ChEMBL ligand: CHEMBL76 (Aralen, Chlorochine, Chloroquine, NSC-187208)
α2A-adrenoceptor/Alpha-2a adrenergic receptor in Human [ChEMBL: CHEMBL1867] [GtoPdb: 25] [UniProtKB: P08913] There should be some charts here, you may need to enable JavaScript!
α2B-adrenoceptor/Alpha-2b adrenergic receptor in Human [ChEMBL: CHEMBL1942] [GtoPdb: 26] [UniProtKB: P18089] There should be some charts here, you may need to enable JavaScript!
α2C-adrenoceptor/Alpha-2c adrenergic receptor in Human [ChEMBL: CHEMBL1916] [GtoPdb: 27] [UniProtKB: P18825] There should be some charts here, you may need to enable JavaScript!
Beta amyloid A4 protein in Human [ChEMBL: CHEMBL2487] [UniProtKB: P05067] There should be some charts here, you may need to enable JavaScript!
beta-secretase 1/Beta-secretase 1 in Human [ChEMBL: CHEMBL4822] [GtoPdb: 2330] [UniProtKB: P56817] There should be some charts here, you may need to enable JavaScript!
Dihydrofolate reductase in Bovine [ChEMBL: CHEMBL1075051] [UniProtKB: P00376] There should be some charts here, you may need to enable JavaScript!
Falcipain 2 in Plasmodium falciparum [ChEMBL: CHEMBL1697672] [UniProtKB: Q9NAW2] There should be some charts here, you may need to enable JavaScript!
Hemozoin in Plasmodium falciparum [ChEMBL: CHEMBL613898] There should be some charts here, you may need to enable JavaScript!
Kv11.1/HERG in Human [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] There should be some charts here, you may need to enable JavaScript!
Histidine-rich protein in Plasmodium falciparum [ChEMBL: CHEMBL1923] [UniProtKB: P05227] There should be some charts here, you may need to enable JavaScript!
M1 receptor/Muscarinic acetylcholine receptor M1 in Human [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229] There should be some charts here, you may need to enable JavaScript!
M2 receptor/Muscarinic acetylcholine receptor M2 in Human [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172] There should be some charts here, you may need to enable JavaScript!
M3 receptor/Muscarinic acetylcholine receptor M3 in Human [ChEMBL: CHEMBL245] [GtoPdb: 15] [UniProtKB: P20309] There should be some charts here, you may need to enable JavaScript!
M4 receptor/Muscarinic acetylcholine receptor M4 in Human [ChEMBL: CHEMBL1821] [GtoPdb: 16] [UniProtKB: P08173] There should be some charts here, you may need to enable JavaScript!
M5 receptor/Muscarinic acetylcholine receptor M5 in Human [ChEMBL: CHEMBL2035] [GtoPdb: 17] [UniProtKB: P08912] There should be some charts here, you may need to enable JavaScript!
Nuclear receptor related 1/Nuclear receptor subfamily 4 group A member 2 in Human [ChEMBL: CHEMBL5002] [GtoPdb: 630] [UniProtKB: P43354] There should be some charts here, you may need to enable JavaScript!
Plasmodium berghei [ChEMBL: CHEMBL612653] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum 3D7 [ChEMBL: CHEMBL2366922] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum D6 [ChEMBL: CHEMBL2367107] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum (isolate FcB1 / Columbia) in Plasmodium falciparum FcB1/Columbia [ChEMBL: CHEMBL612608] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 [ChEMBL: CHEMBL612856] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum NF54 [ChEMBL: CHEMBL2367131] There should be some charts here, you may need to enable JavaScript!
Plasmodium knowlesi [ChEMBL: CHEMBL613011] There should be some charts here, you may need to enable JavaScript!
Plasmodium malariae [ChEMBL: CHEMBL613257] There should be some charts here, you may need to enable JavaScript!
Plasmodium vivax [ChEMBL: CHEMBL613013] There should be some charts here, you may need to enable JavaScript!
Plasmodium yoelii [ChEMBL: CHEMBL612889] There should be some charts here, you may need to enable JavaScript!
Prion protein in Human [ChEMBL: CHEMBL4869] [UniProtKB: P04156] There should be some charts here, you may need to enable JavaScript!
Quinone reductase 2 in Human [ChEMBL: CHEMBL3959] [UniProtKB: P16083] There should be some charts here, you may need to enable JavaScript!
Riboflavin-binding protein in Chicken [ChEMBL: CHEMBL1944489] [UniProtKB: P02752] There should be some charts here, you may need to enable JavaScript!
σ2/Sigma intracellular receptor 2 in Human [ChEMBL: CHEMBL4105907] [GtoPdb: 2553] [UniProtKB: Q5BJF2] There should be some charts here, you may need to enable JavaScript!
sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720] There should be some charts here, you may need to enable JavaScript!
CoV Spike glycoprotein/Spike glycoprotein in Severe acute respiratory syndrome coronavirus 2 [ChEMBL: CHEMBL4662936] [GtoPdb: 3114] [UniProtKB: P0DTC2] There should be some charts here, you may need to enable JavaScript!
MRGPRX1 in Human [GtoPdb: 156] [UniProtKB: Q96LB2] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
α2A-adrenoceptor/Alpha-2a adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1867] [GtoPdb: 25] [UniProtKB: P08913]
ChEMBL	Activity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscine	B	5.36	pKi	4365.16	nM	Ki	A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
α2B-adrenoceptor/Alpha-2b adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1942] [GtoPdb: 26] [UniProtKB: P18089]
ChEMBL	Activity of compound against Alpha 2B (ADRA2B) adrenergic receptor by displacement of [3H]-rauwolscine	B	4.5	pKi	31622.78	nM	Ki	A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
α2C-adrenoceptor/Alpha-2c adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1916] [GtoPdb: 27] [UniProtKB: P18825]
ChEMBL	Activity of compound against Alpha 2C (ADRA2C) adrenergic receptor by displacement of [3H]-rauwolscine	B	5	pKi	10000	nM	Ki	A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
Beta amyloid A4 protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2487] [UniProtKB: P05067]
ChEMBL	Modulation of human wild-type APP695 expressed in SH-SY5Y cells assessed as inhibition of amyloid beta (1 to 42 residues) production measured after 24 hrs by ELISA	B	4.89	pIC50	12800	nM	IC50	Bioorg Med Chem (2018) 26: 2151-2164 [PMID:29559198]
ChEMBL	Modulation of human wild-type APP695 expressed in SH-SY5Y cells assessed as inhibition of amyloid beta (1 to 40 residues) production measured after 24 hrs	B	5.15	pIC50	7000	nM	IC50	Bioorg Med Chem (2018) 26: 2151-2164 [PMID:29559198]
beta-secretase 1/Beta-secretase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4822] [GtoPdb: 2330] [UniProtKB: P56817]
ChEMBL	Inhibition of BACE1 in human SH-SY5Y cells harboring wild type APP695 assessed as reduction in amyloid beta (1 to 42) level after 24 hrs by ELISA method	B	4.9	pIC50	12700	nM	IC50	Eur J Med Chem (2018) 159: 104-125 [PMID:30268822]
ChEMBL	Inhibition of BACE1 in human SH-SY5Y cells harboring wild type APP695 assessed as reduction in amyloid beta (1 to 40) level after 24 hrs by ELISA method	B	5.15	pIC50	7000	nM	IC50	Eur J Med Chem (2018) 159: 104-125 [PMID:30268822]
Dihydrofolate reductase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075051] [UniProtKB: P00376]
ChEMBL	Inhibition of bovine liver DHFR	B	7.52	pIC50	30.1	nM	IC50	Bioorg Med Chem (2017) 25: 5396-5406 [PMID:28789907]
ChEMBL	Inhibition of bovine liver DHFR pre-incubated 2 mins before dihydrofolic acid substrate addition and measured over 10 mins in presence of NADPH	B	7.52	pIC50	30.1	nM	IC50	Bioorg Med Chem (2017) 25: 4064-4075 [PMID:28634040]
Falcipain 2 in Plasmodium falciparum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1697672] [UniProtKB: Q9NAW2]
ChEMBL	Inhibition of falcipain-2 in chloroquine resistant Plasmodium falciparum RKL9 schizont stage infected in human erythrocytes assessed as reduction in bacterial growth after 24 hrs by Giemsa staining based assay	B	6.7	pIC50	200	nM	IC50	Bioorg Med Chem Lett (2018) 28: 1566-1569 [PMID:29602682]
Hemozoin in Plasmodium falciparum (target type: MACROMOLECULE) [ChEMBL: CHEMBL613898]
ChEMBL	Inhibition of beta-hematin formation assessed as reduction in hemozoin formation incubated for 16 hrs by NP40 detergent-mediated assay	B	4.13	pIC50	74000	nM	IC50	Eur J Med Chem (2019) 180: 121-133 [PMID:31301563]
ChEMBL	Inhibition of beta-hematin formation assessed as reduction in hemozoin formation incubated for 5 hrs by NP40 detergent-based assay	B	4.28	pIC50	53000	nM	IC50	Medchemcomm (2019) 10: 450-455 [PMID:31015908]
ChEMBL	Inhibition of beta-hematin	B	4.28	pIC50	53000	nM	IC50	J Med Chem (2016) 59: 6512-6530 [PMID:27299916]
ChEMBL	Inhibition of beta-hematin in water/NP40/DMSO solution incubated for 5 to 6hrs by detergent-mediated pyridine-ferrichrome method	B	4.5	pIC50	31500	nM	IC50	J Med Chem (2016) 59: 6512-6530 [PMID:27299916]
ChEMBL	Inhibition of beta-hematin formation assessed as reduction in hemozoin formation incubated for 5 hrs by NP40 detergent-mediated assay	B	4.68	pIC50	21000	nM	IC50	J Med Chem (2020) 63: 13013-13030 [PMID:33103428]
ChEMBL	Inhibition of beta hematin formation after 5 hrs by NP40 detergent-based assay	B	4.74	pIC50	18000	nM	IC50	J Med Chem (2019) 62: 1022-1035 [PMID:30562027]
ChEMBL	Inhibition of beta-hematin formation assessed as reduction in hemozoin formation incubated for 20 hrs by NP40 detergent-mediated assay	B	4.77	pIC50	16900	nM	IC50	RSC Med Chem (2020) 11: 85-91 [PMID:33479606]
ChEMBL	Inhibition of Beta-hematin in Plasmodium falciparum cells assessed as hemozoin formation after 32 hrs by NP40 detergent-mediated assay	B	4.77	pIC50	16800	nM	IC50	Bioorg Med Chem Lett (2021) 54: 128442-128442 [PMID:34763083]
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL	Inhibition of human ERG expressed in CHO cells	B	5.12	pKi	7500	nM	Ki	ACS Med Chem Lett (2013) 4: 1037-1041 [PMID:24900603]
ChEMBL	Inhibition of human ERG	B	5.6	pIC50	2511.89	nM	IC50	Eur J Med Chem (2011) 46: 618-630 [PMID:21185626]
ChEMBL	Inhibitory concentration against IKr potassium channel	B	5.6	pIC50	2500	nM	IC50	Bioorg Med Chem Lett (2004) 14: 4771-4777 [PMID:15324906]
ChEMBL	Inhibition of human cloned ERG	B	5.6	pIC50	2500	nM	IC50	J Med Chem (2009) 52: 1408-1415 [PMID:19222165]
ChEMBL	Inhibition of human ERG expressed in HEK293 cells assessed as reduction in tail current at membrane potential of +20 mV	B	5.6	pIC50	2500	nM	IC50	Bioorg Med Chem Lett (2015) 25: 1390-1393 [PMID:25746816]
Histidine-rich protein in Plasmodium falciparum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1923] [UniProtKB: P05227]
ChEMBL	Inhibition of 1-monooleoyl glycerol (MOG) induced beta-hematin formation	F	4.12	pIC50	76500	nM	IC50	Bioorg Med Chem Lett (2003) 13: 3783-3787 [PMID:14552779]
ChEMBL	Inhibition of beta-hematin formation in Plasmodium falciparum	F	4.12	pIC50	75000	nM	IC50	Bioorg Med Chem Lett (2001) 11: 2075-2077 [PMID:11514142]
ChEMBL	Inhibition of 1-monooleoyl glycerol induced beta-hematin formation	F	4.22	pIC50	60000	nM	IC50	Bioorg Med Chem Lett (2006) 16: 31-35 [PMID:16263280]
ChEMBL	Inhibition of lipid-induced beta-hematin formation	F	4.33	pIC50	46300	nM	IC50	J Med Chem (2006) 49: 4707-4714 [PMID:16854077]
ChEMBL	Inhibition of beta-hematin formation	F	4.42	pIC50	38000	nM	IC50	J Med Chem (2002) 45: 4975-4983 [PMID:12408708]
ChEMBL	Inhibition of beta-hematin formation after 16 hrs	F	4.81	pIC50	15400	nM	IC50	Antimicrob Agents Chemother (2007) 51: 2842-2847 [PMID:17562796]
ChEMBL	Inhibition of hematin polymerization	F	4.82	pIC50	15000	nM	IC50	J Med Chem (1999) 42: 4630-4639 [PMID:10579825]
ChEMBL	Inhibition of beta-hematin polymerization	B	6.4	pIC50	400	nM	IC50	J Med Chem (2007) 50: 394-398 [PMID:17228883]
ChEMBL	Inhibitory activity against beta-hematin formation	F	7.12	pIC50	76.5	nM	IC50	J Med Chem (2003) 46: 542-557 [PMID:12570376]
M1 receptor/Muscarinic acetylcholine receptor M1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229]
ChEMBL	Activity of compound against Muscarinic acetylcholine receptor M1 (CHRM1) by displacement of 3H-QNB	B	5.04	pKi	9120.11	nM	Ki	A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
M2 receptor/Muscarinic acetylcholine receptor M2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172]
ChEMBL	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	B	5.33	pKi	4677.35	nM	Ki	A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
M3 receptor/Muscarinic acetylcholine receptor M3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL245] [GtoPdb: 15] [UniProtKB: P20309]
ChEMBL	Activity of compound against Muscarinic acetylcholine receptor M3 (CHRM3) by displacement of 3H-QNB	B	5.48	pKi	3311.31	nM	Ki	A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
M4 receptor/Muscarinic acetylcholine receptor M4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1821] [GtoPdb: 16] [UniProtKB: P08173]
ChEMBL	Activity of compound against Muscarinic acetylcholine receptor M4 (CHRM4) by displacement of 3H-QNB	B	5.24	pKi	5754.4	nM	Ki	A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
M5 receptor/Muscarinic acetylcholine receptor M5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2035] [GtoPdb: 17] [UniProtKB: P08912]
ChEMBL	Activity of compound against Muscarinic acetylcholine receptor M5 (CHRM5) by displacement of 3H-QNB	B	4.66	pKi	21877.62	nM	Ki	A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
Nuclear receptor related 1/Nuclear receptor subfamily 4 group A member 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5002] [GtoPdb: 630] [UniProtKB: P43354]
ChEMBL	Agonist activity at Gal4-fused human Nurr1 LBD expressed in HEK293T cells co-expressing firefly luciferase assessed as luciferase activity incubated for 12 to 14 hrs by hybrid reporter gene assay	B	4.33	pEC50	47000	nM	EC50	J Med Chem (2021) 64: 2659-2668 [PMID:33629841]
Plasmodium berghei (target type: ORGANISM) [ChEMBL: CHEMBL612653]
ChEMBL	Antimalarial activity against luciferase-expressing Plasmodium berghei ANKA 676m1cl1 sporozoites infected in human HepG2A16 cells measured after 45 hrs by luciferase-luciferin based reporter assay	F	4.5	pIC50	>31262	nM	IC50	J Med Chem (2019) 62: 3475-3502 [PMID:30852885]
ChEMBL	Antimalarial activity against luciferase-expressing Plasmodium berghei ANKA 676m1cl1 sporozoites infected in human HepG2A16 cells measured after 45 hrs by luciferase-luciferin based reporter gene assay	F	4.5	pIC50	>31262	nM	IC50	J Med Chem (2020) 63: 6179-6202 [PMID:32390431]
ChEMBL	Antiplasmodial activity against Plasmodium berghei liver stage form transfected in human Huh-7 cells assessed as cell viability after 48 hrs by luciferase reporter gene assay	F	4.8	pIC50	15900	nM	IC50	J Med Chem (2013) 56: 556-567 [PMID:23273038]
ChEMBL	Antiplasmodial activity against liver stage of Plasmodium berghei expressing GFP-Luc infected in HuH7 cells incubated at 1 hr prior to infection followed by compound replenisment at 24 hrs post-infection measured after 48 hrs by Alamar blue assay	F	4.82	pIC50	>15000	nM	IC50	Bioorg Med Chem Lett (2013) 23: 610-613 [PMID:23290049]
ChEMBL	Antimalarial activity against exo-erythrocytic form of Plasmodium berghei infected in human HepG2 cells after 48 hrs	F	5	pIC50	>10000	nM	IC50	Eur J Med Chem (2014) 82: 204-213 [PMID:24904967]
ChEMBL	Antimalarial activity against sporozoite stage of Plasmodium berghei yoelii infected in human HepG2 cells	F	5.05	pIC50	9000	nM	IC50	J Med Chem (2016) 59: 264-281 [PMID:26640981]
ChEMBL	Antimalarial activity against schizonts of chloroquine-sensitive Plasmodium berghei ANKA 2.34 after 16 hrs	F	7.22	pIC50	60	nM	IC50	Bioorg Med Chem Lett (2012) 22: 7048-7051 [PMID:23084276]
ChEMBL	Antimicrobial activity against Plasmodium berghei sporozoites infected in 12 hrs compound pretreated human HepG2 cells assessed as reduction in viability of exoerythrocytic forms measured after 48 hrs of incubation by luciferase bioluminescence assay	F	5	pEC50	>10000	nM	EC50	J Med Chem (2014) 57: 2773-2788 [PMID:24641010]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Inhibition of hematin polymerization in Plasmodium falciparum	F	4.1	pIC50	80000	nM	IC50	J Med Chem (1998) 41: 4360-4364 [PMID:9784111]
ChEMBL	Gametocytocidal activity against synchronous stage 4 to 5 of transgenic Plasmodium falciparum NF54 gametocyte harboring pfs16 promoter assessed as parasite viability after 72 hrs by MitoTracker Red CMXRos-based assay	F	4.22	pIC50	60000	nM	IC50	J Med Chem (2013) 56: 6200-6215 [PMID:23837878]
ChEMBL	Inhibition of hydrogen peroxide-mediated haem detoxification in Plasmodium falciparum	F	4.43	pIC50	37000	nM	IC50	Bioorg Med Chem Lett (2001) 11: 2075-2077 [PMID:11514142]
ChEMBL	Antimalarial activity after 72 hrs against chloroquine-sensitive Plasmodium falciparum D6 infected in erythrocytes by LDH assay	F	4.53	pIC50	29700	nM	IC50	Bioorg Med Chem (2009) 17: 741-751 [PMID:19084416]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum	F	4.53	pIC50	29640	nM	IC50	Eur J Med Chem (2019) 166: 206-223 [PMID:30711831]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in erythrocytes after 96 hrs by [3H]hypoxanthine incorporation assay	F	4.68	pIC50	21000	nM	IC50	J Med Chem (2009) 52: 7954-7957 [PMID:19908867]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay	F	4.72	pIC50	19000	nM	IC50	J Med Chem (2009) 52: 7954-7957 [PMID:19908867]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 by lactate dehydrogenase assay	F	4.79	pIC50	16300	nM	IC50	J Nat Prod (2018) 81: 41-48 [PMID:29309141]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7 infected in human O positive erythrocytes assessed as reduction of parasite growth after 24 to 44 hrs by Giemsa staining	F	4.82	pIC50	15000	nM	IC50	Eur J Med Chem (2013) 67: 158-165 [PMID:23851117]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 by LDH assay	F	4.95	pIC50	11300	nM	IC50	Eur J Med Chem (2020) 198: 112330-112330 [PMID:32408064]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K14 infected in human red blood cells after 48 hrs by [3H]hypoxanthine incorporation assay	F	4.96	pIC50	11000	nM	IC50	Eur J Med Chem (2014) 87: 364-371 [PMID:25282260]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 gametocytes (stage 4 & 5)	F	4.97	pIC50	10700	nM	IC50	Antimicrob Agents Chemother (2007) 51: 1463-1472 [PMID:17242150]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum Dd2 after 72 hrs by 1536-well format based SYBR green assay	F	5	pIC50	10000	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay	F	5.26	pIC50	5500	nM	IC50	Eur J Med Chem (2013) 60: 497-502 [PMID:23354072]
ChEMBL	In vitro inhibitory activity against Plasmodium falciparum	F	5.52	pIC50	3000	nM	IC50	Bioorg Med Chem Lett (2001) 11: 1851-1854 [PMID:11459645]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by 1536-well format based SYBR green assay	F	5.7	pIC50	2000	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against chloroquine and pyrimethamine resistant Plasmodium falciparum K1 assessed as reduction in [3H]-hypoxanthine incorporation incubated for 48 hrs by liquid scintillation counting method	F	5.74	pIC50	1828	nM	IC50	Eur J Med Chem (2017) 140: 595-603 [PMID:28988153]
ChEMBL	Displacement of chloroquine from Fe(3+) FPIX-loaded membrane	F	5.75	pIC50	1760	nM	IC50	J Med Chem (2002) 45: 4975-4983 [PMID:12408708]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by 1536-well format based SYBR green assay	F	5.8	pIC50	1600	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by 1536-well format based SYBR green assay	F	5.8	pIC50	1600	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 assessed as inhibition of parasite growth incubated for 48 hrs by SYBR green 1 dye based fluorescence assay	F	5.95	pIC50	1110	nM	IC50	Eur J Med Chem (2016) 121: 640-648 [PMID:27318984]
ChEMBL	Antimalarial activity against Plasmodium falciparum infected in human O+ erythrocytes after 48 hrs by HRP2-ELISA method	F	5.99	pIC50	1030	nM	IC50	Bioorg Med Chem (2010) 18: 5626-5633 [PMID:20621497]
ChEMBL	Antimalarial activity against Plasmodium falciparum V1/S infected in human erythrocytes assessed as reduction in [3H]-hypoxanthine incorporation preincubated for 24 hrs followed by [3H]-hypoxanthine addition measured after 24 hrs by scintillation counting method	F	6	pIC50	>1000	nM	IC50	J Med Chem (2017) 60: 5889-5908 [PMID:28635296]
ChEMBL	Antimalarial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum V1/S assessed as inhibition of parasite growth	F	6	pIC50	>1000	nM	IC50	J Med Chem (2015) 58: 4573-4580 [PMID:25906200]
ChEMBL	Antimalarial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum W2 assessed as inhibition of parasite growth	F	6	pIC50	>1000	nM	IC50	J Med Chem (2015) 58: 4573-4580 [PMID:25906200]
ChEMBL	Antimicrobial activity against Plasmodium falciparum	F	6	pIC50	1000	nM	IC50	Bioorg Med Chem (2010) 18: 2225-2231 [PMID:20185316]
ChEMBL	Antimalarial activity against chloroquine, pyrimethamine, and mefloquine-resistant Plasmodium falciparum Dd2 infected in human O positive red blood cells assessed as inhibition of [3H]-hypoxanthine uptake after 48 hrs	F	6.01	pIC50	980	nM	IC50	J Nat Prod (2011) 74: 74-78 [PMID:21155593]
ChEMBL	Inhibition of chloroquine uptake from intact parasites	F	6.02	pIC50	950	nM	IC50	J Med Chem (2002) 45: 4975-4983 [PMID:12408708]
ChEMBL	In vitro inhibitory activity against multidrug-resistant Plasmodium falciparum W2 Indochina	F	6.05	pIC50	900	nM	IC50	J Med Chem (2002) 45: 3195-3209 [PMID:12109904]
ChEMBL	Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum FCM29 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs	F	6.06	pIC50	879	nM	IC50	J Med Chem (2010) 53: 3214-3226 [PMID:20329733]
ChEMBL	Antimalarial activity against chloroquine, pyrimethamine and cycloguanil-resistant Plasmodium falciparum VS1 after 24 hrs	F	6.07	pIC50	860	nM	IC50	Bioorg Med Chem (2007) 15: 5551-5562 [PMID:17548196]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 asynchronous cultures infected in human erythrocytes measured after 72 hrs by SYBR Green1 dye based fluorescence assay	F	6.08	pIC50	830	nM	IC50	Medchemcomm (2018) 9: 1232-1238 [PMID:30109012]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 by pLDH assay	F	6.09	pIC50	810	nM	IC50	J Med Chem (2006) 49: 7088-7094 [PMID:17125261]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human erythrocytes assessed as inhibition of parasite growth after 24 hrs by [3H]hypoxanthine incorporation assay	F	6.11	pIC50	780	nM	IC50	Eur J Med Chem (2013) 62: 168-176 [PMID:23353738]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 after 48 to 72 hrs by SYBR green-1 assay	F	6.12	pIC50	750	nM	IC50	Bioorg Med Chem Lett (2013) 23: 6167-6171 [PMID:24080459]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum W2 infected in human RBC assessed as parasite growth inhibition measured as LDH activity after 72 hrs by plate reader analysis	F	6.14	pIC50	720	nM	IC50	Eur J Med Chem (2015) 98: 160-169 [PMID:26005918]
ChEMBL	Antimicrobial activity against Plasmodium falciparum W2 after 72 hrs by LDH activity assay	F	6.14	pIC50	720	nM	IC50	Medchemcomm (2013) 4: 1042-1048
ChEMBL	Antiplasmodial activity against drug resistant Plasmodium falciparum Dd2 ring stage cells assessed as reduction parasitemia by Malstat assay	F	6.15	pIC50	710	nM	IC50	Bioorg Med Chem (2012) 20: 5277-5289 [PMID:22858300]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum Dd2 assessed as inhibition of [3H]hypoxanthine incorporation incubated for 24 hrs prior to [3H]hypoxanthine addition measured after 24 hrs by beta scintillation counting	F	6.15	pIC50	710	nM	IC50	ACS Med Chem Lett (2012) 3: 373-377 [PMID:24900481]
ChEMBL	Antimalarial activity against chloroquine, pyrimethamine, proguanil-resistant Plasmodium falciparum infected in human erythrocytes after 48 hrs by flow cytometry	F	6.15	pIC50	700	nM	IC50	Bioorg Med Chem Lett (2009) 19: 5962-5964 [PMID:19748781]
ChEMBL	Antimalarial activity as reduced parasitaemia after 48 hrs against chloroquine, pyrimethamine and proguanil-resistant Plasmodium falciparum W2 infected in type A+ human erythrocytes by flow cytometry	F	6.15	pIC50	700	nM	IC50	Bioorg Med Chem (2009) 17: 4313-4322 [PMID:19482476]
ChEMBL	Antiplasmodial activity against multidrug-resistant Plasmodium falciparum W2 infected human erythrocytes after 48 hrs by flow cytometry	F	6.15	pIC50	700	nM	IC50	Eur J Med Chem (2010) 45: 864-869 [PMID:19914747]
ChEMBL	Antiplasmodial activity against chloroquinone-resistant Plasmodium falciparum W2	F	6.15	pIC50	700	nM	IC50	Bioorg Med Chem Lett (2008) 18: 396-401 [PMID:17981462]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human A+ erythrocytes assessed as inhibition of parasite proliferation after 48 hrs	F	6.15	pIC50	700	nM	IC50	Bioorg Med Chem (2010) 18: 6012-6023 [PMID:20638854]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human erythrocyte after 48 hrs by flow cytometry	F	6.15	pIC50	700	nM	IC50	Eur J Med Chem (2010) 45: 616-622 [PMID:19926173]
ChEMBL	Antiparasitic activity against Plasmodium falciparum W2	F	6.16	pIC50	697.94	nM	IC50	Eur J Med Chem (2019) 181: 111353-111353 [PMID:31525705]
ChEMBL	Antimalarial activity against Plasmodium falciparum Dd2 infected in human erythrocytes assessed as reduction in [3H]-hypoxanthine incorporation preincubated for 24 hrs followed by [3H]-hypoxanthine addition measured after 24 hrs by scintillation counting method	F	6.16	pIC50	690	nM	IC50	J Med Chem (2017) 60: 5889-5908 [PMID:28635296]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human RBCs after 72 hrs by parasite lactate dehydrogenase assay	F	6.17	pIC50	681	nM	IC50	J Med Chem (2012) 55: 10387-10404 [PMID:23145816]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT K14 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter	F	6.18	pIC50	665	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL	Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum K14 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs	F	6.19	pIC50	648.6	nM	IC50	J Med Chem (2010) 53: 3214-3226 [PMID:20329733]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum FCR3	F	6.19	pIC50	645	nM	IC50	Bioorg Med Chem Lett (2007) 17: 6434-6438 [PMID:17949976]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 assessed as inhibition of parasite LDH activity after 72 hrs by spectrophotometry	F	6.2	pIC50	632	nM	IC50	Eur J Med Chem (2011) 46: 1757-1767 [PMID:21396743]
ChEMBL	Antimicrobial activity against chloroquine-sensitive Plasmodium falciparum W2 by ELISA	F	6.2	pIC50	630.6	nM	IC50	Antimicrob Agents Chemother (2010) 54: 1200-1206 [PMID:20065051]
ChEMBL	Antimalarial activity against chloroquine-resistant/mefloquine-sensitive Plasmodium falciparum W2 by malaria SYBR green 1-based fluorescence (MSF) assay	F	6.2	pIC50	630	nM	IC50	Bioorg Med Chem Lett (2015) 25: 327-332 [PMID:25488841]
ChEMBL	Antimalarial activity against multidrug-resistant Plasmodium falciparum TM93-C1088 infected in human O positive red blood cells assessed as inhibition of [3H]-hypoxanthine uptake after 48 hrs	F	6.21	pIC50	620	nM	IC50	J Nat Prod (2011) 74: 74-78 [PMID:21155593]
ChEMBL	Antimalarial activity against Plasmodium falciparum W2	F	6.21	pIC50	616.94	nM	IC50	J Med Chem (2008) 51: 2261-2266 [PMID:18330976]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FcM29 by [3H]hypoxanthine uptake	F	6.22	pIC50	600	nM	IC50	J Nat Prod (2008) 71: 1189-1192 [PMID:18512987]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum indochina W2 assessed as [3H]-hypoxanthine incorporation by liquid scintillation counting analysis	F	6.23	pIC50	595	nM	IC50	Bioorg Med Chem (2015) 23: 2176-2186 [PMID:25801154]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human red blood cells after 48 hrs by SYBR test	F	6.23	pIC50	590	nM	IC50	Bioorg Med Chem Lett (2016) 26: 1881-1884 [PMID:26988303]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human erythrocytes measured after 72 hrs by malstat reagent based LDH release assay	F	6.24	pIC50	570	nM	IC50	ACS Med Chem Lett (2018) 9: 980-985 [PMID:30344903]
ChEMBL	In vitro inhibitory activity against Plasmodium falciparum NF54-R in blood	F	6.24	pIC50	570	nM	IC50	Bioorg Med Chem Lett (2004) 14: 2773-2776 [PMID:15125930]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human A+ erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs by scintillation counting	F	6.25	pIC50	563	nM	IC50	Bioorg Med Chem (2010) 18: 8085-8091 [PMID:20934349]
ChEMBL	Antimalarial activity against Plasmodium falciparum TM90C2B infected in human erythrocytes assessed as reduction in [3H]-hypoxanthine incorporation preincubated for 24 hrs followed by [3H]-hypoxanthine addition measured after 24 hrs by scintillation counting method	F	6.25	pIC50	561	nM	IC50	J Med Chem (2017) 60: 5889-5908 [PMID:28635296]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 asexual gametocytes	F	6.25	pIC50	560	nM	IC50	Antimicrob Agents Chemother (2007) 51: 1463-1472 [PMID:17242150]
ChEMBL	Antimalarial activity against Plasmodium falciparum W2 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter	F	6.25	pIC50	556	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL	Antimalarial activity against chloroquine/sulfadoxine-resistant Plasmodium falciparum W2 infected in human A+ erythrocytes assessed as reduction in parasite growth after 72 hrs by HRP2 detection based ELISA	F	6.26	pIC50	550	nM	IC50	Bioorg Med Chem (2016) 24: 4492-4498 [PMID:27485600]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum INDO assessed as growth inhibition by SYBER green 1 dye based fluorescence assay	F	6.26	pIC50	546	nM	IC50	Eur J Med Chem (2021) 224: 113685-113685 [PMID:34303874]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum PFB Brazil by [3H]hypoxanthine uptake	F	6.27	pIC50	540	nM	IC50	J Nat Prod (2001) 64: 12-16 [PMID:11170658]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum D10	F	6.27	pIC50	540	nM	IC50	Eur J Med Chem (2010) 45: 3245-3264 [PMID:20466465]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 after 24 hrs by [G-3H]-hypoxanthine incorporation assay	F	6.27	pIC50	540	nM	IC50	Eur J Med Chem (2017) 139: 22-47 [PMID:28800458]
ChEMBL	Growth inhibition of chloroquine-resistant Plasmodium falciparum KI	F	6.27	pIC50	540	nM	IC50	Bioorg Med Chem Lett (2001) 11: 2075-2077 [PMID:11514142]
ChEMBL	Antimalarial activity against Plasmodium falciparum K1 infected in human erythrocytes after 72 hrs by lactate dehydrogenase assay	F	6.27	pIC50	540	nM	IC50	J Nat Prod (2017) 80: 3120-3127 [PMID:29182338]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2	F	6.27	pIC50	540	nM	IC50	Bioorg Med Chem Lett (2007) 17: 6434-6438 [PMID:17949976]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT Bres assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter	F	6.27	pIC50	538	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 by LDH assay	F	6.28	pIC50	530	nM	IC50	Medchemcomm (2013) 4: 724-730
