodium falciparum C235 containing mdr1 transporter gene assessed as growth inhibition after 72 hrs by SYBR Green 1-based fluorescence assay	F	6.6	pIC50	250	nM	IC50	Bioorg Med Chem Lett (2013) 23: 584-587 [PMID:23228469]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2	F	6.6	pIC50	>250	nM	IC50	Eur J Med Chem (2009) 44: 3091-3113 [PMID:19361896]
ChEMBL	Antimalarial activity against Plasmodium falciparum K1	F	6.6	pIC50	250	nM	IC50	J Med Chem (1996) 39: 4511-4514 [PMID:8893847]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 measured after 72 hrs by SYBR green 1 dye based fluorescence assay	F	6.6	pIC50	250	nM	IC50	Eur J Med Chem (2017) 138: 1089-1105 [PMID:28763644]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 assessed as parasite growth inhibition after 48 hrs by SYBR green-1 dye-based fluorescence assay	F	6.6	pIC50	250	nM	IC50	Bioorg Med Chem (2013) 21: 7392-7397 [PMID:24148834]
ChEMBL	Antimalarial activity against Plasmodium falciparum K1	F	6.6	pIC50	250	nM	IC50	Bioorg Med Chem Lett (1996) 6: 391-392
ChEMBL	Antiplasmodial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 infected in rat L6 cells	F	6.6	pIC50	250	nM	IC50	Bioorg Med Chem (2010) 18: 142-150 [PMID:19942439]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum IMTL1 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay	F	6.6	pIC50	250	nM	IC50	J Med Chem (2009) 52: 7954-7957 [PMID:19908867]
ChEMBL	Antiparasitic activity against intraerythrocytic form of chloroquine/pyrimethamine-resistant Plasmodium falciparum K1 infected in human RBC preincubated for 48 hrs followed by [3H]-hypoxanthine addition measured after 24 hrs by liquid scintillation counting analysis	F	6.6	pIC50	250	nM	IC50	Bioorg Med Chem Lett (2017) 27: 3945-3949 [PMID:28789893]
ChEMBL	Antimalarial activity against chloroquine-resistant and mefloquine-sensitive Plasmodium falciparum W2 ring stage form infected in human erythrocytes by spectrophotometric analysis	F	6.6	pIC50	250	nM	IC50	Bioorg Med Chem (2019) 27: 1002-1008 [PMID:30737133]
ChEMBL	Growth inhibition of chloroquine-resistant Plasmodium falciparum K1 by [3H]hypoxanthine uptake	F	6.6	pIC50	250	nM	IC50	Bioorg Med Chem Lett (2002) 12: 2299-2302 [PMID:12161120]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human A-positive red blood cells after 72 hrs by lactate dehydrogenase assay	F	6.6	pIC50	250	nM	IC50	Bioorg Med Chem (2011) 19: 312-320 [PMID:21123074]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2	F	6.6	pIC50	>250	nM	IC50	Eur J Med Chem (2009) 44: 3091-3113 [PMID:19361896]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT L1 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter	F	6.6	pIC50	250	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by 1536-well format based SYBR green assay	F	6.6	pIC50	250	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1	F	6.6	pIC50	250	nM	IC50	Bioorg Med Chem Lett (2009) 19: 401-405 [PMID:19091562]
ChEMBL	In vitro inhibition of chloroquine-resistant Plasmodium falciparum K1	F	6.6	pIC50	250	nM	IC50	J Med Chem (1997) 40: 437-448 [PMID:9046333]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2	F	6.6	pIC50	249	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1378-1381 [PMID:18207399]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive asexual erythrocytic stage of Plasmodium falciparum NF54 assessed as parasite growth inhibition by parasite lactate dehydrogenase assay	F	6.61	pIC50	245	nM	IC50	Bioorg Med Chem (2015) 23: 4163-4171 [PMID:26174655]
ChEMBL	Antimalarial activity against multidrug-resistant Plasmodium falciparum TM91C235	F	6.61	pIC50	244.76	nM	IC50	J Med Chem (2008) 51: 2261-2266 [PMID:18330976]
ChEMBL	Antimalarial activity against Plasmodium falciparum 7G8 harbouring Pf-crt, Pf-mdrl,Pf-dhfr, Pf-dhps mutated loci assessed as inhibition of parasite growth incubated for 48 hrs by [3H]hypoxanthine incorporation assay based liquid scintillation counting method	F	6.61	pIC50	243	nM	IC50	J Med Chem (2021) 64: 12582-12602 [PMID:34437804]
ChEMBL	Antimalarial activity against asexual erythrocyte stages of chloroquine-resistant Plasmodium falciparum Dd2	F	6.62	pIC50	242.3	nM	IC50	Eur J Med Chem (2012) 55: 335-345 [PMID:22889556]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum isolate Kenya after 72 hrs by lactate dehydrogenase assay	F	6.62	pIC50	241.3	nM	IC50	Bioorg Med Chem (2012) 20: 5980-5985 [PMID:22901673]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum W2 by fluorometric method	F	6.62	pIC50	240	nM	IC50	J Med Chem (2009) 52: 5662-5672 [PMID:19715342]
ChEMBL	Antimalarial activity against Plasmodium falciparum W2	F	6.62	pIC50	240	nM	IC50	Bioorg Med Chem Lett (2006) 16: 5682-5686 [PMID:16908136]
ChEMBL	Antiplasmodial activity against mefloquine-resistant Plasmodium falciparum D6 assessed as inhibition of [3H]-hypoxanthine uptake after 48 hrs by liquid scintillation counting analysis	F	6.62	pIC50	240	nM	IC50	Bioorg Med Chem Lett (2016) 26: 1048-1051 [PMID:26750257]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 assessed as inhibition of [3H]hypoxanthine incorporation	F	6.62	pIC50	240	nM	IC50	Antimicrob Agents Chemother (2011) 55: 961-966 [PMID:21135175]
ChEMBL	In vitro antimalarial activity against Plasmodium falciparum K1	F	6.62	pIC50	240	nM	IC50	J Med Chem (2004) 47: 1997-2009 [PMID:15055999]
ChEMBL	Antimalarial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 by [3H]hypoxanthine incorporation assay	F	6.62	pIC50	240	nM	IC50	Bioorg Med Chem (2009) 17: 7209-7217 [PMID:19781948]
ChEMBL	In vitro antimalarial activity against chloroquine-resistant Plasmodium falciparum CDC/Indochina III W2	F	6.62	pIC50	240	nM	IC50	J Med Chem (1995) 38: 5031-5037 [PMID:8544179]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2	F	6.62	pIC50	240	nM	IC50	Bioorg Med Chem Lett (2004) 14: 3901-3905 [PMID:15225694]
ChEMBL	Antiparasitic activity against Plasmodium falciparum W2	F	6.62	pIC50	240	nM	IC50	Bioorg Med Chem (2007) 15: 273-282 [PMID:17052908]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FcM29 assessed as [3H]hypoxanthine incorporation after 48 hrs	F	6.62	pIC50	240	nM	IC50	Bioorg Med Chem (2012) 20: 4856-4861 [PMID:22766218]
ChEMBL	Antimalarial activity against chloroquine resistant Plasmodium falciparum W2	F	6.63	pIC50	236	nM	IC50	Eur J Med Chem (2021) 219: 113408-113408 [PMID:33989911]
ChEMBL	Antimalarial activity against multidrug resistant Plasmodium falciparum W2 infected in human erythrocytes assessed as inhibition of parasite proliferation after 96 hrs by SYBR Green I fluorescence based assay	F	6.63	pIC50	233.18	nM	IC50	Bioorg Med Chem Lett (2016) 26: 3006-3009 [PMID:27210430]
ChEMBL	Antimalarial activity against asexual stage of Plasmodium falciparum W2 assessed as reduction in parasite growth incubated for 96 hrs by SYBR Green I dye-based fluorescence assay	F	6.63	pIC50	233	nM	IC50	ACS Med Chem Lett (2020) 11: 49-55 [PMID:31938463]
ChEMBL	Antimalarial activity against asexual stage of Plasmodium falciparum Dd2 infected in erythrocytes assessed as reduction in parasite growth incubated for 48 hrs under hypoxic condition by Hoechst 33342 staining based flow cytometry	F	6.63	pIC50	233	nM	IC50	ACS Med Chem Lett (2020) 11: 49-55 [PMID:31938463]
ChEMBL	Antiplasmodial activity against D-sorbitol synchronized ring stage of chloroquine-resistant Plasmodium falciparum W2 assessed as parasite growth inhibition measured after 48 hrs by YOYO-1 dye based FACSort flow cytometry analysis	F	6.63	pIC50	232.65	nM	IC50	ACS Med Chem Lett (2020) 11: 154-161 [PMID:32071682]
ChEMBL	In vitro antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 Indochina	F	6.63	pIC50	232.6	nM	IC50	J Med Chem (2003) 46: 4244-4258 [PMID:13678403]
ChEMBL	Antiplasmodial activity chloroquinone-resistant Plasmodium falciparum K1 by parasite lactate dehydrogenase assay	F	6.64	pIC50	230	nM	IC50	J Nat Prod (2015) 78: 1848-1858 [PMID:26235033]
ChEMBL	Antiplasmodial activity chloroquinone-resistant Plasmodium falciparum Dd2 by parasite lactate dehydrogenase assay	F	6.64	pIC50	230	nM	IC50	J Nat Prod (2015) 78: 1848-1858 [PMID:26235033]
ChEMBL	Antiplasmodial activity against chloroquine/pyrimethamine-resistant Plasmodium falciparum K1 assessed as growth inhibition after 24 hrs by [3H]-hypoxanthine incorporation assay	F	6.64	pIC50	230	nM	IC50	J Med Chem (2013) 56: 7516-7526 [PMID:24063369]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1	F	6.64	pIC50	230	nM	IC50	Bioorg Med Chem Lett (2009) 19: 481-484 [PMID:19054674]
ChEMBL	Antiplasmodial activity against multidrug resistant asexual blood stage Plasmodium falciparum Dd2 assessed as inhibition of parasite growth incubated for 1 hr by HRP2-ELISA	F	6.64	pIC50	230	nM	IC50	J Med Chem (2021) 64: 3035-3047 [PMID:33666415]