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs	F	6.28	pIC50	527	nM	IC50	J Med Chem (2010) 53: 3214-3226 [PMID:20329733]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT A4 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter	F	6.28	pIC50	525	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 assessed as growth inhibition after 18 hrs by [3H]-hypoxanthine uptake assay	F	6.28	pIC50	525	nM	IC50	J Med Chem (2015) 58: 3411-3431 [PMID:25654185]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT K2 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter	F	6.28	pIC50	523	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum IMT K2 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay	F	6.28	pIC50	523	nM	IC50	J Med Chem (2009) 52: 7954-7957 [PMID:19908867]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum Bre1 by hypoxanthine uptake	F	6.28	pIC50	520	nM	IC50	Bioorg Med Chem (2007) 15: 3278-3289 [PMID:17339112]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2	F	6.28	pIC50	520	nM	IC50	J Nat Prod (2017) 80: 134-140 [PMID:28055207]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Bre1 assessed as inhibition of [3H]hypoxanthine incorporation	F	6.28	pIC50	520	nM	IC50	Bioorg Med Chem (2009) 17: 8032-8039 [PMID:19879150]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human type A-positive red blood cells assessed as parasite lactate dehydrogenase activity after 72 hrs by spectrophotometric analysis	F	6.28	pIC50	520	nM	IC50	J Med Chem (2011) 54: 8526-8540 [PMID:22054038]
ChEMBL	Antiparasitic activity against chloroquine-resistant Plasmodium falciparum K1	F	6.28	pIC50	519.3	nM	IC50	J Med Chem (2008) 51: 1260-1277 [PMID:18260613]
ChEMBL	Antimalarial activity against schizont stage of chloroquine-resistant Plasmodium falciparum W2 infected in erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 48 hrs by scintillation counting analysis	F	6.28	pIC50	519	nM	IC50	Medchemcomm (2011) 2: 430-435
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum FcM29(CQR)Cameroon incubated for 48 hrs by classical radioactive microdilution method	F	6.29	pIC50	518	nM	IC50	Eur J Med Chem (2020) 188: 111983-111983 [PMID:31911292]
ChEMBL	Antimalarial activity against Plasmodium falciparum FCM29 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter	F	6.29	pIC50	508	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum FCM29 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay	F	6.29	pIC50	508	nM	IC50	J Med Chem (2009) 52: 7954-7957 [PMID:19908867]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human RBC assessed as decrease in parasite viability after 72 hrs by LDH assay	F	6.3	pIC50	503	nM	IC50	Eur J Med Chem (2017) 126: 675-686 [PMID:27936446]
ChEMBL	Antimalarial activity against Plasmodium falciparum FCR3 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter	F	6.3	pIC50	501	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 asynchronous cultures infected in human erythrocytes after 72 hrs by SYBR green1 staining based fluorescence assay	F	6.3	pIC50	500	nM	IC50	Eur J Med Chem (2019) 162: 448-454 [PMID:30469040]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FCR3/Gambia assessed as inhibition of [3H]hypoxanthine incorporation	F	6.3	pIC50	500	nM	IC50	Bioorg Med Chem (2009) 17: 8032-8039 [PMID:19879150]
ChEMBL	Antimalarial activity against ring stage chloroquine-resistant Plasmodium falciparum INDO infected in human O positive erythrocytes after 48 hrs by SYBR green 1 fluorescence assay	F	6.3	pIC50	500	nM	IC50	J Med Chem (2012) 55: 297-311 [PMID:22098429]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human erythrocytes after 72 hrs by SYBR Green 1 staining based fluorescence assay	F	6.3	pIC50	500	nM	IC50	Eur J Med Chem (2018) 155: 764-771 [PMID:29940466]
ChEMBL	Antimalarial activity against erythrocytic stage multidrug-resistant Plasmodium falciparum Dd2 after 48 hrs by fluorescence spectrophotometer	F	6.3	pIC50	500	nM	IC50	Bioorg Med Chem (2011) 19: 4562-4573 [PMID:21723734]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 after 48 hrs	F	6.3	pIC50	500	nM	IC50	J Nat Prod (2005) 68: 1297-1299 [PMID:16124784]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum FCR3 by hypoxanthine uptake	F	6.3	pIC50	500	nM	IC50	Bioorg Med Chem (2007) 15: 3278-3289 [PMID:17339112]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum W2	F	6.3	pIC50	500	nM	IC50	J Nat Prod (2009) 72: 906-911 [PMID:19344127]
ChEMBL	Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum K2 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs	F	6.31	pIC50	493.2	nM	IC50	J Med Chem (2010) 53: 3214-3226 [PMID:20329733]
ChEMBL	Antimalarial activity against Plasmodium falciparum W2	F	6.31	pIC50	491.53	nM	IC50	J Med Chem (2007) 50: 5118-5127 [PMID:17887664]
ChEMBL	Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum W2 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs	F	6.31	pIC50	485.3	nM	IC50	J Med Chem (2010) 53: 3214-3226 [PMID:20329733]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in African green monkey (Cercopithecus aethiops) (Cercopithecus aethiops) Vero cells assessed as parasite LDH activity after 72 hrs	F	6.32	pIC50	484	nM	IC50	Bioorg Med Chem (2009) 17: 7775-7782 [PMID:19833520]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 as LDH activity	F	6.32	pIC50	481.2	nM	IC50	Bioorg Med Chem (2008) 16: 6813-6823 [PMID:18562202]
ChEMBL	Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum FCR3 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs	F	6.32	pIC50	477.5	nM	IC50	J Med Chem (2010) 53: 3214-3226 [PMID:20329733]
ChEMBL	Antimalarial activity against schizont stage of atovaquone-resistant Plasmodium falciparum Tm90C2b infected in erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 48 hrs by scintillation counting analysis	F	6.32	pIC50	475	nM	IC50	Medchemcomm (2011) 2: 430-435
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT K4 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter	F	6.33	pIC50	472	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 incubated for 72 hrs by spectrophotometry based parasite lactate dehydrogenase assay	F	6.34	pIC50	462.02	nM	IC50	ACS Med Chem Lett (2021) 12: 1077-1085 [PMID:34267877]
ChEMBL	Antiplasmodial activity against chloroquine and sulfadoxine-resistant and mefloquine-sensitive Plasmodium falciparum W2 infected in human erythrocytes by anti-HRP2 assay	F	6.34	pIC50	460	nM	IC50	Bioorg Med Chem (2015) 23: 5979-5984 [PMID:26190461]
ChEMBL	Antimalarial activity against ring stage Plasmodium falciparum K1 incubated for 48 hrs by Hoechst 33342 staining based fluorescence based assay	F	6.34	pIC50	457	nM	IC50	Eur J Med Chem (2019) 184: 111755-111755 [PMID:31627059]
ChEMBL	Antimalarial activity against CQ-resistant, MFQ-susceptible Plasmodium falciparum W2 clone Indochina 1 isolate assessed as inhibition of parasite proliferation by MSF assay	F	6.34	pIC50	456.2	nM	IC50	J Med Chem (2014) 57: 4134-4153 [PMID:24742203]
ChEMBL	Antimalarial activity against Plasmodium falciparum W2	F	6.34	pIC50	456.2	nM	IC50	J Med Chem (2011) 54: 1157-1169 [PMID:21265542]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 after 48 hrs by [3H]hypoxanthine incorporation assay	F	6.34	pIC50	456	nM	IC50	J Med Chem (2016) 59: 264-281 [PMID:26640981]
ChEMBL	Antimalarial activity against schizont stage of chloroquine-resistant Plasmodium falciparum W2 infected in erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 96 hrs by scintillation counting analysis	F	6.34	pIC50	455	nM	IC50	Medchemcomm (2011) 2: 430-435
ChEMBL	Antimalarial activity against Plasmodium falciparum W2	F	6.34	pIC50	452.4	nM	IC50	J Med Chem (2006) 49: 4707-4714 [PMID:16854077]
ChEMBL	Antimalarial activity against multidrug-resistant Plasmodium falciparum isolate 208432 infected in human erythrocytes after 48 hrs by flow-cytometry	F	6.35	pIC50	451.4	nM	IC50	J Med Chem (2010) 53: 3552-3557 [PMID:20349996]
ChEMBL	Antiplasmodial activity against chloroquine-resistant erythrocyte stage of Plasmodium falciparum FcM29-Cameroon infected in human RBC assessed as reduction in [3H]hypoxanthine incorporation preincubated for 48 hrs followed by [3H]hypoxanthine addition measured after 24 hrs by liquid scintillation counting method	F	6.35	pIC50	450	nM	IC50	Bioorg Med Chem (2017) 25: 4433-4443 [PMID:28666857]
ChEMBL	Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum Bres infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs	F	6.35	pIC50	442.6	nM	IC50	J Med Chem (2010) 53: 3214-3226 [PMID:20329733]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human A+ erythrocytes after 72 hrs by parasite LDH assay	F	6.36	pIC50	440.7	nM	IC50	Bioorg Med Chem (2010) 18: 6625-6633 [PMID:20797868]
ChEMBL	Antiplasmodial activity against synchronized ring stage of chloroquine-resistant Plasmodium falciparum INDO infected in human erythrocytes after 48 hrs by SYBR Green 1 dye based fluorescence assay	F	6.36	pIC50	440	nM	IC50	Eur J Med Chem (2018) 155: 623-638 [PMID:29929118]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 by hypoxanthine uptake	F	6.36	pIC50	440	nM	IC50	Bioorg Med Chem (2007) 15: 3278-3289 [PMID:17339112]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 assessed as inhibition of [3H]hypoxanthine incorporation	F	6.36	pIC50	440	nM	IC50	Bioorg Med Chem (2009) 17: 8032-8039 [PMID:19879150]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human RBC assessed as inhibition of parasite growth after 72 hrs by lactate dehydrogenase assay	F	6.36	pIC50	437.62	nM	IC50	Bioorg Med Chem (2012) 20: 5980-5985 [PMID:22901673]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in type A rhesus-positive human erythrocytes assessed as [3H]hypoxanthine incorporation after 48 hrs by scintillation counting	F	6.37	pIC50	431	nM	IC50	J Med Chem (2012) 55: 3216-3227 [PMID:22380766]
ChEMBL	Antimalarial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum W2 infected in human A-positive erythrocytes assessed as inhibition of [3H]-hypoxanthine incorporation after 48 hrs by semi-automated microdilution technique	F	6.37	pIC50	431	nM	IC50	Eur J Med Chem (2012) 49: 365-378 [PMID:22321992]
ChEMBL	Antiplasmodium activity against multidrug resistant Plasmodium falciparum K1 asexual blood stage forms infected in human erythrocytes assessed as reduction in [3H]-hypoxanthine incorporation incubated for 48 hrs by liquid scintillation counting method	F	6.37	pIC50	431	nM	IC50	Medchemcomm (2019) 10: 450-455 [PMID:31015908]
ChEMBL	Antimalarial activity against CQ-resistant Plasmodium falciparum W2 infected in human erythrocytes after 48 hrs by SYBR Green1 dye based fluorescence assay	F	6.37	pIC50	430.6	nM	IC50	ACS Med Chem Lett (2020) 11: 1450-1456 [PMID:32676153]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in red blood cells after 72 hrs by Malstat reagent based LDH assay	F	6.37	pIC50	430	nM	IC50	Eur J Med Chem (2017) 131: 126-140 [PMID:28315598]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in RBC assessed as plasmodial LDH activity after 72 hrs	F	6.37	pIC50	430	nM	IC50	Bioorg Med Chem Lett (2013) 23: 112-116 [PMID:23218718]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 after 48 hrs by LDH release assay	F	6.37	pIC50	422	nM	IC50	Eur J Med Chem (2018) 143: 866-880 [PMID:29223887]
ChEMBL	Antimalarial activity against chloroquine-resistant, mefloquine-susceptible Plasmodium falciparum W2	F	6.38	pIC50	421.59	nM	IC50	J Med Chem (2008) 51: 6216-6219 [PMID:18774792]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in RBC after 72 hrs by LDH release assay	F	6.38	pIC50	421.5	nM	IC50	Eur J Med Chem (2019) 162: 277-289 [PMID:30448417]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1	F	6.38	pIC50	420	nM	IC50	J Nat Prod (2008) 71: 167-174 [PMID:18220356]
ChEMBL	Antimalarial activity against Plasmodium falciparum W2 assessed as plasmodial LDH activity after 72 hrs	F	6.38	pIC50	420	nM	IC50	Eur J Med Chem (2011) 46: 2816-2827 [PMID:21530018]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human red blood cells assessed as reduction in parasitic LDH activity by Malstat reagent based spectrophotometric method	F	6.38	pIC50	420	nM	IC50	Eur J Med Chem (2017) 139: 22-47 [PMID:28800458]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 by LDH release assay	F	6.38	pIC50	420	nM	IC50	Bioorg Med Chem Lett (2010) 20: 322-325 [PMID:19910192]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2	F	6.38	pIC50	420	nM	IC50	Eur J Med Chem (2019) 166: 206-223 [PMID:30711831]
ChEMBL	Antimalarial activity against asexual blood stage multi drug-resistant Plasmodium falciparum K1 infected in erythrocytes assessed as reduction in parasitemia incubated up to 72 hrs by [3H]hypoxanthine incorporation assay	F	6.38	pIC50	420	nM	IC50	J Med Chem (2021) 64: 5198-5215 [PMID:33844521]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 asexual erythrocyte forms after 48 hrs by parasite LDH assay	F	6.38	pIC50	417	nM	IC50	Bioorg Med Chem (2013) 21: 269-277 [PMID:23168082]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 after 72 hrs by parasite lactate dehydrogenase assay	F	6.39	pIC50	412	nM	IC50	Bioorg Med Chem Lett (2012) 22: 5915-5918 [PMID:22884991]
ChEMBL	Antimalarial activity against Chloroquine-resistant Plasmodium falciparum W2 assessed as parasite growth inhibition after 72 hrs by lactate dehydrogenase assay	F	6.39	pIC50	412	nM	IC50	Medchemcomm (2015) 6: 1173-1177
ChEMBL	Antimalarial activity against Plasmodium falciparum W2 in parasite LDH assay	F	6.39	pIC50	410	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1446-1449 [PMID:18248990]
ChEMBL	Antimalarial activity after 72 hrs against chloroquine-resistant Plasmodium falciparum W2 by Malstat LDH activity	F	6.39	pIC50	410	nM	IC50	Bioorg Med Chem (2009) 17: 5632-5638 [PMID:19574054]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 in erythrocytes after 72 hrs by LDH activity	F	6.39	pIC50	410	nM	IC50	Bioorg Med Chem Lett (2009) 19: 1675-1677 [PMID:19231182]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 after 72 hrs by parasite LDH assay	F	6.39	pIC50	410	nM	IC50	J Nat Prod (2010) 73: 1138-1145 [PMID:20521782]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FCM29 by SYBR green assay	F	6.39	pIC50	410	nM	IC50	Bioorg Med Chem (2009) 17: 2871-2876 [PMID:19282186]
ChEMBL	Antimalarial activity against chloroquine resistant Plasmodium falciparum W2 infected in human red blood cells assessed as reduction in parasite growth measured after 72 hrs by parasite lactate dehydrogenase assay	F	6.39	pIC50	406	nM	IC50	ACS Med Chem Lett (2021) 12: 1726-1732 [PMID:34795860]
ChEMBL	Antimalarial activity against Plasmodium falciparum W2 by hypoxanthine uptake	F	6.39	pIC50	405	nM	IC50	J Med Chem (2008) 51: 3437-3448 [PMID:18494463]
ChEMBL	Antimalarial activity against drug-resistant Plasmodium falciparum W2	F	6.39	pIC50	405	nM	IC50	Antimicrob Agents Chemother (2008) 52: 3467-3477 [PMID:18644969]
ChEMBL	Antiplasmodial activity against chloroquine, pyrimethamine and proguanil-resistant Plasmodium falciparum W2 infected in human A positive erythrocytes after 72 hrs by SYBR Green I assay	F	6.4	pIC50	400	nM	IC50	Eur J Med Chem (2011) 46: 4184-4191 [PMID:21741131]
ChEMBL	In vitro antimalarial activity for Plasmodium falciparum W2	F	6.4	pIC50	400	nM	IC50	Bioorg Med Chem Lett (2004) 14: 1145-1149 [PMID:14980653]
ChEMBL	Antimalarial activity against Plasmodium falciparum K1 assessed as inhibition of parasite growth by microculture radioisotope technique	F	6.4	pIC50	400	nM	IC50	J Nat Prod (2021) 84: 2775-2785 [PMID:34748348]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum FcM29	F	6.4	pIC50	400	nM	IC50	Antimicrob Agents Chemother (2009) 53: 1100-1106 [PMID:19015354]
ChEMBL	Antimalarial activity against chloroquine-resistant/mefloquine-sensitive Plasmodium falciparum W2 ring stage forms infected in human erythrocytes assessed as reduction in parasite growth after 48 hrs by parasite LDH release assay	F	6.4	pIC50	400	nM	IC50	Eur J Med Chem (2018) 145: 191-205 [PMID:29324340]
ChEMBL	Anti-parasitic activity against CQ-resistant Plasmodium falciparum W2 assessed as growth inhibition by measuring increase in LDH release after 72 hrs by spectrophotometric method	F	6.4	pIC50	400	nM	IC50	J Med Chem (2017) 60: 1959-1970 [PMID:28128956]
ChEMBL	Antimalarial activity against CQ-resistant Plasmodium falciparum W2 infected in human type A-positive red blood cells assessed as inhibition of parasite growth incubated for for 72 hrs by spectrophotometry based parasite lactate dehydrogenase assay	F	6.4	pIC50	400	nM	IC50	ACS Med Chem Lett (2019) 10: 590-595 [PMID:30996801]
ChEMBL	Antimalarial activity against chloroquine-resistant, mefloquine-sensitive Plasmodium falciparum W2 assessed as inhibition of [3H]hypoxanthine uptake	F	6.4	pIC50	397	nM	IC50	Bioorg Med Chem Lett (2011) 21: 786-789 [PMID:21168330]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum Bre1	F	6.4	pIC50	396.2	nM	IC50	Bioorg Med Chem Lett (2007) 17: 6434-6438 [PMID:17949976]
ChEMBL	Antimalarial activity against multidrug-resistant Plasmodium falciparum W2	F	6.4	pIC50	394	nM	IC50	J Med Chem (2006) 49: 4535-4543 [PMID:16854059]
ChEMBL	Antimalarial activity against schizont stage of atovaquone-resistant Plasmodium falciparum Tm90C2b infected in erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 96 hrs by scintillation counting analysis	F	6.41	pIC50	393	nM	IC50	Medchemcomm (2011) 2: 430-435
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2	F	6.41	pIC50	392.09	nM	IC50	J Med Chem (2008) 51: 4388-4391 [PMID:18637666]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in red blood cells after 72 hrs by parasitic LDH assay	F	6.41	pIC50	390	nM	IC50	ACS Med Chem Lett (2012) 3: 555-559 [PMID:24900509]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum 7G8 harboring parental pfcrt allele infected in erythrocytes assessed as [3H]hypoxanthine incorporation	F	6.41	pIC50	389.5	nM	IC50	Antimicrob Agents Chemother (2009) 53: 1362-1366 [PMID:19188388]
ChEMBL	Antimalarial activity against Plasmodium falciparum TM90C2A infected in human erythrocytes assessed as reduction in [3H]-hypoxanthine incorporation preincubated for 24 hrs followed by [3H]-hypoxanthine addition measured after 24 hrs by scintillation counting method	F	6.42	pIC50	384	nM	IC50	J Med Chem (2017) 60: 5889-5908 [PMID:28635296]
ChEMBL	Antimalarial activity against Plasmodium falciparum T9/94 infected in human erythrocytes assessed as reduction in [3H]-hypoxanthine incorporation preincubated for 24 hrs followed by [3H]-hypoxanthine addition measured after 24 hrs by scintillation counting method	F	6.42	pIC50	384	nM	IC50	J Med Chem (2017) 60: 5889-5908 [PMID:28635296]
ChEMBL	Antimalarial activity against Plasmodium falciparum W2 by FACS assay	F	6.42	pIC50	382	nM	IC50	J Med Chem (2010) 53: 3685-3695 [PMID:20361799]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum W2 infected in RBCs by parasitic LDH release assay	F	6.42	pIC50	378.3	nM	IC50	Bioorg Med Chem (2009) 17: 7949-7957 [PMID:19879765]
ChEMBL	Antiplasmodial activity chloroquine-resistant Plasmodium falciparum Dd2 by lactate dehydrogenase assay	F	6.42	pIC50	378	nM	IC50	Bioorg Med Chem Lett (2014) 24: 1214-1217 [PMID:24468411]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum W2 harboring mutations conferring drug-resistance by SYBR-green based assay	F	6.43	pIC50	374.7	nM	IC50	J Med Chem (2014) 57: 6642-6652 [PMID:25007124]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR I method	F	6.43	pIC50	374.66	nM	IC50	J Med Chem (2014) 57: 5702-5713 [PMID:24914738]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 assessed as inhibition of parasite growth after 72 hrs by parasite LDH release assay	F	6.44	pIC50	367	nM	IC50	Eur J Med Chem (2015) 89: 490-502 [PMID:25462261]
ChEMBL	Antiprotozoal activity against chloroquine and pyrimethamine-resistant erythrocytic stage of Plasmodium falciparum K1 assessed as reduction in [3H]hypoxanthine incorporation preincubated for 48 hrs followed by [3H]hypoxanthine addition and measured after 24 hrs by liquid scintillation counting method	F	6.44	pIC50	360	nM	IC50	J Nat Prod (2019) 82: 3150-3164 [PMID:31630523]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2	F	6.44	pIC50	360	nM	IC50	Bioorg Med Chem Lett (2013) 23: 1507-1510 [PMID:23347684]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 assessed as inhibition of parasite growth after 72 hrs by parasite lactate dehydrogenase assay	F	6.44	pIC50	360	nM	IC50	Bioorg Med Chem (2015) 23: 55-65 [PMID:25497962]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1	F	6.45	pIC50	352.3	nM	IC50	Bioorg Med Chem (2007) 15: 6510-6516 [PMID:17693090]
ChEMBL	Antimalarial activity against Plasmodium falciparum K1	F	6.46	pIC50	350	nM	IC50	Eur J Med Chem (2018) 143: 283-291 [PMID:29197733]
ChEMBL	Parasite growth in chloroquine-sensitive Plasmodium falciparum K1	F	6.46	pIC50	350	nM	IC50	J Med Chem (1999) 42: 4630-4639 [PMID:10579825]
ChEMBL	Growth inhibition against Plasmodium falciparum K1	F	6.46	pIC50	350	nM	IC50	Bioorg Med Chem Lett (2006) 16: 2283-2292 [PMID:16458512]
ChEMBL	Antimalarial activity against Plasmodium falciparum W2	F	6.46	pIC50	349.4	nM	IC50	J Med Chem (2006) 49: 3790-3799 [PMID:16789736]
ChEMBL	Antimalarial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum W2	F	6.46	pIC50	349.35	nM	IC50	Bioorg Med Chem (2008) 16: 7039-7045 [PMID:18550377]
ChEMBL	Antimalarial activity against Plasmodium falciparum W2 by [3H]hypoxanthine uptake	F	6.47	pIC50	340	nM	IC50	Eur J Med Chem (2009) 44: 3816-3820 [PMID:19403210]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 after 72 hrs by LDH assay	F	6.47	pIC50	340	nM	IC50	J Nat Prod (2010) 73: 1448-1452 [PMID:20669933]
ChEMBL	Antiplasmodial activity against erythrocyte form of chloroquine-resistant Plasmodium falciparum Dd2 by parasite lactate dehydrogenase assay	F	6.47	pIC50	340	nM	IC50	Bioorg Med Chem Lett (2013) 23: 318-322 [PMID:23195733]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2	F	6.47	pIC50	338	nM	IC50	Bioorg Med Chem Lett (2006) 16: 1854-1858 [PMID:16434194]
ChEMBL	Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum PA infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs	F	6.48	pIC50	330.4	nM	IC50	J Med Chem (2010) 53: 3214-3226 [PMID:20329733]
ChEMBL	Antimalarial activity against chloroquine,pyrimethamine-resistant Plasmodium falciparum K1 after 24 hrs	F	6.49	pIC50	320	nM	IC50	Bioorg Med Chem (2007) 15: 5551-5562 [PMID:17548196]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 assessed as inhibition of parasite growth after 72 hrs by parasite lactate dehydrogenase assay	F	6.49	pIC50	320	nM	IC50	Bioorg Med Chem (2015) 23: 4681-4687 [PMID:26081764]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by 1536-well format based SYBR green assay	F	6.49	pIC50	320	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human red blood cells after 72 hrs by parasite lactate dehydrogenase assay	F	6.5	pIC50	317.1	nM	IC50	Bioorg Med Chem (2012) 20: 5965-5979 [PMID:22917857]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in red blood cells after 72 hrs by Malstat reagent based LDH assay	F	6.5	pIC50	317	nM	IC50	Eur J Med Chem (2017) 129: 175-185 [PMID:28222317]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human type A+ erythrocytes after 48 hrs by [3H]-hypoxanthine incorporation assay	F	6.5	pIC50	316	nM	IC50	Eur J Med Chem (2017) 139: 22-47 [PMID:28800458]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human type A-positive red blood cells assessed as growth inhibition after 72 hrs by spectrophotometrically	F	6.5	pIC50	316	nM	IC50	Bioorg Med Chem (2014) 22: 5757-5765 [PMID:25311562]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 by [3H]hypoxanthine uptake	F	6.5	pIC50	315	nM	IC50	J Med Chem (2008) 51: 3466-3479 [PMID:18512900]
ChEMBL	Antimalarial activity against Plasmodium falciparum W2mef by hypoxanthine uptake assay	F	6.51	pIC50	311	nM	IC50	Bioorg Med Chem Lett (2009) 19: 5452-5457 [PMID:19666223]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2	F	6.51	pIC50	310	nM	IC50	Bioorg Med Chem Lett (2007) 17: 6101-6106 [PMID:17900897]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 after 72 hrs by lactate dehydrogenase assay	F	6.51	pIC50	310	nM	IC50	Eur J Med Chem (2018) 150: 698-718 [PMID:29571157]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in RBC assessed as parasite LDH activity after 72 hrs	F	6.51	pIC50	310	nM	IC50	J Nat Prod (2012) 75: 883-889 [PMID:22530813]
ChEMBL	Antiplasmodial activity against multidrug-resistant Plasmodium falciparum K1 infected in human RBC incubated for 18 to 20 hrs by microdilution radioisotope method	F	6.52	pIC50	300	nM	IC50	J Nat Prod (2016) 79: 978-983 [PMID:26928423]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 infected in normal type A human erythrocytes incubated for 72 hrs by spectrophotometry based parasite lactate dehydrogenase assay	F	6.52	pIC50	300	nM	IC50	Bioorg Med Chem Lett (2018) 28: 1287-1291 [PMID:29559277]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 infected in human erythrocytes after 48 hrs	F	6.52	pIC50	300	nM	IC50	Antimicrob Agents Chemother (2007) 51: 2842-2847 [PMID:17562796]
ChEMBL	Antimalarial activity against Plasmodium falciparum K1	F	6.52	pIC50	300	nM	IC50	J Med Chem (1994) 37: 1362-1370 [PMID:8176713]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FCR-3 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs	F	6.52	pIC50	300	nM	IC50	Bioorg Med Chem Lett (2011) 21: 4498-4502 [PMID:21724395]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 gametocytes (stage 2 & 3)	F	6.52	pIC50	300	nM	IC50	Antimicrob Agents Chemother (2007) 51: 1463-1472 [PMID:17242150]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum 34-1/E	F	6.52	pIC50	299.45	nM	IC50	Antimicrob Agents Chemother (2007) 51: 2265-2267 [PMID:17404003]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum W2	F	6.52	pIC50	299	nM	IC50	Antimicrob Agents Chemother (2009) 53: 1100-1106 [PMID:19015354]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 infected in O+ human erythrocytes by [3H]hypoxanthine incorporation assay	F	6.53	pIC50	293	nM	IC50	Antimicrob Agents Chemother (2008) 52: 1454-1461 [PMID:18212103]
ChEMBL	Antiplasmodial activity after 48 hrs against chloroquine-resistant Plasmodium falciparum FcM29-Cameroon by [3H]hypoxanthine uptake	F	6.54	pIC50	291	nM	IC50	Bioorg Med Chem Lett (2007) 17: 6075-6078 [PMID:17904365]
ChEMBL	Antiplasmodial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 assessed as reduction in [3H]-hypoxanthine incorporation pretreated for 48 hrs followed by [3H]-hypoxanthine addition measured after 24 hrs by liquid scintillation counting method	F	6.54	pIC50	291	nM	IC50	J Nat Prod (2018) 81: 918-933 [PMID:29560715]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum 7G8-mdr7G8	F	6.54	pIC50	290.05	nM	IC50	Antimicrob Agents Chemother (2007) 51: 2265-2267 [PMID:17404003]
ChEMBL	Antimalarial activity against chloroquine and pyrimethamine-resistant early trophozoite stage of Plasmodium falciparum W2 in human red blood cells assessed as [3H]hypoxanthine uptake after 96 hrs	F	6.54	pIC50	290	nM	IC50	J Med Chem (2013) 56: 2513-2526 [PMID:23448281]
ChEMBL	Antiplasmodial activity against asynchronous form of Plasmodium falciparum W2 infected in human erythrocytes assessed as parasite growth inhibition after 48 hrs by SYBR green1 staining based flow cytometry	F	6.54	pIC50	290	nM	IC50	Eur J Med Chem (2019) 161: 277-291 [PMID:30366254]
ChEMBL	Antimalarial activity against Plasmodium falciparum W2 in MSF assay	F	6.54	pIC50	290	nM	IC50	Bioorg Med Chem (2008) 16: 1174-1183 [PMID:18023189]
ChEMBL	Antimalarial activity against Plasmodium falciparum PA assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter	F	6.55	pIC50	284	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2/Indochina by [3H]hypoxanthine uptake	F	6.55	pIC50	284	nM	IC50	J Nat Prod (2002) 65: 1381-1386 [PMID:12398531]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum PA infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay	F	6.55	pIC50	284	nM	IC50	J Med Chem (2009) 52: 7954-7957 [PMID:19908867]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 Indochina by [3H]hypoxanthine uptake	F	6.55	pIC50	284	nM	IC50	J Nat Prod (2001) 64: 12-16 [PMID:11170658]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 assessed as [3H]hypoxanthine incorporation	F	6.55	pIC50	283.5	nM	IC50	Antimicrob Agents Chemother (2009) 53: 1320-1324 [PMID:19171802]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human erythrocytes assessed as parasite growth inhibition after 48 hrs by YOYO1 probe-based flow cytometric method	F	6.55	pIC50	282	nM	IC50	Bioorg Med Chem Lett (2017) 27: 1693-1697 [PMID:28318947]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human type A-positive RBC assessed as inhibition of parasite LDH activity after 72 hrs by spectrophotometric analysis	F	6.55	pIC50	280	nM	IC50	J Med Chem (2011) 54: 5949-5953 [PMID:21761935]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 by [3H]hypoxanthine incorporation	F	6.55	pIC50	280	nM	IC50	J Med Chem (2008) 51: 1278-1294 [PMID:18278860]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 by [3H]hypoxanthine incorporation	F	6.55	pIC50	280	nM	IC50	J Med Chem (2008) 51: 1333-1343 [PMID:18278859]
ChEMBL	Antimalarial activity against multidrug-resistant Plasmodium falciparum TM90-C2B infected in human O positive red blood cells assessed as inhibition of [3H]-hypoxanthine uptake after 48 hrs	F	6.55	pIC50	280	nM	IC50	J Nat Prod (2011) 74: 74-78 [PMID:21155593]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2	F	6.55	pIC50	280	nM	IC50	Bioorg Med Chem Lett (2006) 16: 5384-5388 [PMID:16890433]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2	F	6.55	pIC50	280	nM	IC50	J Med Chem (2007) 50: 595-598 [PMID:17263523]
ChEMBL	Antiplasmodial activity against multidrug-resistant asexual blood stage Plasmodium falciparum K1 strain assessed as reduction in parasite growth after 72 hrs by NBT reagent based LDH assay	F	6.55	pIC50	280	nM	IC50	J Med Chem (2020) 63: 13013-13030 [PMID:33103428]
ChEMBL	Antimalarial activity against Plasmodium falciparum W2 by parasite lactate dehydrogenase assay	F	6.55	pIC50	280	nM	IC50	Eur J Med Chem (2021) 215: 113227-113227 [PMID:33601312]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human RBC after 72 hrs by parasite lactate dehydrogenase assay	F	6.55	pIC50	280	nM	IC50	J Med Chem (2012) 55: 6948-6967 [PMID:22783984]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum schizonts assessed as [3H]hypoxanthine incorporation by liquid scintillation counting	F	6.55	pIC50	280	nM	IC50	J Nat Prod (1997) 60: 1017-1022 [PMID:9358645]
ChEMBL	Antimalarial activity after 72 hrs against chloroquine-resistant Plasmodium falciparum W2 infected human A+ erythrocytes by Makler LDH reporter assay	F	6.55	pIC50	280	nM	IC50	J Med Chem (2009) 52: 502-513 [PMID:19113955]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 incubated for 48 hrs by parasite lactate dehydrogenase assay	F	6.55	pIC50	279	nM	IC50	J Med Chem (2020) 63: 14470-14501 [PMID:33023291]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum K1 in [3H]hypoxanthine incorporation assay	F	6.56	pIC50	278	nM	IC50	J Med Chem (2008) 51: 909-923 [PMID:18247550]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2	F	6.56	pIC50	276.5	nM	IC50	Antimicrob Agents Chemother (2009) 53: 4339-4344 [PMID:19651905]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 by LDH release assay	F	6.56	pIC50	275	nM	IC50	Eur J Med Chem (2018) 148: 39-53 [PMID:29454189]
ChEMBL	Antiplasmodial activity against chloroquine-resistant asexual erythrocytic stage of Plasmodium falciparum Dd2 assessed as [3H]-hypoxanthine incorporation by lactate dehydrogenase assay	F	6.56	pIC50	274	nM	IC50	Eur J Med Chem (2015) 92: 91-102 [PMID:25544689]