ChEMBL	Antiparasitic activity against chloroquine, pyrimethamine-resistant Plasmodium falciparum K1 erythrocyte stage infected rat L6 cells	F	6.64	pIC50	230	nM	IC50	J Med Chem (2007) 50: 5833-5839 [PMID:17949068]
ChEMBL	Antimalarial activity against chloroquine /mefloquine/pyrimethamine-resistant Plasmodium falciparum C235 by malaria SYBR green 1-based fluorescence (MSF) assay	F	6.64	pIC50	230	nM	IC50	Bioorg Med Chem Lett (2015) 25: 327-332 [PMID:25488841]
ChEMBL	Antimalarial activity against ring stage Plasmodium falciparum W2 infected with human red blood cells incubated for 48 hrs by flow cytometry	F	6.64	pIC50	229	nM	IC50	Bioorg Med Chem (2015) 23: 1530-1539 [PMID:25725608]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human A positive erythrocyte assessed as inhibition of parasite growth after 72 hrs by parasite lactate dehydrogenase assay	F	6.64	pIC50	228	nM	IC50	Medchemcomm (2015) 6: 357-362
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum PFB infected human erythrocytes after 24 hrs by [3H]hypoxanthine uptake	F	6.65	pIC50	225.7	nM	IC50	Bioorg Med Chem (2008) 16: 9133-9144 [PMID:18819813]
ChEMBL	Antispasmodial activity against multidrug-resistant asexual blood stages of Plasmodium falciparum Dd2 after 72 hrs by HRP2-based ELISA	F	6.65	pIC50	224.7	nM	IC50	J Med Chem (2017) 60: 6036-6044 [PMID:28653845]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 after 72 hrs by SYBR green 1 dye based fluorometric method	F	6.65	pIC50	224	nM	IC50	J Nat Prod (2011) 74: 2174-2180 [PMID:21995542]
ChEMBL	Antimalarial activity against CQ-resistant Plasmodium falciparum K1 infected in human type O+ erythrocytes assessed as growth inhibition incubated for 48 hrs by LDH assay	F	6.65	pIC50	222	nM	IC50	J Med Chem (2016) 59: 6512-6530 [PMID:27299916]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 incubated for 48 hrs by parasite lactate dehydrogenase assay	F	6.65	pIC50	222	nM	IC50	ACS Med Chem Lett (2019) 10: 714-719 [PMID:31097988]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2	F	6.65	pIC50	221.9	nM	IC50	Eur J Med Chem (2013) 66: 314-323 [PMID:23811093]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum RSA11	F	6.66	pIC50	220.36	nM	IC50	Antimicrob Agents Chemother (2007) 51: 2265-2267 [PMID:17404003]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum 7G8 assessed as inhibition of parasite growth incubated for 3 days by HRP2-ELISA	F	6.66	pIC50	220.3	nM	IC50	Eur J Med Chem (2022) 238: 114408-114408 [PMID:35551033]
ChEMBL	Antibacterial activity against intraerythrocytic form of Plasmodium falciparum	F	6.66	pIC50	220	nM	IC50	Bioorg Med Chem Lett (2009) 19: 3031-3035 [PMID:19414258]
ChEMBL	Antiplasmodial activity against chloroquine- and pyrimethamine-resistant Plasmodium falciparum K1 infected in human red blood cells assessed as [3H]hypoxanthine incorporation after 48 hrs by liquid scintillation counting	F	6.66	pIC50	220	nM	IC50	J Nat Prod (2011) 74: 559-566 [PMID:21438586]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 after 24 hrs by [3H]hypoxanthine incorporation assay	F	6.66	pIC50	220	nM	IC50	ACS Med Chem Lett (2013) 4: 1198-1202 [PMID:24900630]
ChEMBL	Antimalarial activity against Plasmodium falciparum W2mef ring form by hoechst 33342-thiazole orange stain based flow cytometry assay	F	6.66	pIC50	219	nM	IC50	Bioorg Med Chem Lett (2009) 19: 5452-5457 [PMID:19666223]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum K1	F	6.66	pIC50	219	nM	IC50	Eur J Med Chem (2021) 219: 113408-113408 [PMID:33989911]
ChEMBL	Antiplasmodial activity against CQ-resistant Plasmodium falciparum K1	F	6.66	pIC50	219	nM	IC50	Bioorg Med Chem (2015) 23: 5098-5119 [PMID:25593097]
ChEMBL	Inhibition of Plasmodium falciparum W2	F	6.66	pIC50	219	nM	IC50	J Med Chem (2000) 43: 2646-2654 [PMID:10893302]
ChEMBL	Inhibition of Plasmodium falciparum FCM29	F	6.67	pIC50	216	nM	IC50	J Med Chem (2000) 43: 2646-2654 [PMID:10893302]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 by parasite LDH assay	F	6.67	pIC50	215	nM	IC50	Eur J Med Chem (2011) 46: 579-587 [PMID:21183259]
ChEMBL	Antimalarial activity against Plasmodium falciparum K1 assessed as inhibition of [3H] hypoxanthine uptake by liquid scintillation counting	F	6.67	pIC50	213	nM	IC50	ACS Med Chem Lett (2013) 4: 128-131 [PMID:24900574]
ChEMBL	Antimalarial activity against asexual stage of Plasmodium falciparum K1 assessed as reduction in parasite growth incubated for 48 hrs under hypoxic condition by Hoechst 33342 staining based flow cytometry	F	6.67	pIC50	212	nM	IC50	ACS Med Chem Lett (2020) 11: 49-55 [PMID:31938463]
ChEMBL	Antimalarial activity against chloroquine-resistant erythrocytic stage of Plasmodium falciparum K1 infected in human red blood cells assessed as growth inhibition after 48 hrs by [3H]-hypoxanthine incorporation assay	F	6.68	pIC50	210	nM	IC50	Eur J Med Chem (2013) 64: 498-511 [PMID:23685569]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2	F	6.68	pIC50	210	nM	IC50	Eur J Med Chem (2019) 161: 101-117 [PMID:30343191]
ChEMBL	Antimalarial activity against erythrocytic stage of chloroquine/pyrimethamine-resistant Plasmodium falciparum K1 after 48 hrs by [3H]-hypoxanthine incorporation assay	F	6.68	pIC50	209.5	nM	IC50	Bioorg Med Chem (2014) 22: 2629-2642 [PMID:24721829]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1	F	6.68	pIC50	209.5	nM	IC50	Medchemcomm (2014) 5: 927-931
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 after 72 hrs by [3H]hypoxanthine incorporation assay	F	6.68	pIC50	209.5	nM	IC50	J Med Chem (2013) 56: 1431-1442 [PMID:23360309]
ChEMBL	Antimalarial activity against multidrug resistant Plasmodium falciparum Tm90-C2B infected in human erythrocytes measured after after 72 hrs by SYBR green dye based fluorescence assay	F	6.68	pIC50	208	nM	IC50	J Med Chem (2020) 63: 6179-6202 [PMID:32390431]
ChEMBL	Antiplasmodial activity against asexual blood stage of multidrug-resistant Plasmodium falciparum TM90C2B infected in human erythrocytes assessed as reduction in parasite growth incubated for 72 hrs by SYBR green 1 staining based assay	F	6.68	pIC50	208	nM	IC50	J Med Chem (2021) 64: 8739-8754 [PMID:34111350]
ChEMBL	Antimalarial activity against atovaquone-resistant Plasmodium falciparum Tm90-C2B infected in human erythrocytes by SYBR green 1-based fluorescence assay	F	6.68	pIC50	208	nM	IC50	J Med Chem (2019) 62: 3475-3502 [PMID:30852885]
ChEMBL	Antiplasmodial activity against the multidrug-resistant Plasmodium falciparum FRC-3 infected in human red blood cells assessed as reduction in parasite growth after 48 hrs by Hoechst 33342 staining based flow cytometric analysis	F	6.68	pIC50	207	nM	IC50	Eur J Med Chem (2018) 158: 68-81 [PMID:30199706]
ChEMBL	Antimalarial activity against multidrug-resistant Plasmodium falciparum thailand TM91C235 assessed as [3H]-hypoxanthine incorporation by liquid scintillation counting analysis	F	6.69	pIC50	206	nM	IC50	Bioorg Med Chem (2015) 23: 2176-2186 [PMID:25801154]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum C235 assessed as growth inhibition after 18 hrs by [3H]-hypoxanthine uptake assay	F	6.69	pIC50	206	nM	IC50	J Med Chem (2015) 58: 3411-3431 [PMID:25654185]
ChEMBL	Antiplasmodial activity against chloroquine-resistant asexual blood stage of Plasmodium falciparum K1 by LDH assay	F	6.69	pIC50	205	nM	IC50	Eur J Med Chem (2019) 180: 121-133 [PMID:31301563]
ChEMBL	Antiplasmodial activity against multidrug-resistant Plasmodium falciparum VS/1 by [3H]hypoxanthine incorporation assay	F	6.69	pIC50	205	nM	IC50	Antimicrob Agents Chemother (2009) 53: 3131-3134 [PMID:19364853]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum 7G8 harboring D10 pfcrt allele infected in erythrocytes assessed as [3H]hypoxanthine incorporation	F	6.69	pIC50	204.1	nM	IC50	Antimicrob Agents Chemother (2009) 53: 1362-1366 [PMID:19188388]
ChEMBL	Antiplasmodial activity chloroquine-resistant Plasmodium falciparum K1 infected in human A+ erythrocytes assessed as inhibition of [3H]-hypoxanthine incorporation after 24 hrs by scintillation counting	F	6.7	pIC50	201.8	nM	IC50	Eur J Med Chem (2012) 52: 82-97 [PMID:22459876]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum	F	6.7	pIC50	201	nM	IC50	Antimicrob Agents Chemother (2008) 52: 237-243 [PMID:17967917]
ChEMBL	Antiparasitic activity against Plasmodium falciparum K1	F	6.7	pIC50	201	nM	IC50	Eur J Med Chem (2007) 42: 552-557 [PMID:17178177]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1	F	6.7	pIC50	201	nM	IC50	Eur J Med Chem (2013) 67: 310-324 [PMID:23871911]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 in human erythrocytes by [3H]hypoxanthine uptake	F	6.7	pIC50	200	nM	IC50	Eur J Med Chem (2008) 43: 1983-1988 [PMID:18222568]