ChEMBL	Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum L1 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs	F	6.56	pIC50	273.5	nM	IC50	J Med Chem (2010) 53: 3214-3226 [PMID:20329733]
ChEMBL	Antiplasmodial activity against multidrug-resistant Plasmodium falciparum K1	F	6.57	pIC50	272	nM	IC50	Bioorg Med Chem Lett (2021) 54: 128442-128442 [PMID:34763083]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 assessed as Plasmodium lactate dehydrogenase release after 48 hrs by colorimetry	F	6.57	pIC50	271	nM	IC50	Antimicrob Agents Chemother (2009) 53: 2212-2214 [PMID:19258270]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum E8B assessed as Plasmodium lactate dehydrogenase release after 48 hrs by colorimetry	F	6.57	pIC50	271	nM	IC50	Antimicrob Agents Chemother (2009) 53: 2212-2214 [PMID:19258270]
ChEMBL	Antimalarial activity against Plasmodium falciparum W2 by [3H]hypoxanthine uptake	F	6.57	pIC50	270	nM	IC50	J Nat Prod (2006) 69: 346-350 [PMID:16562832]
ChEMBL	Antiplasmodial activity against chloroquine and pyrimethamine resistant Plasmodium falciparum K1 strain	F	6.57	pIC50	270	nM	IC50	Eur J Med Chem (2021) 210: 112969-112969 [PMID:33148495]
ChEMBL	Inhibition of [3H]hypoxanthine incorporation in Plasmodium falciparum K1	F	6.57	pIC50	270	nM	IC50	J Med Chem (2001) 44: 4443-4452 [PMID:11728189]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1	F	6.57	pIC50	270	nM	IC50	Bioorg Med Chem Lett (2007) 17: 959-963 [PMID:17166718]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum IMTVo1 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay	F	6.57	pIC50	267	nM	IC50	J Med Chem (2009) 52: 7954-7957 [PMID:19908867]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT Vol assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter	F	6.57	pIC50	267	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1	F	6.57	pIC50	266.58	nM	IC50	Antimicrob Agents Chemother (2007) 51: 2265-2267 [PMID:17404003]
ChEMBL	Antimalarial activity against Plasmodium falciparum W2 after 24 hrs by [3H]hypoxanthine uptake	F	6.58	pIC50	266	nM	IC50	J Nat Prod (2002) 65: 614-615 [PMID:11975516]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum FCM29 by [3H]hypoxanthine uptake	F	6.58	pIC50	264	nM	IC50	Bioorg Med Chem (2007) 15: 6018-6026 [PMID:17624792]
ChEMBL	Antiprotozoal activity against Plasmodium falciparum assessed as parasite growth inhibition	F	6.58	pIC50	263	nM	IC50	J Med Chem (2013) 56: 7442-7448 [PMID:23968432]
ChEMBL	Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum Voll infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs	F	6.58	pIC50	262.4	nM	IC50	J Med Chem (2010) 53: 3214-3226 [PMID:20329733]
ChEMBL	Antiparasitic activity against chloroquine-resistant Plasmodium falciparum R1H6/2 pretreated with 0.1 uM phenobarbitone for 48 hrs by [3H]hypoxanthine incorporation assay	F	6.58	pIC50	262	nM	IC50	Antimicrob Agents Chemother (2008) 52: 1438-1445 [PMID:18195056]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 by [3H]hypoxanthine incorporation	F	6.59	pIC50	260	nM	IC50	J Med Chem (2008) 51: 1278-1294 [PMID:18278860]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 by [3H]hypoxanthine incorporation	F	6.59	pIC50	260	nM	IC50	J Med Chem (2008) 51: 1333-1343 [PMID:18278859]
ChEMBL	Antimalarial activity against drug-resistant Plasmodium falciparum Dd2 harboring V259L mutant infected in human erythrocytes after 72 hrs by SYBR green 1-based fluorescence assay	F	6.59	pIC50	260	nM	IC50	J Med Chem (2019) 62: 3475-3502 [PMID:30852885]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum FcM29 infected in human red blood cells after 48 hrs by [3H]-hypoxanthine incorporation assay	F	6.59	pIC50	260	nM	IC50	Eur J Med Chem (2017) 139: 22-47 [PMID:28800458]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1	F	6.59	pIC50	260	nM	IC50	J Med Chem (2007) 50: 595-598 [PMID:17263523]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1	F	6.59	pIC50	258	nM	IC50	Bioorg Med Chem Lett (2006) 16: 5384-5388 [PMID:16890433]
ChEMBL	Antimalarial activity against chloroquine-resistant asexual intraerythrocytic stage of Plasmodium falciparum Dd2 assessed as inhibition of parasite growth by lactate dehydrogenase assay	F	6.59	pIC50	257.6	nM	IC50	Eur J Med Chem (2015) 101: 52-62 [PMID:26114811]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 after 48 hrs by LDH reporter assay	F	6.59	pIC50	256	nM	IC50	Bioorg Med Chem (2008) 16: 5254-5265 [PMID:18362073]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1	F	6.59	pIC50	255	nM	IC50	Eur J Med Chem (2019) 161: 101-117 [PMID:30343191]
ChEMBL	In vitro inhibitory concentration against chloroquine-resistant Plasmodium falciparum K1	F	6.59	pIC50	255	nM	IC50	J Med Chem (2002) 45: 1052-1063 [PMID:11855985]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human erythrocytes after 48 hrs by flow-cytometry	F	6.6	pIC50	252.4	nM	IC50	J Med Chem (2010) 53: 3552-3557 [PMID:20349996]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum Dd2 after 72 hrs by SYBR I method	F	6.6	pIC50	251.34	nM	IC50	J Med Chem (2014) 57: 5702-5713 [PMID:24914738]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum Dd2 harboring mutations conferring drug-resistance by SYBR-green based assay	F	6.6	pIC50	251.3	nM	IC50	J Med Chem (2014) 57: 6642-6652 [PMID:25007124]
ChEMBL	Antimalarial activity against chloroquine-resistant and mefloquine-sensitive Plasmodium falciparum W2 ring stage form infected in human erythrocytes by spectrophotometric analysis	F	6.6	pIC50	250	nM	IC50	Bioorg Med Chem (2019) 27: 1002-1008 [PMID:30737133]
ChEMBL	Growth inhibition of chloroquine-resistant Plasmodium falciparum K1 by [3H]hypoxanthine uptake	F	6.6	pIC50	250	nM	IC50	Bioorg Med Chem Lett (2002) 12: 2299-2302 [PMID:12161120]
ChEMBL	Antimalarial activity against Plasmodium falciparum C235 containing mdr1 transporter gene assessed as growth inhibition after 72 hrs by SYBR Green 1-based fluorescence assay	F	6.6	pIC50	250	nM	IC50	Bioorg Med Chem Lett (2013) 23: 584-587 [PMID:23228469]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by 1536-well format based SYBR green assay	F	6.6	pIC50	250	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 assessed as parasite growth inhibition after 48 hrs by SYBR green-1 dye-based fluorescence assay	F	6.6	pIC50	250	nM	IC50	Bioorg Med Chem (2013) 21: 7392-7397 [PMID:24148834]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7	F	6.6	pIC50	250	nM	IC50	Bioorg Med Chem Lett (2007) 17: 4733-4736 [PMID:17644333]
ChEMBL	Antimalarial activity against Plasmodium falciparum K1	F	6.6	pIC50	250	nM	IC50	Bioorg Med Chem Lett (1996) 6: 391-392
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 measured after 72 hrs by SYBR green 1 dye based fluorescence assay	F	6.6	pIC50	250	nM	IC50	Eur J Med Chem (2017) 138: 1089-1105 [PMID:28763644]
ChEMBL	Antimalarial activity against Plasmodium falciparum K1	F	6.6	pIC50	250	nM	IC50	J Med Chem (1996) 39: 4511-4514 [PMID:8893847]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human A-positive red blood cells after 72 hrs by lactate dehydrogenase assay	F	6.6	pIC50	250	nM	IC50	Bioorg Med Chem (2011) 19: 312-320 [PMID:21123074]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2	F	6.6	pIC50	>250	nM	IC50	Eur J Med Chem (2009) 44: 3091-3113 [PMID:19361896]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum IMTL1 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay	F	6.6	pIC50	250	nM	IC50	J Med Chem (2009) 52: 7954-7957 [PMID:19908867]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT L1 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter	F	6.6	pIC50	250	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL	In vitro inhibition of chloroquine-resistant Plasmodium falciparum K1	F	6.6	pIC50	250	nM	IC50	J Med Chem (1997) 40: 437-448 [PMID:9046333]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2	F	6.6	pIC50	>250	nM	IC50	Eur J Med Chem (2009) 44: 3091-3113 [PMID:19361896]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2	F	6.6	pIC50	249	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1378-1381 [PMID:18207399]
ChEMBL	Antimalarial activity against multidrug-resistant Plasmodium falciparum TM91C235	F	6.61	pIC50	244.76	nM	IC50	J Med Chem (2008) 51: 2261-2266 [PMID:18330976]
ChEMBL	Antimalarial activity against Plasmodium falciparum 7G8 harbouring Pf-crt, Pf-mdrl,Pf-dhfr, Pf-dhps mutated loci assessed as inhibition of parasite growth incubated for 48 hrs by [3H]hypoxanthine incorporation assay based liquid scintillation counting method	F	6.61	pIC50	243	nM	IC50	J Med Chem (2021) 64: 12582-12602 [PMID:34437804]
ChEMBL	Antimalarial activity against asexual erythrocyte stages of chloroquine-resistant Plasmodium falciparum Dd2	F	6.62	pIC50	242.3	nM	IC50	Eur J Med Chem (2012) 55: 335-345 [PMID:22889556]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum isolate Kenya after 72 hrs by lactate dehydrogenase assay	F	6.62	pIC50	241.3	nM	IC50	Bioorg Med Chem (2012) 20: 5980-5985 [PMID:22901673]
ChEMBL	In vitro antimalarial activity against Plasmodium falciparum K1	F	6.62	pIC50	240	nM	IC50	J Med Chem (2004) 47: 1997-2009 [PMID:15055999]
ChEMBL	In vitro antimalarial activity against chloroquine-resistant Plasmodium falciparum CDC/Indochina III W2	F	6.62	pIC50	240	nM	IC50	J Med Chem (1995) 38: 5031-5037 [PMID:8544179]
ChEMBL	Antiparasitic activity against Plasmodium falciparum W2	F	6.62	pIC50	240	nM	IC50	Bioorg Med Chem (2007) 15: 273-282 [PMID:17052908]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum W2 by fluorometric method	F	6.62	pIC50	240	nM	IC50	J Med Chem (2009) 52: 5662-5672 [PMID:19715342]
ChEMBL	Antimalarial activity against Plasmodium falciparum W2	F	6.62	pIC50	240	nM	IC50	Bioorg Med Chem Lett (2006) 16: 5682-5686 [PMID:16908136]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FcM29 assessed as [3H]hypoxanthine incorporation after 48 hrs	F	6.62	pIC50	240	nM	IC50	Bioorg Med Chem (2012) 20: 4856-4861 [PMID:22766218]
ChEMBL	Antimalarial activity against multidrug resistant Plasmodium falciparum W2 infected in human erythrocytes assessed as inhibition of parasite proliferation after 96 hrs by SYBR Green I fluorescence based assay	F	6.63	pIC50	233.18	nM	IC50	Bioorg Med Chem Lett (2016) 26: 3006-3009 [PMID:27210430]
ChEMBL	Antimalarial activity against asexual stage of Plasmodium falciparum Dd2 infected in erythrocytes assessed as reduction in parasite growth incubated for 48 hrs under hypoxic condition by Hoechst 33342 staining based flow cytometry	F	6.63	pIC50	233	nM	IC50	ACS Med Chem Lett (2020) 11: 49-55 [PMID:31938463]
ChEMBL	Antimalarial activity against asexual stage of Plasmodium falciparum W2 assessed as reduction in parasite growth incubated for 96 hrs by SYBR Green I dye-based fluorescence assay	F	6.63	pIC50	233	nM	IC50	ACS Med Chem Lett (2020) 11: 49-55 [PMID:31938463]
ChEMBL	Antiplasmodial activity against D-sorbitol synchronized ring stage of chloroquine-resistant Plasmodium falciparum W2 assessed as parasite growth inhibition measured after 48 hrs by YOYO-1 dye based FACSort flow cytometry analysis	F	6.63	pIC50	232.65	nM	IC50	ACS Med Chem Lett (2020) 11: 154-161 [PMID:32071682]
ChEMBL	In vitro antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 Indochina	F	6.63	pIC50	232.6	nM	IC50	J Med Chem (2003) 46: 4244-4258 [PMID:13678403]
ChEMBL	Antimalarial activity against chloroquine /mefloquine/pyrimethamine-resistant Plasmodium falciparum C235 by malaria SYBR green 1-based fluorescence (MSF) assay	F	6.64	pIC50	230	nM	IC50	Bioorg Med Chem Lett (2015) 25: 327-332 [PMID:25488841]
ChEMBL	Antiplasmodial activity chloroquinone-resistant Plasmodium falciparum Dd2 by parasite lactate dehydrogenase assay	F	6.64	pIC50	230	nM	IC50	J Nat Prod (2015) 78: 1848-1858 [PMID:26235033]
ChEMBL	Antiparasitic activity against chloroquine, pyrimethamine-resistant Plasmodium falciparum K1 erythrocyte stage infected rat L6 cells	F	6.64	pIC50	230	nM	IC50	J Med Chem (2007) 50: 5833-5839 [PMID:17949068]
ChEMBL	Antimalarial activity against ring stage Plasmodium falciparum W2 infected with human red blood cells incubated for 48 hrs by flow cytometry	F	6.64	pIC50	229	nM	IC50	Bioorg Med Chem (2015) 23: 1530-1539 [PMID:25725608]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human A positive erythrocyte assessed as inhibition of parasite growth after 72 hrs by parasite lactate dehydrogenase assay	F	6.64	pIC50	228	nM	IC50	Medchemcomm (2015) 6: 357-362
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum PFB infected human erythrocytes after 24 hrs by [3H]hypoxanthine uptake	F	6.65	pIC50	225.7	nM	IC50	Bioorg Med Chem (2008) 16: 9133-9144 [PMID:18819813]
ChEMBL	Antispasmodial activity against multidrug-resistant asexual blood stages of Plasmodium falciparum Dd2 after 72 hrs by HRP2-based ELISA	F	6.65	pIC50	224.7	nM	IC50	J Med Chem (2017) 60: 6036-6044 [PMID:28653845]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 after 72 hrs by SYBR green 1 dye based fluorometric method	F	6.65	pIC50	224	nM	IC50	J Nat Prod (2011) 74: 2174-2180 [PMID:21995542]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 incubated for 48 hrs by parasite lactate dehydrogenase assay	F	6.65	pIC50	222	nM	IC50	ACS Med Chem Lett (2019) 10: 714-719 [PMID:31097988]
ChEMBL	Antimalarial activity against CQ-resistant Plasmodium falciparum K1 infected in human type O+ erythrocytes assessed as growth inhibition incubated for 48 hrs by LDH assay	F	6.65	pIC50	222	nM	IC50	J Med Chem (2016) 59: 6512-6530 [PMID:27299916]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2	F	6.65	pIC50	221.9	nM	IC50	Eur J Med Chem (2013) 66: 314-323 [PMID:23811093]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum RSA11	F	6.66	pIC50	220.36	nM	IC50	Antimicrob Agents Chemother (2007) 51: 2265-2267 [PMID:17404003]
ChEMBL	Antibacterial activity against intraerythrocytic form of Plasmodium falciparum	F	6.66	pIC50	220	nM	IC50	Bioorg Med Chem Lett (2009) 19: 3031-3035 [PMID:19414258]
ChEMBL	Antimalarial activity against Plasmodium falciparum W2mef ring form by hoechst 33342-thiazole orange stain based flow cytometry assay	F	6.66	pIC50	219	nM	IC50	Bioorg Med Chem Lett (2009) 19: 5452-5457 [PMID:19666223]
ChEMBL	Inhibition of Plasmodium falciparum W2	F	6.66	pIC50	219	nM	IC50	J Med Chem (2000) 43: 2646-2654 [PMID:10893302]
ChEMBL	Inhibition of Plasmodium falciparum FCM29	F	6.67	pIC50	216	nM	IC50	J Med Chem (2000) 43: 2646-2654 [PMID:10893302]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 by parasite LDH assay	F	6.67	pIC50	215	nM	IC50	Eur J Med Chem (2011) 46: 579-587 [PMID:21183259]
ChEMBL	Antimalarial activity against asexual stage of Plasmodium falciparum K1 assessed as reduction in parasite growth incubated for 48 hrs under hypoxic condition by Hoechst 33342 staining based flow cytometry	F	6.67	pIC50	212	nM	IC50	ACS Med Chem Lett (2020) 11: 49-55 [PMID:31938463]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2	F	6.68	pIC50	210	nM	IC50	Eur J Med Chem (2019) 161: 101-117 [PMID:30343191]
ChEMBL	Antimalarial activity against atovaquone-resistant Plasmodium falciparum Tm90-C2B infected in human erythrocytes by SYBR green 1-based fluorescence assay	F	6.68	pIC50	208	nM	IC50	J Med Chem (2019) 62: 3475-3502 [PMID:30852885]
ChEMBL	Antimalarial activity against multidrug resistant Plasmodium falciparum Tm90-C2B infected in human erythrocytes measured after after 72 hrs by SYBR green dye based fluorescence assay	F	6.68	pIC50	208	nM	IC50	J Med Chem (2020) 63: 6179-6202 [PMID:32390431]
ChEMBL	Antiplasmodial activity against asexual blood stage of multidrug-resistant Plasmodium falciparum TM90C2B infected in human erythrocytes assessed as reduction in parasite growth incubated for 72 hrs by SYBR green 1 staining based assay	F	6.68	pIC50	208	nM	IC50	J Med Chem (2021) 64: 8739-8754 [PMID:34111350]
ChEMBL	Antiplasmodial activity against the multidrug-resistant Plasmodium falciparum FRC-3 infected in human red blood cells assessed as reduction in parasite growth after 48 hrs by Hoechst 33342 staining based flow cytometric analysis	F	6.68	pIC50	207	nM	IC50	Eur J Med Chem (2018) 158: 68-81 [PMID:30199706]
ChEMBL	Antimalarial activity against multidrug-resistant Plasmodium falciparum thailand TM91C235 assessed as [3H]-hypoxanthine incorporation by liquid scintillation counting analysis	F	6.69	pIC50	206	nM	IC50	Bioorg Med Chem (2015) 23: 2176-2186 [PMID:25801154]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum C235 assessed as growth inhibition after 18 hrs by [3H]-hypoxanthine uptake assay	F	6.69	pIC50	206	nM	IC50	J Med Chem (2015) 58: 3411-3431 [PMID:25654185]
ChEMBL	Antiplasmodial activity against multidrug-resistant Plasmodium falciparum VS/1 by [3H]hypoxanthine incorporation assay	F	6.69	pIC50	205	nM	IC50	Antimicrob Agents Chemother (2009) 53: 3131-3134 [PMID:19364853]
ChEMBL	Antiplasmodial activity against chloroquine-resistant asexual blood stage of Plasmodium falciparum K1 by LDH assay	F	6.69	pIC50	205	nM	IC50	Eur J Med Chem (2019) 180: 121-133 [PMID:31301563]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum 7G8 harboring D10 pfcrt allele infected in erythrocytes assessed as [3H]hypoxanthine incorporation	F	6.69	pIC50	204.1	nM	IC50	Antimicrob Agents Chemother (2009) 53: 1362-1366 [PMID:19188388]
ChEMBL	Antiparasitic activity against Plasmodium falciparum K1	F	6.7	pIC50	201	nM	IC50	Eur J Med Chem (2007) 42: 552-557 [PMID:17178177]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum	F	6.7	pIC50	201	nM	IC50	Antimicrob Agents Chemother (2008) 52: 237-243 [PMID:17967917]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum FcB1	F	6.7	pIC50	200	nM	IC50	Bioorg Med Chem Lett (2007) 17: 959-963 [PMID:17166718]
ChEMBL	In vitro antimalarial activity for Plasmodium falciparum BHz26/86	F	6.7	pIC50	200	nM	IC50	Bioorg Med Chem Lett (2004) 14: 1145-1149 [PMID:14980653]
ChEMBL	In vitro antiparasitic activity against chloroquine-resistant Plasmodium falciparum Indochina I	F	6.7	pIC50	200	nM	IC50	J Med Chem (2004) 47: 2700-2705 [PMID:15115412]
ChEMBL	Growth inhibition after 6 hrs in chloroquine-resistant Plasmodium falciparum FcB1	F	6.7	pIC50	200	nM	IC50	Antimicrob Agents Chemother (2007) 51: 1463-1472 [PMID:17242150]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 in human erythrocytes by [3H]hypoxanthine uptake	F	6.7	pIC50	200	nM	IC50	Eur J Med Chem (2008) 43: 1983-1988 [PMID:18222568]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 infected in erythrocytes after 48 hrs by SYBR Green 1-based fluorescence assay	F	6.7	pIC50	200	nM	IC50	Bioorg Med Chem (2010) 18: 5254-5260 [PMID:20541427]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 infected in erythrocytes after 48 hrs by SYBR green 1-based fluorescence assay	F	6.7	pIC50	200	nM	IC50	Bioorg Med Chem (2011) 19: 7474-7481 [PMID:22071523]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum ItG after 72 hrs by lactate dehydrogenase assay	F	6.7	pIC50	200	nM	IC50	J Med Chem (2013) 56: 2348-2358 [PMID:23410043]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum K1 infected in human erythrocytes after 72 hrs by Malstat reagent-based spectrophotometric analysis	F	6.7	pIC50	200	nM	IC50	Eur J Med Chem (2018) 151: 18-26 [PMID:29604541]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 erythrocytic stage measured after 3 days by HRP2 assay	F	6.7	pIC50	200	nM	IC50	Eur J Med Chem (2020) 187: 111927-111927 [PMID:31812035]
ChEMBL	Antimalarial activity against Plasmodium falciparum CQR (W2 clone) infected in human erythrocyte assessed as reduction in parasite growth incubated for 48 hrs by SYBR assay	F	6.7	pIC50	200	nM	IC50	Bioorg Med Chem (2020) 28: 115832-115832 [PMID:33166927]
ChEMBL	Antiplasmodial activity against chloroquine-resistant erythrocytic stage Plasmodium falciparum Dd2 assessed as inhibition of parasite growth incubated for 3 days by HRP2-ELISA	F	6.7	pIC50	200	nM	IC50	Eur J Med Chem (2021) 224: 113687-113687 [PMID:34274829]
ChEMBL	Antimicrobial activity against chloroquine-resistant and mefloquine-sensitive Plasmodium falciparum W2 infected in human erythrocytes after 48 hrs by SYBR Green I assay	F	6.7	pIC50	198	nM	IC50	Eur J Med Chem (2014) 81: 378-393 [PMID:24858543]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum W2 assessed as suppression of parasitemia after 4 hrs by Giemsa staining	F	6.71	pIC50	196	nM	IC50	Antimicrob Agents Chemother (2009) 53: 4393-4398 [PMID:19667291]
ChEMBL	Antimalarial activity against multidrug-resistant Plasmodium falciparum Dd2 measured after 72 hrs by SYBR Green 1 dye based fluorescence assay	F	6.71	pIC50	196	nM	IC50	J Med Chem (2019) 62: 3503-3512 [PMID:30856324]
ChEMBL	Antiplasmodial activity against multidrug-resistant Plasmodium falciparum K1 infected in erythrocytes assessed as reduction in [3H]hypoxanthine incorporation preincubated for 48 hrs followed by [3H]hypoxanthine addition and measured after 24 hrs by liquid scintillation counting method	F	6.71	pIC50	194	nM	IC50	J Med Chem (2016) 59: 9890-9905 [PMID:27748596]
ChEMBL	Antiplasmodial activity against 4-aminoquinoline/antifolates-resistant Plasmodium falciparum Dd2 ring stage infected in human erythrocytes after 72 hrs by DAPI staining based method	F	6.71	pIC50	194	nM	IC50	J Nat Prod (2018) 81: 1588-1597 [PMID:29969262]
ChEMBL	Antimalarial activity against multidrug-resistant Plasmodium falciparum K1	F	6.71	pIC50	194	nM	IC50	J Med Chem (2018) 61: 4213-4227 [PMID:29665687]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 measured after 72 hrs by DAPI staining based high throughput screening assay	F	6.71	pIC50	194	nM	IC50	Bioorg Med Chem Lett (2017) 27: 2602-2607 [PMID:28400231]
ChEMBL	Antiplasmodial activity against chloroquine-resistant asexual blood stage of Plasmodium falciparum K1 infected in human RBC assessed as reduction in [3H]hypoxanthine incorporation preincubated for 48 hrs followed by [3H]hypoxanthine addition measured after 24 hrs by liquid scintillation counting method	F	6.71	pIC50	194	nM	IC50	J Med Chem (2019) 62: 1022-1035 [PMID:30562027]
ChEMBL	Antimalarial activity against chloroquine-resistant, mefloquine-sensitive Plasmodium falciparum RCS	F	6.72	pIC50	192.45	nM	IC50	Bioorg Med Chem (2008) 16: 7039-7045 [PMID:18550377]
ChEMBL	Antimalarial activity against chloroquine-resistant and mefloquine-sensitive Plasmodium falciparum W2 infected in human erythrocytes after 48 hrs by HRP2-ELISA	F	6.72	pIC50	190.55	nM	IC50	Eur J Med Chem (2014) 73: 295-309 [PMID:24469080]
ChEMBL	Antimalarial activity against chloroquine-resistant and mefloquine-sensitive Plasmodium falciparum W2 infected in human erythrocytes after 48 hrs by HRP2-ELISA	F	6.72	pIC50	190	nM	IC50	Eur J Med Chem (2014) 73: 295-309 [PMID:24469080]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum FcB1/columbia infected in human erythrocytes	F	6.72	pIC50	190	nM	IC50	Bioorg Med Chem (2010) 18: 5724-5731 [PMID:20630767]
ChEMBL	In vitro inhibitory concentration against chloroquine-resistant Plasmodium falciparum K1	F	6.72	pIC50	190	nM	IC50	J Med Chem (2002) 45: 4975-4983 [PMID:12408708]
ChEMBL	In vitro antimalarial activity against Plasmodium falciparum W2 in human erythrocytes by [3H]hypoxanthine uptake	F	6.72	pIC50	190	nM	IC50	Bioorg Med Chem Lett (2002) 12: 1351-1355 [PMID:11992775]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 infected human erythrocytes after 72 hrs by [3H]hypoxanthine uptake	F	6.72	pIC50	190	nM	IC50	Bioorg Med Chem (2009) 17: 1527-1533 [PMID:19195901]
ChEMBL	In vitro antimalarial activity against Plasmodium falciparum K1 by [3H]hypoxanthine uptake	F	6.72	pIC50	190	nM	IC50	J Med Chem (2004) 47: 1290-1298 [PMID:14971909]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FCR-3 infected in human A positive erythrocytes by [3H]-hypoxanthine incorporation assay	F	6.72	pIC50	190	nM	IC50	Bioorg Med Chem Lett (2013) 23: 327-329 [PMID:23164712]
ChEMBL	Antiplasmodial activity growth inhibition of chloroquine-resistant Plasmodium falciparum BHz 26/86 after 72 hrs	F	6.72	pIC50	190	nM	IC50	Antimicrob Agents Chemother (2007) 51: 2346-2350 [PMID:17438049]
ChEMBL	Antimalarial activity against Plasmodium falciparum TM90C2A by hypoxanthine uptake	F	6.72	pIC50	189	nM	IC50	J Med Chem (2008) 51: 3437-3448 [PMID:18494463]
ChEMBL	Antimalarial activity against drug-resistant Plasmodium falciparum TM90C2A	F	6.72	pIC50	189	nM	IC50	Antimicrob Agents Chemother (2008) 52: 3467-3477 [PMID:18644969]
ChEMBL	Antimalarial activity against drug-resistant Plasmodium falciparum Dd2 harboring M133I/A138T double mutant infected in human erythrocytes after 72 hrs by SYBR green 1-based fluorescence assay	F	6.73	pIC50	186	nM	IC50	J Med Chem (2019) 62: 3475-3502 [PMID:30852885]
ChEMBL	Antiplasmodial activity against blood stage of chloroquine-resistant Plasmodium falciparum W2 infected in human RBC assessed as parasite growth inhibition after 48 hrs by flow cytometric analysis	F	6.73	pIC50	186	nM	IC50	J Med Chem (2013) 56: 7679-7690 [PMID:24020770]
ChEMBL	Antiplasmodial activity against chloroquine-resistant blood stage of Plasmodium falciparum W2 infected in human RBC after 48 hrs by flow cytometric analysis	F	6.73	pIC50	186	nM	IC50	Eur J Med Chem (2013) 69: 872-880 [PMID:24125849]
ChEMBL	In vitro inhibitory activity against chloroquine-resistant Plasmodium falciparum W2 Indochina	F	6.73	pIC50	185.38	nM	IC50	J Med Chem (2002) 45: 3331-3336 [PMID:12139444]
ChEMBL	In vitro antimalarial activity against chloroquine-resistant Plasmodium falciparum K1	F	6.74	pIC50	183.82	nM	IC50	J Med Chem (2003) 46: 4933-4945 [PMID:14584944]
ChEMBL	Inhibitory activity against chloroquine-resistant Plasmodium falciparum K1	F	6.74	pIC50	183	nM	IC50	J Med Chem (2001) 44: 2827-2833 [PMID:11495593]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 after 24 hrs by semiautomated micro dilution assay	F	6.74	pIC50	183	nM	IC50	Eur J Med Chem (2008) 43: 252-260 [PMID:17485145]
ChEMBL	Antimalarial activity after 24 hrs against chloroquine-resistant Plasmodium falciparum K1/Thailand by [3H]hypoxanthine uptake	F	6.74	pIC50	183	nM	IC50	Eur J Med Chem (2008) 43: 2045-2055 [PMID:18226428]
ChEMBL	Antimalarial activity against drug-resistant Plasmodium falciparum Dd2 harboring M133I mutant infected in human erythrocytes after 72 hrs by SYBR green 1-based fluorescence assay	F	6.74	pIC50	182	nM	IC50	J Med Chem (2019) 62: 3475-3502 [PMID:30852885]
ChEMBL	In vitro inhibitory activity against chloroquine-resistant Plasmodium falciparum K1	F	6.74	pIC50	182	nM	IC50	J Med Chem (1999) 42: 2747-2751 [PMID:10425085]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FcB1 by [3H]hypoxanthine uptake	F	6.74	pIC50	180	nM	IC50	J Nat Prod (2008) 71: 1189-1192 [PMID:18512987]
ChEMBL	Antimicrobial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human erythrocytes assessed as incorporation of [3H]-hypoxanthine by beta counting analysis	F	6.74	pIC50	180	nM	IC50	Eur J Med Chem (2015) 90: 280-295 [PMID:25461328]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum Dd2 after 72 hrs by 96-well format based SYBR green assay	F	6.74	pIC50	180	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 incubated for 48 hrs by parasite lactate dehydrogenase assay	F	6.74	pIC50	180	nM	IC50	J Med Chem (2020) 63: 14470-14501 [PMID:33023291]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 ring stage incubated for 72 hrs by DAPI-staining based imaging analysis	F	6.74	pIC50	180	nM	IC50	J Nat Prod (2020) 83: 3435-3444 [PMID:33105995]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum FcM29	F	6.74	pIC50	180	nM	IC50	Antimicrob Agents Chemother (2007) 51: 1463-1472 [PMID:17242150]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in O-positive human RBC assessed as [3H]-hypoxanthine incorporation after 48 hrs by scintillation counting	F	6.74	pIC50	180	nM	IC50	ACS Med Chem Lett (2012) 3: 43-47 [PMID:24900369]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum D6	F	6.74	pIC50	180	nM	IC50	Bioorg Med Chem Lett (2007) 17: 959-963 [PMID:17166718]
ChEMBL	Growth inhibition of chloroquine-sensitive Plasmodium falciparum K1	F	6.75	pIC50	179.2	nM	IC50	J Med Chem (2003) 46: 542-557 [PMID:12570376]
ChEMBL	In vitro growth inhibition of Plasmodium falciparum W2	F	6.76	pIC50	175	nM	IC50	J Med Chem (2001) 44: 1658-1665 [PMID:11356101]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 ring forms infected in human RBC incubated for 15 mins followed by compound removal and further incubation for 48 hrs by [3H]-hypoxanthine incorporation assay	F	6.76	pIC50	174.5	nM	IC50	Eur J Med Chem (2018) 152: 489-514 [PMID:29754074]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 late forms infected in human RBC incubated for 15 mins followed by compound removal and further incubation for 48 hrs by [3H]-hypoxanthine incorporation assay	F	6.76	pIC50	174.5	nM	IC50	Eur J Med Chem (2018) 152: 489-514 [PMID:29754074]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 assessed as growth inhibition after 48 hrs by flow cytometer	F	6.76	pIC50	174.5	nM	IC50	RSC Med Chem (2021) 12: 970-981 [PMID:34223162]
ChEMBL	Antiprotozoal activity against erythrocytic stage of Plasmodium falciparum K1 after 48 hrs by [3H]- hypoxanthine incorporation assay	F	6.76	pIC50	174	nM	IC50	J Med Chem (2019) 62: 1330-1347 [PMID:30615444]
ChEMBL	Antimalarial activity against chloroquine- and mefloquine-resistant Plasmodium falciparum W2-Mef infected in human O-positive erythrocytes assessed as inhibition of ring-stage parasite growth after 48 hrs	F	6.76	pIC50	174	nM	IC50	Bioorg Med Chem (2011) 19: 6604-6607 [PMID:21696970]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2	F	6.76	pIC50	172	nM	IC50	J Nat Prod (2002) 65: 1325-1327 [PMID:12350157]
ChEMBL	Antimalarial activity against ring stage chloroquine-resistant Plasmodium falciparum Dd2 infected in human O positive erythrocytes after 48 hrs by SYBR green 1 fluorescence assay	F	6.76	pIC50	172	nM	IC50	J Med Chem (2012) 55: 297-311 [PMID:22098429]
ChEMBL	Antimalarial activity against multidrug-resistant Plasmodium falciparum 7G8 infected in human erythrocytes by SYBR green 1-based fluorescence assay	F	6.77	pIC50	171	nM	IC50	J Med Chem (2019) 62: 3475-3502 [PMID:30852885]
ChEMBL	Antiplasmodial activity against asexual blood stage of multidrug-resistant Plasmodium falciparum 7G8 infected in human erythrocytes assessed as reduction in parasite growth incubated for 72 hrs by SYBR green 1 staining based assay	F	6.77	pIC50	171	nM	IC50	J Med Chem (2021) 64: 8739-8754 [PMID:34111350]
ChEMBL	Antimalarial activity against multidrug resistant Plasmodium falciparum 7G8 infected in human erythrocytes measured after after 72 hrs by SYBR green dye based fluorescence assay	F	6.77	pIC50	171	nM	IC50	J Med Chem (2020) 63: 6179-6202 [PMID:32390431]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 infected in human O+ erythrocytes after 72 hrs by SYBR Green-1 fluorescence based assay	F	6.77	pIC50	170	nM	IC50	Eur J Med Chem (2010) 45: 5292-5301 [PMID:20863599]
ChEMBL	Inhibitory concentration against multidrug-resistant Plasmodium falciparum Dd2.	F	6.77	pIC50	170	nM	IC50	Bioorg Med Chem Lett (2002) 12: 2681-2683 [PMID:12217353]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum Dd2 by SYBR Green I fluorescence assay	F	6.77	pIC50	170	nM	IC50	Bioorg Med Chem Lett (2018) 28: 1219-1222 [PMID:29519737]