ChEMBL	Antimalarial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 assessed as inhibition of [3H]hypoxanthine incorporation after 48 hrs by scintillation counting	F	6.7	pIC50	200	nM	IC50	J Nat Prod (2010) 73: 1404-1410 [PMID:20614907]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human erythrocytes assessed as reduction in parasitemia after 72 hrs by lactate dehydrogenase assay	F	6.7	pIC50	200	nM	IC50	J Nat Prod (2016) 79: 1746-1751 [PMID:27351950]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum FcB1	F	6.7	pIC50	200	nM	IC50	Bioorg Med Chem Lett (2007) 17: 959-963 [PMID:17166718]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 infected in erythrocytes after 48 hrs by SYBR green 1-based fluorescence assay	F	6.7	pIC50	200	nM	IC50	Bioorg Med Chem (2011) 19: 7474-7481 [PMID:22071523]
ChEMBL	In vitro antimalarial activity for Plasmodium falciparum BHz26/86	F	6.7	pIC50	200	nM	IC50	Bioorg Med Chem Lett (2004) 14: 1145-1149 [PMID:14980653]
ChEMBL	In vitro inhibition of Plasmodium falciparum K1 (0.0638 ug/mL)	F	6.7	pIC50	200	nM	IC50	Bioorg Med Chem Lett (2005) 15: 595-597 [PMID:15664819]
ChEMBL	Antiplasmodial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 infected mice (Mus musculus) macrophage by reporter dye assay	F	6.7	pIC50	200	nM	IC50	Antimicrob Agents Chemother (2007) 51: 3796-3802 [PMID:17698622]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 erythrocytic stage measured after 3 days by HRP2 assay	F	6.7	pIC50	200	nM	IC50	Eur J Med Chem (2020) 187: 111927-111927 [PMID:31812035]
ChEMBL	Growth inhibition after 6 hrs in chloroquine-resistant Plasmodium falciparum FcB1	F	6.7	pIC50	200	nM	IC50	Antimicrob Agents Chemother (2007) 51: 1463-1472 [PMID:17242150]
ChEMBL	Antiprotozoal activity against erythrocytic stages chloroquine- and pyrimethamine-resistant Plasmodium falciparum K1 assessed as inhibition of [3H]hypoxanthine incorporation pre-incubated for 48 hrs prior [3H]hypoxanthine addition measured after 24 hrs by liquid scintillation counting	F	6.7	pIC50	200	nM	IC50	Bioorg Med Chem (2012) 20: 1482-1493 [PMID:22285027]
ChEMBL	Antiplasmodial activity against chloroquine-resistant erythrocytic stage Plasmodium falciparum Dd2 assessed as inhibition of parasite growth incubated for 3 days by HRP2-ELISA	F	6.7	pIC50	200	nM	IC50	Eur J Med Chem (2021) 224: 113687-113687 [PMID:34274829]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum K1 infected in human erythrocytes after 72 hrs by Malstat reagent-based spectrophotometric analysis	F	6.7	pIC50	200	nM	IC50	Eur J Med Chem (2018) 151: 18-26 [PMID:29604541]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 infected in erythrocytes after 48 hrs by SYBR Green 1-based fluorescence assay	F	6.7	pIC50	200	nM	IC50	Bioorg Med Chem (2010) 18: 5254-5260 [PMID:20541427]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum ItG after 72 hrs by lactate dehydrogenase assay	F	6.7	pIC50	200	nM	IC50	J Med Chem (2013) 56: 2348-2358 [PMID:23410043]
ChEMBL	Antimalarial activity against Plasmodium falciparum CQR (W2 clone) infected in human erythrocyte assessed as reduction in parasite growth incubated for 48 hrs by SYBR assay	F	6.7	pIC50	200	nM	IC50	Bioorg Med Chem (2020) 28: 115832-115832 [PMID:33166927]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum K1 infected in erythrocytes assessed as [3H]hypoxanthine incorporation after 24 hrs by microbeta scintillation counting analysis	F	6.7	pIC50	200	nM	IC50	Bioorg Med Chem Lett (2014) 24: 3263-3267 [PMID:24974345]
ChEMBL	Antimalarial activity against chloroquine- and pyrimethamine-resistant Plasmodium falciparum K1 assessed as [3H]-hypoxanthine incorporation after 48 hrs by liquid scintillation counting	F	6.7	pIC50	200	nM	IC50	J Nat Prod (2011) 74: 888-892 [PMID:21348447]
ChEMBL	In vitro antiparasitic activity against chloroquine-resistant Plasmodium falciparum Indochina I	F	6.7	pIC50	200	nM	IC50	J Med Chem (2004) 47: 2700-2705 [PMID:15115412]
ChEMBL	Antiplasmodial activity against CQ-resistant Plasmodium falciparum W2 assessed as inhibition of parasite growth measured after 48 hrs by SYBR Green 1 dye based fluorescence assay	F	6.7	pIC50	198.8	nM	IC50	Eur J Med Chem (2022) 228: 113981-113981 [PMID:34782182]
ChEMBL	Antimalarial activity against Plasmodium falciparum K1 assessed as inhibition of [3H]hypoxanthine incorporation preincubated for 48 hrs measured 24 hrs post [3H]hypoxanthine addition by liquid scintillation counting	F	6.7	pIC50	198	nM	IC50	Bioorg Med Chem (2014) 22: 3749-3752 [PMID:24856305]
ChEMBL	Antimicrobial activity against chloroquine-resistant and mefloquine-sensitive Plasmodium falciparum W2 infected in human erythrocytes after 48 hrs by SYBR Green I assay	F	6.7	pIC50	198	nM	IC50	Eur J Med Chem (2014) 81: 378-393 [PMID:24858543]
ChEMBL	Antimalarial activity against multidrug-resistant Plasmodium falciparum Dd2 measured after 72 hrs by SYBR Green 1 dye based fluorescence assay	F	6.71	pIC50	196	nM	IC50	J Med Chem (2019) 62: 3503-3512 [PMID:30856324]
ChEMBL	Antiplasmodial activity against chloroquine resistant Plasmodium falciparum by HRP2 ELISA analysis	F	6.71	pIC50	196	nM	IC50	Eur J Med Chem (2021) 219: 113408-113408 [PMID:33989911]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum W2 assessed as suppression of parasitemia after 4 hrs by Giemsa staining	F	6.71	pIC50	196	nM	IC50	Antimicrob Agents Chemother (2009) 53: 4393-4398 [PMID:19667291]
ChEMBL	Antiplasmodial activity against 4-aminoquinoline/antifolates-resistant Plasmodium falciparum Dd2 ring stage infected in human erythrocytes after 72 hrs by DAPI staining based method	F	6.71	pIC50	194	nM	IC50	J Nat Prod (2018) 81: 1588-1597 [PMID:29969262]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 measured after 72 hrs by DAPI staining based high throughput screening assay	F	6.71	pIC50	194	nM	IC50	Bioorg Med Chem Lett (2017) 27: 2602-2607 [PMID:28400231]
ChEMBL	Antiplasmodial activity against chloroquine-resistant asexual blood stage of Plasmodium falciparum K1 infected in human RBC assessed as reduction in [3H]hypoxanthine incorporation preincubated for 48 hrs followed by [3H]hypoxanthine addition measured after 24 hrs by liquid scintillation counting method	F	6.71	pIC50	194	nM	IC50	J Med Chem (2019) 62: 1022-1035 [PMID:30562027]
ChEMBL	Antiplasmodial activity against drug sensitive Plasmodium falciparum NF54 infected in human erythrocytes after 48 hrs by [3H]-hypoxanthine incorporation assay	F	6.71	pIC50	194	nM	IC50	J Med Chem (2015) 58: 8713-8722 [PMID:26502160]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum K1	F	6.71	pIC50	194	nM	IC50	J Med Chem (2011) 54: 7713-7719 [PMID:21966980]
ChEMBL	Antimalarial activity against multidrug-resistant Plasmodium falciparum K1	F	6.71	pIC50	194	nM	IC50	J Med Chem (2018) 61: 4213-4227 [PMID:29665687]
ChEMBL	Antiplasmodial activity against multidrug-resistant Plasmodium falciparum K1 infected in erythrocytes assessed as reduction in [3H]hypoxanthine incorporation preincubated for 48 hrs followed by [3H]hypoxanthine addition and measured after 24 hrs by liquid scintillation counting method	F	6.71	pIC50	194	nM	IC50	J Med Chem (2016) 59: 9890-9905 [PMID:27748596]
ChEMBL	Antimalarial activity against multidrug-resistant Plasmodium falciparum K1	F	6.71	pIC50	194	nM	IC50	J Med Chem (2014) 57: 2789-2798 [PMID:24568587]
ChEMBL	Antiplasmodial activity against multidrug-resistant Plasmodium falciparum K1 by [3H]-hypoxanthine incorporation assay	F	6.71	pIC50	194	nM	IC50	J Med Chem (2015) 58: 7572-7579 [PMID:26322748]
ChEMBL	Antimalarial activity against chloroquine-resistant, mefloquine-sensitive Plasmodium falciparum RCS	F	6.72	pIC50	192.45	nM	IC50	Bioorg Med Chem (2008) 16: 7039-7045 [PMID:18550377]
ChEMBL	Antimalarial activity against chloroquine-resistant and mefloquine-sensitive Plasmodium falciparum W2 infected in human erythrocytes after 48 hrs by HRP2-ELISA	F	6.72	pIC50	190.55	nM	IC50	Eur J Med Chem (2014) 73: 295-309 [PMID:24469080]
ChEMBL	In vitro inhibitory concentration against chloroquine-resistant Plasmodium falciparum K1	F	6.72	pIC50	190	nM	IC50	J Med Chem (2002) 45: 4975-4983 [PMID:12408708]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 after 48 hrs by [G-3H]hypoxanthine uptake	F	6.72	pIC50	190	nM	IC50	Eur J Med Chem (2008) 43: 2840-2852 [PMID:18395298]
ChEMBL	In vitro antimalarial activity against Plasmodium falciparum W2 in human erythrocytes by [3H]hypoxanthine uptake	F	6.72	pIC50	190	nM	IC50	Bioorg Med Chem Lett (2002) 12: 1351-1355 [PMID:11992775]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FCR-3 infected in human A positive erythrocytes by [3H]-hypoxanthine incorporation assay	F	6.72	pIC50	190	nM	IC50	Bioorg Med Chem Lett (2013) 23: 327-329 [PMID:23164712]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 infected human erythrocytes after 72 hrs by [3H]hypoxanthine uptake	F	6.72	pIC50	190	nM	IC50	Bioorg Med Chem (2009) 17: 1527-1533 [PMID:19195901]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 assessed as incorporation of [3H]hypoxanthine after 48 hr microdilution method	F	6.72	pIC50	190	nM	IC50	Med Chem Res (2007) 16: 213-229
ChEMBL	In vitro antimalarial activity against Plasmodium falciparum K1 by [3H]hypoxanthine uptake	F	6.72	pIC50	190	nM	IC50	J Med Chem (2004) 47: 1290-1298 [PMID:14971909]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum FcB1/columbia infected in human erythrocytes	F	6.72	pIC50	190	nM	IC50	Bioorg Med Chem (2010) 18: 5724-5731 [PMID:20630767]
ChEMBL	Antiplasmodial activity growth inhibition of chloroquine-resistant Plasmodium falciparum BHz 26/86 after 72 hrs	F	6.72	pIC50	190	nM	IC50	Antimicrob Agents Chemother (2007) 51: 2346-2350 [PMID:17438049]
ChEMBL	Antimalarial activity against chloroquine-resistant and mefloquine-sensitive Plasmodium falciparum W2 infected in human erythrocytes after 48 hrs by HRP2-ELISA	F	6.72	pIC50	190	nM	IC50	Eur J Med Chem (2014) 73: 295-309 [PMID:24469080]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1	F	6.72	pIC50	190	nM	IC50	Eur J Med Chem (2009) 44: 3091-3113 [PMID:19361896]
ChEMBL	Antimalarial activity against drug-resistant Plasmodium falciparum TM90C2A	F	6.72	pIC50	189	nM	IC50	Antimicrob Agents Chemother (2008) 52: 3467-3477 [PMID:18644969]
ChEMBL	Antimalarial activity against Plasmodium falciparum TM90C2A by hypoxanthine uptake	F	6.72	pIC50	189	nM	IC50	J Med Chem (2008) 51: 3437-3448 [PMID:18494463]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 infected type A+ human erythrocytes after 24 hrs by [G-3H]hypoxanthine uptake	F	6.73	pIC50	187.34	nM	IC50	Bioorg Med Chem Lett (2009) 19: 2038-2043 [PMID:19251414]
ChEMBL	Antiplasmodial activity against chloroquine-resistant blood stage of Plasmodium falciparum W2 infected in human RBC after 48 hrs by flow cytometric analysis	F	6.73	pIC50	186	nM	IC50	Eur J Med Chem (2013) 69: 872-880 [PMID:24125849]
ChEMBL	Antiplasmodial activity against blood stage of chloroquine-resistant Plasmodium falciparum W2 infected in human RBC assessed as parasite growth inhibition after 48 hrs by flow cytometric analysis	F	6.73	pIC50	186	nM	IC50	J Med Chem (2013) 56: 7679-7690 [PMID:24020770]
ChEMBL	Antimalarial activity against drug-resistant Plasmodium falciparum Dd2 harboring M133I/A138T double mutant infected in human erythrocytes after 72 hrs by SYBR green 1-based fluorescence assay	F	6.73	pIC50	186	nM	IC50	J Med Chem (2019) 62: 3475-3502 [PMID:30852885]
ChEMBL	In vitro inhibitory activity against chloroquine-resistant Plasmodium falciparum W2 Indochina	F	6.73	pIC50	185.38	nM	IC50	J Med Chem (2002) 45: 3331-3336 [PMID:12139444]
ChEMBL	Antiplasmodial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 assessed as inhibition of [3H]hypoxanthine incorporation incubated for 48 hrs prior to [3H] hypoxanthine addition measured after 24 hrs by liquid scintillation counting	F	6.74	pIC50	184	nM	IC50	Bioorg Med Chem (2011) 19: 7493-7500 [PMID:22061825]
ChEMBL	In vitro antimalarial activity against chloroquine-resistant Plasmodium falciparum K1	F	6.74	pIC50	183.82	nM	IC50	J Med Chem (2003) 46: 4933-4945 [PMID:14584944]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 in human erythrocytes after 48 hrs by [3H]hypoxanthine uptake	F	6.74	pIC50	183.2	nM	IC50	J Med Chem (2009) 52: 1408-1415 [PMID:19222165]
ChEMBL	Inhibitory activity against chloroquine-resistant Plasmodium falciparum K1	F	6.74	pIC50	183	nM	IC50	J Med Chem (2001) 44: 2827-2833 [PMID:11495593]
ChEMBL	Antimalarial activity after 24 hrs against chloroquine-resistant Plasmodium falciparum K1/Thailand by [3H]hypoxanthine uptake	F	6.74	pIC50	183	nM	IC50	Eur J Med Chem (2008) 43: 2045-2055 [PMID:18226428]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 after 24 hrs by semiautomated micro dilution assay	F	6.74	pIC50	183	nM	IC50	Eur J Med Chem (2008) 43: 252-260 [PMID:17485145]
ChEMBL	In vitro inhibitory activity against chloroquine-resistant Plasmodium falciparum K1	F	6.74	pIC50	182	nM	IC50	J Med Chem (1999) 42: 2747-2751 [PMID:10425085]
ChEMBL	Antimalarial activity against drug-resistant Plasmodium falciparum Dd2 harboring M133I mutant infected in human erythrocytes after 72 hrs by SYBR green 1-based fluorescence assay	F	6.74	pIC50	182	nM	IC50	J Med Chem (2019) 62: 3475-3502 [PMID:30852885]
ChEMBL	Antimicrobial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human erythrocytes assessed as incorporation of [3H]-hypoxanthine by beta counting analysis	F	6.74	pIC50	180	nM	IC50	Eur J Med Chem (2015) 90: 280-295 [PMID:25461328]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum D6	F	6.74	pIC50	180	nM	IC50	Bioorg Med Chem Lett (2007) 17: 959-963 [PMID:17166718]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum Dd2 after 72 hrs by 96-well format based SYBR green assay	F	6.74	pIC50	180	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum FcM29	F	6.74	pIC50	180	nM	IC50	Antimicrob Agents Chemother (2007) 51: 1463-1472 [PMID:17242150]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 ring stage incubated for 72 hrs by DAPI-staining based imaging analysis	F	6.74	pIC50	180	nM	IC50	J Nat Prod (2020) 83: 3435-3444 [PMID:33105995]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in O-positive human RBC assessed as [3H]-hypoxanthine incorporation after 48 hrs by scintillation counting	F	6.74	pIC50	180	nM	IC50	ACS Med Chem Lett (2012) 3: 43-47 [PMID:24900369]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FcB1 by [3H]hypoxanthine uptake	F	6.74	pIC50	180	nM	IC50	J Nat Prod (2008) 71: 1189-1192 [PMID:18512987]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 incubated for 48 hrs by parasite lactate dehydrogenase assay	F	6.74	pIC50	180	nM	IC50	J Med Chem (2020) 63: 14470-14501 [PMID:33023291]
ChEMBL	Growth inhibition of chloroquine-sensitive Plasmodium falciparum K1	F	6.75	pIC50	179.2	nM	IC50	J Med Chem (2003) 46: 542-557 [PMID:12570376]
ChEMBL	Antiparasitic activity against Plasmodium falciparum K1 infected in rat L6 cells assessed as inhibition of parasite growth preincubated for 48 hrs before [3H]hypoxanthine addition measured after 24 hrs by [3H]hypoxanthine incorporation assay	F	6.75	pIC50	178	nM	IC50	Bioorg Med Chem Lett (2011) 21: 6319-6321 [PMID:21937228]
ChEMBL	In vitro growth inhibition of Plasmodium falciparum W2	F	6.76	pIC50	175	nM	IC50	J Med Chem (2001) 44: 1658-1665 [PMID:11356101]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 assessed as growth inhibition after 48 hrs by flow cytometer	F	6.76	pIC50	174.5	nM	IC50	RSC Med Chem (2021) 12: 970-981 [PMID:34223162]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 ring forms infected in human RBC incubated for 15 mins followed by compound removal and further incubation for 48 hrs by [3H]-hypoxanthine incorporation assay	F	6.76	pIC50	174.5	nM	IC50	Eur J Med Chem (2018) 152: 489-514 [PMID:29754074]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 late forms infected in human RBC incubated for 15 mins followed by compound removal and further incubation for 48 hrs by [3H]-hypoxanthine incorporation assay	F	6.76	pIC50	174.5	nM	IC50	Eur J Med Chem (2018) 152: 489-514 [PMID:29754074]
ChEMBL	Antiprotozoal activity against erythrocytic stage of Plasmodium falciparum K1 after 48 hrs by [3H]- hypoxanthine incorporation assay	F	6.76	pIC50	174	nM	IC50	J Med Chem (2019) 62: 1330-1347 [PMID:30615444]
ChEMBL	Antimalarial activity against chloroquine- and mefloquine-resistant Plasmodium falciparum W2-Mef infected in human O-positive erythrocytes assessed as inhibition of ring-stage parasite growth after 48 hrs	F	6.76	pIC50	174	nM	IC50	Bioorg Med Chem (2011) 19: 6604-6607 [PMID:21696970]
ChEMBL	Antimalarial activity against Plasmodium falciparum	F	6.76	pIC50	173	nM	IC50	Eur J Med Chem (2020) 193: 112215-112215 [PMID:32179331]
ChEMBL	Antiplasmodial activity against erythrocytic stage of chloroquine - and pyrimethamine-resistant Plasmodium falciparum K1 assessed as [3H]hypoxanthine incorporation after 48 hrs	F	6.76	pIC50	172	nM	IC50	Antimicrob Agents Chemother (2009) 53: 3815-3821 [PMID:19564359]
ChEMBL	Antimalarial activity against ring stage chloroquine-resistant Plasmodium falciparum Dd2 infected in human O positive erythrocytes after 48 hrs by SYBR green 1 fluorescence assay	F	6.76	pIC50	172	nM	IC50	J Med Chem (2012) 55: 297-311 [PMID:22098429]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2	F	6.76	pIC50	172	nM	IC50	J Nat Prod (2002) 65: 1325-1327 [PMID:12350157]