ChEMBL	Inhibition against Plasmodium falciparum Dd2 in erythrocytes in semiautomated micro dilution assay	F	6.77	pIC50	170	nM	IC50	Bioorg Med Chem Lett (2003) 13: 2159-2161 [PMID:12798326]
ChEMBL	In vitro antimalarial activity against Plasmodium falciparum FCR3	F	6.77	pIC50	170	nM	IC50	Bioorg Med Chem Lett (2003) 13: 75-77 [PMID:12467620]
ChEMBL	Antimalarial activity against Plasmodium falciparum Dd2 in erythrocytes	F	6.77	pIC50	170	nM	IC50	Bioorg Med Chem Lett (2002) 12: 543-545 [PMID:11844668]
ChEMBL	Inhibitory activity against Plasmodium falciparum Dd2 in erythrocytes by semiautomated micro dilution	F	6.77	pIC50	170	nM	IC50	Bioorg Med Chem Lett (2003) 13: 361-363 [PMID:12565929]
ChEMBL	DNDI: Malaria in Vitro, 72 hour	F	6.77	pIC50	170	nM	IC50	Antiprotozoal Activity Profiling of Approved Drugs: A Starting Point toward Drug Repositioning
ChEMBL	Inhibitory activity against Plasmodium falciparum Dd2 in erythrocytes	F	6.77	pIC50	170	nM	IC50	Bioorg Med Chem Lett (2001) 11: 423-424 [PMID:11212126]
ChEMBL	Anti-malarial activity against Plasmodium falciparum Dd2	F	6.77	pIC50	170	nM	IC50	Bioorg Med Chem Lett (2003) 13: 1539-1541 [PMID:12699750]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FCB after 72 hrs by SYBR green 1 assay	F	6.77	pIC50	170	nM	IC50	J Med Chem (2008) 51: 1995-1998 [PMID:18345611]
ChEMBL	Antimalarial activity against erythrocyte stages of chloroquine-resistant Plasmodium falciparum RSA11 infected in human erythrocytes by lactate dehydrogenase assay	F	6.77	pIC50	170	nM	IC50	J Med Chem (2011) 54: 6956-6968 [PMID:21875063]
ChEMBL	Antiplasmodial activity against synchronized ring stage of chloroquine-resistant Plasmodium falciparum Dd2 infected in human erythrocytes after 48 hrs by SYBR Green 1 dye based fluorescence assay	F	6.77	pIC50	170	nM	IC50	Eur J Med Chem (2018) 155: 623-638 [PMID:29929118]
ChEMBL	Antimalarial activity against asexual erythrocyte stage of chloroquine-resistant Plasmodium falciparum Dd2 by parasite lactate dehydrogenase assay	F	6.77	pIC50	168.74	nM	IC50	Bioorg Med Chem (2012) 20: 4701-4709 [PMID:22750008]
ChEMBL	Antiplasmodial activity against chloroquine/cycloguanil/pyrimethamine-resistant blood stage Plasmodium falciparum K1 by SYBR green 1 staining based fluorescence assay	F	6.78	pIC50	167	nM	IC50	J Nat Prod (2018) 81: 188-202 [PMID:29297684]
ChEMBL	Antimalarial activity against chloroquine-,pyrimethamine-resistant Plasmodium falciparum W2 assessed as inhibition of [3H]hypoxanthine incorporation after 96 hrs by microtiter plate scintillation counting	F	6.78	pIC50	166.6	nM	IC50	Bioorg Med Chem (2011) 19: 1692-1701 [PMID:21316974]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR I method	F	6.79	pIC50	163.91	nM	IC50	J Med Chem (2014) 57: 5702-5713 [PMID:24914738]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 7G8 harboring mutations conferring drug-resistance by SYBR-green based assay	F	6.79	pIC50	163.9	nM	IC50	J Med Chem (2014) 57: 6642-6652 [PMID:25007124]
ChEMBL	Antimalarial activity against multidrug resistant Plasmodium falciparum Dd2 infected in human erythrocytes measured after after 72 hrs by SYBR green dye based fluorescence assay	F	6.79	pIC50	163	nM	IC50	J Med Chem (2020) 63: 6179-6202 [PMID:32390431]
ChEMBL	Antiplasmodial activity against asexual blood stage of multidrug-resistant Plasmodium falciparum Dd2 infected in human erythrocytes assessed as reduction in parasite growth incubated for 72 hrs by SYBR green 1 staining based assay	F	6.79	pIC50	163	nM	IC50	J Med Chem (2021) 64: 8739-8754 [PMID:34111350]
ChEMBL	Antimalarial activity against multidrug-resistant Plasmodium falciparum Dd2 infected in human erythrocytes by SYBR green 1-based fluorescence assay	F	6.79	pIC50	163	nM	IC50	J Med Chem (2019) 62: 3475-3502 [PMID:30852885]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 3D7 ring stage forms infected in immunoliposome encapsulated compound pre-loaded human RBC by [3H]-hypoxanthine incorporation assay	F	6.79	pIC50	162.8	nM	IC50	Eur J Med Chem (2018) 152: 489-514 [PMID:29754074]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 3D7 late stage forms infected in immunoliposome encapsulated compound pre-loaded human RBC by [3H]-hypoxanthine incorporation assay	F	6.79	pIC50	162.3	nM	IC50	Eur J Med Chem (2018) 152: 489-514 [PMID:29754074]
ChEMBL	Antimalarial activity against chloroquine- and mefloquine-resistant Plasmodium falciparum W2-Mef infected in human O-positive erythrocytes assessed as inhibition of trophozoites growth after 48 hrs	F	6.79	pIC50	162	nM	IC50	Bioorg Med Chem (2011) 19: 6604-6607 [PMID:21696970]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum 7G8 infected in erythrocytes assessed as [3H]hypoxanthine incorporation	F	6.8	pIC50	160.3	nM	IC50	Antimicrob Agents Chemother (2009) 53: 1362-1366 [PMID:19188388]
ChEMBL	Antimalarial activity against Plasmodium falciparum Cam3.1 harbouring Pf-crt, Pf-mdrl,Pf-dhfr, Pf-dhps, pf-kelch13 mutated loci assessed as inhibition of parasite growth incubated for 48 hrs by [3H]hypoxanthine incorporation assay based liquid scintillation counting method	F	6.8	pIC50	160	nM	IC50	J Med Chem (2021) 64: 12582-12602 [PMID:34437804]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by 96-well format based SYBR green assay	F	6.8	pIC50	160	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum TM6 infected in erythrocytes assessed as [3H]hypoxanthine incorporation	F	6.8	pIC50	159.8	nM	IC50	Antimicrob Agents Chemother (2009) 53: 1362-1366 [PMID:19188388]
ChEMBL	Antimalarial activity against Plasmodium falciparum FCM29	F	6.8	pIC50	158	nM	IC50	Bioorg Med Chem Lett (2007) 17: 593-596 [PMID:17123818]
ChEMBL	Antiplasmodial activity against multidrug-resistant Plasmodium falciparum VS/1 after 18 hrs by [3H]hypoxanthine incorporation assay	F	6.8	pIC50	158	nM	IC50	Antimicrob Agents Chemother (2009) 53: 5069-5073 [PMID:19770282]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2	F	6.8	pIC50	157.9	nM	IC50	Bioorg Med Chem Lett (2010) 20: 6975-6977 [PMID:20971006]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 by lactate dehydrogenase assay	F	6.8	pIC50	157.9	nM	IC50	Bioorg Med Chem Lett (2011) 21: 1683-1686 [PMID:21316959]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum FCB after 72 hrs by SYBR green assay	F	6.8	pIC50	157	nM	IC50	J Med Chem (2008) 51: 3466-3479 [PMID:18512900]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human erythrocytes	F	6.81	pIC50	156	nM	IC50	Bioorg Med Chem Lett (2018) 28: 265-272 [PMID:29326018]
ChEMBL	In vitro antimalarial activity against chloroquine-sensitive Plasmodium falciparum K1	F	6.81	pIC50	156	nM	IC50	J Med Chem (2004) 47: 2926-2934 [PMID:15139771]
ChEMBL	Antiparasitic activity against chloroquine-sensitive Plasmodium falciparum by [3H]hypoxanthine incorporation	F	6.81	pIC50	155	nM	IC50	J Med Chem (2008) 51: 1260-1277 [PMID:18260613]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum V1/S	F	6.81	pIC50	154	nM	IC50	J Med Chem (2009) 52: 1828-1844 [PMID:19284751]
ChEMBL	Antimalarial activity against asexual stage of Plasmodium falciparum K1 assessed as reduction in parasite growth incubated for 96 hrs by SYBR Green I dye-based fluorescence assay	F	6.81	pIC50	154	nM	IC50	ACS Med Chem Lett (2020) 11: 49-55 [PMID:31938463]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum FCR3 infected in human erythrocytes incubated for 48 hrs by [3H]-hypoxanthine incorporation assay	F	6.82	pIC50	152.2	nM	IC50	Eur J Med Chem (2020) 188: 111983-111983 [PMID:31911292]
ChEMBL	Antimicrobial activity against Plasmodium falciparum at ring stage	F	6.82	pIC50	152	nM	IC50	Antimicrob Agents Chemother (2008) 52: 2435-2441 [PMID:18443130]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FcB1 infected in human RBC assessed as [3H]-hypoxanthine incorporation after 48 hrs by liquid scintillation counting analysis	F	6.82	pIC50	151	nM	IC50	Eur J Med Chem (2014) 76: 369-375 [PMID:24594524]
ChEMBL	Antimalarial activity against CQ-sensitive Plasmodium falciparum 3D7 assessed as parasite growth inhibition incubated for 48 hrs by SYBR Green I dye based fluorescence assay	F	6.82	pIC50	150.8	nM	IC50	ACS Med Chem Lett (2022) 13: 225-235 [PMID:35178179]
ChEMBL	Antimalarial activity against erythrocyte stages of chloroquine-resistant Plasmodium falciparum Dd2 infected in human erythrocytes by lactate dehydrogenase assay	F	6.82	pIC50	150	nM	IC50	J Med Chem (2011) 54: 6956-6968 [PMID:21875063]
ChEMBL	Antiplasmodial activity against chloroquine and pyrimethamine resistant Plasmodium falciparum K1 erythrocytic stages incubated for 48 hrs by [3H]-hypoxanthine incorporation assay	F	6.82	pIC50	150	nM	IC50	Bioorg Med Chem (2019) 27: 2052-2065 [PMID:30962114]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 after 48 hrs by YOYO-1 dye-based flow cytometry	F	6.82	pIC50	150	nM	IC50	Eur J Med Chem (2017) 138: 993-1001 [PMID:28756265]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 measured after 72 hrs by lactate dehydrogenase assay	F	6.82	pIC50	150	nM	IC50	J Nat Prod (2021) 84: 666-675 [PMID:33667089]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum TM6 in human erythrocytes by [3H]hypoxanthine uptake	F	6.82	pIC50	150	nM	IC50	Bioorg Med Chem Lett (2008) 18: 4210-4214 [PMID:18554905]
ChEMBL	Antiplasmodial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 after 48 hrs	F	6.82	pIC50	150	nM	IC50	Bioorg Med Chem (2008) 16: 6371-6378 [PMID:18502136]
ChEMBL	Antimicrobial activity against erythrocytic stage of chloroquine-resistant Plasmodium falciparum W2 infected in human erythrocytes assessed as [3H]hypoxanthine incorporation after 24 hrs by beta-radiation counting analysis	F	6.82	pIC50	150	nM	IC50	Eur J Med Chem (2014) 75: 67-76 [PMID:24530492]
ChEMBL	Antiplasmodial activity against asexual erythrocyte stage of chloroquine-resistant Plasmodium falciparum Dd2 infected in human red blood cells after 48 hrs by lactate dehydrogenase assay	F	6.82	pIC50	150	nM	IC50	Eur J Med Chem (2018) 159: 243-254 [PMID:30296683]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 by [G-3H]hypoxanthine uptake	F	6.82	pIC50	150	nM	IC50	J Nat Prod (1997) 60: 458-461 [PMID:9170288]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 by [3H]hypoxanthine incorporation assay	F	6.82	pIC50	150	nM	IC50	J Nat Prod (1997) 60: 739-742 [PMID:9249982]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FcB1 infected in RBC (unknown origin) incubated for 48 hrs by SYBR green dye based fluorescence analysis	F	6.82	pIC50	150	nM	IC50	J Nat Prod (2019) 82: 3233-3241 [PMID:31800248]
ChEMBL	Antimalarial activity against chloroquine- and mefloquine-resistant Plasmodium falciparum W2-Mef infected in human O-positive erythrocytes after 48 hrs	F	6.83	pIC50	149	nM	IC50	Bioorg Med Chem (2011) 19: 6604-6607 [PMID:21696970]
ChEMBL	Antiplasmodial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1	F	6.83	pIC50	148	nM	IC50	J Med Chem (2008) 51: 3654-3658 [PMID:18476684]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 by SYBR green assay	F	6.83	pIC50	147	nM	IC50	Bioorg Med Chem (2009) 17: 2871-2876 [PMID:19282186]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2	F	6.84	pIC50	145.4	nM	IC50	Bioorg Med Chem Lett (2011) 21: 2882-2886 [PMID:21489789]
ChEMBL	Antiplasmodial activity against chloroquine/mefloquine-resistant Plasmodium falciparum SRIV35	F	6.84	pIC50	145	nM	IC50	Eur J Med Chem (2015) 94: 56-62 [PMID:25747499]
ChEMBL	Antimalarial activity against Plasmodium falciparum TM91C235	F	6.84	pIC50	144.9	nM	IC50	J Med Chem (2007) 50: 5118-5127 [PMID:17887664]
ChEMBL	Antimalarial activity against mefloquine, chloroquine and quinine-resistant Plasmodium falciparum TM91C235	F	6.84	pIC50	144.9	nM	IC50	Bioorg Med Chem (2008) 16: 7039-7045 [PMID:18550377]
ChEMBL	Antimalarial activity against Plasmodium falciparum TM91C235	F	6.84	pIC50	144.9	nM	IC50	J Med Chem (2006) 49: 3790-3799 [PMID:16789736]
ChEMBL	Antimalarial activity against Plasmodium falciparum K1 incubated for 48 hrs by [3H]-hypoxanthine incorporation assay	F	6.84	pIC50	144	nM	IC50	ACS Med Chem Lett (2020) 11: 49-55 [PMID:31938463]
ChEMBL	Inhibitory concentration against Plasmodium falciparum W2 infected erythrocytes	F	6.84	pIC50	144	nM	IC50	J Med Chem (1994) 37: 1486-1494 [PMID:8182707]
ChEMBL	Antimalarial activity against Plasmodium falciparum K1 harbouring Pf-crt, Pf-mdrl,Pf-dhfr, Pf-dhps mutated loci assessed as inhibition of parasite growth incubated for 48 hrs by [3H]hypoxanthine incorporation assay based liquid scintillation counting method	F	6.84	pIC50	144	nM	IC50	J Med Chem (2021) 64: 12582-12602 [PMID:34437804]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2mef infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 48 hrs by beta liquid scintillation counting method	F	6.84	pIC50	144	nM	IC50	Bioorg Med Chem (2011) 19: 7519-7525 [PMID:22055713]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum C3 harboring Dd2 pfcrt allele infected in erythrocytes assessed as [3H]hypoxanthine incorporation	F	6.84	pIC50	143.8	nM	IC50	Antimicrob Agents Chemother (2009) 53: 1362-1366 [PMID:19188388]
ChEMBL	Antimalarial activity against Plasmodium falciparum W2	F	6.84	pIC50	143	nM	IC50	Bioorg Med Chem Lett (2007) 17: 593-596 [PMID:17123818]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human erythrocytes assessed as reduction in parasitemia after 48 hrs by flow cytometry analysis	F	6.85	pIC50	142.7	nM	IC50	ACS Med Chem Lett (2012) 3: 1029-1033 [PMID:24936235]
ChEMBL	Antiplasmodial activity against CQ-resistant Plasmodium falciparum W2	F	6.85	pIC50	141.9	nM	IC50	Bioorg Med Chem (2021) 39: 116159-116159 [PMID:33895706]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum V1/S after 48 hrs by [3H]hypoxanthine uptake	F	6.85	pIC50	140	nM	IC50	J Nat Prod (1997) 60: 1017-1022 [PMID:9358645]
ChEMBL	Antiplasmodial activity against chloroquine-resistant ring stage Plasmodium falciparum W2 infected in human RBC after 48 hrs by flow cytometric analysis	F	6.85	pIC50	140	nM	IC50	Eur J Med Chem (2014) 80: 523-534 [PMID:24813880]
ChEMBL	Antiplasmodial activity against multi drug resistant synchronized Plasmodium falciparum K1 late trophozoite stage assessed as reduction in parasite survival incubated for 72 hrs under hypoxic condition by parasite lactate dehydrogenase based NBT microplate reader assay	F	6.85	pIC50	140	nM	IC50	ACS Med Chem Lett (2021) 12: 1333-1341 [PMID:34413963]
ChEMBL	Antiplasmodial activity against chloroquine/cycloguanil-resistant Plasmodium falciparum FCR3 by [3H]-hypoxanthine incorporation assay	F	6.85	pIC50	140	nM	IC50	Bioorg Med Chem Lett (2017) 27: 1820-1825 [PMID:28291694]
ChEMBL	Antimalarial activity against Plasmodium falciparum TM90C2B incubated for 48 hrs by [3H]-hypoxanthine incorporation assay	F	6.85	pIC50	140	nM	IC50	ACS Med Chem Lett (2020) 11: 49-55 [PMID:31938463]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum Dd2 asexual blood stages after 3 days by HRP2 detection based ELISA method	F	6.85	pIC50	140	nM	IC50	J Med Chem (2014) 57: 7971-7976 [PMID:25195945]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human red blood cells assessed as inhibition of ring-stage parasite growth after 48 hrs by flow cytometry	F	6.85	pIC50	140	nM	IC50	Eur J Med Chem (2011) 46: 927-933 [PMID:21295887]
ChEMBL	Antiplasmodial activity against chloroquine-resistant erythrocyte stages of Plasmodium falciparum Dd2 by parasite lactate dehydrogenase assay	F	6.85	pIC50	140	nM	IC50	Eur J Med Chem (2013) 69: 90-98 [PMID:24012713]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 after 72 hrs by SYBR green 1 assay	F	6.85	pIC50	140	nM	IC50	J Med Chem (2008) 51: 1995-1998 [PMID:18345611]
ChEMBL	Antiplasmodial activity against ring stage of chloroquine-resistant Plasmodium falciparum W2 infected in human RBC after 48 hrs by flow cytometric analysis	F	6.85	pIC50	140	nM	IC50	Eur J Med Chem (2013) 69: 365-372 [PMID:24077527]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum FcB1	F	6.85	pIC50	140	nM	IC50	Medchemcomm (2011) 2: 860-869
ChEMBL	Antimalarial activity against mutidrug resistant Plasmodium falciparum TM91C235 after 48 hrs by [3H]hypoxanthine incorporation assay	F	6.86	pIC50	139	nM	IC50	J Med Chem (2016) 59: 264-281 [PMID:26640981]
ChEMBL	Antimalarial activity against CQ, MFQ-resistant Plasmodium falciparum TM91C235 clone Southeast asian isolate assessed as inhibition of parasite proliferation by MSF assay	F	6.86	pIC50	138.82	nM	IC50	J Med Chem (2014) 57: 4134-4153 [PMID:24742203]
ChEMBL	Antimalarial activity against Plasmodium falciparum C235	F	6.86	pIC50	138.82	nM	IC50	J Med Chem (2011) 54: 1157-1169 [PMID:21265542]
ChEMBL	In vitro sensitivity for Plasmodium falciparum FcB1R	F	6.86	pIC50	138.6	nM	IC50	J Med Chem (2000) 43: 2646-2654 [PMID:10893302]
ChEMBL	Antimalarial activity against drug-resistant Plasmodium falciparum TM91C235	F	6.86	pIC50	138	nM	IC50	Antimicrob Agents Chemother (2008) 52: 3467-3477 [PMID:18644969]
ChEMBL	Antimalarial activity against Plasmodium falciparum TM91C235 by hypoxanthine uptake	F	6.86	pIC50	138	nM	IC50	J Med Chem (2008) 51: 3437-3448 [PMID:18494463]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2	F	6.86	pIC50	138	nM	IC50	Bioorg Med Chem Lett (2010) 20: 5634-5637 [PMID:20801652]
ChEMBL	Antiplasmodial activity against chloroquine-resistant ring stage Plasmodium falciparum W2 infected in human red blood cells after 48 hrs	F	6.86	pIC50	138	nM	IC50	J Med Chem (2011) 54: 734-750 [PMID:21207937]
ChEMBL	Antiplasmodial activity against drug-resistant Plasmodium falciparum Dd2 ring stage forms assessed as inhibition of parasite growth after 72 hrs by DAPI staining-based confocal microscopic analysis	F	6.87	pIC50	136	nM	IC50	J Nat Prod (2019) 82: 1019-1023 [PMID:30865443]
ChEMBL	Antimalarial activity multidrug-resistant Plasmodium falciparum Dd2 after 72 hrs by SYBR Green I based fluorescence assay	F	6.87	pIC50	135	nM	IC50	J Med Chem (2011) 54: 5296-5306 [PMID:21736388]
ChEMBL	Antimalarial activity after 72 hrs against chloroquine-resistant Plasmodium falciparum W2 as LDH activity	F	6.87	pIC50	135	nM	IC50	Bioorg Med Chem (2008) 16: 6702-6706 [PMID:18595720]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected human erythrocytes as [3H]hypoxanthine uptake after 24 hrs	F	6.87	pIC50	135	nM	IC50	J Nat Prod (1999) 62: 59-66 [PMID:9917283]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum J164	F	6.87	pIC50	133.5	nM	IC50	J Med Chem (2009) 52: 1828-1844 [PMID:19284751]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum FcB1 infected in human red blood cells after 48 hrs by [3H]-hypoxanthine incorporation assay	F	6.88	pIC50	132	nM	IC50	Eur J Med Chem (2017) 139: 22-47 [PMID:28800458]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in erythrocytes assessed as reduction in [3H]hypoxanthine incorporation preincubated for 48 hrs followed by [3H]hypoxanthine addition and measured after 18 hrs by topcount scintillation counting analysis	F	6.88	pIC50	131	nM	IC50	J Med Chem (2020) 63: 8069-8087 [PMID:32687714]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum FcB1 after 24 hrs	F	6.89	pIC50	130	nM	IC50	Bioorg Med Chem (2008) 16: 771-782 [PMID:17967541]
ChEMBL	In vitro antimalarial activity against Plasmodium falciparum FcB1	F	6.89	pIC50	130	nM	IC50	J Med Chem (2004) 47: 1997-2009 [PMID:15055999]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 assessed as growth inhibition after 72 hrs by DAPI staining	F	6.89	pIC50	130	nM	IC50	J Med Chem (2012) 55: 5851-5858 [PMID:22686608]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human erythrocytes measured after 72 hrs Malstat/NBT reagent based assay	F	6.89	pIC50	130	nM	IC50	Bioorg Med Chem (2019) 27: 729-747 [PMID:30692024]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 after 72 hrs by DAPI staining based confocal microplate imaging method	F	6.89	pIC50	130	nM	IC50	J Nat Prod (2017) 80: 3211-3217 [PMID:29236492]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum K1 infected in human erythrocytes assessed as reduction in parasite multiplication incubated for 72 hrs by Malstat method	F	6.89	pIC50	130	nM	IC50	Bioorg Med Chem Lett (2019) 29: 1232-1235 [PMID:30879839]
ChEMBL	Gametocytocidal activity against synchronous stage 1 to 3 of transgenic Plasmodium falciparum NF54 gametocyte harboring pfs16 promoter assessed as parasite viability after 72 hrs by luciferase reporter gene assay	F	6.89	pIC50	130	nM	IC50	J Med Chem (2013) 56: 6200-6215 [PMID:23837878]
ChEMBL	Antiplasmodial activity after 18 hrs against chloroquine-resistant Plasmodium falciparum FcB1 in human blood by [3H]hypoxanthine uptake	F	6.89	pIC50	130	nM	IC50	J Nat Prod (2003) 66: 1447-1450 [PMID:14640516]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by DAPI staining method	F	6.89	pIC50	130	nM	IC50	J Nat Prod (2009) 72: 1541-1543 [PMID:19637893]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 rings after 48 hrs by FACS analysis	F	6.89	pIC50	130	nM	IC50	J Nat Prod (2009) 72: 2130-2134 [PMID:19904919]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 after 72 hrs by fluorescence assay	F	6.89	pIC50	130	nM	IC50	J Nat Prod (2010) 73: 985-987 [PMID:20462236]
ChEMBL	Antimalarial activity as 3rd generation ring-stage chloroquine-resistant Plasmodium falciparum W2 after 48 hrs dose then 48 hrs drug-free	F	6.89	pIC50	130	nM	IC50	Antimicrob Agents Chemother (2007) 51: 3485-3490 [PMID:17698630]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum assessed as inhibition of [3H]hypoxanthine incorporation incubated for 20 to 24 hr prior to [3H]hypoxanthine addition measured after 24 grs by microbeta scintillation counting	F	6.89	pIC50	130	nM	IC50	Med Chem Res (2008) 17: 19-29
ChEMBL	Antimalarial activity against Chloroquine-resistant Plasmodium falciparum K1 measured after 72 hrs by malstat/NBT dye based assay	F	6.89	pIC50	130	nM	IC50	Bioorg Med Chem Lett (2019) 29: 1051-1053 [PMID:30857749]
ChEMBL	Antimalarial activity against multidrug-resistant Plasmodium falciparum TM91C235	F	6.89	pIC50	129.78	nM	IC50	J Med Chem (2008) 51: 6216-6219 [PMID:18774792]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 after 72 hrs	F	6.9	pIC50	127	nM	IC50	Bioorg Med Chem (2009) 17: 270-283 [PMID:19041248]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum C6harboring 7G8 pfcrt allele infected in erythrocytes assessed as [3H]hypoxanthine incorporation	F	6.9	pIC50	126.9	nM	IC50	Antimicrob Agents Chemother (2009) 53: 1362-1366 [PMID:19188388]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum FcB1	F	6.9	pIC50	126	nM	IC50	Bioorg Med Chem Lett (2002) 12: 2595-2598 [PMID:12182868]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum FcB1	F	6.9	pIC50	126	nM	IC50	Bioorg Med Chem Lett (2003) 13: 3783-3787 [PMID:14552779]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum FcB1R after 24 hrs by semiautomated micro dilution assay	F	6.9	pIC50	126	nM	IC50	Eur J Med Chem (2008) 43: 252-260 [PMID:17485145]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum FcB1	F	6.9	pIC50	126	nM	IC50	Eur J Med Chem (2019) 161: 101-117 [PMID:30343191]
ChEMBL	Antimalarial activity against Plasmodium falciparum NF54 assessed as inhibition of parasite growth incubated for 48 hrs by [3H]hypoxanthine incorporation assay based liquid scintillation counting method	F	6.9	pIC50	126	nM	IC50	J Med Chem (2021) 64: 12582-12602 [PMID:34437804]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum FcB1	F	6.9	pIC50	126	nM	IC50	Bioorg Med Chem Lett (2006) 16: 31-35 [PMID:16263280]
ChEMBL	Antimalarial activity after 24 hrs against chloroquine-resistant Plasmodium falciparum FcB1R/Colombia by [3H]hypoxanthine uptake	F	6.9	pIC50	126	nM	IC50	Eur J Med Chem (2008) 43: 2045-2055 [PMID:18226428]
ChEMBL	Antimalarial activity against Plasmodium falciparum FcB1	F	6.9	pIC50	126	nM	IC50	J Med Chem (2003) 46: 542-557 [PMID:12570376]
ChEMBL	Inhibitory activity against chloroquine-resistant Plasmodium falciparum FcB1R	F	6.9	pIC50	126	nM	IC50	J Med Chem (2001) 44: 2827-2833 [PMID:11495593]
ChEMBL	Growth inhibition of chloroquine-sensitive Plasmodium falciparum FcB1	F	6.9	pIC50	126	nM	IC50	J Med Chem (2003) 46: 542-557 [PMID:12570376]
ChEMBL	Inhibitory activity against Plasmodium falciparum FcB1	F	6.9	pIC50	126	nM	IC50	Bioorg Med Chem Lett (2003) 13: 2659-2662 [PMID:12873488]
ChEMBL	Antimalarial activity against Plasmodium falciparum Nigerian assessed as [3H]hypoxanthine uptake after 48 hrs by liquid scintillation counting	F	6.9	pIC50	125	nM	IC50	Eur J Med Chem (2009) 44: 4778-4782 [PMID:19747753]
ChEMBL	Antimalarial activity against erythrocyte stages of chloroquine-resistant Plasmodium falciparum W2 infected in human erythrocytes by lactate dehydrogenase assay	F	6.9	pIC50	125	nM	IC50	J Med Chem (2011) 54: 6956-6968 [PMID:21875063]
ChEMBL	Growth inhibition of Plasmodium falciparum Dd2 ring stage infected erythrocytes after 72 hrs by DAPI fluorimetry	F	6.9	pIC50	124.61	nM	IC50	Antimicrob Agents Chemother (2007) 51: 716-723 [PMID:17116676]
ChEMBL	Antimalarial activity against multidrug-resistant Plasmodium falciparum TM91C235	F	6.91	pIC50	124.24	nM	IC50	J Med Chem (2008) 51: 4388-4391 [PMID:18637666]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1	F	6.91	pIC50	124	nM	IC50	J Med Chem (2007) 50: 5807-5823 [PMID:17948982]
ChEMBL	Antiplasmodial activity against multidrug resistant Plasmodium falciparum Dd2 by spectroscopic method	F	6.91	pIC50	124	nM	IC50	Bioorg Med Chem Lett (2016) 26: 1151-1155 [PMID:26832222]
ChEMBL	Antimalarial activity against Plasmodium falciparum W2mef assessed as DNA positive erythrocytes by hoechst 33342-thiazole orange stain based flow cytometry assay	F	6.91	pIC50	123	nM	IC50	Bioorg Med Chem Lett (2009) 19: 5452-5457 [PMID:19666223]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 assessed as SYBR Green 1 fluorescence emission after 72 hrs	F	6.91	pIC50	122	nM	IC50	Bioorg Med Chem (2009) 17: 6560-6566 [PMID:19703776]
ChEMBL	Antiplasmodial activity against multidrug-resistant Plasmodium falciparum FCR-3 by [3H]-hypoxanthine incorporation assay	F	6.92	pIC50	120	nM	IC50	Eur J Med Chem (2018) 152: 489-514 [PMID:29754074]
ChEMBL	Antiplasmodial activity against chloroquine, pyrimethamine-resistant Plasmodium falciparum K1 after 48 hrs	F	6.92	pIC50	120	nM	IC50	Bioorg Med Chem (2007) 15: 5543-5550 [PMID:17544672]
ChEMBL	Antimalarial activity against early (1 to 3) gametocytic stage of Plasmodium falciparum after 72 hrs by image-based HTS assay	F	6.92	pIC50	120	nM	IC50	J Med Chem (2013) 56: 7727-7740 [PMID:23927763]
ChEMBL	Antiprotozoal activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1	F	6.92	pIC50	120	nM	IC50	Eur J Med Chem (2008) 43: 800-807 [PMID:17698258]
ChEMBL	Antiprotozoal activity against chloroquine-sensitive Plasmodium falciparum	F	6.92	pIC50	120	nM	IC50	Bioorg Med Chem Lett (2006) 16: 5457-5461 [PMID:16889962]
ChEMBL	Inhibition of Plasmodium falciparum K1 as [3H]hypoxanthine uptake	F	6.92	pIC50	120	nM	IC50	Bioorg Med Chem Lett (2006) 16: 2283-2292 [PMID:16458512]
ChEMBL	Antimalarial activity against Plasmodium falciparum W2 after 48 hrs by LDH colorimetric assay	F	6.92	pIC50	120	nM	IC50	Bioorg Med Chem (2014) 22: 1128-1138 [PMID:24411478]
ChEMBL	Antimalarial activity against mefloquine-resistant Plasmodium falciparum W2 after 48 hrs by LDH assay	F	6.93	pIC50	118	nM	IC50	J Med Chem (2011) 54: 4581-4589 [PMID:21644541]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FcM29 infected in erythrocytes assessed as reduction in [3H]hypoxanthine incorporation preincubated for 48 hrs followed by [3H]hypoxanthine addition and measured after 18 hrs by topcount scintillation counting analysis	F	6.93	pIC50	117	nM	IC50	J Med Chem (2020) 63: 8069-8087 [PMID:32687714]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 after 72 hrs by SYBR green assay	F	6.94	pIC50	116	nM	IC50	J Med Chem (2008) 51: 3466-3479 [PMID:18512900]
ChEMBL	Antimalarial activity against Plasmodium falciparum TM4 infected in human A positive erythrocytes assessed as inhibition of [G-3H]-hypoxanthine uptake after 24 hrs by liquid scintillation counting	F	6.94	pIC50	115.2	nM	IC50	Bioorg Med Chem (2012) 20: 927-932 [PMID:22182577]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum FcB1	F	6.94	pIC50	115	nM	IC50	Antimicrob Agents Chemother (2007) 51: 1463-1472 [PMID:17242150]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum Dd2	F	6.94	pIC50	114	nM	IC50	Antimicrob Agents Chemother (2009) 53: 1100-1106 [PMID:19015354]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum TM4	F	6.95	pIC50	112.8	nM	IC50	J Med Chem (2009) 52: 1828-1844 [PMID:19284751]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 after 72 hrs by malaria SYBR Green I-based fluorescence assay	F	6.95	pIC50	112.6	nM	IC50	J Nat Prod (2010) 73: 885-889 [PMID:20429578]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human RBC assessed as reduction in parasite growth after 35 to 56 hrs by nucleic acid staining based flow cytometry	F	6.95	pIC50	111.2	nM	IC50	J Med Chem (2019) 62: 2485-2498 [PMID:30715882]
ChEMBL	Antimalarial activity against Plasmodium falciparum W2mef trophozoite form by hoechst 33342-thiazole orange stain based flow cytometry assay	F	6.95	pIC50	111	nM	IC50	Bioorg Med Chem Lett (2009) 19: 5452-5457 [PMID:19666223]
ChEMBL	In vitro growth inhibition of Plasmodium falciparum FcB1R	F	6.96	pIC50	110	nM	IC50	J Med Chem (2001) 44: 1658-1665 [PMID:11356101]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 by [G-3H]hypoxanthine uptake	F	6.96	pIC50	110	nM	IC50	J Nat Prod (1997) 60: 458-461 [PMID:9170288]
ChEMBL	In vitro anti-protozoal activity against Plasmodium falciparum W2	F	6.96	pIC50	110	nM	IC50	Bioorg Med Chem Lett (2004) 14: 3635-3638 [PMID:15203133]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FCB1 in human blood as [G-3H]hypoxanthine uptake	F	6.96	pIC50	110	nM	IC50	J Nat Prod (2005) 68: 800-803 [PMID:15921436]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum FcB1	F	6.96	pIC50	110	nM	IC50	J Med Chem (2006) 49: 5300-5308 [PMID:16913719]
ChEMBL	Antimalarial activity after 96 hrs against azithromycin-resistant Plasmodium falciparum Dd2 by [3H]hypoxanthine uptake	F	6.96	pIC50	108.5	nM	IC50	J Biol Chem (2007) 282: 2494-2504 [PMID:17110371]
ChEMBL	Antimalarial activity after 72 hrs against chloroquine-resistant Plasmodium falciparum Dd2 infected human erythrocytes by SYBR green assay	F	6.97	pIC50	106.4	nM	IC50	Antimicrob Agents Chemother (2007) 51: 4133-4140 [PMID:17846138]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum NF54	F	6.97	pIC50	106	nM	IC50	J Med Chem (2007) 50: 394-398 [PMID:17228883]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum 7G8 after 72 hrs by SYBR green 1 fluorescence-based method	F	6.97	pIC50	106	nM	IC50	J Med Chem (2010) 53: 6477-6489 [PMID:20684562]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1	F	6.99	pIC50	103.5	nM	IC50	J Med Chem (2007) 50: 2468-2485 [PMID:17439202]
ChEMBL	Antimalarial activity after 72 hrs against chloroquine-resistant transporter 106/1'76T mutant Plasmodium falciparum infected human erythrocytes by SYBR green assay	F	6.99	pIC50	102.2	nM	IC50	Antimicrob Agents Chemother (2007) 51: 4133-4140 [PMID:17846138]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 after 72 hrs by SYBR green 1 fluorescence-based method	F	6.99	pIC50	102	nM	IC50	J Med Chem (2010) 53: 6477-6489 [PMID:20684562]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2	F	6.99	pIC50	102	nM	IC50	J Med Chem (2006) 49: 5623-5625 [PMID:16942036]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 after 72 hrs by fluorescence based method	F	6.99	pIC50	102	nM	IC50	J Med Chem (2010) 53: 916-919 [PMID:20088608]