ChEMBL	Antimalarial activity against multidrug-resistant Plasmodium falciparum 7G8 infected in human erythrocytes by SYBR green 1-based fluorescence assay	F	6.77	pIC50	171	nM	IC50	J Med Chem (2019) 62: 3475-3502 [PMID:30852885]
ChEMBL	Antiplasmodial activity against asexual blood stage of multidrug-resistant Plasmodium falciparum 7G8 infected in human erythrocytes assessed as reduction in parasite growth incubated for 72 hrs by SYBR green 1 staining based assay	F	6.77	pIC50	171	nM	IC50	J Med Chem (2021) 64: 8739-8754 [PMID:34111350]
ChEMBL	Antimalarial activity against multidrug resistant Plasmodium falciparum 7G8 infected in human erythrocytes measured after after 72 hrs by SYBR green dye based fluorescence assay	F	6.77	pIC50	171	nM	IC50	J Med Chem (2020) 63: 6179-6202 [PMID:32390431]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum K1	F	6.77	pIC50	170.6	nM	IC50	J Med Chem (2009) 52: 1828-1844 [PMID:19284751]
ChEMBL	Antimalarial activity against erythrocyte stages of chloroquine-resistant Plasmodium falciparum RSA11 infected in human erythrocytes by lactate dehydrogenase assay	F	6.77	pIC50	170	nM	IC50	J Med Chem (2011) 54: 6956-6968 [PMID:21875063]
ChEMBL	Inhibitory activity against Plasmodium falciparum Dd2 in erythrocytes	F	6.77	pIC50	170	nM	IC50	Bioorg Med Chem Lett (2001) 11: 423-424 [PMID:11212126]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FcB1/Columbia assessed as [3H]hypoxanthine incorporation after 48 hrs	F	6.77	pIC50	170	nM	IC50	Bioorg Med Chem (2012) 20: 4856-4861 [PMID:22766218]
ChEMBL	Anti-malarial activity against Plasmodium falciparum Dd2	F	6.77	pIC50	170	nM	IC50	Bioorg Med Chem Lett (2003) 13: 1539-1541 [PMID:12699750]
ChEMBL	Antiplasmodial activity against synchronized ring stage of chloroquine-resistant Plasmodium falciparum Dd2 infected in human erythrocytes after 48 hrs by SYBR Green 1 dye based fluorescence assay	F	6.77	pIC50	170	nM	IC50	Eur J Med Chem (2018) 155: 623-638 [PMID:29929118]
ChEMBL	Inhibition against Plasmodium falciparum Dd2 in erythrocytes in semiautomated micro dilution assay	F	6.77	pIC50	170	nM	IC50	Bioorg Med Chem Lett (2003) 13: 2159-2161 [PMID:12798326]
ChEMBL	Inhibitory activity against Plasmodium falciparum Dd2 in erythrocytes by semiautomated micro dilution	F	6.77	pIC50	170	nM	IC50	Bioorg Med Chem Lett (2003) 13: 361-363 [PMID:12565929]
ChEMBL	DNDI: Malaria in Vitro, 72 hour	F	6.77	pIC50	170	nM	IC50	Antiprotozoal Activity Profiling of Approved Drugs: A Starting Point toward Drug Repositioning
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 infected in human O+ erythrocytes after 72 hrs by SYBR Green-1 fluorescence based assay	F	6.77	pIC50	170	nM	IC50	Eur J Med Chem (2010) 45: 5292-5301 [PMID:20863599]
ChEMBL	Inhibitory concentration against multidrug-resistant Plasmodium falciparum Dd2.	F	6.77	pIC50	170	nM	IC50	Bioorg Med Chem Lett (2002) 12: 2681-2683 [PMID:12217353]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum Dd2 by SYBR Green I fluorescence assay	F	6.77	pIC50	170	nM	IC50	Bioorg Med Chem Lett (2018) 28: 1219-1222 [PMID:29519737]
ChEMBL	Antimalarial activity against Plasmodium falciparum Dd2 in erythrocytes	F	6.77	pIC50	170	nM	IC50	Bioorg Med Chem Lett (2002) 12: 543-545 [PMID:11844668]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FCB after 72 hrs by SYBR green 1 assay	F	6.77	pIC50	170	nM	IC50	J Med Chem (2008) 51: 1995-1998 [PMID:18345611]
ChEMBL	Antimalarial activity against multidrug-resistant Plasmodium falciparum K1 infected in human red blood cells assessed as 3H-hypoxanthine incorporation after 48 hrs by liquid scintillation counting	F	6.77	pIC50	170	nM	IC50	J Med Chem (2011) 54: 4581-4589 [PMID:21644541]
ChEMBL	In vitro antimalarial activity against Plasmodium falciparum FCR3	F	6.77	pIC50	170	nM	IC50	Bioorg Med Chem Lett (2003) 13: 75-77 [PMID:12467620]
ChEMBL	Antimalarial activity against asexual erythrocyte stage of chloroquine-resistant Plasmodium falciparum Dd2 by parasite lactate dehydrogenase assay	F	6.77	pIC50	168.74	nM	IC50	Bioorg Med Chem (2012) 20: 4701-4709 [PMID:22750008]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum FcB1/Columbia assessed as suppression of parasitemia after 4 hrs by Giemsa staining	F	6.78	pIC50	167	nM	IC50	Antimicrob Agents Chemother (2009) 53: 4393-4398 [PMID:19667291]
ChEMBL	Antiplasmodial activity against chloroquine/cycloguanil/pyrimethamine-resistant blood stage Plasmodium falciparum K1 by SYBR green 1 staining based fluorescence assay	F	6.78	pIC50	167	nM	IC50	J Nat Prod (2018) 81: 188-202 [PMID:29297684]
ChEMBL	Antimalarial activity against chloroquine-,pyrimethamine-resistant Plasmodium falciparum W2 assessed as inhibition of [3H]hypoxanthine incorporation after 96 hrs by microtiter plate scintillation counting	F	6.78	pIC50	166.6	nM	IC50	Bioorg Med Chem (2011) 19: 1692-1701 [PMID:21316974]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human A positive erythrocytes assessed as inhibition of [G-3H]-hypoxanthine uptake after 24 hrs by liquid scintillation counting	F	6.78	pIC50	165.6	nM	IC50	Bioorg Med Chem (2012) 20: 927-932 [PMID:22182577]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR I method	F	6.79	pIC50	163.91	nM	IC50	J Med Chem (2014) 57: 5702-5713 [PMID:24914738]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 7G8 harboring mutations conferring drug-resistance by SYBR-green based assay	F	6.79	pIC50	163.9	nM	IC50	J Med Chem (2014) 57: 6642-6652 [PMID:25007124]
ChEMBL	Antimalarial activity against multidrug resistant Plasmodium falciparum Dd2 infected in human erythrocytes measured after after 72 hrs by SYBR green dye based fluorescence assay	F	6.79	pIC50	163	nM	IC50	J Med Chem (2020) 63: 6179-6202 [PMID:32390431]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1	F	6.79	pIC50	163	nM	IC50	Antimicrob Agents Chemother (2009) 53: 622-630 [PMID:19015351]
ChEMBL	Antimalarial activity against multidrug-resistant Plasmodium falciparum Dd2 infected in human erythrocytes by SYBR green 1-based fluorescence assay	F	6.79	pIC50	163	nM	IC50	J Med Chem (2019) 62: 3475-3502 [PMID:30852885]
ChEMBL	Antiplasmodial activity against asexual blood stage of multidrug-resistant Plasmodium falciparum Dd2 infected in human erythrocytes assessed as reduction in parasite growth incubated for 72 hrs by SYBR green 1 staining based assay	F	6.79	pIC50	163	nM	IC50	J Med Chem (2021) 64: 8739-8754 [PMID:34111350]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 3D7 ring stage forms infected in immunoliposome encapsulated compound pre-loaded human RBC by [3H]-hypoxanthine incorporation assay	F	6.79	pIC50	162.8	nM	IC50	Eur J Med Chem (2018) 152: 489-514 [PMID:29754074]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 3D7 late stage forms infected in immunoliposome encapsulated compound pre-loaded human RBC by [3H]-hypoxanthine incorporation assay	F	6.79	pIC50	162.3	nM	IC50	Eur J Med Chem (2018) 152: 489-514 [PMID:29754074]
ChEMBL	Antimalarial activity against chloroquine- and mefloquine-resistant Plasmodium falciparum W2-Mef infected in human O-positive erythrocytes assessed as inhibition of trophozoites growth after 48 hrs	F	6.79	pIC50	162	nM	IC50	Bioorg Med Chem (2011) 19: 6604-6607 [PMID:21696970]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum 7G8 infected in erythrocytes assessed as [3H]hypoxanthine incorporation	F	6.8	pIC50	160.3	nM	IC50	Antimicrob Agents Chemother (2009) 53: 1362-1366 [PMID:19188388]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by 96-well format based SYBR green assay	F	6.8	pIC50	160	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antimalarial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1	F	6.8	pIC50	160	nM	IC50	Eur J Med Chem (2009) 44: 736-744 [PMID:18571774]
ChEMBL	Antimalarial activity against Plasmodium falciparum Cam3.1 harbouring Pf-crt, Pf-mdrl,Pf-dhfr, Pf-dhps, pf-kelch13 mutated loci assessed as inhibition of parasite growth incubated for 48 hrs by [3H]hypoxanthine incorporation assay based liquid scintillation counting method	F	6.8	pIC50	160	nM	IC50	J Med Chem (2021) 64: 12582-12602 [PMID:34437804]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FcB1/Columbia infected in erythrocytes assessed as inhibition of parasite growth after 48 hrs by 3H-hypoxanthine incorporation assay	F	6.8	pIC50	160	nM	IC50	J Nat Prod (2016) 79: 607-610 [PMID:26670413]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum TM6 infected in erythrocytes assessed as [3H]hypoxanthine incorporation	F	6.8	pIC50	159.8	nM	IC50	Antimicrob Agents Chemother (2009) 53: 1362-1366 [PMID:19188388]
ChEMBL	Antimalarial activity against Plasmodium falciparum FCM29	F	6.8	pIC50	158	nM	IC50	Bioorg Med Chem Lett (2007) 17: 593-596 [PMID:17123818]
ChEMBL	Antiplasmodial activity against multidrug-resistant Plasmodium falciparum VS/1 after 18 hrs by [3H]hypoxanthine incorporation assay	F	6.8	pIC50	158	nM	IC50	Antimicrob Agents Chemother (2009) 53: 5069-5073 [PMID:19770282]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 by lactate dehydrogenase assay	F	6.8	pIC50	157.9	nM	IC50	Bioorg Med Chem Lett (2011) 21: 1683-1686 [PMID:21316959]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2	F	6.8	pIC50	157.9	nM	IC50	Bioorg Med Chem Lett (2010) 20: 6975-6977 [PMID:20971006]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum FCB after 72 hrs by SYBR green assay	F	6.8	pIC50	157	nM	IC50	J Med Chem (2008) 51: 3466-3479 [PMID:18512900]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human erythrocytes	F	6.81	pIC50	156	nM	IC50	Bioorg Med Chem Lett (2018) 28: 265-272 [PMID:29326018]
ChEMBL	In vitro antimalarial activity against chloroquine-sensitive Plasmodium falciparum K1	F	6.81	pIC50	156	nM	IC50	J Med Chem (2004) 47: 2926-2934 [PMID:15139771]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FcB1/Columbia after 48 hrs	F	6.81	pIC50	155	nM	IC50	Eur J Med Chem (2010) 45: 2854-2859 [PMID:20362359]
ChEMBL	Antiparasitic activity against chloroquine-sensitive Plasmodium falciparum by [3H]hypoxanthine incorporation	F	6.81	pIC50	155	nM	IC50	J Med Chem (2008) 51: 1260-1277 [PMID:18260613]
ChEMBL	Antimalarial activity against multidrug resistant Plasmodium falciparum K1 infected in human erythrocytes assessed as inhibition of parasite proliferation after 96 hrs by SYBR Green I fluorescence based assay	F	6.81	pIC50	154.73	nM	IC50	Bioorg Med Chem Lett (2016) 26: 3006-3009 [PMID:27210430]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum V1/S	F	6.81	pIC50	154	nM	IC50	J Med Chem (2009) 52: 1828-1844 [PMID:19284751]
ChEMBL	Antimalarial activity after 48 hrs against chloroquine-resistant asynchronous Plasmodium falciparum K1 infected human A+ erythrocytes by [3H]hypoxanthine uptake	F	6.81	pIC50	154	nM	IC50	J Med Chem (2009) 52: 502-513 [PMID:19113955]
ChEMBL	Antimalarial activity against Plasmodium falciparum K1 infected in human O positive erythrocytes under low oxygen atmosphere after 72 hrs by spectrophotometric analysis	F	6.81	pIC50	154	nM	IC50	J Med Chem (2012) 55: 10909-10917 [PMID:23176597]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation incubated for 48 hrs prior to [3H]hypoxanthine addition measured after 48 hrs by liquid scintillation counting	F	6.81	pIC50	154	nM	IC50	J Med Chem (2012) 55: 6948-6967 [PMID:22783984]
ChEMBL	Antimalarial activity against asexual stage of Plasmodium falciparum K1 assessed as reduction in parasite growth incubated for 96 hrs by SYBR Green I dye-based fluorescence assay	F	6.81	pIC50	154	nM	IC50	ACS Med Chem Lett (2020) 11: 49-55 [PMID:31938463]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum VS/1 infected in human A positive erythrocytes assessed as inhibition of [G-3H]-hypoxanthine uptake after 24 hrs by liquid scintillation counting	F	6.82	pIC50	152.2	nM	IC50	Bioorg Med Chem (2012) 20: 927-932 [PMID:22182577]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum FCR3 infected in human erythrocytes incubated for 48 hrs by [3H]-hypoxanthine incorporation assay	F	6.82	pIC50	152.2	nM	IC50	Eur J Med Chem (2020) 188: 111983-111983 [PMID:31911292]
ChEMBL	Antimicrobial activity against Plasmodium falciparum at ring stage	F	6.82	pIC50	152	nM	IC50	Antimicrob Agents Chemother (2008) 52: 2435-2441 [PMID:18443130]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FcB1 infected in RBC assessed as inhibition of [3H]-hypoxanthine incorporation after 48 hrs by beta-counting	F	6.82	pIC50	151	nM	IC50	Eur J Med Chem (2014) 78: 269-274 [PMID:24686013]
ChEMBL	Antimalarial activity against Plasmodium falciparum K1	F	6.82	pIC50	151	nM	IC50	J Med Chem (2011) 54: 4581-4589 [PMID:21644541]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FcB1 infected in human RBC assessed as [3H]-hypoxanthine incorporation after 48 hrs by liquid scintillation counting analysis	F	6.82	pIC50	151	nM	IC50	Eur J Med Chem (2014) 76: 369-375 [PMID:24594524]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum FcB1 assessed as [3H]hypoxanthine incorporation after 48 hrs by beta-counter	F	6.82	pIC50	151	nM	IC50	J Med Chem (2010) 53: 699-714 [PMID:20014857]
ChEMBL	Antimalarial activity against CQ-sensitive Plasmodium falciparum 3D7 assessed as parasite growth inhibition incubated for 48 hrs by SYBR Green I dye based fluorescence assay	F	6.82	pIC50	150.8	nM	IC50	ACS Med Chem Lett (2022) 13: 225-235 [PMID:35178179]
ChEMBL	Antiplasmodial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 after 48 hrs	F	6.82	pIC50	150	nM	IC50	Bioorg Med Chem (2008) 16: 6371-6378 [PMID:18502136]
ChEMBL	Antiplasmodial activity against chloroquine/pyrimethamine-resistant Plasmodium falciparum K1 infected in human RBC assessed as reduction in [3H]hypoxanthine incorporation preincubated for 48 hrs followed by [3H]hypoxanthine addition measured after 24 hrs by liquid scintillation counting method	F	6.82	pIC50	150	nM	IC50	Bioorg Med Chem (2017) 25: 941-948 [PMID:28031151]
ChEMBL	Antiprotozoal activity against chloroquine- and pyrimethamine-resistant Plasmodium falciparum K1 after 48 hrs by [3H]-hypoxanthine incorporation assay	F	6.82	pIC50	150	nM	IC50	Bioorg Med Chem (2013) 21: 4988-4996 [PMID:23880082]
ChEMBL	Antimalarial activity against erythrocyte stages of chloroquine-resistant Plasmodium falciparum Dd2 infected in human erythrocytes by lactate dehydrogenase assay	F	6.82	pIC50	150	nM	IC50	J Med Chem (2011) 54: 6956-6968 [PMID:21875063]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum K1 infected in human blood by [3H]hypoxanthine incorporation assay	F	6.82	pIC50	150	nM	IC50	Bioorg Med Chem (2010) 18: 6796-6804 [PMID:20709557]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FcB1 after 48 hrs	F	6.82	pIC50	150	nM	IC50	Bioorg Med Chem (2010) 18: 6006-6011 [PMID:20634081]
ChEMBL	Antiplasmodial activity against asexual erythrocyte stage of chloroquine-resistant Plasmodium falciparum Dd2 infected in human red blood cells after 48 hrs by lactate dehydrogenase assay	F	6.82	pIC50	150	nM	IC50	Eur J Med Chem (2018) 159: 243-254 [PMID:30296683]
ChEMBL	Growth inhibitory concentration against Plasmodium falciparum K1	F	6.82	pIC50	150	nM	IC50	J Med Chem (2003) 46: 3166-3169 [PMID:12825955]
ChEMBL	Antiplasmodial activity against chloroquine and pyrimethamine resistant Plasmodium falciparum K1 erythrocytic stages incubated for 48 hrs by [3H]-hypoxanthine incorporation assay	F	6.82	pIC50	150	nM	IC50	Bioorg Med Chem (2019) 27: 2052-2065 [PMID:30962114]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 by [3H]hypoxanthine incorporation assay	F	6.82	pIC50	150	nM	IC50	J Nat Prod (1997) 60: 739-742 [PMID:9249982]
ChEMBL	Antimalarial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 after 48 hrs as [3H]hypoxanthine uptake	F	6.82	pIC50	150	nM	IC50	Bioorg Med Chem (2009) 17: 3595-3603 [PMID:19395265]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 by [G-3H]hypoxanthine uptake	F	6.82	pIC50	150	nM	IC50	J Nat Prod (1997) 60: 458-461 [PMID:9170288]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FcB1 infected in RBC (unknown origin) incubated for 48 hrs by SYBR green dye based fluorescence analysis	F	6.82	pIC50	150	nM	IC50	J Nat Prod (2019) 82: 3233-3241 [PMID:31800248]
ChEMBL	Antiplasmodial activity against chloroquine/pyrimethamine resistant Plasmodium falciparum K1 infected in human red blood cells after 48 hrs by [3H]hypoxanthine incorporation assay	F	6.82	pIC50	150	nM	IC50	Bioorg Med Chem (2016) 24: 3781-3789 [PMID:27344215]
ChEMBL	Antiplasmodial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 assessed as [3H]hypoxanthine incorporation after 48 hrs by liquid scintillation counter	F	6.82	pIC50	150	nM	IC50	Eur J Med Chem (2012) 47: 510-519 [PMID:22136906]
ChEMBL	Antimicrobial activity against erythrocytic stage of chloroquine-resistant Plasmodium falciparum W2 infected in human erythrocytes assessed as [3H]hypoxanthine incorporation after 24 hrs by beta-radiation counting analysis	F	6.82	pIC50	150	nM	IC50	Eur J Med Chem (2014) 75: 67-76 [PMID:24530492]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum TM6 in human erythrocytes by [3H]hypoxanthine uptake	F	6.82	pIC50	150	nM	IC50	Bioorg Med Chem Lett (2008) 18: 4210-4214 [PMID:18554905]