ChEMBL	Inhibition of Plasmodium falciparum FCR3	F	6.99	pIC50	102	nM	IC50	J Med Chem (2000) 43: 2646-2654 [PMID:10893302]
ChEMBL	Antimicrobial activity against Plasmodium falciparum by ELISA	F	7	pIC50	101.1	nM	IC50	Antimicrob Agents Chemother (2010) 54: 1200-1206 [PMID:20065051]
ChEMBL	Antiparasitic activity against chloroquine-resistant Plasmodium falciparum R1H6/2 by [3H]hypoxanthine incorporation assay	F	7	pIC50	101	nM	IC50	Antimicrob Agents Chemother (2008) 52: 1438-1445 [PMID:18195056]
ChEMBL	In vitro activity against drug-resistant Plasmodium falciparum D6	F	7	pIC50	>100	nM	IC50	J Med Chem (2001) 44: 1658-1665 [PMID:11356101]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2/Indochina infected in human erythrocytes after 24 hrs by [3H]-hypoxanthine incorporation assay	F	7	pIC50	>100	nM	IC50	Eur J Med Chem (2017) 139: 22-47 [PMID:28800458]
ChEMBL	Antiprotozoal activity against chloroquine-resistant Plasmodium falciparum W2	F	7	pIC50	100	nM	IC50	Eur J Med Chem (2019) 161: 101-117 [PMID:30343191]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum F32/Tanzania infected in human erythrocytes after 24 hrs by [3H]-hypoxanthine incorporation assay	F	7	pIC50	>100	nM	IC50	Eur J Med Chem (2017) 139: 22-47 [PMID:28800458]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum FcB1R/Colombia infected in human erythrocytes after 24 hrs by [3H]-hypoxanthine incorporation assay	F	7	pIC50	>100	nM	IC50	Eur J Med Chem (2017) 139: 22-47 [PMID:28800458]
ChEMBL	In vitro activity against drug-resistant Plasmodium falciparum W2	F	7	pIC50	>100	nM	IC50	J Med Chem (2001) 44: 1658-1665 [PMID:11356101]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6/Sierra-Leone infected in human erythrocytes after 24 hrs by [3H]-hypoxanthine incorporation assay	F	7	pIC50	>100	nM	IC50	Eur J Med Chem (2017) 139: 22-47 [PMID:28800458]
ChEMBL	Antimalarial activity against Plasmodium falciparum infected erythrocytes	F	7	pIC50	100	nM	IC50	J Nat Prod (2005) 68: 897-903 [PMID:15974615]
ChEMBL	Antimalarial activity against Plasmodium falciparum	F	7	pIC50	100	nM	IC50	J Nat Prod (2008) 71: 1544-1550 [PMID:18715036]
ChEMBL	In vitro activity against drug-resistant Plasmodium falciparum FcB1R	F	7	pIC50	>100	nM	IC50	J Med Chem (2001) 44: 1658-1665 [PMID:11356101]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 assessed as parasite survival after 2 days by YOYO-1 staining-based flow cytometric analysis	F	7	pIC50	100	nM	IC50	ACS Med Chem Lett (2013) 4: 642-646 [PMID:24900724]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum FcB1 as [3H]hypoxanthine uptake after 24 hrs	F	7	pIC50	100	nM	IC50	J Nat Prod (2008) 71: 2057-2059 [PMID:19053513]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by 1536-well format based SYBR green assay	F	7	pIC50	100	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	In vitro activity against drug-resistant Plasmodium falciparum F32	F	7	pIC50	>100	nM	IC50	J Med Chem (2001) 44: 1658-1665 [PMID:11356101]
ChEMBL	In vitro activity against Plasmodium falciparum W-2	F	7	pIC50	100	nM	IC50	J Med Chem (1992) 35: 2129-2134 [PMID:1597862]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum D6	F	7	pIC50	100	nM	IC50	J Nat Prod (2009) 72: 906-911 [PMID:19344127]
ChEMBL	Antimalarial activity against ring stage of chloroquine-resistant Plasmodium falciparum Dd2 infected in erythrocytes assessed as [3H]-hypoxanthine incorporation after 48 hrs by liquid scintillation counting analysis	F	7	pIC50	100	nM	IC50	Bioorg Med Chem Lett (2013) 23: 6114-6117 [PMID:24084158]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum	F	7	pIC50	100	nM	IC50	J Med Chem (2006) 49: 4183-4195 [PMID:16821778]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 3D7 infected in RBC by flow cytometry analysis	F	7	pIC50	100	nM	IC50	Eur J Med Chem (2013) 59: 48-53 [PMID:23202850]
ChEMBL	Inhibitory concentration against Plasmodium falciparum W2 Indochina	F	7	pIC50	99.97	nM	IC50	J Med Chem (1988) 31: 645-650 [PMID:3279208]
ChEMBL	Antimicrobial activity against Plasmodium falciparum at the ring stage by microscopy	F	7	pIC50	99.7	nM	IC50	Antimicrob Agents Chemother (2008) 52: 1040-1045 [PMID:18180357]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in erythrocytes by [3H]-hypoxanthine incorporation assay	F	7	pIC50	99	nM	IC50	Eur J Med Chem (2017) 139: 22-47 [PMID:28800458]
ChEMBL	In vitro antimalarial activity against ring stage of chloroquine-resistant Plasmodium falciparum W2 cultured in medium containing 10% human serum assessed as inhibition of parasite growth after 48 hrs by YOYO-1 dye based flow cytometry	F	7	pIC50	99	nM	IC50	Eur J Med Chem (2013) 62: 590-596 [PMID:23434528]
ChEMBL	In vitro antimalarial activity against chloroquine-resistant Plasmodium falciparum W2	F	7	pIC50	99	nM	IC50	J Med Chem (1998) 41: 4360-4364 [PMID:9784111]
ChEMBL	Antimalarial activity against chloroquine-resistant ring stage Plasmodium falciparum W2 assessed as parasitemia after 48 hrs by flow cytometry	F	7	pIC50	99	nM	IC50	Eur J Med Chem (2014) 84: 425-432 [PMID:25038484]
ChEMBL	Antiplasmodial activity against multidrug-resistant Plasmodium falciparum Dd2 assessed as parasitaemia after 72 hrs using SYBR Green 1 staining by fluorescence method	F	7.01	pIC50	97.4	nM	IC50	J Nat Prod (2011) 74: 2122-2127 [PMID:21977916]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 after 48 hrs	F	7.01	pIC50	97	nM	IC50	Bioorg Med Chem (2010) 18: 8243-8256 [PMID:21044845]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 by FACS-based assay	F	7.01	pIC50	97	nM	IC50	J Med Chem (2011) 54: 3637-3649 [PMID:21500839]
ChEMBL	Antimalarial activity after 48 hrs against Plasmodium falciparum Dd2 by [3H]hypoxanthine uptake	F	7.01	pIC50	96.8	nM	IC50	J Biol Chem (2007) 282: 2494-2504 [PMID:17110371]
ChEMBL	Antimalarial activity after 24 hrs against chloroquine-resistant Plasmodium falciparum 3D7 by [3H]phenylalanine uptake	F	7.02	pIC50	96.5	nM	IC50	J Nat Prod (2001) 64: 1398-1403 [PMID:11720520]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum TM6 infected in human A positive erythrocytes assessed as inhibition of [G-3H]-hypoxanthine uptake after 24 hrs by liquid scintillation counting	F	7.02	pIC50	96.4	nM	IC50	Bioorg Med Chem (2012) 20: 927-932 [PMID:22182577]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum TM6	F	7.02	pIC50	95.1	nM	IC50	J Med Chem (2009) 52: 1828-1844 [PMID:19284751]
ChEMBL	In vitro antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Indochina I	F	7.02	pIC50	95	nM	IC50	J Med Chem (1998) 41: 4918-4926 [PMID:9836608]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum Indochina I by [3H]hypoxanthine uptake	F	7.02	pIC50	95	nM	IC50	J Med Chem (2008) 51: 3466-3479 [PMID:18512900]
ChEMBL	Antimalarial activity against multidrug-resistant Plasmodium falciparum clinical isolates infected assessed as reduction in parasite growth after 35 to 56 hrs by nucleic acid staining based flow cytometry	F	7.02	pIC50	95	nM	IC50	J Med Chem (2019) 62: 2485-2498 [PMID:30715882]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2	F	7.03	pIC50	93	nM	IC50	Antimicrob Agents Chemother (2009) 53: 622-630 [PMID:19015351]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in O-positive human RBC assessed as [3H]-hypoxanthine incorporation after 48 hrs by scintillation counting in presence of BSA	F	7.03	pIC50	93	nM	IC50	ACS Med Chem Lett (2012) 3: 43-47 [PMID:24900369]
ChEMBL	Antimalarial activity after 48 hrs against Plasmodium falciparum 7G8 by [3H]hypoxanthine uptake	F	7.03	pIC50	92.3	nM	IC50	J Biol Chem (2007) 282: 2494-2504 [PMID:17110371]
ChEMBL	Antimalarial activity against Plasmodium falciparum TM4	F	7.04	pIC50	91.3	nM	IC50	J Med Chem (2008) 51: 2170-2177 [PMID:18341274]
ChEMBL	Antimalarial activity against Plasmodium falciparum Dd2 after 72 hrs by DAPI staining-based confocal imaging analysis	F	7.04	pIC50	90.3	nM	IC50	J Med Chem (2019) 62: 622-640 [PMID:30537832]
ChEMBL	Antiparasitic activity against drug-resistant Plasmodium falciparum Dd2 infected in erythrocytes assessed as growth inhibition after 48 hrs by [3H]-hypoxanthine incorporation assay	F	7.05	pIC50	90	nM	IC50	Eur J Med Chem (2017) 127: 22-40 [PMID:28038325]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum Indochina W2 infected human erythrocytes assessed as uptake of PicoGreen after 48 hrs	F	7.05	pIC50	90	nM	IC50	J Nat Prod (2010) 73: 60-66 [PMID:20030365]
ChEMBL	Antimalarial activity against morfloquine-resistant Plasmodium falciparum TM91C235 assessed as [3H]hypoxanthine incorporation	F	7.05	pIC50	90	nM	IC50	Antimicrob Agents Chemother (2009) 53: 1320-1324 [PMID:19171802]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2	F	7.05	pIC50	90	nM	IC50	J Nat Prod (2009) 72: 14-17 [PMID:19161344]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by 96-well format based SYBR green assay	F	7.05	pIC50	90	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antimalarial activity after 96 hrs against azithromycin-resistant Plasmodium falciparum 7G8 by [3H]hypoxanthine uptake	F	7.05	pIC50	89.6	nM	IC50	J Biol Chem (2007) 282: 2494-2504 [PMID:17110371]
ChEMBL	Antiapicomplexan activity against chloroquine-resistant Plasmodium falciparum TM91-C235 assessed as growth inhibition after 72 hrs by MSF assay	F	7.05	pIC50	89	nM	IC50	J Med Chem (2012) 55: 8375-8391 [PMID:22970937]
ChEMBL	Antimicrobial activity against Plasmodium falciparum harboring SVMNT genotype after 72 hrs by SYBR green I assay	F	7.05	pIC50	89	nM	IC50	Antimicrob Agents Chemother (2009) 53: 2042-2051 [PMID:19258269]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive ring stage Plasmodium falciparum 3D7 infected in human red blood cells after 48 hrs	F	7.05	pIC50	89	nM	IC50	J Med Chem (2011) 54: 734-750 [PMID:21207937]
ChEMBL	Antiparasitic activity against chloroquine, pyrimethamine-resistant Plasmodium falciparum K1 in erythrocytes by [3H]hypoxanthine uptake	F	7.05	pIC50	89	nM	IC50	Bioorg Med Chem (2007) 15: 2782-2788 [PMID:17280835]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT 16332 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter	F	7.06	pIC50	88	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL	Antimalarial activity against synchronous ring stage of Plasmodium falciparum Dd2 assessed as parasite growth inhibition incubated for 72 hrs by Griffith assay based fluorescence analysis	F	7.06	pIC50	87.9	nM	IC50	Eur J Med Chem (2021) 221: 113518-113518 [PMID:34058708]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 after 72 hrs	F	7.06	pIC50	87.2	nM	IC50	Antimicrob Agents Chemother (2009) 53: 1320-1324 [PMID:19171802]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum assessed as inhibition of [3H]hypoxanthine incorporation	F	7.06	pIC50	87	nM	IC50	Med Chem Res (2011) 20: 321-332
ChEMBL	Antiparasitic activity against chloroquine-sensitive Plasmodium falciparum K1AM pretreated with 0.1 uM phenobarbitone for 48 hrs by [3H]hypoxanthine incorporation assay	F	7.08	pIC50	84	nM	IC50	Antimicrob Agents Chemother (2008) 52: 1438-1445 [PMID:18195056]
ChEMBL	Antiparasitic activity against Plasmodium falciparum	F	7.08	pIC50	84	nM	IC50	J Nat Prod (2007) 70: 1565-1569 [PMID:17922552]
ChEMBL	Antimalarial activity against Plasmodium falciparum V1/S	F	7.08	pIC50	83.7	nM	IC50	J Med Chem (2008) 51: 2170-2177 [PMID:18341274]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 after 48 hrs by LDH release assay	F	7.08	pIC50	83	nM	IC50	Eur J Med Chem (2018) 143: 866-880 [PMID:29223887]
ChEMBL	Antimalarial activity against Plasmodium falciparum Dd2 after 72 hrs by DAPI staining-based fluorescence microscopic analysis	F	7.08	pIC50	82.3	nM	IC50	Bioorg Med Chem Lett (2017) 27: 4091-4095 [PMID:28774427]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 after 72 hrs by DAPI staining based fluorescence assay	F	7.09	pIC50	82	nM	IC50	J Nat Prod (2018) 81: 1079-1083 [PMID:29533611]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by 96-well format based SYBR green assay	F	7.09	pIC50	82	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum FCR3 Gambia as 24 hrs [3H]hypoxanthine uptake	F	7.09	pIC50	81	nM	IC50	J Nat Prod (2006) 69: 62-67 [PMID:16441070]
ChEMBL	Antimalarial activity against Plasmodium falciparum DD2	F	7.09	pIC50	80.5	nM	IC50	J Med Chem (2008) 51: 2170-2177 [PMID:18341274]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 in human erythrocyte after 72 hrs by SYBR Green I assay	F	7.1	pIC50	80	nM	IC50	J Nat Prod (2015) 78: 413-420 [PMID:25562664]
ChEMBL	Antimalarial activity against Plasmodium falciparum	F	7.1	pIC50	80	nM	IC50	J Nat Prod (2008) 71: 2011-2014 [PMID:19007286]
ChEMBL	In vitro antimalarial activity for Plasmodium falciparum D6	F	7.1	pIC50	80	nM	IC50	Bioorg Med Chem Lett (2004) 14: 1145-1149 [PMID:14980653]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum D6 infected in human RBC assessed as parasite growth inhibition measured as LDH activity after 72 hrs by plate reader analysis	F	7.1	pIC50	<80	nM	IC50	Eur J Med Chem (2015) 98: 160-169 [PMID:26005918]
ChEMBL	Antiplasmodial activity against chloroquinone-sensitive Plasmodium falciparum 3D7	F	7.1	pIC50	80	nM	IC50	Bioorg Med Chem Lett (2008) 18: 396-401 [PMID:17981462]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 after 48 hrs by fluorometric method	F	7.1	pIC50	80	nM	IC50	J Med Chem (2010) 53: 4187-4197 [PMID:20441198]
ChEMBL	Antimalarial activity against chloroquine- and mefloquine-resistant Plasmodium falciparum W2-Mef infected in human O-positive erythrocytes assessed as inhibition of schizonts growth after 48 hrs	F	7.1	pIC50	80	nM	IC50	Bioorg Med Chem (2011) 19: 6604-6607 [PMID:21696970]
ChEMBL	Antiparasitic activity against chloroquine-resistant Plasmodium falciparum R1H6/2 pretreated with 0.1 uM phenobarbitone for 48 hrs and in presence of 5 uM verapamil by [3H]hypoxanthine incorporation assay	F	7.1	pIC50	79	nM	IC50	Antimicrob Agents Chemother (2008) 52: 1438-1445 [PMID:18195056]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 synchronized ring stage parasites infected in erythrocytes assessed as reduction in parasitemia after 48 hrs by Giemsa staining	F	7.11	pIC50	78.1	nM	IC50	Bioorg Med Chem Lett (2009) 19: 3229-3232 [PMID:19435664]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 24 hrs as reduced [3H]phenylalanine uptake	F	7.11	pIC50	78	nM	IC50	J Nat Prod (2002) 65: 1754-1758 [PMID:12502308]
ChEMBL	Antiplasmodial activity against ring-stage of chloroquine-resistant/mefloquine-sensitive Plasmodium falciparum W2 assessed as parasite growth inhibition after 48 hrs by YOYO-1 dye-based flow cytometric method	F	7.11	pIC50	77	nM	IC50	Eur J Med Chem (2018) 143: 150-156 [PMID:29174811]
ChEMBL	Antiplasmodial activity against chloroquine/mefloquine-resistant Plasmodium falciparum SKF58	F	7.12	pIC50	76	nM	IC50	Eur J Med Chem (2015) 94: 56-62 [PMID:25747499]
ChEMBL	Antiplasmodial activity against chloroquine-resistant blood-stage Plasmodium falciparum W2 after 48 hrs by flow cytometric analysis	F	7.12	pIC50	76	nM	IC50	Eur J Med Chem (2012) 54: 887-899 [PMID:22683112]
ChEMBL	Antimicrobial activity against Plasmodium falciparum harboring CVMNT genotype after 72 hrs by SYBR green I assay	F	7.12	pIC50	75	nM	IC50	Antimicrob Agents Chemother (2009) 53: 2042-2051 [PMID:19258269]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2	F	7.12	pIC50	75	nM	IC50	Bioorg Med Chem Lett (2020) 30: 126810-126810 [PMID:31740250]
ChEMBL	Antimalarial activity against Plasmodium falciparum isolates assessed as parasite growth inhibition after 72 hrs by ELISA based histidine-rich protein 2 in vitro drug susceptibility assay	F	7.13	pIC50	73.97	nM	IC50	Antimicrob Agents Chemother (2009) 53: 4040-4042 [PMID:19596882]
ChEMBL	Antimalarial activity against Plasmodium falciparum K1	F	7.13	pIC50	73.9	nM	IC50	J Med Chem (2008) 51: 2170-2177 [PMID:18341274]
ChEMBL	Antimalarial activity against Plasmodium falciparum PH3	F	7.14	pIC50	72	nM	IC50	J Med Chem (2008) 51: 2170-2177 [PMID:18341274]
ChEMBL	Antiplasmodial activity against chloroquine resistant Plasmodium falciparum FcB1/Columbia infected in human erythrocytes preincubated for 24 hrs followed by [3H]-hypoxanthine addition and measured after 24 hrs by liquid scintillation analysis	F	7.14	pIC50	72	nM	IC50	ACS Med Chem Lett (2020) 11: 921-927 [PMID:32435406]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum harboring mutant pfcrt-76 and mutant pfmdr-1-86 gene after 18 hrs by [3H]hypoxanthine incorporation assay	F	7.14	pIC50	72	nM	IC50	Antimicrob Agents Chemother (2009) 53: 5069-5073 [PMID:19770282]
ChEMBL	Antimalarial activity against multidrug-resistant Plasmodium falciparum TM91C235 assessed as inhibition of [3H]hypoxanthine uptake	F	7.15	pIC50	71.2	nM	IC50	Bioorg Med Chem Lett (2011) 21: 786-789 [PMID:21168330]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum 7G8 in human erythrocyte after 72 hrs by SYBR Green I assay	F	7.15	pIC50	71	nM	IC50	J Nat Prod (2015) 78: 413-420 [PMID:25562664]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 assessed as inhibition of parasite proliferation after 96 hrs by SYBR Green I-based fluorescence method	F	7.15	pIC50	70.1	nM	IC50	Eur J Med Chem (2015) 90: 33-44 [PMID:25461309]
ChEMBL	Antimalarial activity against Plasmodium falciparum W2mef schizont form by hoechst 33342-thiazole orange stain based flow cytometry assay	F	7.15	pIC50	70	nM	IC50	Bioorg Med Chem Lett (2009) 19: 5452-5457 [PMID:19666223]
ChEMBL	Antimalarial activity against Plasmodium falciparum T9-96 infected Rhesus positive human erythrocytes by [3H]hypoxanthine uptake	F	7.15	pIC50	70	nM	IC50	J Med Chem (2008) 51: 2845-2852 [PMID:18396855]
ChEMBL	Antiplasmodial activity against asexual intraerythrocytic ring stage of chloroquine-resistant Plasmodium falciparum W2 infected in human O+ erythrocytes assessed as inhibition of parasitic proliferation after 96 hrs by SYBR Green-1 based fluorescence assay	F	7.15	pIC50	70	nM	IC50	Bioorg Med Chem (2015) 23: 5131-5143 [PMID:25684422]
ChEMBL	Antiparasitic activity against chloroquine-sensitive Plasmodium falciparum K1Hf pretreated with 0.1 uM phenobarbitone for 48 hrs by [3H]hypoxanthine incorporation assay	F	7.15	pIC50	70	nM	IC50	Antimicrob Agents Chemother (2008) 52: 1438-1445 [PMID:18195056]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum W2 by flow cytometry	F	7.15	pIC50	70	nM	IC50	J Med Chem (2010) 53: 1951-1963 [PMID:20131843]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human O-positive erythrocytes assessed as decrease in parasitaemia after 72 hrs by NBT dye-based spectrophotometric method	F	7.15	pIC50	70	nM	IC50	Eur J Med Chem (2018) 143: 306-319 [PMID:29197735]
ChEMBL	Antimalarial activity against antifolate-resistant Plasmodium falciparum W2 infected in human erythrocytes after 96 hrs by SYBR Green I-based fluorescence assay	F	7.15	pIC50	70	nM	IC50	J Med Chem (2011) 54: 6624-6633 [PMID:21882831]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 as parasite DNA microfluorimetric assay	F	7.15	pIC50	70	nM	IC50	J Nat Prod (2006) 69: 1379-1383 [PMID:17067146]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum W2	F	7.16	pIC50	69.4	nM	IC50	Bioorg Med Chem Lett (2011) 21: 2055-2058 [PMID:21376591]
ChEMBL	Antiprotozoal activity against erythrocytic stage of chloroquine and pyrimethamine resistant Plasmodium falciparum K1 assessed as reduction in [3H]-hypoxanthine incorporation preincubated for 24 hrs followed by [3H]-hypoxanthine addition measured after 24 hrs by scintillation counting method	F	7.16	pIC50	69	nM	IC50	Eur J Med Chem (2018) 156: 53-60 [PMID:30006174]
ChEMBL	Antimicrobial activity against chloroquine-resistant Plasmodium falciparum W2	F	7.16	pIC50	69	nM	IC50	Bioorg Med Chem Lett (2010) 20: 942-944 [PMID:20045640]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 after 48 hrs by FACS analysis in presence of 10 % human serum	F	7.16	pIC50	69	nM	IC50	Bioorg Med Chem (2010) 18: 8243-8256 [PMID:21044845]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 by FACS-based assay	F	7.16	pIC50	69	nM	IC50	J Med Chem (2011) 54: 3637-3649 [PMID:21500839]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay	F	7.17	pIC50	68	nM	IC50	Nat Chem Biol (2008) 4: 347-356 [PMID:18454143]
ChEMBL	Antimalarial activity against Plasmodium falciparum TM90C2b harbouring Pf-crt, Pf-mdrl,Pfd-hfr, Pf-cytbQ0 mutated loci assessed as inhibition of parasite growth incubated for 48 hrs by [3H]hypoxanthine incorporation assay based liquid scintillation counting method	F	7.17	pIC50	67	nM	IC50	J Med Chem (2021) 64: 12582-12602 [PMID:34437804]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum W2 infected in human erythrocytes	F	7.17	pIC50	66.9	nM	IC50	Bioorg Med Chem Lett (2012) 22: 2976-2979 [PMID:22414614]
ChEMBL	Antiplasmodial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum V1/S	F	7.19	pIC50	65	nM	IC50	Bioorg Med Chem Lett (2009) 19: 3229-3232 [PMID:19435664]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT 10354 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter	F	7.19	pIC50	65	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 after 48 hrs by FACS analysis	F	7.19	pIC50	64.7	nM	IC50	J Med Chem (2014) 57: 4916-4923 [PMID:24824551]
ChEMBL	Antimalarial activity after 96 hrs against Plasmodium falciparum Dd2 by [3H]hypoxanthine uptake	F	7.19	pIC50	64.2	nM	IC50	J Biol Chem (2007) 282: 2494-2504 [PMID:17110371]
ChEMBL	Antimalarial activity against Plasmodium falciparum FCR3 after 48 hrs by parasite lactate dehydrogenase assay	F	7.19	pIC50	64	nM	IC50	Eur J Med Chem (2014) 87: 197-202 [PMID:25255435]
ChEMBL	Antimalarial activity against trophozoites stage of Plasmodium falciparum assessed as parasites growth inhibition using giemsa staining after 24 to 56 hrs by microscopic analysis in presence of 10% human serum	F	7.2	pIC50	63.2	nM	IC50	Antimicrob Agents Chemother (2011) 55: 961-966 [PMID:21135175]
ChEMBL	Antimalarial activity against Plasmodium falciparum ring stage forms after 48 hrs	F	7.2	pIC50	63	nM	IC50	Bioorg Med Chem (2017) 25: 4064-4075 [PMID:28634040]
ChEMBL	Antimalarial activity against Plasmodium falciparum	F	7.2	pIC50	63	nM	IC50	Bioorg Med Chem (2017) 25: 5396-5406 [PMID:28789907]
ChEMBL	Gametocytocidal activity against transgenic GFP-fused Plasmodium falciparum NF54 early stage gametocytes after 72 hrs by Mitotracker Red CMH2XRos staining based confocal microscopic method	F	7.2	pIC50	63	nM	IC50	J Med Chem (2017) 60: 6036-6044 [PMID:28653845]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum HB3 by pico-green dye based fluorescence assay	F	7.2	pIC50	63	nM	IC50	J Nat Prod (2018) 81: 211-215 [PMID:29327931]
ChEMBL	Antimalarial activity against Plasmodium falciparum W2	F	7.21	pIC50	62	nM	IC50	Medchemcomm (2011) 2: 1201-1207
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 infected in erythrocytes assessed as parasite growth inhibition after 72 hrs by SYBR green 1 dye-based fluorometric analysis	F	7.21	pIC50	62	nM	IC50	J Med Chem (2013) 56: 7911-7924 [PMID:24073986]
ChEMBL	Antimalarial activity against Plasmodium falciparum after 48 hrs	F	7.21	pIC50	62	nM	IC50	Eur J Med Chem (2016) 112: 270-279 [PMID:26900659]
ChEMBL	Antimicrobial activity against chloroquine-resistant Plasmodium falciparum HB3 by ELISA	F	7.21	pIC50	61.8	nM	IC50	Antimicrob Agents Chemother (2010) 54: 1200-1206 [PMID:20065051]
ChEMBL	Antimalarial activity against Plasmodium falciparum Dd2	F	7.21	pIC50	61.8	nM	IC50	J Med Chem (2006) 49: 4707-4714 [PMID:16854077]
ChEMBL	Antimalarial activity against Plasmodium falciparum trophozoites infected in human erythrocytes assessed as growth inhibition by microscopic analysis using giemsa staining	F	7.22	pIC50	60.6	nM	IC50	Antimicrob Agents Chemother (2010) 54: 5146-5150 [PMID:20876370]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as inhibition of parasite growth incubated for 48 hrs by SYBR green 1 dye based fluorescence assay	F	7.22	pIC50	60	nM	IC50	Eur J Med Chem (2016) 121: 640-648 [PMID:27318984]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FcB1/Colombia infected in human red blood cells assessed as reduction in [3H]-hypoxanthine incorporation measured after 24 hrs liquid scintillation counting method	F	7.22	pIC50	60	nM	IC50	J Nat Prod (2021) 84: 1409-1413 [PMID:33825474]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2	F	7.22	pIC50	60	nM	IC50	J Nat Prod (2006) 69: 826-828 [PMID:16724851]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum Nigeria	F	7.22	pIC50	60	nM	IC50	Antimicrob Agents Chemother (2007) 51: 1463-1472 [PMID:17242150]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 after 48 hrs by flow cytometry	F	7.22	pIC50	60	nM	IC50	Bioorg Med Chem Lett (2014) 24: 756-759 [PMID:24424135]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum F32 by [3H]hypoxanthine uptake	F	7.22	pIC50	60	nM	IC50	J Nat Prod (2008) 71: 1189-1192 [PMID:18512987]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum Dd2	F	7.23	pIC50	59.3	nM	IC50	J Med Chem (2009) 52: 1828-1844 [PMID:19284751]
ChEMBL	Antiplasmodial activity against chloroquine-resistant ring stage Plasmodium falciparum W2 assessed as parasitemia after 48 hrs by flow cytometry	F	7.23	pIC50	59.09	nM	IC50	Eur J Med Chem (2014) 71: 128-134 [PMID:24287561]
ChEMBL	Antiplasmodial activity against CQ-resistant Plasmodium falciparum W2 assessed as inhibition of parasite growth	F	7.23	pIC50	59	nM	IC50	Bioorg Med Chem (2015) 23: 5098-5119 [PMID:25593097]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 after 48 hrs by FACS	F	7.23	pIC50	59	nM	IC50	Eur J Med Chem (2007) 42: 735-742 [PMID:17321641]
ChEMBL	Antiplasmodial activity chloroquine-resistant Plasmodium falciparum W2 using YOYO-1 staining after 48 hrs by FACS analysis	F	7.23	pIC50	59	nM	IC50	Bioorg Med Chem (2013) 21: 4904-4913 [PMID:23896611]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 after 24 hrs by [3H]hypoxanthine incorporation assay	F	7.23	pIC50	59	nM	IC50	ACS Med Chem Lett (2013) 4: 1198-1202 [PMID:24900630]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum harboring mutant pfcrt-76 gene after 18 hrs by [3H]hypoxanthine incorporation assay	F	7.24	pIC50	57	nM	IC50	Antimicrob Agents Chemother (2009) 53: 5069-5073 [PMID:19770282]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 ring forms infected in human RBC using compound encapsulated in to immunoliposome targeted to GPA incubated for 15 mins followed by compound removal and further incubation for 48 hrs by [3H]-hypoxanthine incorporation assay	F	7.25	pIC50	56.3	nM	IC50	Eur J Med Chem (2018) 152: 489-514 [PMID:29754074]
ChEMBL	Antimalarial activity against Plasmodium falciparum	F	7.25	pIC50	56	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL	Antimicrobial activity against fast-growing synchronous Plasmodium falciparum by microscopy	F	7.25	pIC50	55.9	nM	IC50	Antimicrob Agents Chemother (2008) 52: 1040-1045 [PMID:18180357]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum in human red blood cells after 4 hrs	F	7.26	pIC50	55	nM	IC50	J Med Chem (2007) 50: 6104-6115 [PMID:17990865]
ChEMBL	Antimalarial activity against synchronized ring stage CQ-resistant Plasmodium falciparum W2 infected in human erythrocytes incubated for 24 hrs followed by compound washout and subsequent compound addition and measured after 48 hrs by YOYO-1 probe-based flow cytometry	F	7.26	pIC50	55	nM	IC50	J Med Chem (2019) 62: 5562-5578 [PMID:31062592]
ChEMBL	Antiplasmodial activity against artemisinin-resistant Plasmodium falciparum Cam 3.1 R539 assessed as growth inhibition by SYBER green 1 dye based fluorescence assay	F	7.26	pIC50	54.5	nM	IC50	Eur J Med Chem (2021) 224: 113685-113685 [PMID:34303874]
ChEMBL	Antimalarial activity against CQ-sensitive Plasmodium falciparum 3D7 incubated for 72 hrs by SYBR Green-1 dye based fluorescence assay	F	7.27	pIC50	54	nM	IC50	ACS Med Chem Lett (2019) 10: 966-971 [PMID:31223456]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT 10336 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter	F	7.27	pIC50	54	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum harboring mutant pfcrt-76 and wild type pfmdr-1-86 gene after 18 hrs by [3H]hypoxanthine incorporation assay	F	7.27	pIC50	54	nM	IC50	Antimicrob Agents Chemother (2009) 53: 5069-5073 [PMID:19770282]
ChEMBL	In vitro growth inhibition of Plasmodium falciparum D6	F	7.27	pIC50	54	nM	IC50	J Med Chem (2001) 44: 1658-1665 [PMID:11356101]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 infected in RBC assessed as plasmodial LDH activity after 72 hrs	F	7.28	pIC50	53	nM	IC50	Bioorg Med Chem Lett (2013) 23: 112-116 [PMID:23218718]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human RBC assessed as reduction in HRP2 level by ELISA	F	7.28	pIC50	53	nM	IC50	Eur J Med Chem (2021) 215: 113271-113271 [PMID:33596489]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D10 harboring 7G8 pfcrt allele infected in erythrocytes assessed as [3H]hypoxanthine incorporation	F	7.28	pIC50	52.7	nM	IC50	Antimicrob Agents Chemother (2009) 53: 1362-1366 [PMID:19188388]
ChEMBL	Antiplasmodial activity against CQ-resistant Plasmodium falciparum 3D7 blood stage form after 48 hrs by FACSort cytometry	F	7.28	pIC50	52.45	nM	IC50	J Med Chem (2013) 56: 556-567 [PMID:23273038]
ChEMBL	Antimalarial activity after 48 hrs against chloroquine-resistant Plasmodium falciparum W2 by [3H]hypoxanthine uptake	F	7.28	pIC50	52	nM	IC50	Bioorg Med Chem Lett (2009) 19: 3476-3480 [PMID:19467600]
ChEMBL	Antiplasmodial activity against ring stage Plasmodium falciparum W2 infected in human RBC after 48 hrs by FACS analysis	F	7.28	pIC50	52	nM	IC50	J Med Chem (2013) 56: 4811-4815 [PMID:23701465]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 infected in human RBCs after 72 hrs by SYBR Green based parasite proliferation assay	F	7.28	pIC50	51.9	nM	IC50	Bioorg Med Chem Lett (2016) 26: 854-857 [PMID:26748697]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 3D7 by [3H]phenylalanine uptake	F	7.29	pIC50	51.2	nM	IC50	J Nat Prod (2004) 67: 631-637 [PMID:15104493]
ChEMBL	Antiplasmodial activity against atovaquone-resistant Plasmodium falciparum FCR3	F	7.29	pIC50	51.1	nM	IC50	Bioorg Med Chem Lett (2009) 19: 3229-3232 [PMID:19435664]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 late forms infected in human RBC using compound encapsulated in to immunoliposome targeted to GPA incubated for 15 mins followed by compound removal and further incubation for 48 hrs by [3H]-hypoxanthine incorporation assay	F	7.29	pIC50	51.1	nM	IC50	Eur J Med Chem (2018) 152: 489-514 [PMID:29754074]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum IMT10500 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay	F	7.29	pIC50	51	nM	IC50	J Med Chem (2009) 52: 7954-7957 [PMID:19908867]