ChEMBL	Antiplasmodial activity against erythrocytic stage of chloroquine/pyrimethamine-resistant Plasmodium falciparum K1 assessed as reduction in [3H]hypoxanthine incorporation after 48 hrs by liquid scintillation counting method	F	6.82	pIC50	150	nM	IC50	Bioorg Med Chem (2017) 25: 2251-2259 [PMID:28279559]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 after 48 hrs by YOYO-1 dye-based flow cytometry	F	6.82	pIC50	150	nM	IC50	Eur J Med Chem (2017) 138: 993-1001 [PMID:28756265]
ChEMBL	Antiplasmodial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 by microplate assay	F	6.82	pIC50	150	nM	IC50	Eur J Med Chem (2010) 45: 179-185 [PMID:19879671]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 measured after 72 hrs by lactate dehydrogenase assay	F	6.82	pIC50	150	nM	IC50	J Nat Prod (2021) 84: 666-675 [PMID:33667089]
ChEMBL	Antimalarial activity against chloroquine- and mefloquine-resistant Plasmodium falciparum W2-Mef infected in human O-positive erythrocytes after 48 hrs	F	6.83	pIC50	149	nM	IC50	Bioorg Med Chem (2011) 19: 6604-6607 [PMID:21696970]
ChEMBL	Antiplasmodial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1	F	6.83	pIC50	148	nM	IC50	J Med Chem (2008) 51: 3654-3658 [PMID:18476684]
ChEMBL	Antimalarial activity against Plasmodium falciparum K1 at pH 7.4 by microplate assay	F	6.83	pIC50	148	nM	IC50	Bioorg Med Chem Lett (2011) 21: 5804-5807 [PMID:21868222]
ChEMBL	Antiprotozoal activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1	F	6.83	pIC50	148	nM	IC50	Medchemcomm (2012) 3: 1435-1442
ChEMBL	Antimalarial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1	F	6.83	pIC50	147.72	nM	IC50	Bioorg Med Chem (2009) 17: 1481-1485 [PMID:19181530]
ChEMBL	Antimalarial activity against chloroquine resistant Plasmodium falciparum FcB1 Colombia	F	6.83	pIC50	147	nM	IC50	Eur J Med Chem (2021) 219: 113408-113408 [PMID:33989911]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 by SYBR green assay	F	6.83	pIC50	147	nM	IC50	Bioorg Med Chem (2009) 17: 2871-2876 [PMID:19282186]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2	F	6.84	pIC50	145.4	nM	IC50	Bioorg Med Chem Lett (2011) 21: 2882-2886 [PMID:21489789]
ChEMBL	Antiplasmodial activity against Chloroquine resistant Plasmodium falciparum FcB1 incubated for 48 hrs	F	6.84	pIC50	145	nM	IC50	Eur J Med Chem (2021) 210: 113084-113084 [PMID:33333397]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FcB1 by [3H]hypoxanthine uptake	F	6.84	pIC50	145	nM	IC50	J Nat Prod (2008) 71: 1451-1454 [PMID:18572964]
ChEMBL	Antiplasmodial activity against chloroquine/mefloquine-resistant Plasmodium falciparum SRIV35	F	6.84	pIC50	145	nM	IC50	Eur J Med Chem (2015) 94: 56-62 [PMID:25747499]
ChEMBL	Antimalarial activity against Plasmodium falciparum TM91C235	F	6.84	pIC50	144.9	nM	IC50	J Med Chem (2007) 50: 5118-5127 [PMID:17887664]
ChEMBL	Antimalarial activity against Plasmodium falciparum TM91C235	F	6.84	pIC50	144.9	nM	IC50	J Med Chem (2006) 49: 3790-3799 [PMID:16789736]
ChEMBL	Antimalarial activity against mefloquine, chloroquine and quinine-resistant Plasmodium falciparum TM91C235	F	6.84	pIC50	144.9	nM	IC50	Bioorg Med Chem (2008) 16: 7039-7045 [PMID:18550377]
ChEMBL	Antimalarial activity against Plasmodium falciparum K1 incubated for 48 hrs by [3H]-hypoxanthine incorporation assay	F	6.84	pIC50	144	nM	IC50	ACS Med Chem Lett (2020) 11: 49-55 [PMID:31938463]
ChEMBL	Antimalarial activity against Plasmodium falciparum K1 harbouring Pf-crt, Pf-mdrl,Pf-dhfr, Pf-dhps mutated loci assessed as inhibition of parasite growth incubated for 48 hrs by [3H]hypoxanthine incorporation assay based liquid scintillation counting method	F	6.84	pIC50	144	nM	IC50	J Med Chem (2021) 64: 12582-12602 [PMID:34437804]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2mef infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 48 hrs by beta liquid scintillation counting method	F	6.84	pIC50	144	nM	IC50	Bioorg Med Chem (2011) 19: 7519-7525 [PMID:22055713]
ChEMBL	Antimalarial activity against erythrocyte stages of chloroquine-resistant Plasmodium falciparum K1 infected in human erythrocytes by lactate dehydrogenase assay	F	6.84	pIC50	144	nM	IC50	J Med Chem (2011) 54: 6956-6968 [PMID:21875063]
ChEMBL	Inhibitory concentration against Plasmodium falciparum W2 infected erythrocytes	F	6.84	pIC50	144	nM	IC50	J Med Chem (1994) 37: 1486-1494 [PMID:8182707]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum C3 harboring Dd2 pfcrt allele infected in erythrocytes assessed as [3H]hypoxanthine incorporation	F	6.84	pIC50	143.8	nM	IC50	Antimicrob Agents Chemother (2009) 53: 1362-1366 [PMID:19188388]
ChEMBL	Antimalarial activity against Plasmodium falciparum W2	F	6.84	pIC50	143	nM	IC50	Bioorg Med Chem Lett (2007) 17: 593-596 [PMID:17123818]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human erythrocytes assessed as reduction in parasitemia after 48 hrs by flow cytometry analysis	F	6.85	pIC50	142.7	nM	IC50	ACS Med Chem Lett (2012) 3: 1029-1033 [PMID:24936235]
ChEMBL	Antiplasmodial activity against CQ-resistant Plasmodium falciparum W2	F	6.85	pIC50	141.9	nM	IC50	Bioorg Med Chem (2021) 39: 116159-116159 [PMID:33895706]
ChEMBL	Antimalarial activity against Plasmodium falciparum K1 intra-erythrocytic form	F	6.85	pIC50	141	nM	IC50	J Nat Prod (2011) 74: 603-608 [PMID:21456549]
ChEMBL	Antimalarial activity against chloroquine-resistant asexual erythrocyte stage of Plasmodium falciparum K1 infected in human type O+ erythrocytes assessed as growth inhibition incubated for 48 hrs by NBT dye based LDH release assay	F	6.85	pIC50	140	nM	IC50	ACS Med Chem Lett (2017) 8: 201-205 [PMID:28197312]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum FcB1	F	6.85	pIC50	140	nM	IC50	Medchemcomm (2011) 2: 860-869
ChEMBL	Antiplasmodial activity against chloroquine/cycloguanil-resistant Plasmodium falciparum FCR3 by [3H]-hypoxanthine incorporation assay	F	6.85	pIC50	140	nM	IC50	Bioorg Med Chem Lett (2017) 27: 1820-1825 [PMID:28291694]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum V1/S after 48 hrs by [3H]hypoxanthine uptake	F	6.85	pIC50	140	nM	IC50	J Nat Prod (1997) 60: 1017-1022 [PMID:9358645]
ChEMBL	Antimalarial activity against Plasmodium falciparum Dd2 by HRP2 assay	F	6.85	pIC50	140	nM	IC50	Eur J Med Chem (2021) 212: 113034-113034 [PMID:33276991]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human red blood cells assessed as inhibition of ring-stage parasite growth after 48 hrs by flow cytometry	F	6.85	pIC50	140	nM	IC50	Eur J Med Chem (2011) 46: 927-933 [PMID:21295887]
ChEMBL	Antiplasmodial activity against chloroquine-resistant erythrocyte stages of Plasmodium falciparum Dd2 by parasite lactate dehydrogenase assay	F	6.85	pIC50	140	nM	IC50	Eur J Med Chem (2013) 69: 90-98 [PMID:24012713]
ChEMBL	Antiplasmodial activity against chloroquine-resistant ring stage Plasmodium falciparum W2 infected in human RBC after 48 hrs by flow cytometric analysis	F	6.85	pIC50	140	nM	IC50	Eur J Med Chem (2014) 80: 523-534 [PMID:24813880]
ChEMBL	Antiplasmodial activity against ring stage of chloroquine-resistant Plasmodium falciparum W2 infected in human RBC after 48 hrs by flow cytometric analysis	F	6.85	pIC50	140	nM	IC50	Eur J Med Chem (2013) 69: 365-372 [PMID:24077527]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum Dd2 asexual blood stages after 3 days by HRP2 detection based ELISA method	F	6.85	pIC50	140	nM	IC50	J Med Chem (2014) 57: 7971-7976 [PMID:25195945]
ChEMBL	Antimalarial activity against CQ-resistant Plasmodium falciparum Dd2	F	6.85	pIC50	140	nM	IC50	Eur J Med Chem (2021) 226: 113865-113865 [PMID:34655985]
ChEMBL	Antiplasmodial activity against chloroquine resistant Plasmodium falciparum K1 erythrocytic stage assessed as reduction in [3H]hypoxanthine incorporation after 48 hrs by liquid scintillation counting assay	F	6.85	pIC50	140	nM	IC50	Bioorg Med Chem (2017) 25: 2091-2104 [PMID:28284860]
ChEMBL	Antiplasmodial activity against multi drug resistant synchronized Plasmodium falciparum K1 late trophozoite stage assessed as reduction in parasite survival incubated for 72 hrs under hypoxic condition by parasite lactate dehydrogenase based NBT microplate reader assay	F	6.85	pIC50	140	nM	IC50	ACS Med Chem Lett (2021) 12: 1333-1341 [PMID:34413963]
ChEMBL	Antimalarial activity against Plasmodium falciparum TM90C2B incubated for 48 hrs by [3H]-hypoxanthine incorporation assay	F	6.85	pIC50	140	nM	IC50	ACS Med Chem Lett (2020) 11: 49-55 [PMID:31938463]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 after 72 hrs by SYBR green 1 assay	F	6.85	pIC50	140	nM	IC50	J Med Chem (2008) 51: 1995-1998 [PMID:18345611]