ChEMBL	Antiplasmodial activity against multidrug-resistant Plasmodium falciparum TM90C2B by SYBR Green 1-based fluorescence assay	F	7.29	pIC50	51	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3597-3604 [PMID:20547797]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT 10500 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter	F	7.29	pIC50	51	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL	Antimalarial activity after 48 hrs against atovaquone-resistant Plasmodium falciparum FCR3 by [3H]hypoxanthine uptake	F	7.29	pIC50	51	nM	IC50	Bioorg Med Chem Lett (2009) 19: 3476-3480 [PMID:19467600]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum W2	F	7.3	pIC50	50.5	nM	IC50	Eur J Med Chem (2015) 93: 373-380 [PMID:25721025]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 after 72 hrs by SYBR Green I fluorescence based method	F	7.3	pIC50	50.5	nM	IC50	Eur J Med Chem (2010) 45: 4990-4996 [PMID:20805010]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 3D7 ring stage forms infected in human non-washed human RBC containing full drug dosages by [3H]-hypoxanthine incorporation assay	F	7.3	pIC50	50.4	nM	IC50	Eur J Med Chem (2018) 152: 489-514 [PMID:29754074]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D6 after 48 hrs	F	7.3	pIC50	50	nM	IC50	J Nat Prod (2005) 68: 1297-1299 [PMID:16124784]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D10 by pLDH assay	F	7.3	pIC50	50	nM	IC50	J Med Chem (2006) 49: 7088-7094 [PMID:17125261]
ChEMBL	Antimalarial activity against Plasmodium falciparum D6 in parasite LDH assay	F	7.3	pIC50	50	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1446-1449 [PMID:18248990]
ChEMBL	Antiplasmodial activity against erythrocytic stage of chloroquine-resistant Plasmodium falciparum IndoChina W2 infected in human A positive RBC after 48 hrs by [3H]hypoxanthine incorporation assay	F	7.3	pIC50	50	nM	IC50	ACS Med Chem Lett (2013) 4: 637-641 [PMID:24900723]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 infected in African green monkey (Cercopithecus aethiops) Vero cells assessed as parasite LDH activity after 72 hrs	F	7.3	pIC50	50	nM	IC50	Bioorg Med Chem (2009) 17: 7775-7782 [PMID:19833520]
ChEMBL	Antimalarial activity after 72 hrs against chloroquine-sensitive Plasmodium falciparum D6 by Malstat LDH activity	F	7.3	pIC50	50	nM	IC50	Bioorg Med Chem (2009) 17: 5632-5638 [PMID:19574054]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum FcB1/Columbia infected in human erythrocytes assessed as reduction in [3H]-hypoxanthine incorporation pretreated for 24 hrs followed by [3H]-hypoxanthine addition measured after 24 hrs by liquid scintillation counting method	F	7.3	pIC50	50	nM	IC50	J Nat Prod (2020) 83: 1207-1216 [PMID:32091210]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 after 72 hr by LDJH assay	F	7.3	pIC50	50	nM	IC50	Med Chem Res (2011) 20: 401-407
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 in erythrocytes after 72 hrs by LDH activity	F	7.3	pIC50	50	nM	IC50	Bioorg Med Chem Lett (2009) 19: 1675-1677 [PMID:19231182]
ChEMBL	Antiplasmodial activity against multidrug-resistant Plasmodium falciparum C235 after 72 hrs by MSF assay	F	7.3	pIC50	50	nM	IC50	Eur J Med Chem (2018) 152: 489-514 [PMID:29754074]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum W2 infected in human erythrocytes after 48 hrs by [3H]-hypoxanthine incorporation assay	F	7.31	pIC50	49	nM	IC50	Bioorg Med Chem (2015) 23: 5419-5432 [PMID:26264839]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum W2 infected in human erythrocytes after 48 hrs by Geimsa staining	F	7.31	pIC50	49	nM	IC50	Bioorg Med Chem Lett (2012) 22: 5046-5050 [PMID:22749280]
ChEMBL	Antiplasmodial activity against multidrug-resistant asexual ring stage Plasmodium falciparum Dd2 infected in human erythrocytes by [3H]-hypoxanthine incorporation assay	F	7.31	pIC50	49	nM	IC50	Eur J Med Chem (2018) 158: 801-813 [PMID:30245402]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT Guy assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter	F	7.31	pIC50	49	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 106/1	F	7.31	pIC50	48.52	nM	IC50	Antimicrob Agents Chemother (2007) 51: 2265-2267 [PMID:17404003]
ChEMBL	Antimalarial activity after 72 hrs against chloroquine-resistant transporter 106/1'76N mutant Plasmodium falciparum infected human erythrocytes by SYBR green assay	F	7.32	pIC50	48	nM	IC50	Antimicrob Agents Chemother (2007) 51: 4133-4140 [PMID:17846138]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D6 infected in human RBC assessed as decrease in parasite viability after 72 hrs by LDH assay	F	7.32	pIC50	48	nM	IC50	Eur J Med Chem (2017) 126: 675-686 [PMID:27936446]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D10 infected in human RBCs after 72 hrs by parasite lactate dehydrogenase assay	F	7.32	pIC50	48	nM	IC50	J Med Chem (2012) 55: 10387-10404 [PMID:23145816]
ChEMBL	Antimicrobial activity against chloroquine-sensitive Plasmodium falciparum D6 by ELISA	F	7.32	pIC50	47.8	nM	IC50	Antimicrob Agents Chemother (2010) 54: 1200-1206 [PMID:20065051]
ChEMBL	Antimalarial activity against asexual erythrocyte stage of chloroquine-sensitive Plasmodium falciparum D10 by parasite lactate dehydrogenase assay	F	7.33	pIC50	46.64	nM	IC50	Bioorg Med Chem (2012) 20: 4701-4709 [PMID:22750008]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 infected in human RBC after 72 hrs by DAPI staining based confocal microscopic method	F	7.34	pIC50	46	nM	IC50	J Nat Prod (2017) 80: 114-125 [PMID:28001067]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum F32 after 48 hrs	F	7.34	pIC50	46	nM	IC50	Eur J Med Chem (2010) 45: 2854-2859 [PMID:20362359]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 assessed as reduction in parasite growth incubated for 72 hrs by DAPI staining based fluorescence assay	F	7.34	pIC50	46	nM	IC50	J Nat Prod (2020) 83: 316-322 [PMID:32067457]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum FCR-3 infected in human erythrocytes measured after 72 hrs by malstat reagent based LDH release assay	F	7.34	pIC50	46	nM	IC50	ACS Med Chem Lett (2018) 9: 980-985 [PMID:30344903]
ChEMBL	Antimalarial activity against Plasmodium falciparum Dd2 infected in human A positive erythrocytes assessed as inhibition of [G-3H]-hypoxanthine uptake after 24 hrs by liquid scintillation counting	F	7.34	pIC50	45.8	nM	IC50	Bioorg Med Chem (2012) 20: 927-932 [PMID:22182577]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 assessed as inhibition of parasite growth after 72 hrs by DAPI staining-based confocal microscopic analysis	F	7.34	pIC50	45.5	nM	IC50	J Nat Prod (2015) 78: 2932-2939 [PMID:26651537]
ChEMBL	Antimalarial activity as 2nd generation ring-stage chloroquine-resistant Plasmodium falciparum W2 after 48 hrs by flow cytometry	F	7.34	pIC50	45.2	nM	IC50	Antimicrob Agents Chemother (2007) 51: 3485-3490 [PMID:17698630]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D10 infected in erythrocytes assessed as [3H]hypoxanthine incorporation	F	7.34	pIC50	45.2	nM	IC50	Antimicrob Agents Chemother (2009) 53: 1362-1366 [PMID:19188388]
ChEMBL	Antimalarial activity against Plasmodium falciparum infected in human erythrocytes assessed as growth inhibition by microscopic analysis using giemsa staining	F	7.36	pIC50	43.6	nM	IC50	Antimicrob Agents Chemother (2010) 54: 5146-5150 [PMID:20876370]
ChEMBL	Antimalarial activity against multidrug-resistant Plasmodium falciparum TM91C235 assessed as inhibition of [3H]hypoxanthine incorporation after 96 hrs by microtiter plate scintillation counting	F	7.37	pIC50	42.4	nM	IC50	Bioorg Med Chem (2011) 19: 1692-1701 [PMID:21316974]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D6 by LDH release assay	F	7.38	pIC50	42	nM	IC50	Bioorg Med Chem Lett (2010) 20: 322-325 [PMID:19910192]
ChEMBL	Antimalarial activity against Plasmodium falciparum D6 assessed as plasmodial LDH activity after 72 hrs	F	7.38	pIC50	42	nM	IC50	Eur J Med Chem (2011) 46: 2816-2827 [PMID:21530018]
ChEMBL	Antimalarial activity against drug-resistant Plasmodium falciparum Dd2	F	7.38	pIC50	41.7	nM	IC50	Bioorg Med Chem Lett (2020) 30: 127037-127037 [PMID:32081449]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum D6 infected in RBCs by parasitic LDH release assay	F	7.38	pIC50	41.6	nM	IC50	Bioorg Med Chem (2009) 17: 7949-7957 [PMID:19879765]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum	F	7.38	pIC50	41.6	nM	IC50	Antimicrob Agents Chemother (2008) 52: 237-243 [PMID:17967917]
ChEMBL	Antimalarial activity after 96hrs against Plasmodium falciparum 7G8 by [3H]hypoxanthine uptake	F	7.38	pIC50	41.6	nM	IC50	J Biol Chem (2007) 282: 2494-2504 [PMID:17110371]
ChEMBL	Antimalarial activity against Plasmodium falciparum HB3	F	7.39	pIC50	41	nM	IC50	J Med Chem (2011) 54: 4581-4589 [PMID:21644541]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7	F	7.39	pIC50	41	nM	IC50	J Nat Prod (2017) 80: 134-140 [PMID:28055207]
ChEMBL	Antimalarial activity against Plasmodium falciparum HB3 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter	F	7.39	pIC50	41	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum clinical isolate after 18 hrs by [3H]hypoxanthine incorporation assay	F	7.39	pIC50	41	nM	IC50	Antimicrob Agents Chemother (2009) 53: 5069-5073 [PMID:19770282]
ChEMBL	Antiplasmodial activity after 72 hrs against chloroquine-sensitive Plasmodium falciparum FCA10/GHA as LDH activity	F	7.39	pIC50	41	nM	IC50	J Nat Prod (2002) 65: 789-793 [PMID:12027771]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum F32-Tanzania after 24 hrs	F	7.4	pIC50	40	nM	IC50	Bioorg Med Chem (2010) 18: 4694-4701 [PMID:20627737]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human O+ erythrocytes after 72 hrs by SYBR Green-1 fluorescence based assay	F	7.4	pIC50	40	nM	IC50	Eur J Med Chem (2010) 45: 5292-5301 [PMID:20863599]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D6 infected in red blood cells after 72 hrs by Malstat reagent based LDH assay	F	7.4	pIC50	40	nM	IC50	Eur J Med Chem (2017) 131: 126-140 [PMID:28315598]
ChEMBL	Antiplasmodial activity against synchronized ring stage of chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes after 48 hrs by SYBR Green 1 dye based fluorescence assay	F	7.4	pIC50	40	nM	IC50	Eur J Med Chem (2018) 155: 623-638 [PMID:29929118]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 48 hrs	F	7.4	pIC50	40	nM	IC50	Bioorg Med Chem (2010) 18: 6006-6011 [PMID:20634081]
ChEMBL	In vitro inhibitory concentration against Plasmodium falciparum F32	F	7.4	pIC50	40	nM	IC50	Bioorg Med Chem Lett (2003) 13: 2769-2772 [PMID:12873511]
ChEMBL	Growth inhibition of chloroquine-sensitive Plasmodium falciparum D10	F	7.4	pIC50	40	nM	IC50	Bioorg Med Chem Lett (2001) 11: 2075-2077 [PMID:11514142]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 by [3H]hypoxanthine uptake	F	7.4	pIC50	40	nM	IC50	Bioorg Med Chem Lett (2008) 18: 5294-5298 [PMID:18774709]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D6 infected in red blood cells after 72 hrs by parasitic LDH assay	F	7.4	pIC50	40	nM	IC50	ACS Med Chem Lett (2012) 3: 555-559 [PMID:24900509]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum F-32 Tanzania assessed as inhibition of parasitemia after 3 days	F	7.4	pIC50	40	nM	IC50	Bioorg Med Chem (2012) 20: 5464-5472 [PMID:22910226]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6	F	7.4	pIC50	40	nM	IC50	Eur J Med Chem (2019) 166: 206-223 [PMID:30711831]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D10	F	7.4	pIC50	40	nM	IC50	Eur J Med Chem (2019) 161: 101-117 [PMID:30343191]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D10 after 24 hrs by [G-3H]-hypoxanthine incorporation assay	F	7.4	pIC50	40	nM	IC50	Eur J Med Chem (2017) 139: 22-47 [PMID:28800458]
ChEMBL	Antiplasmodial activity against erythrocyte form of chloroquine-sensitive Plasmodium falciparum D10 by parasite lactate dehydrogenase assay	F	7.4	pIC50	40	nM	IC50	Bioorg Med Chem Lett (2013) 23: 318-322 [PMID:23195733]
ChEMBL	Antimalarial activity against chloroquine-susceptible Plasmodium falciparum D10 asexual erythrocyte forms after 48 hrs by parasite LDH assay	F	7.4	pIC50	40	nM	IC50	Bioorg Med Chem (2013) 21: 269-277 [PMID:23168082]
ChEMBL	Antimalarial activity against ring stage chloroquine-sensitive Plasmodium falciparum 3D7 infected in human O positive erythrocytes after 48 hrs by SYBR green 1 fluorescence assay	F	7.4	pIC50	40	nM	IC50	J Med Chem (2012) 55: 297-311 [PMID:22098429]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 infected in human red blood cells assessed as reduction in parasitic LDH activity by Malstat reagent based spectrophotometric method	F	7.4	pIC50	40	nM	IC50	Eur J Med Chem (2017) 139: 22-47 [PMID:28800458]
ChEMBL	Antimalarial activity against chloroquine-sensitive ring stage plasmodium falciparum 3D7 infected in erythrocytes assessed as [3H]hypoxanthine incorporation after 48 hrs by liquid scintillation counting	F	7.4	pIC50	40	nM	IC50	Bioorg Med Chem (2012) 20: 7167-7174 [PMID:23117170]
ChEMBL	Antimalarial activity against Plasmodium falciparum 106/1 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter	F	7.41	pIC50	39	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL	Inhibition of Plasmodium falciparum GP1	F	7.41	pIC50	39	nM	IC50	J Med Chem (2000) 43: 2646-2654 [PMID:10893302]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT 9881 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter	F	7.41	pIC50	39	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D10 by [3H]hypoxanthine incorporation	F	7.41	pIC50	39	nM	IC50	J Med Chem (2008) 51: 1333-1343 [PMID:18278859]
ChEMBL	In vitro antiplasmodial activity against Plasmodium falciparum D10	F	7.42	pIC50	38	nM	IC50	J Med Chem (2000) 43: 283-291 [PMID:10649984]
ChEMBL	Antimicrobial activity against chloroquine-sensitive Plasmodium falciparum D10	F	7.42	pIC50	38	nM	IC50	Bioorg Med Chem Lett (2010) 20: 942-944 [PMID:20045640]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 measured after 72 hrs by SYBR Green 1 dye based fluorescence assay	F	7.42	pIC50	38	nM	IC50	J Med Chem (2019) 62: 3503-3512 [PMID:30856324]
ChEMBL	Antimicrobial activity against slow-growing synchronous Plasmodium falciparum by microscopy	F	7.43	pIC50	36.9	nM	IC50	Antimicrob Agents Chemother (2008) 52: 1040-1045 [PMID:18180357]
ChEMBL	Antimalarial activity against chloroquine-resistant ring stage Plasmodium falciparum W2 assessed as parasitemia after 48 hrs by flow cytometry	F	7.44	pIC50	36.37	nM	IC50	Eur J Med Chem (2014) 84: 566-573 [PMID:25062007]
ChEMBL	Antiplasmodial activity against atovaquone-resistant Plasmodium falciparum FCR3 after 48 hrs by FACS analysis	F	7.44	pIC50	36.2	nM	IC50	J Med Chem (2014) 57: 4916-4923 [PMID:24824551]
ChEMBL	Antimalarial activity against asexual erythrocyte stages of chloroquine-sensitive Plasmodium falciparum D10	F	7.44	pIC50	36.11	nM	IC50	Eur J Med Chem (2012) 55: 335-345 [PMID:22889556]
ChEMBL	Antimicrobial activity against Plasmodium falciparum trophozoites by microscopy treated during ring stage	F	7.44	pIC50	36.1	nM	IC50	Antimicrob Agents Chemother (2008) 52: 1040-1045 [PMID:18180357]
ChEMBL	Anti-plasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 infected in human erythrocytes after 50 hrs by SYBR green dye based fluorescence assay	F	7.44	pIC50	36	nM	IC50	Eur J Med Chem (2017) 134: 242-257 [PMID:28419927]
ChEMBL	In vitro inhibition of parasite development of Plasmodium falciparum W2 in human erythrocytes	F	7.44	pIC50	36	nM	IC50	Bioorg Med Chem Lett (2002) 12: 1351-1355 [PMID:11992775]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7A infected in red blood cells assessed as inhibition of parasite growth after 24 hrs by [3H]hypoxanthine incorporation assay	F	7.44	pIC50	36	nM	IC50	J Med Chem (2015) 58: 4573-4580 [PMID:25906200]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum F32 assessed as suppression of parasitemia after 4 hrs by Giemsa staining	F	7.44	pIC50	36	nM	IC50	Antimicrob Agents Chemother (2009) 53: 4393-4398 [PMID:19667291]
ChEMBL	Antimalarial activity against drug-sensitive Plasmodium falciparum 3D7 assessed as [3H]hypoxanthine incorporation by scintillation counting	F	7.46	pIC50	35	nM	IC50	J Med Chem (2010) 53: 699-714 [PMID:20014857]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D10 by two-fold dilution technique	F	7.46	pIC50	35	nM	IC50	Eur J Med Chem (2013) 66: 314-323 [PMID:23811093]
ChEMBL	In vitro antimalarial activity against chloroquine-sensitive Plasmodium falciparum D10	F	7.46	pIC50	35	nM	IC50	J Med Chem (2004) 47: 2926-2934 [PMID:15139771]
ChEMBL	Antimalarial activity against Plasmodium falciparum at the ring stage infected in human erythrocytes assessed as growth inhibition by microscopic analysis using giemsa staining	F	7.46	pIC50	34.6	nM	IC50	Antimicrob Agents Chemother (2010) 54: 5146-5150 [PMID:20876370]
ChEMBL	Antimalarial activity against ring stage Plasmodium falciparum 3D7 incubated for 48 hrs by Hoechst 33342 staining based fluorescence based assay	F	7.47	pIC50	34	nM	IC50	Eur J Med Chem (2019) 184: 111755-111755 [PMID:31627059]
ChEMBL	Antimalarial activity against Plasmodium falciparum clinical isolates measured after 72 hrs by SYBR green dye based fluorescence assay	F	7.47	pIC50	34	nM	IC50	J Med Chem (2020) 63: 6179-6202 [PMID:32390431]
ChEMBL	Antimalarial activity against Plasmodium falciparum PH3 infected in human A positive erythrocytes assessed as inhibition of [G-3H]-hypoxanthine uptake after 24 hrs by liquid scintillation counting	F	7.48	pIC50	33.4	nM	IC50	Bioorg Med Chem (2012) 20: 927-932 [PMID:22182577]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D10	F	7.48	pIC50	33	nM	IC50	Eur J Med Chem (2009) 44: 3091-3113 [PMID:19361896]
ChEMBL	Antiparasitic activity against chloroquine-sensitive Plasmodium falciparum K1Hf in presence of 5 uM verapamil by [3H]hypoxanthine incorporation assay	F	7.49	pIC50	32	nM	IC50	Antimicrob Agents Chemother (2008) 52: 1438-1445 [PMID:18195056]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as [3H]hypoxanthine incorporation after 48 hrs	F	7.49	pIC50	32	nM	IC50	Bioorg Med Chem (2012) 20: 4856-4861 [PMID:22766218]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FCB1-R/Colombia by [3H]hypoxanthine uptake	F	7.49	pIC50	32	nM	IC50	J Nat Prod (2002) 65: 1381-1386 [PMID:12398531]
ChEMBL	Antiparasitic activity against chloroquine-sensitive Plasmodium falciparum K1Hf by [3H]hypoxanthine incorporation assay	F	7.49	pIC50	32	nM	IC50	Antimicrob Agents Chemother (2008) 52: 1438-1445 [PMID:18195056]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D10 incubated for 72 hrs by spectrophotometry based parasite lactate dehydrogenase assay	F	7.5	pIC50	31.92	nM	IC50	ACS Med Chem Lett (2021) 12: 1077-1085 [PMID:34267877]
ChEMBL	Antimalarial activity against asexual stage of Plasmodium falciparum 3D7 after 72 hrs by image-based HTS assay	F	7.51	pIC50	31	nM	IC50	J Med Chem (2013) 56: 7727-7740 [PMID:23927763]
ChEMBL	Antiparasitic activity against chloroquine-resistant Plasmodium falciparum R1H6/2 in presence of 5 uM verapamil by [3H]hypoxanthine incorporation assay	F	7.51	pIC50	31	nM	IC50	Antimicrob Agents Chemother (2008) 52: 1438-1445 [PMID:18195056]
ChEMBL	Antiparasitic activity against chloroquine-sensitive Plasmodium falciparum K1Hf pretreated with 0.1 uM phenobarbitone for 48 hrs and in presence of 5 uM verapamil by [3H]hypoxanthine incorporation assay	F	7.51	pIC50	31	nM	IC50	Antimicrob Agents Chemother (2008) 52: 1438-1445 [PMID:18195056]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum PH3	F	7.51	pIC50	30.8	nM	IC50	J Med Chem (2009) 52: 1828-1844 [PMID:19284751]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D10	F	7.51	pIC50	30.6	nM	IC50	Bioorg Med Chem Lett (2011) 21: 2882-2886 [PMID:21489789]
ChEMBL	Antimalarial activity against ring stage of Plasmodium falciparum assessed as parasites growth inhibition using giemsa staining after 24 to 56 hrs by microscopic analysis in presence of 10% human serum	F	7.52	pIC50	30.2	nM	IC50	Antimicrob Agents Chemother (2011) 55: 961-966 [PMID:21135175]
ChEMBL	Antimalarial activity against Plasmodium falciparum assessed as parasites growth inhibition using giemsa staining after 24 to 56 hrs by microscopic analysis in presence of 10% human serum	F	7.52	pIC50	30.2	nM	IC50	Antimicrob Agents Chemother (2011) 55: 961-966 [PMID:21135175]
ChEMBL	Growth inhibition of CQ-sensitive GFP-fused Plasmodium falciparum D10 after 90 hrs by ethidium bromide staining based flow cytometry	F	7.52	pIC50	30	nM	IC50	Eur J Med Chem (2018) 148: 507-518 [PMID:29269132]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 48 to 72 hrs by SYBR green-1 assay	F	7.52	pIC50	30	nM	IC50	Bioorg Med Chem Lett (2013) 23: 6167-6171 [PMID:24080459]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 3D7 ring stage cells assessed as reduction parasitemia by Malstat assay	F	7.52	pIC50	30	nM	IC50	Bioorg Med Chem (2012) 20: 5277-5289 [PMID:22858300]
ChEMBL	Antiplasmodial activity against chloroquine/antifolate-sensitive Plasmodium falciparum TM4 infected in human RBC incubated for 18 to 20 hrs by microdilution radioisotope method	F	7.52	pIC50	30	nM	IC50	J Nat Prod (2016) 79: 978-983 [PMID:26928423]
ChEMBL	Antimalarial activity against CQ-sensitive Plasmodium falciparum 3D7 infected in erythrocytes by SYBR Green dye based fluorescence assay	F	7.52	pIC50	30	nM	IC50	Eur J Med Chem (2021) 209: 112941-112941 [PMID:33158577]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 infected in RBC assessed as parasite LDH activity after 72 hrs	F	7.52	pIC50	30	nM	IC50	J Nat Prod (2012) 75: 883-889 [PMID:22530813]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive/sulfadoxine-resistant Plasmodium falciparum 3D7 by [3H]-hypoxanthine incorporation assay	F	7.52	pIC50	30	nM	IC50	Bioorg Med Chem Lett (2017) 27: 1820-1825 [PMID:28291694]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D10	F	7.52	pIC50	30	nM	IC50	Bioorg Med Chem Lett (2013) 23: 1507-1510 [PMID:23347684]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive ring-stage Plasmodium falciparum 3D7 assessed as [3H]hypoxanthine incorporation after 48 hrs by liquid scintillation counter	F	7.52	pIC50	30	nM	IC50	Bioorg Med Chem (2012) 20: 1527-1534 [PMID:22269277]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D10 infected in human A-positive red blood cells after 72 hrs by lactate dehydrogenase assay	F	7.52	pIC50	30	nM	IC50	Bioorg Med Chem (2011) 19: 312-320 [PMID:21123074]
ChEMBL	In vitro antimalarial activity against Plasmodium falciparum D2	F	7.52	pIC50	30	nM	IC50	J Med Chem (2004) 47: 1833-1839 [PMID:15027875]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum F-32 Tanzania infected in blood assessed as decrease in parasitaemia after 48 hrs	F	7.52	pIC50	30	nM	IC50	Eur J Med Chem (2013) 63: 722-730 [PMID:23567962]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as Plasmodium lactate dehydrogenase release after 48 hrs by colorimetry	F	7.52	pIC50	30	nM	IC50	Antimicrob Agents Chemother (2009) 53: 2212-2214 [PMID:19258270]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D10 by parasite LDH assay	F	7.52	pIC50	30	nM	IC50	Eur J Med Chem (2011) 46: 579-587 [PMID:21183259]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum T9-96	F	7.52	pIC50	30	nM	IC50	J Nat Prod (2002) 65: 85-88 [PMID:11809075]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D10 after 72 hrs by LDH assay	F	7.52	pIC50	30	nM	IC50	J Nat Prod (2010) 73: 1448-1452 [PMID:20669933]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 by [3H]hypoxanthine uptake	F	7.52	pIC50	30	nM	IC50	Eur J Med Chem (2009) 44: 3816-3820 [PMID:19403210]
ChEMBL	Antimalarial activity against ring stage of chloroquine-sensitive Plasmodium falciparum 3D7 infected in erythrocytes assessed as [3H]-hypoxanthine incorporation after 48 hrs by liquid scintillation counting analysis	F	7.52	pIC50	30	nM	IC50	Bioorg Med Chem Lett (2013) 23: 6114-6117 [PMID:24084158]
ChEMBL	Antimalarial activity against trophozoite stage of Plasmodium falciparum 3D7 infected in RBC assessed as growth inhibition after 5 hrs by SYBR Green-I fluorescence assay	F	7.52	pIC50	30	nM	IC50	J Med Chem (2013) 56: 6200-6215 [PMID:23837878]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum F32	F	7.54	pIC50	29	nM	IC50	Antimicrob Agents Chemother (2009) 53: 1100-1106 [PMID:19015354]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D10 infected in human type A-positive red blood cells assessed as parasite lactate dehydrogenase activity after 72 hrs by spectrophotometric analysis	F	7.54	pIC50	29	nM	IC50	J Med Chem (2011) 54: 8526-8540 [PMID:22054038]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive blood parasite forms of Plasmodium falciparum 3D7 infected in RBC by SYBR green assay	F	7.54	pIC50	29	nM	IC50	J Med Chem (2018) 61: 5547-5568 [PMID:29879353]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocyte assessed as intraerythrocytic growth inhibition incubated for 72 hrs by DAPI-staining based imaging analysis	F	7.55	pIC50	28	nM	IC50	J Med Chem (2021) 64: 12582-12602 [PMID:34437804]
ChEMBL	Antimalarial activity against chloroquine sensitive Plasmodium falciparum D10 infected in human red blood cells assessed as reduction in parasite growth measured after 72 hrs by parasite lactate dehydrogenase assay	F	7.55	pIC50	28	nM	IC50	ACS Med Chem Lett (2021) 12: 1726-1732 [PMID:34795860]
ChEMBL	Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum FCR3	F	7.55	pIC50	28	nM	IC50	J Nat Prod (2008) 71: 167-174 [PMID:18220356]
ChEMBL	Antimalarial activity against asexual blood stage of Plasmodium falciparum 3D7 after 48 hrs by candle jar method	F	7.57	pIC50	27.2	nM	IC50	Eur J Med Chem (2008) 43: 1530-1535 [PMID:17977622]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D10 as LDH reporter activity	F	7.57	pIC50	27.2	nM	IC50	Bioorg Med Chem (2008) 16: 6813-6823 [PMID:18562202]
ChEMBL	Antimalarial activity against Plasmodium falciparum T9-96	F	7.57	pIC50	27	nM	IC50	J Med Chem (1994) 37: 1362-1370 [PMID:8176713]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum HB3 infected in human erythrocytes incubated for 48 hrs by [3H]-hypoxanthine incorporation assay	F	7.57	pIC50	27	nM	IC50	Eur J Med Chem (2020) 188: 111983-111983 [PMID:31911292]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT 31 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter	F	7.57	pIC50	27	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 incubated for 48 hrs by parasite lactate dehydrogenase assay	F	7.57	pIC50	27	nM	IC50	ACS Med Chem Lett (2019) 10: 714-719 [PMID:31097988]
ChEMBL	Antimalarial activity against Plasmodium falciparum HB3 infected in human erythrocytes assessed as reduction in [3H]-hypoxanthine incorporation preincubated for 24 hrs followed by [3H]-hypoxanthine addition measured after 24 hrs by scintillation counting method	F	7.57	pIC50	27	nM	IC50	J Med Chem (2017) 60: 5889-5908 [PMID:28635296]
ChEMBL	Antimalarial activity against erythrocytic stage chloroquine-sensitive Plasmodium falciparum 3D7 after 48 hrs by fluorescence spectrophotometer	F	7.57	pIC50	27	nM	IC50	Bioorg Med Chem (2011) 19: 4562-4573 [PMID:21723734]
ChEMBL	Antiparasitic activity against chloroquine-sensitive Plasmodium falciparum K1AM by [3H]hypoxanthine incorporation assay	F	7.59	pIC50	26	nM	IC50	Antimicrob Agents Chemother (2008) 52: 1438-1445 [PMID:18195056]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT 8425 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter	F	7.59	pIC50	26	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D10 after 72 hrs by parasite LDH assay	F	7.59	pIC50	26	nM	IC50	J Nat Prod (2010) 73: 1138-1145 [PMID:20521782]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D10 after 72 hrs by lactate dehydrogenase assay	F	7.59	pIC50	26	nM	IC50	Eur J Med Chem (2018) 150: 698-718 [PMID:29571157]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human red blood cells assessed as reduction in parasite growth after 48 hrs by Hoechst 33342 staining based flow cytometric analysis	F	7.59	pIC50	26	nM	IC50	Eur J Med Chem (2018) 158: 68-81 [PMID:30199706]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 by LDH assay	F	7.59	pIC50	25.6	nM	IC50	Bioorg Med Chem Lett (2017) 27: 658-661 [PMID:28012840]
ChEMBL	Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum 8425 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs	F	7.59	pIC50	25.5	nM	IC50	J Med Chem (2010) 53: 3214-3226 [PMID:20329733]
ChEMBL	Antimalarial activity against Plasmodium falciparum FCM29 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.6	pIC50	25	nM	IC50	Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D10 assessed as inhibition of parasite LDH activity after 72 hrs by spectrophotometry	F	7.6	pIC50	25	nM	IC50	Eur J Med Chem (2011) 46: 1757-1767 [PMID:21396743]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7	F	7.6	pIC50	25	nM	IC50	Eur J Med Chem (2009) 44: 3091-3113 [PMID:19361896]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as growth inhibition after 72 hrs by DAPI staining	F	7.6	pIC50	25	nM	IC50	J Med Chem (2012) 55: 5851-5858 [PMID:22686608]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 after 72 hrs by DAPI staining method	F	7.6	pIC50	25	nM	IC50	J Nat Prod (2009) 72: 1541-1543 [PMID:19637893]
ChEMBL	Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum 3D7 after 24 hrs by [3H]hypoxanthine uptake	F	7.6	pIC50	25	nM	IC50	J Nat Prod (1997) 60: 1017-1022 [PMID:9358645]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter	F	7.6	pIC50	25	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL	Antimalarial activity against Plasmodium falciparum D6 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter	F	7.6	pIC50	25	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum F32	F	7.6	pIC50	25	nM	IC50	Antimicrob Agents Chemother (2007) 51: 1463-1472 [PMID:17242150]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT Vol assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.6	pIC50	25	nM	IC50	Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT L1 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.6	pIC50	25	nM	IC50	Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT K4 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.6	pIC50	25	nM	IC50	Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT K2 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.6	pIC50	25	nM	IC50	Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT K14 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.6	pIC50	25	nM	IC50	Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum Nigerian infected in human red blood cells after 48 hrs by [3H]-hypoxanthine incorporation assay	F	7.6	pIC50	25	nM	IC50	Eur J Med Chem (2017) 139: 22-47 [PMID:28800458]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT 16332 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.6	pIC50	25	nM	IC50	Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT 10500 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.6	pIC50	25	nM	IC50	Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT 10336 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.6	pIC50	25	nM	IC50	Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT 9881 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.6	pIC50	25	nM	IC50	Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT 8425 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.6	pIC50	25	nM	IC50	Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT 31 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.6	pIC50	25	nM	IC50	Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT A4 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.6	pIC50	25	nM	IC50	Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT Guy assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.6	pIC50	25	nM	IC50	Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT Bres assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.6	pIC50	25	nM	IC50	Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum 106/1 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.6	pIC50	25	nM	IC50	Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum HB3 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.6	pIC50	25	nM	IC50	Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum PA assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.6	pIC50	25	nM	IC50	Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum FCR3 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.6	pIC50	25	nM	IC50	Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum D6 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.6	pIC50	25	nM	IC50	Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum W2 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.6	pIC50	25	nM	IC50	Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.6	pIC50	25	nM	IC50	Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 ring stage incubated for 72 hrs by DAPI-staining based imaging analysis	F	7.6	pIC50	25	nM	IC50	J Nat Prod (2020) 83: 3435-3444 [PMID:33105995]