ChEMBL	Antiplasmodial activity against multidrug resistant Plasmodium falciparum K1 incubated for 72 hrs by microplate reader assay	F	6.85	pIC50	140	nM	IC50	J Med Chem (2022) 65: 16695-16715 [PMID:36507890]
ChEMBL	Antiparasitic activity against chloroquine-resistant erythrocytic stage of Plasmodium falciparum K1 infected in human RPMI1640 cells after 72 hrs by NBT staining based spectroscopic analysis	F	6.85	pIC50	140	nM	IC50	Eur J Med Chem (2016) 113: 28-33 [PMID:26922226]
ChEMBL	Antimalarial activity against mutidrug resistant Plasmodium falciparum TM91C235 after 48 hrs by [3H]hypoxanthine incorporation assay	F	6.86	pIC50	139	nM	IC50	J Med Chem (2016) 59: 264-281 [PMID:26640981]
ChEMBL	Antimalarial activity against Plasmodium falciparum C235	F	6.86	pIC50	138.82	nM	IC50	J Med Chem (2011) 54: 1157-1169 [PMID:21265542]
ChEMBL	Antimalarial activity against CQ, MFQ-resistant Plasmodium falciparum TM91C235 clone Southeast asian isolate assessed as inhibition of parasite proliferation by MSF assay	F	6.86	pIC50	138.82	nM	IC50	J Med Chem (2014) 57: 4134-4153 [PMID:24742203]
ChEMBL	In vitro sensitivity for Plasmodium falciparum FcB1R	F	6.86	pIC50	138.6	nM	IC50	J Med Chem (2000) 43: 2646-2654 [PMID:10893302]
ChEMBL	Antimalarial activity against drug-resistant Plasmodium falciparum TM91C235	F	6.86	pIC50	138	nM	IC50	Antimicrob Agents Chemother (2008) 52: 3467-3477 [PMID:18644969]
ChEMBL	Antiplasmodial activity against chloroquine-resistant ring stage Plasmodium falciparum W2 infected in human red blood cells after 48 hrs	F	6.86	pIC50	138	nM	IC50	J Med Chem (2011) 54: 734-750 [PMID:21207937]
ChEMBL	Antimalarial activity against Plasmodium falciparum TM91C235 by hypoxanthine uptake	F	6.86	pIC50	138	nM	IC50	J Med Chem (2008) 51: 3437-3448 [PMID:18494463]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2	F	6.86	pIC50	138	nM	IC50	Bioorg Med Chem Lett (2010) 20: 5634-5637 [PMID:20801652]
ChEMBL	Antiplasmodial activity against drug-resistant Plasmodium falciparum Dd2 ring stage forms assessed as inhibition of parasite growth after 72 hrs by DAPI staining-based confocal microscopic analysis	F	6.87	pIC50	136	nM	IC50	J Nat Prod (2019) 82: 1019-1023 [PMID:30865443]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected human erythrocytes as [3H]hypoxanthine uptake after 24 hrs	F	6.87	pIC50	135	nM	IC50	J Nat Prod (1999) 62: 59-66 [PMID:9917283]
ChEMBL	Antimalarial activity multidrug-resistant Plasmodium falciparum Dd2 after 72 hrs by SYBR Green I based fluorescence assay	F	6.87	pIC50	135	nM	IC50	J Med Chem (2011) 54: 5296-5306 [PMID:21736388]
ChEMBL	Antimalarial activity after 72 hrs against chloroquine-resistant Plasmodium falciparum W2 as LDH activity	F	6.87	pIC50	135	nM	IC50	Bioorg Med Chem (2008) 16: 6702-6706 [PMID:18595720]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum Tm90-C2B infected in human Erythrocyte measured after 72 hrs by SYBR green fluorescence dye based microplate reader analysis	F	6.87	pIC50	134	nM	IC50	Eur J Med Chem (2018) 146: 1-14 [PMID:29360043]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum J164	F	6.87	pIC50	133.5	nM	IC50	J Med Chem (2009) 52: 1828-1844 [PMID:19284751]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum FcB1 infected in human red blood cells after 48 hrs by [3H]-hypoxanthine incorporation assay	F	6.88	pIC50	132	nM	IC50	Eur J Med Chem (2017) 139: 22-47 [PMID:28800458]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1	F	6.88	pIC50	131	nM	IC50	Eur J Med Chem (2015) 94: 56-62 [PMID:25747499]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in erythrocytes assessed as reduction in [3H]hypoxanthine incorporation preincubated for 48 hrs followed by [3H]hypoxanthine addition and measured after 18 hrs by topcount scintillation counting analysis	F	6.88	pIC50	131	nM	IC50	J Med Chem (2020) 63: 8069-8087 [PMID:32687714]
ChEMBL	Antimalarial activity as 3rd generation ring-stage chloroquine-resistant Plasmodium falciparum W2 after 48 hrs dose then 48 hrs drug-free	F	6.89	pIC50	130	nM	IC50	Antimicrob Agents Chemother (2007) 51: 3485-3490 [PMID:17698630]
ChEMBL	Antiprotozoal activity against intraerythrocytic stage of chloroquine/pyrimethamine-resistant Plasmodium falciparum K1 by [3H]hypoxanthine incorporation assay	F	6.89	pIC50	130	nM	IC50	J Med Chem (2015) 58: 1940-1949 [PMID:25642604]
ChEMBL	In vitro antimalarial activity against Plasmodium falciparum FcB1	F	6.89	pIC50	130	nM	IC50	J Med Chem (2004) 47: 1997-2009 [PMID:15055999]
ChEMBL	In vitro antiplasmodial activity for chloroquine-resistant Plasmodium falciparum FcB1	F	6.89	pIC50	130	nM	IC50	Bioorg Med Chem Lett (2005) 15: 2637-2640 [PMID:15863333]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum FcB1 after 24 hrs	F	6.89	pIC50	130	nM	IC50	Bioorg Med Chem (2008) 16: 771-782 [PMID:17967541]
ChEMBL	Antiplasmodial activity after 18 hrs against chloroquine-resistant Plasmodium falciparum FcB1 in human blood by [3H]hypoxanthine uptake	F	6.89	pIC50	130	nM	IC50	J Nat Prod (2003) 66: 1447-1450 [PMID:14640516]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human erythrocytes measured after 72 hrs Malstat/NBT reagent based assay	F	6.89	pIC50	130	nM	IC50	Bioorg Med Chem (2019) 27: 729-747 [PMID:30692024]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 rings after 48 hrs by FACS analysis	F	6.89	pIC50	130	nM	IC50	J Nat Prod (2009) 72: 2130-2134 [PMID:19904919]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by DAPI staining method	F	6.89	pIC50	130	nM	IC50	J Nat Prod (2009) 72: 1541-1543 [PMID:19637893]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 after 72 hrs by fluorescence assay	F	6.89	pIC50	130	nM	IC50	J Nat Prod (2010) 73: 985-987 [PMID:20462236]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum K1 infected in human erythrocytes assessed as reduction in parasite multiplication incubated for 72 hrs by Malstat method	F	6.89	pIC50	130	nM	IC50	Bioorg Med Chem Lett (2019) 29: 1232-1235 [PMID:30879839]
ChEMBL	Antimalarial activity against Chloroquine-resistant Plasmodium falciparum K1 measured after 72 hrs by malstat/NBT dye based assay	F	6.89	pIC50	130	nM	IC50	Bioorg Med Chem Lett (2019) 29: 1051-1053 [PMID:30857749]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 after 72 hrs by DAPI staining based confocal microplate imaging method	F	6.89	pIC50	130	nM	IC50	J Nat Prod (2017) 80: 3211-3217 [PMID:29236492]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 assessed as growth inhibition after 72 hrs by DAPI staining	F	6.89	pIC50	130	nM	IC50	J Med Chem (2012) 55: 5851-5858 [PMID:22686608]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum assessed as inhibition of [3H]hypoxanthine incorporation incubated for 20 to 24 hr prior to [3H]hypoxanthine addition measured after 24 grs by microbeta scintillation counting	F	6.89	pIC50	130	nM	IC50	Med Chem Res (2008) 17: 19-29
ChEMBL	Gametocytocidal activity against synchronous stage 1 to 3 of transgenic Plasmodium falciparum NF54 gametocyte harboring pfs16 promoter assessed as parasite viability after 72 hrs by luciferase reporter gene assay	F	6.89	pIC50	130	nM	IC50	J Med Chem (2013) 56: 6200-6215 [PMID:23837878]
ChEMBL	Antimalarial activity against chloroquine and mefloquine-resistant Plasmodium falciparum Dd2 assessed as [3H]-hypoxanthine incorporation after 48 hrs by liquid scintillation counting analysis	F	6.89	pIC50	130	nM	IC50	ACS Med Chem Lett (2014) 5: 178-182 [PMID:24900794]
ChEMBL	Antimalarial activity against multidrug-resistant Plasmodium falciparum TM91C235	F	6.89	pIC50	129.78	nM	IC50	J Med Chem (2008) 51: 6216-6219 [PMID:18774792]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 after 72 hrs	F	6.9	pIC50	127	nM	IC50	Bioorg Med Chem (2009) 17: 270-283 [PMID:19041248]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum C6harboring 7G8 pfcrt allele infected in erythrocytes assessed as [3H]hypoxanthine incorporation	F	6.9	pIC50	126.9	nM	IC50	Antimicrob Agents Chemother (2009) 53: 1362-1366 [PMID:19188388]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum FcB1R after 24 hrs by semiautomated micro dilution assay	F	6.9	pIC50	126	nM	IC50	Eur J Med Chem (2008) 43: 252-260 [PMID:17485145]
ChEMBL	Antimalarial activity against Plasmodium falciparum NF54 assessed as inhibition of parasite growth incubated for 48 hrs by [3H]hypoxanthine incorporation assay based liquid scintillation counting method	F	6.9	pIC50	126	nM	IC50	J Med Chem (2021) 64: 12582-12602 [PMID:34437804]
ChEMBL	Antimalarial activity after 24 hrs against chloroquine-resistant Plasmodium falciparum FcB1R/Colombia by [3H]hypoxanthine uptake	F	6.9	pIC50	126	nM	IC50	Eur J Med Chem (2008) 43: 2045-2055 [PMID:18226428]
ChEMBL	Antimalarial activity against chloroquine resistant Plasmodium falciparum PaloAlto	F	6.9