ChEMBL	Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum 3D7 after 72 hrs by fluorescence assay	F	7.6	pIC50	25	nM	IC50	J Nat Prod (2010) 73: 985-987 [PMID:20462236]
ChEMBL	Antiparasitic activity against chloroquine-sensitive Plasmodium falciparum K1AM in presence of 5 uM verapamil by [3H]hypoxanthine incorporation assay	F	7.6	pIC50	25	nM	IC50	Antimicrob Agents Chemother (2008) 52: 1438-1445 [PMID:18195056]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D10 infected in human A+ RBC after 72 hrs by parasite LDH assay	F	7.61	pIC50	24.8	nM	IC50	Bioorg Med Chem (2010) 18: 6625-6633 [PMID:20797868]
ChEMBL	Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum D10	F	7.61	pIC50	24.7	nM	IC50	Antimicrob Agents Chemother (2009) 53: 4339-4344 [PMID:19651905]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7 A infected in red blood cells assessed as inhibition of [3H]hypoxanthine incorporation after 24 hrs by scintillation counting	F	7.62	pIC50	24	nM	IC50	ACS Med Chem Lett (2011) 2: 741-746 [PMID:24900261]
ChEMBL	Antimalarial activity against multidrug-resistant Plasmodium falciparum TM91C235 after 24 hrs by [3H]hypoxanthine uptake	F	7.62	pIC50	24	nM	IC50	J Nat Prod (2002) 65: 614-615 [PMID:11975516]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 24 hrs by microbeta counter	F	7.62	pIC50	24	nM	IC50	ACS Med Chem Lett (2011) 2: 840-844 [PMID:24900273]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7	F	7.62	pIC50	23.9	nM	IC50	Bioorg Med Chem Lett (2007) 17: 6434-6438 [PMID:17949976]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D10 infected in human RBC assessed as inhibition of parasite growth after 72 hrs by lactate dehydrogenase assay	F	7.62	pIC50	23.72	nM	IC50	Bioorg Med Chem (2012) 20: 5980-5985 [PMID:22901673]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive ring-stage synchronized cultures of Plasmodium falciparum NF54 incubated for 48 hrs by SYBR green I dye based flow cytometry	F	7.63	pIC50	23.7	nM	IC50	J Med Chem (2020) 63: 1750-1762 [PMID:32011136]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2	F	7.63	pIC50	23.66	nM	IC50	Bioorg Med Chem Lett (2011) 21: 4561-4563 [PMID:21705220]
ChEMBL	Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum 3D7 after 72 hrs by malaria SYBR Green I-based fluorescence assay	F	7.63	pIC50	23.5	nM	IC50	J Nat Prod (2010) 73: 885-889 [PMID:20429578]
ChEMBL	Antimalarial activity against asexual stage of Plasmodium falciparum 3D7 infected in erythrocytes assessed as reduction in parasite growth incubated for 48 hrs under hypoxic condition by Hoechst 33342 staining based flow cytometry	F	7.63	pIC50	23.4	nM	IC50	ACS Med Chem Lett (2020) 11: 49-55 [PMID:31938463]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum T996	F	7.63	pIC50	23.37	nM	IC50	Antimicrob Agents Chemother (2007) 51: 2265-2267 [PMID:17404003]
ChEMBL	Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum D6 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs	F	7.64	pIC50	23	nM	IC50	J Med Chem (2010) 53: 3214-3226 [PMID:20329733]
ChEMBL	OSM: Inhibition of Plasmodium falciparum 3D7 growth using a SYBR green I fluorescence based assay. GSK Tres Cantos.	F	7.64	pIC50	23	nM	IC50	Open Source Malaria Deposition 1. http://malaria.ourexperiment.org
ChEMBL	Antimalarial activity against chloroquine-susceptible Plasmodium falciparum 3D7 infected in human A+ RBC assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs by scintillation counting	F	7.64	pIC50	23	nM	IC50	Bioorg Med Chem (2010) 18: 8085-8091 [PMID:20934349]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D10 incubated for 48 hrs by parasite lactate dehydrogenase assay	F	7.64	pIC50	23	nM	IC50	J Med Chem (2020) 63: 14470-14501 [PMID:33023291]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D10 in LDH reporter assay after 48 hrs	F	7.64	pIC50	23	nM	IC50	Bioorg Med Chem Lett (2007) 17: 5683-5685 [PMID:17768052]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6	F	7.64	pIC50	23	nM	IC50	Bioorg Med Chem Lett (2006) 16: 1854-1858 [PMID:16434194]
ChEMBL	Antimalarial activity against Chloroquine-sensitive Plasmodium falciparum D10 assessed as parasite growth inhibition after 72 hrs by lactate dehydrogenase assay	F	7.64	pIC50	23	nM	IC50	Medchemcomm (2015) 6: 1173-1177
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by DAPI staining based confocal microplate imaging method	F	7.64	pIC50	23	nM	IC50	J Nat Prod (2017) 80: 3211-3217 [PMID:29236492]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as parasite growth inhibition	F	7.64	pIC50	23	nM	IC50	Bioorg Med Chem Lett (2021) 38: 127855-127855 [PMID:33609655]
ChEMBL	Antimalarial activity against erythrocyte stages of chloroquine-sensitive Plasmodium falciparum D10 infected in human erythrocytes by lactate dehydrogenase assay	F	7.64	pIC50	23	nM	IC50	J Med Chem (2011) 54: 6956-6968 [PMID:21875063]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum Nigerian infected in human blood after 48 hrs by [3H]-hypoxanthine incorporation assay	F	7.64	pIC50	23	nM	IC50	Bioorg Med Chem Lett (2019) 29: 2203-2207 [PMID:31255483]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D10 after 72 hrs by parasite lactate dehydrogenase assay	F	7.64	pIC50	23	nM	IC50	Bioorg Med Chem Lett (2012) 22: 5915-5918 [PMID:22884991]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum assessed as inhibition of [3H]hypoxanthine incorporation after 48 hrs	F	7.64	pIC50	23	nM	IC50	J Med Chem (2012) 55: 4619-4628 [PMID:22591034]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D10 infected in human O+ RBC by parasite LDH assay	F	7.64	pIC50	22.9	nM	IC50	Bioorg Med Chem Lett (2010) 20: 1078-1080 [PMID:20034790]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D10	F	7.64	pIC50	22.9	nM	IC50	Bioorg Med Chem (2007) 15: 6510-6516 [PMID:17693090]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum C2 infected in erythrocytes assessed as [3H]hypoxanthine incorporation	F	7.64	pIC50	22.9	nM	IC50	Antimicrob Agents Chemother (2009) 53: 1362-1366 [PMID:19188388]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7	F	7.64	pIC50	22.76	nM	IC50	Antimicrob Agents Chemother (2007) 51: 2265-2267 [PMID:17404003]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D10	F	7.65	pIC50	22.5	nM	IC50	Bioorg Med Chem Lett (2006) 16: 5384-5388 [PMID:16890433]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D10 by [3H]hypoxanthine incorporation	F	7.66	pIC50	22	nM	IC50	J Med Chem (2008) 51: 1278-1294 [PMID:18278860]
ChEMBL	Antimalarial activity against Plasmodium falciparum D10 by parasite lactate dehydrogenase assay	F	7.66	pIC50	22	nM	IC50	Eur J Med Chem (2021) 215: 113227-113227 [PMID:33601312]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D10	F	7.66	pIC50	22	nM	IC50	J Med Chem (2007) 50: 595-598 [PMID:17263523]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7	F	7.66	pIC50	22	nM	IC50	J Nat Prod (2002) 65: 1325-1327 [PMID:12350157]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D10 infected in human RBC after 72 hrs by parasite lactate dehydrogenase assay	F	7.66	pIC50	22	nM	IC50	J Med Chem (2012) 55: 6948-6967 [PMID:22783984]
ChEMBL	Inhibition of Plasmodium falciparum F32A	F	7.66	pIC50	22	nM	IC50	J Med Chem (2000) 43: 2646-2654 [PMID:10893302]
ChEMBL	Antimalarial activity after 72 hrs against chloroquine-sensitive Plasmodium falciparum D10 infected human A+ erythrocytes in Makler LDH reporter assay	F	7.66	pIC50	22	nM	IC50	J Med Chem (2009) 52: 502-513 [PMID:19113955]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7	F	7.66	pIC50	22	nM	IC50	J Med Chem (2011) 54: 2891-2901 [PMID:21417464]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 3D7 infected in RBCs by firefly luciferase reporter gene assay	F	7.66	pIC50	22	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3597-3604 [PMID:20547797]
ChEMBL	Antimalarial activity against Plasmodium falciparum HB3	F	7.66	pIC50	21.8	nM	IC50	J Med Chem (2006) 49: 4707-4714 [PMID:16854077]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D10 by lactate dehydrogenase assay	F	7.67	pIC50	21.54	nM	IC50	Bioorg Med Chem Lett (2011) 21: 1683-1686 [PMID:21316959]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D10	F	7.67	pIC50	21.54	nM	IC50	Bioorg Med Chem Lett (2010) 20: 6975-6977 [PMID:20971006]
ChEMBL	Antiplasmodial activity against asynchronous form of Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 48 hrs by SYBR green1 staining based flow cytometry	F	7.67	pIC50	21.5	nM	IC50	Eur J Med Chem (2019) 161: 277-291 [PMID:30366254]
ChEMBL	Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum 3D7 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs	F	7.67	pIC50	21.3	nM	IC50	J Med Chem (2010) 53: 3214-3226 [PMID:20329733]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7	F	7.68	pIC50	21	nM	IC50	Eur J Med Chem (2019) 161: 101-117 [PMID:30343191]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum harboring wild type and mutant pfcrt-76 gene after 18 hrs by [3H]hypoxanthine incorporation assay	F	7.68	pIC50	21	nM	IC50	Antimicrob Agents Chemother (2009) 53: 5069-5073 [PMID:19770282]
ChEMBL	Antimalarial activity against CQ-sensitive Plasmodium falciparum D10 infected in human type O+ erythrocytes assessed as growth inhibition incubated for 48 hrs by LDH assay	F	7.68	pIC50	21	nM	IC50	J Med Chem (2016) 59: 6512-6530 [PMID:27299916]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 3D7	F	7.68	pIC50	21	nM	IC50	Bioorg Med Chem Lett (2006) 16: 1312-1315 [PMID:16343898]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 cultured in human erythrocytes assessed as inhibition of parasite growth incubated for 48 hrs by YOYO-1 staining based flow cytometry	F	7.68	pIC50	21	nM	IC50	J Med Chem (2015) 58: 5344-5354 [PMID:26067904]
ChEMBL	Antiparasitic activity against chloroquine-sensitive Plasmodium falciparum K1AM pretreated with 0.1 uM phenobarbitone for 48 hrs and in presence of 5 uM verapamil by [3H]hypoxanthine incorporation assay	F	7.68	pIC50	21	nM	IC50	Antimicrob Agents Chemother (2008) 52: 1438-1445 [PMID:18195056]
ChEMBL	Growth inhibition of chloroquine-sensitive Plasmodium falciparum F32	F	7.68	pIC50	21	nM	IC50	J Med Chem (2003) 46: 542-557 [PMID:12570376]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human erythrocytes after 48 hrs by YOYO-1 dye based flow cytometric analysis	F	7.68	pIC50	21	nM	IC50	J Med Chem (2017) 60: 5889-5908 [PMID:28635296]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 infected in RBC after 72 hrs by LDH release assay	F	7.69	pIC50	20.4	nM	IC50	Eur J Med Chem (2019) 162: 277-289 [PMID:30448417]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum HB3	F	7.69	pIC50	20.2	nM	IC50	J Med Chem (2009) 52: 1828-1844 [PMID:19284751]
ChEMBL	Antimalarial activity against Plasmodium falciparum D6 assessed as growth inhibition after 72 hrs by SYBR Green 1-based fluorescence assay	F	7.7	pIC50	20	nM	IC50	Bioorg Med Chem Lett (2013) 23: 584-587 [PMID:23228469]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 48 hrs by beta liquid scintillation counting method	F	7.7	pIC50	20	nM	IC50	Bioorg Med Chem (2011) 19: 7519-7525 [PMID:22055713]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1	F	7.7	pIC50	20	nM	IC50	Bioorg Med Chem Lett (2007) 17: 4733-4736 [PMID:17644333]
ChEMBL	Antimalarial activity against CQ-susceptible Plasmodium falciparum D10 infected in human type A-positive red blood cells assessed as inhibition of parasite growth incubated for 72 hrs by spectrophotometry based parasite lactate dehydrogenase assay	F	7.7	pIC50	20	nM	IC50	ACS Med Chem Lett (2019) 10: 590-595 [PMID:30996801]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D10 infected in human type A-positive RBC assessed as inhibition of parasite LDH activity after 72 hrs by spectrophotometrically	F	7.7	pIC50	20	nM	IC50	J Med Chem (2011) 54: 5949-5953 [PMID:21761935]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in erythrocytes assessed as [3H] incorporation after 48 hrs by scintillation counter	F	7.7	pIC50	20	nM	IC50	Bioorg Med Chem (2011) 19: 5199-5206 [PMID:21824783]
ChEMBL	In vitro antimalarial activity against Plasmodium falciparum HB3 by [3H]hypoxanthine uptake	F	7.7	pIC50	20	nM	IC50	J Med Chem (2004) 47: 1290-1298 [PMID:14971909]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum assessed as inhibition of [3H]hypoxanthine incorporation incubated for 20 to 24 hr prior to [3H]hypoxanthine addition measured after 24 grs by microbeta scintillation counting	F	7.7	pIC50	20	nM	IC50	Med Chem Res (2008) 17: 19-29
ChEMBL	Antimalarial activity against Plasmodium falciparum FCR3 infected in human erythrocytes by Giemsa staining analysis	F	7.7	pIC50	20	nM	IC50	Bioorg Med Chem (2019) 27: 3574-3586 [PMID:31272837]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 infected in O-positive human RBC assessed as [3H]-hypoxanthine incorporation after 48 hrs by scintillation counting	F	7.7	pIC50	20	nM	IC50	ACS Med Chem Lett (2012) 3: 43-47 [PMID:24900369]
ChEMBL	Antimalarial activity against Plasmodium falciparum Nigerian	F	7.7	pIC50	20	nM	IC50	Bioorg Med Chem Lett (2007) 17: 593-596 [PMID:17123818]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human O positive red blood cells assessed as inhibition of [3H]-hypoxanthine uptake after 48 hrs	F	7.7	pIC50	20	nM	IC50	J Nat Prod (2011) 74: 74-78 [PMID:21155593]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7 infected in RBC assessed as growth inhibition after 48 hrs by SYBR Green-I fluorescence assay	F	7.7	pIC50	20	nM	IC50	J Med Chem (2013) 56: 6200-6215 [PMID:23837878]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive erythrocyte stages of Plasmodium falciparum NF54 by parasite lactate dehydrogenase assay	F	7.7	pIC50	20	nM	IC50	Eur J Med Chem (2013) 69: 90-98 [PMID:24012713]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum FCA 20 Ghana by [3H]hypoxanthine uptake	F	7.7	pIC50	20	nM	IC50	J Nat Prod (2001) 64: 12-16 [PMID:11170658]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human red blood cells incubated for 48 hrs by [3H]-hypoxanthine incorporation assay	F	7.7	pIC50	20	nM	IC50	Eur J Med Chem (2020) 188: 111983-111983 [PMID:31911292]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7 in erythrocytes	F	7.7	pIC50	20	nM	IC50	Bioorg Med Chem Lett (2002) 12: 543-545 [PMID:11844668]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D10 assessed as inhibition of parasite growth after 72 hrs by parasite lactate dehydrogenase assay	F	7.7	pIC50	20	nM	IC50	Bioorg Med Chem (2015) 23: 55-65 [PMID:25497962]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 ring-stage infected in human erythrocytes after 48 hrs by [3H]hypoxanthine assay	F	7.7	pIC50	20	nM	IC50	Bioorg Med Chem Lett (2011) 21: 846-848 [PMID:21190857]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54	F	7.7	pIC50	20	nM	IC50	Bioorg Med Chem Lett (2021) 54: 128442-128442 [PMID:34763083]
ChEMBL	Antiplasmodial activity chloroquinone-sensitive Plasmodium falciparum D10 by parasite lactate dehydrogenase assay	F	7.7	pIC50	20	nM	IC50	J Nat Prod (2015) 78: 1848-1858 [PMID:26235033]
ChEMBL	Antiplasmodial activity against CQ-sensitive Plasmodium falciparum D10	F	7.7	pIC50	20	nM	IC50	Bioorg Med Chem (2015) 23: 5098-5119 [PMID:25593097]
ChEMBL	Antiparasitic activity against drug-sensitive Plasmodium falciparum 3D7 infected in erythrocytes assessed as growth inhibition after 48 hrs by SYBR green 1 dye-based flow cytometry	F	7.7	pIC50	20	nM	IC50	Eur J Med Chem (2017) 127: 22-40 [PMID:28038325]
ChEMBL	Inhibition of Plasmodium falciparum 3D7	F	7.7	pIC50	20	nM	IC50	J Med Chem (2000) 43: 2646-2654 [PMID:10893302]
ChEMBL	In vitro antimalarial activity for Plasmodium falciparum HB3	F	7.7	pIC50	20	nM	IC50	Bioorg Med Chem Lett (2004) 14: 1145-1149 [PMID:14980653]
ChEMBL	Antimalarial activity against Plasmodium falciparum NF54 infected in human erythrocytes assessed as reduction in [3H]-hypoxanthine incorporation preincubated for 24 hrs followed by [3H]-hypoxanthine addition measured after 24 hrs by scintillation counting method	F	7.7	pIC50	20	nM	IC50	J Med Chem (2017) 60: 5889-5908 [PMID:28635296]
ChEMBL	In vitro inhibitory activity against Plasmodium falciparum D6	F	7.7	pIC50	20	nM	IC50	Bioorg Med Chem Lett (1995) 5: 1927-1932
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7	F	7.7	pIC50	20	nM	IC50	Bioorg Med Chem Lett (1996) 6: 391-392
ChEMBL	Antimalarial activity against Plasmodium falciparum HB3	F	7.7	pIC50	20	nM	IC50	J Med Chem (1996) 39: 4511-4514 [PMID:8893847]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 by [3H]-hypoxanthine incorporation assay	F	7.7	pIC50	20	nM	IC50	Eur J Med Chem (2018) 152: 489-514 [PMID:29754074]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum FC32 infected human erythrocytes after 24 hrs by [3H]hypoxanthine uptake	F	7.71	pIC50	19.5	nM	IC50	Bioorg Med Chem (2008) 16: 9133-9144 [PMID:18819813]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 in human erythrocytes after 48 hrs by [3H]hypoxanthine uptake	F	7.71	pIC50	19.4	nM	IC50	J Med Chem (2009) 52: 1408-1415 [PMID:19222165]
ChEMBL	Antiplasmodial activity against chloroquine-susceptible blood forms of Plasmodium falciparum 3D7 infected in human erythrocytes measured after 48 hrs by SYBR green1 staining based fluorescence assay	F	7.72	pIC50	19	nM	IC50	Bioorg Med Chem (2018) 26: 3837-3844 [PMID:29983285]
ChEMBL	In vitro growth inhibition of Plasmodium falciparum F32	F	7.72	pIC50	19	nM	IC50	J Med Chem (2001) 44: 1658-1665 [PMID:11356101]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 incubated for 48 hrs by parasite lactate dehydrogenase assay	F	7.72	pIC50	19	nM	IC50	J Med Chem (2020) 63: 14470-14501 [PMID:33023291]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes incubated for 48 hrs by lactate dehydrogenase colorimetric enzyme assay	F	7.72	pIC50	19	nM	IC50	J Med Chem (2020) 63: 14243-14275 [PMID:32870008]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum HB3	F	7.72	pIC50	19	nM	IC50	Eur J Med Chem (2009) 44: 3091-3113 [PMID:19361896]
ChEMBL	Antimalarial activity after 72 hrs against chloroquine-resistant transporter 106/1'76I mutant Plasmodium falciparum infected in human erythrocytes by SYBR green assay	F	7.72	pIC50	19	nM	IC50	Antimicrob Agents Chemother (2007) 51: 4133-4140 [PMID:17846138]
ChEMBL	In vitro inhibitory activity against chloroquine-sensitive Plasmodium falciparum HB3	F	7.72	pIC50	19	nM	IC50	J Med Chem (1999) 42: 2747-2751 [PMID:10425085]
ChEMBL	Selectivity for FM3A cells over Plasmodium falciparum as mean EC50 ratio	F	7.72	pIC50	19	nM	IC50	J Med Chem (2002) 45: 4975-4983 [PMID:12408708]
ChEMBL	Antimalarial activity against chloroquine-sensitive asexual intraerythrocytic stage of Plasmodium falciparum NF54 assessed as inhibition of parasite growth by lactate dehydrogenase assay	F	7.73	pIC50	18.5	nM	IC50	Eur J Med Chem (2015) 101: 52-62 [PMID:26114811]
ChEMBL	Antimalarial activity against Plasmodium falciparum assessed as parasite growth inhibition after 48 hrs by [3H]hypoxanthin incorporation assay	F	7.73	pIC50	18.5	nM	IC50	Antimicrob Agents Chemother (2009) 53: 4588-4597 [PMID:19704124]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as inhibition of [3H]hypoxanthine incorporation	F	7.74	pIC50	18	nM	IC50	Bioorg Med Chem (2009) 17: 8032-8039 [PMID:19879150]
ChEMBL	In vitro anti-protozoal activity against Plasmodium falciparum Ghana strain	F	7.74	pIC50	18	nM	IC50	Bioorg Med Chem Lett (2004) 14: 3635-3638 [PMID:15203133]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 by LDH release assay	F	7.74	pIC50	18	nM	IC50	Eur J Med Chem (2018) 148: 39-53 [PMID:29454189]
ChEMBL	In vivo antimalarial activity against Plasmodium falciparum	F	7.74	pIC50	18	nM	IC50	J Med Chem (2002) 45: 748-751 [PMID:11806727]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 by hypoxanthine uptake	F	7.74	pIC50	18	nM	IC50	Bioorg Med Chem (2007) 15: 3278-3289 [PMID:17339112]
ChEMBL	Antimalarial activity against ring stage of Plasmodium falciparum 3D7 infected in erythrocytes assessed as [3H]-hypoxanthine incorporation after 48 hrs by liquid scintillation counting analysis	F	7.74	pIC50	18	nM	IC50	Bioorg Med Chem Lett (2013) 23: 5915-5918 [PMID:24035096]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 3D7 late stage forms infected in human non-washed human RBC containing full drug dosages by [3H]-hypoxanthine incorporation assay	F	7.75	pIC50	17.8	nM	IC50	Eur J Med Chem (2018) 152: 489-514 [PMID:29754074]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 48 hrs using Hema 3 staining by microscopic analysis	F	7.75	pIC50	17.7	nM	IC50	Bioorg Med Chem Lett (2011) 21: 4512-4515 [PMID:21723121]
ChEMBL	Antimalarial activity against Plasmodium falciparum D6	F	7.75	pIC50	17.63	nM	IC50	J Med Chem (2007) 50: 5118-5127 [PMID:17887664]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D10 after 48 hrs	F	7.76	pIC50	17.4	nM	IC50	Eur J Med Chem (2013) 69: 338-347 [PMID:24077524]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D10 by FACS-based assay	F	7.77	pIC50	17	nM	IC50	J Med Chem (2011) 54: 3637-3649 [PMID:21500839]
ChEMBL	In vitro antimalarial activity against Plasmodium falciparum Dd2	F	7.77	pIC50	17	nM	IC50	Bioorg Med Chem Lett (2004) 14: 1979-1982 [PMID:15050641]
ChEMBL	Gametocytocidal activity against transgenic GFP-fused Plasmodium falciparum NF54 ring stage gametocytes after 72 hrs by Mitotracker Red CMH2XRos staining based confocal microscopic method	F	7.77	pIC50	17	nM	IC50	J Med Chem (2017) 60: 6036-6044 [PMID:28653845]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D10 after 48 hrs	F	7.77	pIC50	17	nM	IC50	Bioorg Med Chem (2010) 18: 8243-8256 [PMID:21044845]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7	F	7.77	pIC50	17	nM	IC50	J Med Chem (2006) 49: 4535-4543 [PMID:16854059]
ChEMBL	Antiplasmodial activity after 48 hrs against chloroquine-sensitive Plasmodium falciparum D10 infected human erythrocytes by LDH reporter assay	F	7.77	pIC50	17	nM	IC50	J Med Chem (2009) 52: 4058-4062 [PMID:19463002]
ChEMBL	Antimalarial activity against schizont stage of chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green I-based fluorescence assay	F	7.77	pIC50	17	nM	IC50	J Med Chem (2013) 56: 31-45 [PMID:23270565]
ChEMBL	Antimalarial activity against wild type early trophozoite stage of Plasmodium falciparum D6 in human red blood cells assessed as [3H]hypoxanthine uptake after 96 hrs	F	7.77	pIC50	17	nM	IC50	J Med Chem (2013) 56: 2513-2526 [PMID:23448281]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7 by FACS assay	F	7.77	pIC50	17	nM	IC50	J Med Chem (2010) 53: 3685-3695 [PMID:20361799]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human RBC assessed as inhibition of parasite growth after 72 hrs by lactate dehydrogenase assay	F	7.77	pIC50	16.92	nM	IC50	Bioorg Med Chem (2012) 20: 5980-5985 [PMID:22901673]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive and mefloquine-resistant Plasmodium falciparum D6	F	7.77	pIC50	16.9	nM	IC50	Bioorg Med Chem Lett (2009) 19: 3229-3232 [PMID:19435664]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in erythrocytes assessed as [3H]hypoxanthine incorporation	F	7.78	pIC50	16.7	nM	IC50	Antimicrob Agents Chemother (2009) 53: 1362-1366 [PMID:19188388]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7 assessed as inhibition of parasite growth	F	7.78	pIC50	16.6	nM	IC50	Bioorg Med Chem Lett (2021) 47: 128196-128196 [PMID:34116159]
ChEMBL	In vitro antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 Sierra Leone	F	7.78	pIC50	16.5	nM	IC50	J Med Chem (2003) 46: 4244-4258 [PMID:13678403]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum FC27	F	7.78	pIC50	16.48	nM	IC50	Antimicrob Agents Chemother (2007) 51: 2265-2267 [PMID:17404003]
ChEMBL	Antiparasitic activity against Plasmodium falciparum D6	F	7.79	pIC50	16.11	nM	IC50	Eur J Med Chem (2019) 181: 111353-111353 [PMID:31525705]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in erythrocytes after 48 hrs by SYBR green 1-based fluorescence assay	F	7.8	pIC50	16	nM	IC50	Bioorg Med Chem (2011) 19: 7474-7481 [PMID:22071523]
ChEMBL	Antiplasmodial activity against multidrug-sensitive Plasmodium falciparum NF54 infected in human erythrocytes assessed as reduction in [3H]hypoxanthine incorporation preincubated for 48 hrs followed by [3H]hypoxanthine addition and measured after 24 hrs by liquid scintillation counting method	F	7.8	pIC50	16	nM	IC50	J Med Chem (2016) 59: 9890-9905 [PMID:27748596]
ChEMBL	Antimalarial activity against Plasmodium falciparum NF54 infected in human erythrocytes assessed as reduction in [3H]hypoxanthine incorporation preincubated for 48 hrs followed by [3H]hypoxanthine addition measured after 24 hrs by liquid scintillation counting	F	7.8	pIC50	16	nM	IC50	Medchemcomm (2017) 8: 1152-1157 [PMID:30108825]
ChEMBL	Antiplasmodial activity against asexual erythrocyte stage of chloroquine-sensitive Plasmodium falciparum NF54 infected in human red blood cells after 48 hrs by lactate dehydrogenase assay	F	7.8	pIC50	16	nM	IC50	Eur J Med Chem (2018) 159: 243-254 [PMID:30296683]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum NF54 after 48 hrs by lactate dehydrogenase assay	F	7.8	pIC50	16	nM	IC50	J Med Chem (2018) 61: 9371-9385 [PMID:30256636]
ChEMBL	Antimalarial activity against Plasmodium falciparum NF54 infected in human erythrocytes preincubated for 48 hrs followed by [3H]-hypoxanthine addition and measured after 24 hrs by liquid scintillation counting	F	7.8	pIC50	16	nM	IC50	J Med Chem (2018) 61: 9371-9385 [PMID:30256636]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7A infected in human A-positive erythrocytes assessed as inhibition of [3H]-hypoxanthine incorporation after 48 hrs by semi-automated microdilution technique	F	7.8	pIC50	16	nM	IC50	Eur J Med Chem (2012) 49: 365-378 [PMID:22321992]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum GCO3 after 72 hrs by SYBR green 1 assay	F	7.8	pIC50	16	nM	IC50	J Med Chem (2008) 51: 1995-1998 [PMID:18345611]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive asexual blood stage of Plasmodium falciparum NF54 infected in human RBC assessed as reduction in [3H]hypoxanthine incorporation preincubated for 48 hrs followed by [3H]hypoxanthine addition measured after 24 hrs by liquid scintillation counting method	F	7.8	pIC50	16	nM	IC50	J Med Chem (2019) 62: 1022-1035 [PMID:30562027]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7A infected in type A rhesus-positive human erythrocytes assessed as [3H]hypoxanthine incorporation after 48 hrs by scintillation counting	F	7.8	pIC50	16	nM	IC50	J Med Chem (2012) 55: 3216-3227 [PMID:22380766]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum HB3	F	7.8	pIC50	16	nM	IC50	Antimicrob Agents Chemother (2009) 53: 622-630 [PMID:19015351]
ChEMBL	Antimalarial activity against drug-sensitive Plasmodium falciparum NF54	F	7.8	pIC50	16	nM	IC50	J Med Chem (2018) 61: 4213-4227 [PMID:29665687]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54 by [3H]hypoxanthine uptake	F	7.8	pIC50	16	nM	IC50	J Med Chem (2008) 51: 3466-3479 [PMID:18512900]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7 assessed as reduction in parasite growth measured after 72 hrs by Monash assay based fluorescence analysis	F	7.8	pIC50	16	nM	IC50	Eur J Med Chem (2021) 221: 113518-113518 [PMID:34058708]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum NF54	F	7.8	pIC50	16	nM	IC50	J Med Chem (2011) 54: 7713-7719 [PMID:21966980]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54 infected in human type A+ erythrocytes after 48 hrs by [3H]-hypoxanthine incorporation assay	F	7.8	pIC50	16	nM	IC50	Eur J Med Chem (2017) 139: 22-47 [PMID:28800458]
ChEMBL	Anti-parasitic activity against CQ-sensitive Plasmodium falciparum D10 assessed as growth inhibition by measuring increase in LDH release after 72 hrs by spectrophotometric method	F	7.8	pIC50	16	nM	IC50	J Med Chem (2017) 60: 1959-1970 [PMID:28128956]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in erythrocytes after 48 hrs by SYBR Green 1-based fluorescence assay	F	7.8	pIC50	16	nM	IC50	Bioorg Med Chem (2010) 18: 5254-5260 [PMID:20541427]
ChEMBL	Antimalarial activity against CQ-resistant Plasmodium falciparum W2 assessed as parasite growth inhibition after 48 hrs by YOYO-1 dye based flow cytometry	F	7.8	pIC50	15.9	nM	IC50	Eur J Med Chem (2015) 95: 230-239 [PMID:25817773]
ChEMBL	Antimicrobial activity against Plasmodium falciparum harboring mdr1 N86Y/D1246Y/Y184F mutant gene by ELISA	F	7.8	pIC50	15.7	nM	IC50	Antimicrob Agents Chemother (2010) 54: 1200-1206 [PMID:20065051]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected type A+ human erythrocytes after 24 hrs by [G-3H]hypoxanthine uptake	F	7.81	pIC50	15.62	nM	IC50	Bioorg Med Chem Lett (2009) 19: 2038-2043 [PMID:19251414]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7	F	7.82	pIC50	15	nM	IC50	Bioorg Med Chem (2009) 17: 3229-3256 [PMID:19299148]
ChEMBL	Antimalarial activity against Plasmodium falciparum D10	F	7.82	pIC50	15	nM	IC50	Bioorg Med Chem Lett (2010) 20: 4611-4613 [PMID:20580556]
ChEMBL	Antiplasmodial activity against asexual stage of chloroquine-sensitive Plasmodium falciparum D6 infected in human erythrocytes assessed as reduction in parasite growth incubated for 72 hrs by SYBR green 1 staining based assay	F	7.82	pIC50	15	nM	IC50	J Med Chem (2021) 64: 8739-8754 [PMID:34111350]
ChEMBL	Antiparasitic activity against chloroquine-sensitive Plasmodium falciparum 3D7	F	7.82	pIC50	15	nM	IC50	J Med Chem (2008) 51: 1260-1277 [PMID:18260613]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 infected in human erythrocytes by SYBR green 1-based fluorescence assay	F	7.82	pIC50	15	nM	IC50	J Med Chem (2019) 62: 3475-3502 [PMID:30852885]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum after 30 to 34 hr by schizont maturation assay	F	7.82	pIC50	15	nM	IC50	Med Chem Res (2008) 17: 487-494
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D10 infected in human A positive erythrocyte assessed as inhibition of parasite growth after 72 hrs by parasite lactate dehydrogenase assay	F	7.82	pIC50	15	nM	IC50	Medchemcomm (2015) 6: 357-362
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in erythrocytes assessed as parasite growth inhibition after 72 hrs by SYBR green 1 dye-based fluorometric analysis	F	7.82	pIC50	15	nM	IC50	J Med Chem (2013) 56: 7911-7924 [PMID:24073986]
ChEMBL	Antimalarial activity against multidrug resistant Plasmodium falciparum D6 infected in human erythrocytes measured after after 72 hrs by SYBR green dye based fluorescence assay	F	7.82	pIC50	15	nM	IC50	J Med Chem (2020) 63: 6179-6202 [PMID:32390431]
ChEMBL	OSM: Inhibition of Plasmodium falciparum 3D7 growth. IC50 values determined from 21 point dose response curves. Avery Group Griffith.	F	7.82	pIC50	15	nM	IC50	Open Source Malaria Deposition 1. http://malaria.ourexperiment.org
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 in human erythrocytes by [3H]hypoxanthine uptake	F	7.82	pIC50	15	nM	IC50	Bioorg Med Chem Lett (2008) 18: 4210-4214 [PMID:18554905]
ChEMBL	In vitro antimalarial activity against Plasmodium falciparum HB	F	7.82	pIC50	14.98	nM	IC50	J Med Chem (2003) 46: 4933-4945 [PMID:14584944]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum HB3 in human erythrocytes after 48 hrs by [3H]hypoxanthine uptake	F	7.83	pIC50	14.9	nM	IC50	J Med Chem (2009) 52: 1408-1415 [PMID:19222165]
ChEMBL	Antimalarial activity after 72 hrs against chloroquine-sensitive Plasmodium falciparum D6 infected human erythrocytes by SYBR green assay	F	7.83	pIC50	14.7	nM	IC50	Antimicrob Agents Chemother (2007) 51: 4133-4140 [PMID:17846138]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum HB3 after 72 hrs SYBR green 1 dye based by fluorometric method	F	7.83	pIC50	14.7	nM	IC50	J Nat Prod (2011) 74: 2174-2180 [PMID:21995542]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum TM90C2B harboring Y268S mutant measured after 48 hrs by SYBR green1 dye based fluorescence assay	F	7.84	pIC50	14.5	nM	IC50	ACS Med Chem Lett (2018) 9: 1205-1210 [PMID:30613327]
ChEMBL	Antimalarial activity against drug resistant Plasmodium falciparum TM90C2B infected in human erythrocytes assessed as growth inhibition after 48 hrs by SYBR Green 1 staining-based fluorescence assay	F	7.84	pIC50	14.5	nM	IC50	Medchemcomm (2015) 6: 1252-1259
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum THAI/Thailand as [3H]hypoxanthine uptake after 24 hrs by semi-automated micro dilution	F	7.84	pIC50	14.3	nM	IC50	Eur J Med Chem (2008) 43: 2045-2055 [PMID:18226428]
ChEMBL	Inhibitory activity against chloroquine-resistant Plasmodium falciparum THAI	F	7.84	pIC50	14.3	nM	IC50	J Med Chem (2001) 44: 2827-2833 [PMID:11495593]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D10 infected in human red blood cells after 72 hrs by parasite lactate dehydrogenase assay	F	7.84	pIC50	14.3	nM	IC50	Bioorg Med Chem (2012) 20: 5965-5979 [PMID:22917857]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7 assessed as reduction in parasite viability by parasite lactate dehydrogenase release based colorimetric assay	F	7.84	pIC50	14.3	nM	IC50	Bioorg Med Chem Lett (2019) 29: 1572-1575 [PMID:31080006]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum Thai after 24 hrs by semiautomated micro dilution assay	F	7.84	pIC50	14.3	nM	IC50	Eur J Med Chem (2008) 43: 252-260 [PMID:17485145]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive, mefloquine-resistant ring stage Plasmodium falciparum D6 infected in human red blood cells after 48 hrs	F	7.85	pIC50	14.2	nM	IC50	J Med Chem (2011) 54: 734-750 [PMID:21207937]
ChEMBL	Anti-plasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes after 50 hrs by SYBR green dye based fluorescence assay	F	7.85	pIC50	14	nM	IC50	Eur J Med Chem (2017) 134: 242-257 [PMID:28419927]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum F32-Tanzania by [3H]hypoxanthine uptake	F	7.85	pIC50	14	nM	IC50	J Nat Prod (2001) 64: 12-16 [PMID:11170658]
ChEMBL	Antimalarial activity against Plasmodium falciparum D6 by hypoxanthine uptake	F	7.85	pIC50	14	nM	IC50	J Med Chem (2008) 51: 3437-3448 [PMID:18494463]
ChEMBL	Antimalarial activity against drug-resistant Plasmodium falciparum D6 infected in Aotus lemurinus lemurinus monkey	F	7.85	pIC50	14	nM	IC50	Antimicrob Agents Chemother (2008) 52: 3467-3477 [PMID:18644969]
ChEMBL	Antiplasmodial activity against multidrug-resistant asexual intraerythrocytic stage of Plasmodium falciparum Dd2 assessed as inhibition of parasite growth incubated for 48 hrs followed by addition of [3H]hypoxanthine for 24 hrs by [3H]hypoxanthine incorporation assay	F	7.85	pIC50	14	nM	IC50	Eur J Med Chem (2021) 211: 113065-113065 [PMID:33360801]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 3D7 infected in erythrocytes assessed as reduction in [3H]hypoxanthine incorporation preincubated for 48 hrs followed by [3H]hypoxanthine addition and measured after 18 hrs by topcount scintillation counting analysis	F	7.85	pIC50	14	nM	IC50	J Med Chem (2020) 63: 8069-8087 [PMID:32687714]
ChEMBL	Antiplasmodial activity as reduced parasitaemia against Plasmodium yoelii N67 infected Swiss mice (Mus musculus) at 10 mg/kg peroral dose	F	7.85	pIC50	14	nM	IC50	Bioorg Med Chem Lett (2007) 17: 959-963 [PMID:17166718]
ChEMBL	Antiplasmodial activity against drug-sensitive Plasmodium falciparum 3D7 ring stage forms assessed as inhibition of parasite growth after 72 hrs by DAPI staining-based confocal microscopic analysis	F	7.86	pIC50	13.9	nM	IC50	J Nat Prod (2019) 82: 1019-1023 [PMID:30865443]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum FC27 infected in human RBC assessed as reduction in parasite growth after 35 to 56 hrs by nucleic acid staining based flow cytometry	F	7.86	pIC50	13.9	nM	IC50	J Med Chem (2019) 62: 2485-2498 [PMID:30715882]
ChEMBL	In vitro inhibitory activity against chloroquine-sensitive Plasmodium falciparum African D6	F	7.86	pIC50	13.76	nM	IC50	J Med Chem (2002) 45: 3331-3336 [PMID:12139444]
ChEMBL	Antimalarial activity against chloroquine and pyrimethamine-sensitive Plasmodium falciparum D6	F	7.86	pIC50	13.72	nM	IC50	Bioorg Med Chem (2008) 16: 7039-7045 [PMID:18550377]
ChEMBL	Antimalarial activity against Plasmodium falciparum D6	F	7.86	pIC50	13.7	nM	IC50	J Med Chem (2006) 49: 3790-3799 [PMID:16789736]
ChEMBL	Antimalarial activity after 48 hrs against chloroquine-sensitive Plasmodium falciparum 3D7 by [3H]hypoxanthine uptake	F	7.87	pIC50	13.5	nM	IC50	Eur J Med Chem (2008) 43: 1903-1910 [PMID:18215443]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum HB3 after 72 hrs by SYBR green 1 assay	F	7.87	pIC50	13.5	nM	IC50	J Med Chem (2008) 51: 1995-1998 [PMID:18345611]
ChEMBL	Antimalarial activity against mefloquine-resistant, chloroquine-sensitive Plasmodium falciparum D6 assessed as inhibition of [3H]hypoxanthine uptake	F	7.87	pIC50	13.4	nM	IC50	Bioorg Med Chem Lett (2011) 21: 786-789 [PMID:21168330]
ChEMBL	Antimalarial activity against Plasmodium falciparum D6	F	7.88	pIC50	13.17	nM	IC50	J Med Chem (2008) 51: 2261-2266 [PMID:18330976]
ChEMBL	Antimalarial activity after 72 hrs against chloroquine-sensitive Plasmodium falciparum D6 as LDH activity	F	7.89	pIC50	13	nM	IC50	Bioorg Med Chem (2008) 16: 6702-6706 [PMID:18595720]
ChEMBL	Antiplasmodial activity against drug-sensitive blood stage Plasmodium falciparum 3D7 by SYBR green 1 staining based fluorescence assay	F	7.89	pIC50	13	nM	IC50	J Nat Prod (2018) 81: 188-202 [PMID:29297684]
ChEMBL	Antimalarial activity against Plasmodium falciparum D6	F	7.89	pIC50	13	nM	IC50	Bioorg Med Chem Lett (2006) 16: 5682-5686 [PMID:16908136]
ChEMBL	In vitro antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 (CDC/Sierra Leone I)	F	7.89	pIC50	13	nM	IC50	J Med Chem (1995) 38: 5031-5037 [PMID:8544179]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by 96-well format based SYBR green assay	F	7.89	pIC50	13	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum harboring wild type pfcrt-76 gene after 18 hrs by [3H]hypoxanthine incorporation assay	F	7.89	pIC50	13	nM	IC50	Antimicrob Agents Chemother (2009) 53: 5069-5073 [PMID:19770282]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum harboring wild type pfcrt-76 and mutant pfmdr-1-86 gene after 18 hrs by [3H]hypoxanthine incorporation assay	F	7.89	pIC50	13	nM	IC50	Antimicrob Agents Chemother (2009) 53: 5069-5073 [PMID:19770282]
ChEMBL	Antiplasmodial activity against chloroquine, quinine and pyrimethamine-resistant Plasmodium falciparum W2 assessed as inhibition of [3H]-hypoxanthine uptake after 48 hrs by liquid scintillation counting analysis	F	7.89	pIC50	13	nM	IC50	Bioorg Med Chem Lett (2016) 26: 1048-1051 [PMID:26750257]
ChEMBL	Parasite growth in chloroquine-sensitive Plasmodium falciparum NF54	F	7.89	pIC50	13	nM	IC50	J Med Chem (1999) 42: 4630-4639 [PMID:10579825]
ChEMBL	Antiparasitic activity against chloroquine-sensitive Plasmodium falciparum NF54 in erythrocytes by [3H]hypoxanthine uptake	F	7.89	pIC50	13	nM	IC50	Bioorg Med Chem (2007) 15: 2782-2788 [PMID:17280835]
ChEMBL	Antiplasmodial activity against drug-sensitive Plasmodium falciparum 3D7 assessed as parasitaemia after 72 hrs using SYBR Green 1 staining by fluorescence method	F	7.89	pIC50	12.8	nM	IC50	J Nat Prod (2011) 74: 2122-2127 [PMID:21977916]
ChEMBL	Growth inhibition of Plasmodium falciparum ring stage in infected erythrocytes by DAPI growth assay	F	7.9	pIC50	12.63	nM	IC50	Antimicrob Agents Chemother (2007) 51: 716-723 [PMID:17116676]
ChEMBL	Growth inhibition of Plasmodium falciparum 3D7 ring stage in infected erythrocytes after 72 hrs in DAPI fluorimetry	F	7.9	pIC50	12.63	nM	IC50	Antimicrob Agents Chemother (2007) 51: 716-723 [PMID:17116676]
ChEMBL	Antimicrobial activity against Plasmodium falciparum 3D7 by DAPI growth inhibition assay	F	7.9	pIC50	12.6	nM	IC50	Antimicrob Agents Chemother (2009) 53: 2564-2568 [PMID:19307367]
ChEMBL	Antimalarial activity against CQ-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes after 48 hrs by SYBR Green1 dye based fluorescence assay	F	7.9	pIC50	12.56	nM	IC50	ACS Med Chem Lett (2020) 11: 1450-1456 [PMID:32676153]
ChEMBL	Antimalarial activity against chloroquine,mefloquine-sensitive Plasmodium falciparum D6	F	7.91	pIC50	12.44	nM	IC50	J Med Chem (2008) 51: 4388-4391 [PMID:18637666]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 after 48 hrs by LDH reporter assay	F	7.91	pIC50	12.4	nM	IC50	Bioorg Med Chem (2008) 16: 5254-5265 [PMID:18362073]
ChEMBL	Antimalarial activity against drug resistant Plasmodium falciparum W2 infected in human erythrocytes assessed as growth inhibition after 48 hrs by SYBR Green 1 staining-based fluorescence assay	F	7.91	pIC50	12.3	nM	IC50	Medchemcomm (2015) 6: 1252-1259
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 measured after 48 hrs by SYBR green1 dye based fluorescence assay	F	7.91	pIC50	12.3	nM	IC50	ACS Med Chem Lett (2018) 9: 1205-1210 [PMID:30613327]
ChEMBL	Antimalarial activity against Plasmodium falciparum D6	F	7.91	pIC50	12.27	nM	IC50	J Med Chem (2011) 54: 1157-1169 [PMID:21265542]
ChEMBL	Antiplasmodial activity against chloroquine-resistant asexual erythrocytic stage of Plasmodium falciparum Dd2 assessed as parasite growth inhibition by parasite lactate dehydrogenase assay	F	7.92	pIC50	12.1	nM	IC50	Bioorg Med Chem (2015) 23: 4163-4171 [PMID:26174655]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6	F	7.92	pIC50	12.08	nM	IC50	J Med Chem (2008) 51: 6216-6219 [PMID:18774792]
ChEMBL	Growth inhibition of Plasmodium falciparum as reduced [3H]hypoxanthine incorporation	F	7.92	pIC50	12.07	nM	IC50	Antimicrob Agents Chemother (2007) 51: 716-723 [PMID:17116676]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54 infected in human erythrocytes assessed as inhibition of parasite growth after 24 hrs by Geimsa staining based light microscopic analysis	F	7.92	pIC50	12	nM	IC50	J Med Chem (2011) 54: 4913-4917 [PMID:21591758]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as inhibition of parasite viability incubated for 48 hrs by parasite LDH release based colorimetric assay	F	7.92	pIC50	12	nM	IC50	Bioorg Med Chem Lett (2020) 30: 126911-126911 [PMID:31952962]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 infected in erythrocytes assessed as reduction in parasite growth incubated for 48 hrs by lactate dehydrogenase assay	F	7.92	pIC50	12	nM	IC50	Eur J Med Chem (2021) 217: 113330-113330 [PMID:33744688]
ChEMBL	Antiprotozoal activity against chloroquine-sensitive Plasmodium falciparum NF54 assessed as growth inhibition incubated for 48 hrs by [3H]-hypoxanthine incorporation assay	F	7.92	pIC50	12	nM	IC50	J Nat Prod (2019) 82: 3033-3046 [PMID:31642313]
ChEMBL	Antiplasmodium activity against chloroquine-sensitive Plasmodium falciparum NF54 asexual blood stage forms infected in human erythrocytes assessed as reduction in [3H]-hypoxanthine incorporation incubated for 48 hrs by liquid scintillation counting method	F	7.92	pIC50	12	nM	IC50	Medchemcomm (2019) 10: 450-455 [PMID:31015908]
ChEMBL	In vitro antimalarial activity against chloroquine-sensitive Plasmodium falciparum	F	7.92	pIC50	12	nM	IC50	Bioorg Med Chem Lett (2002) 12: 1701-1704 [PMID:12067541]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in O+ human erythrocytes by [3H]hypoxanthine incorporation assay	F	7.92	pIC50	12	nM	IC50	Antimicrob Agents Chemother (2008) 52: 1454-1461 [PMID:18212103]
ChEMBL	In vitro growth inhibition against Plasmodium falciparum	F	7.92	pIC50	12	nM	IC50	J Med Chem (2004) 47: 175-187 [PMID:14695831]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum NF54 infected in human erythrocytes after 24 hrs by geimsa staining	F	7.92	pIC50	12	nM	IC50	Eur J Med Chem (2012) 54: 936-942 [PMID:22781704]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum NF54 measured after 24 hrs in presence of [3H] hypoxanthine by liquid scintillation counter analysis	F	7.92	pIC50	12	nM	IC50	Bioorg Med Chem (2020) 28: 115185-115185 [PMID:31784198]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as inhibition of [3H]hypoxanthine incorporation	F	7.92	pIC50	12	nM	IC50	Antimicrob Agents Chemother (2011) 55: 961-966 [PMID:21135175]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum SB1 after 72 hrs by SYBR I method	F	7.93	pIC50	11.81	nM	IC50	J Med Chem (2014) 57: 5702-5713 [PMID:24914738]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum SB1-A6 harboring mutations conferring drug-resistance by SYBR-green based assay	F	7.93	pIC50	11.81	nM	IC50	J Med Chem (2014) 57: 6642-6652 [PMID:25007124]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7 after 72 hrs by DAPI staining-based confocal imaging analysis	F	7.93	pIC50	11.7	nM	IC50	J Med Chem (2019) 62: 622-640 [PMID:30537832]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7	F	7.94	pIC50	11.6	nM	IC50	Bioorg Med Chem Lett (2009) 19: 3229-3232 [PMID:19435664]
ChEMBL	Antimicrobial activity against leupeptin resistant-Plasmodium falciparum HB3-leuR1 mutant infected in erythrocytes assessed as growth inhibition after 72 hrs by SYBR Green I-based fluorescence assay	F	7.94	pIC50	11.57	nM	IC50	Antimicrob Agents Chemother (2008) 52: 2346-2354 [PMID:18443109]
ChEMBL	Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum NF54 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs	F	7.95	pIC50	11.2	nM	IC50	J Med Chem (2010) 53: 3214-3226 [PMID:20329733]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum harboring wild type pfcrt-76 and wild type pfmdr-1-86 gene after 18 hrs by [3H]hypoxanthine incorporation assay	F	7.96	pIC50	11	nM	IC50	Antimicrob Agents Chemother (2009) 53: 5069-5073 [PMID:19770282]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum 3D7 by giemsa stain	F	7.96	pIC50	11	nM	IC50	Bioorg Med Chem (2009) 17: 8234-8240 [PMID:19892554]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum HB3 after 72 hrs by SYBR green assay	F	7.96	pIC50	11	nM	IC50	J Med Chem (2008) 51: 3466-3479 [PMID:18512900]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum FCA 20/ Ghana by [3H]hypoxanthine uptake	F	7.96	pIC50	11	nM	IC50	J Nat Prod (2002) 65: 1381-1386 [PMID:12398531]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum Palo Alto(CQR)Ouganda incubated for 48 hrs by classical radioactive microdilution method	F	7.96	pIC50	11	nM	IC50	Eur J Med Chem (2020) 188: 111983-111983 [PMID:31911292]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum NF54 erythrocytic stages assessed as inhibition of parasite growth after 48 hrs by liquid scintillation counting method	F	7.96	pIC50	11	nM	IC50	J Nat Prod (2021) 84: 1335-1344 [PMID:33843232]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2(CQR)Indo-China incubated for 48 hrs by classical radioactive microdilution method	F	7.96	pIC50	11	nM	IC50	Eur J Med Chem (2020) 188: 111983-111983 [PMID:31911292]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum FcR3(CQR)Gambia incubated for 48 hrs by classical radioactive microdilution method	F	7.96	pIC50	11	nM	IC50	Eur J Med Chem (2020) 188: 111983-111983 [PMID:31911292]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum FcB1(CQR)Colombia incubated for 48 hrs by classical radioactive microdilution method	F	7.96	pIC50	11	nM	IC50	Eur J Med Chem (2020) 188: 111983-111983 [PMID:31911292]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum F32(CQS)Tanzania incubated for 48 hrs by classical radioactive microdilution method	F	7.96	pIC50	11	nM	IC50	Eur J Med Chem (2020) 188: 111983-111983 [PMID:31911292]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6(CQS)Sierra Leone incubated for 48 hrs by classical radioactive microdilution method	F	7.96	pIC50	11	nM	IC50	Eur J Med Chem (2020) 188: 111983-111983 [PMID:31911292]
ChEMBL	Antimalarial activity Plasmodium falciparum D6 after 72 hrs by SYBR Green I based fluorescence assay	F	7.96	pIC50	11	nM	IC50	J Med Chem (2011) 54: 5296-5306 [PMID:21736388]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 infected in red blood cells after 72 hrs by Malstat reagent based LDH assay	F	7.96	pIC50	11	nM	IC50	Eur J Med Chem (2017) 129: 175-185 [PMID:28222317]
ChEMBL	Antimalarial activity against Plasmodium falciparum NFS4 assessed as inhibition of [3H]hypoxanthine incorporation preincubated for 48 hrs measured 24 hrs post [3H]hypoxanthine addition by liquid scintillation counting	F	7.96	pIC50	11	nM	IC50	Bioorg Med Chem (2014) 22: 3749-3752 [PMID:24856305]
ChEMBL	Antimicrobial activity against Plasmodium falciparum NF54	F	7.96	pIC50	11	nM	IC50	ACS Med Chem Lett (2011) 2: 316-319 [PMID:21666827]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D10 assessed as inhibition of parasite growth after 72 hrs by parasite lactate dehydrogenase assay	F	7.96	pIC50	11	nM	IC50	Bioorg Med Chem (2015) 23: 4681-4687 [PMID:26081764]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 3D7 by Geimsa staining method	F	7.96	pIC50	11	nM	IC50	Bioorg Med Chem Lett (2011) 21: 3417-3419 [PMID:21524573]
ChEMBL	Antiplasmodial activity against drug-sensitive asexual ring stage Plasmodium falciparum 3D7 infected in human erythrocytes by [3H]-hypoxanthine incorporation assay	F	7.96	pIC50	11	nM	IC50	Eur J Med Chem (2018) 158: 801-813 [PMID:30245402]
ChEMBL	Inhibitory concentration against Plasmodium falciparum D6 (Sierra Leone)	F	7.96	pIC50	10.84	nM	IC50	J Med Chem (1988) 31: 645-650 [PMID:3279208]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 after 72 hrs	F	7.97	pIC50	10.7	nM	IC50	Antimicrob Agents Chemother (2009) 53: 1320-1324 [PMID:19171802]
ChEMBL	Antimicrobial activity against wild type Plasmodium falciparum HB3 infected in erythrocytes assessed as growth inhibition after 72 hrs by SYBR Green I-based fluorescence assay	F	7.98	pIC50	10.41	nM	IC50	Antimicrob Agents Chemother (2008) 52: 2346-2354 [PMID:18443109]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive asexual blood stage of Plasmodium falciparum NF54 by LDH assay	F	7.99	pIC50	10.2	nM	IC50	Eur J Med Chem (2019) 180: 121-133 [PMID:31301563]
ChEMBL	Growth inhibition of Plasmodium falciparum ring stage in infected erythrocytes by DAPI growth assay	F	8	pIC50	10.11	nM	IC50	Antimicrob Agents Chemother (2007) 51: 716-723 [PMID:17116676]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7	F	8	pIC50	10.1	nM	IC50	Bioorg Med Chem Lett (2006) 16: 5384-5388 [PMID:16890433]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by 96-well format based SYBR green assay	F	8	pIC50	10	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7	F	8	pIC50	10	nM	IC50	J Med Chem (2007) 50: 595-598 [PMID:17263523]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as parasite growth inhibition after 24 hrs by [3H]-hypoxathine incorporation assay	F	8	pIC50	10	nM	IC50	ACS Med Chem Lett (2013) 4: 642-646 [PMID:24900724]
ChEMBL	Antimalarial activity against asexual stage of Plasmodium falciparum NF54 assessed as reduction in parasite growth incubated for 96 hrs by SYBR Green I dye-based fluorescence assay	F	8	pIC50	10	nM	IC50	ACS Med Chem Lett (2020) 11: 49-55 [PMID:31938463]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7 infected in human O positive erythrocytes under low oxygen atmosphere after 72 hrs by spectrophotometric analysis	F	8	pIC50	10	nM	IC50	J Med Chem (2012) 55: 10909-10917 [PMID:23176597]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 3D7A assessed as inhibition of [3H]hypoxanthine incorporation incubated for 24 hrs prior to [3H]hypoxanthine addition measured after 24 hrs by beta scintillation counting	F	8	pIC50	10	nM	IC50	ACS Med Chem Lett (2012) 3: 373-377 [PMID:24900481]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 infected in O-positive human RBC assessed as [3H]-hypoxanthine incorporation after 48 hrs by scintillation counting in presence of BSA	F	8	pIC50	10	nM	IC50	ACS Med Chem Lett (2012) 3: 43-47 [PMID:24900369]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum Thai after 24 hrs	F	8	pIC50	10	nM	IC50	Bioorg Med Chem (2008) 16: 771-782 [PMID:17967541]
ChEMBL	In vitro antimalarial activity against Thai strain of Plasmodium falciparum	F	8	pIC50	10	nM	IC50	J Med Chem (2004) 47: 1997-2009 [PMID:15055999]
ChEMBL	Antiplasmodial activity against IEF stage of Plasmodium falciparum NF54 assessed as reduction in [3H]hypoxanthine incorporation preincubated for 48 hrs followed by [3H]hypoxanthine addition measured after 24 hrs by liquid scintillation counting method	F	8	pIC50	10	nM	IC50	J Nat Prod (2018) 81: 2682-2691 [PMID:30565934]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human O positive erythrocytes after 48 hrs by SYBR green-I based fluorescence assay	F	8	pIC50	10	nM	IC50	Eur J Med Chem (2011) 46: 5379-5386 [PMID:21940072]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum D6 after 72 hrs by MSF assay	F	8	pIC50	10	nM	IC50	Eur J Med Chem (2018) 152: 489-514 [PMID:29754074]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 by [3H]hypoxanthine incorporation	F	8	pIC50	10	nM	IC50	J Med Chem (2008) 51: 1333-1343 [PMID:18278859]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 by [3H]hypoxanthine incorporation	F	8	pIC50	10	nM	IC50	J Med Chem (2008) 51: 1278-1294 [PMID:18278860]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 infected in human O positive red blood cells assessed as inhibition of [3H]-hypoxanthine uptake after 48 hrs	F	8	pIC50	10	nM	IC50	J Nat Prod (2011) 74: 74-78 [PMID:21155593]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7 infected in human Erythrocyte assessed as reduction in plasmodial growth incubated for 48 hrs by FACS analysis	F	8	pIC50	10	nM	IC50	RSC Med Chem (2020) 11: 85-91 [PMID:33479606]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 after 72 hrs by SYBR Green I fluorescence based method	F	8	pIC50	10	nM	IC50	Eur J Med Chem (2010) 45: 4990-4996 [PMID:20805010]
ChEMBL	Antimalarial activity after 24 hrs against chloroquine-sensitive Plasmodium falciparum 3D7 infected human A+ erythrocytes by [3H]hypoxanthine uptake	F	8	pIC50	10	nM	IC50	J Med Chem (2009) 52: 502-513 [PMID:19113955]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum HB3 after 72 hrs	F	8	pIC50	10	nM	IC50	Bioorg Med Chem (2009) 17: 270-283 [PMID:19041248]
ChEMBL	Antimalarial activity against Plasmodium falciparum Dd2 harbouring Pf-crt, Pf-mdrl,Pf-dhfr, Pf-dhps mutated loci assessed as inhibition of parasite growth incubated for 48 hrs by [3H]hypoxanthine incorporation assay based liquid scintillation counting method	F	8	pIC50	10	nM	IC50	J Med Chem (2021) 64: 12582-12602 [PMID:34437804]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum GCO3 after 72 hrs by SYBR green assay	F	8	pIC50	10	nM	IC50	J Med Chem (2008) 51: 3466-3479 [PMID:18512900]
ChEMBL	Antimalarial activity against asexual blood stage drug-sensitive Plasmodium falciparum NF54 infected in erythrocytes assessed as reduction in parasitemia incubated up to 72 hrs by [3H]hypoxanthine incorporation assay	F	8	pIC50	10	nM	IC50	J Med Chem (2021) 64: 5198-5215 [PMID:33844521]
ChEMBL	Antimalarial activity against synchronous ring stage of Plasmodium falciparum 3D7 assessed as parasite growth inhibition incubated for 72 hrs by Griffith assay based fluorescence analysis	F	8	pIC50	10	nM	IC50	Eur J Med Chem (2021) 221: 113518-113518 [PMID:34058708]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum Ghana in human erythrocytes after 72 hrs by Malstat assay	F	8	pIC50	10	nM	IC50	J Med Chem (2009) 52: 2979-2988 [PMID:19364118]
ChEMBL	Antiplasmodial activity against drug-sensitive erythrocyte stage of Plasmodium falciparum NF54 assessed as reduction in [3H]-hypoxanthine incorporation pretreated for 48 hrs followed by [3H]-hypoxanthine addition measured after 24 hrs by liquid scintillation counting method	F	8	pIC50	10	nM	IC50	J Nat Prod (2018) 81: 1384-1390 [PMID:29896963]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54 infected in mouse at 30 mg/kg, po	F	8	pIC50	9.9	nM	IC50	J Med Chem (2013) 56: 2547-2555 [PMID:23489135]
ChEMBL	In vitro inhibition of chloroquine-sensitive Plasmodium falciparum HB3	F	8.01	pIC50	9.75	nM	IC50	J Med Chem (1997) 40: 437-448 [PMID:9046333]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human A positive erythrocytes assessed as inhibition of [G-3H]-hypoxanthine uptake after 24 hrs by liquid scintillation counting	F	8.01	pIC50	9.7	nM	IC50	Bioorg Med Chem (2012) 20: 927-932 [PMID:22182577]
ChEMBL	Antimalarial activity against drug-resistant Plasmodium falciparum 3D7 harboring A82T/V259L double mutant infected in human erythrocytes after 72 hrs by SYBR green 1-based fluorescence assay	F	8.02	pIC50	9.6	nM	IC50	J Med Chem (2019) 62: 3475-3502 [PMID:30852885]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7 infected in human erythrocytes after 72 hrs by SYBR green 1-based fluorescence assay	F	8.02	pIC50	9.6	nM	IC50	J Med Chem (2019) 62: 3475-3502 [PMID:30852885]
ChEMBL	Antimalarial activity against erythrocyte stage of Plasmodium falciparum 3D7 preincubated for 48 hrs followed by [3H]-hypoxanthine addition measured after 18 hrs by liquid scintillation counting	F	8.02	pIC50	9.6	nM	IC50	J Med Chem (2018) 61: 1231-1240 [PMID:29323491]
ChEMBL	Antimalarial activity against Plasmodium falciparum D6 by [3H]hypoxanthine uptake	F	8.02	pIC50	9.5	nM	IC50	J Nat Prod (2006) 69: 346-350 [PMID:16562832]
ChEMBL	Growth inhibition of Plasmodium falciparum HB3 ring stage in infected erythrocytes after 72 hrs in DAPI fluorimetry	F	8.02	pIC50	9.47	nM	IC50	Antimicrob Agents Chemother (2007) 51: 716-723 [PMID:17116676]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 3D7 erythrocytic stage	F	8.03	pIC50	9.4	nM	IC50	Antimicrob Agents Chemother (2009) 53: 2824-2833 [PMID:19364854]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54 after 72 hrs by [3H]hypoxanthine incorporation assay	F	8.03	pIC50	9.4	nM	IC50	J Med Chem (2013) 56: 1431-1442 [PMID:23360309]
ChEMBL	Antimalarial activity against chloroquine-sensitive erythrocytic stage of Plasmodium falciparum NF54 infected in human red blood cells assessed as growth inhibition after 48 hrs by [3H]-hypoxanthine incorporation assay	F	8.03	pIC50	9.4	nM	IC50	Eur J Med Chem (2013) 64: 498-511 [PMID:23685569]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D6 by SYBR green I-based assay	F	8.03	pIC50	9.4	nM	IC50	J Nat Prod (2012) 75: 1299-1304 [PMID:22709138]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54	F	8.03	pIC50	9.4	nM	IC50	Medchemcomm (2014) 5: 927-931
ChEMBL	Antimalarial activity against Plasmodium falciparum D6 after 24 hrs by [3H]hypoxanthine uptake	F	8.03	pIC50	9.3	nM	IC50	J Nat Prod (2002) 65: 614-615 [PMID:11975516]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 measured after 72 hrs by DAPI staining based high throughput screening assay	F	8.03	pIC50	9.3	nM	IC50	Bioorg Med Chem Lett (2017) 27: 2602-2607 [PMID:28400231]
ChEMBL	Antiplasmodial activity against drug-sensitive Plasmodium falciparum 3D7 ring stage infected in human erythrocytes after 72 hrs by DAPI staining based method	F	8.05	pIC50	9	nM	IC50	J Nat Prod (2018) 81: 1588-1597 [PMID:29969262]
ChEMBL	Antimalarial activity against drug-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes after 96 hrs by SYBR Green I-based fluorescence assay	F	8.05	pIC50	9	nM	IC50	J Med Chem (2011) 54: 6624-6633 [PMID:21882831]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum K39 after 48 hrs by [3H]hypoxanthine uptake	F	8.05	pIC50	9	nM	IC50	J Nat Prod (1997) 60: 1017-1022 [PMID:9358645]
ChEMBL	Antimalarial activity after 24 hrs against chloroquine-sensitive Plasmodium falciparum 3D7 by [3H]hypoxanthine uptake	F	8.05	pIC50	9	nM	IC50	J Nat Prod (2006) 69: 62-67 [PMID:16441070]
ChEMBL	Antiprotozoal activity against erythrocytic stage of Plasmodium falciparum NF54 after 48 hrs by [3H]- hypoxanthine incorporation assay	F	8.05	pIC50	9	nM	IC50	J Nat Prod (2017) 80: 443-458 [PMID:28121440]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum NF54 assessed as reduction in [3H]hypoxanthine incorporation pretreated for 48 hrs followed by [3H]hypoxanthine addition measured after 24 hrs by liquid scintillation counting method	F	8.05	pIC50	9	nM	IC50	J Nat Prod (2017) 80: 2807-2817 [PMID:29043798]
ChEMBL	Antiprotozoal activity against erythrocytic form of chloroquine/pyrimethamine-resistant Plasmodium falciparum K1 after 48 hrs by [3H]-hypoxanthine incorporation assay	F	8.05	pIC50	9	nM	IC50	J Nat Prod (2017) 80: 2566-2571 [PMID:28840725]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum NF54 measured after 24 hrs in presence of [3H] hypoxanthine by liquid scintillation counter analysis	F	8.05	pIC50	9	nM	IC50	J Nat Prod (2019) 82: 3499-3503 [PMID:31799840]
ChEMBL	In vitro activity against Plasmodium falciparum D6	F	8.05	pIC50	8.9	nM	IC50	J Med Chem (1992) 35: 2129-2134 [PMID:1597862]
ChEMBL	Antimalarial activity against Plasmodium falciparum by flow cytometry	F	8.06	pIC50	8.7	nM	IC50	Bioorg Med Chem Lett (2011) 21: 2606-2610 [PMID:21474310]
ChEMBL	Antimalarial activity against Plasmodium falciparum NF54 incubated for 48 hrs by [3H]-hypoxanthine incorporation assay	F	8.07	pIC50	8.6	nM	IC50	ACS Med Chem Lett (2020) 11: 49-55 [PMID:31938463]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7	F	8.07	pIC50	8.6	nM	IC50	Antimicrob Agents Chemother (2009) 53: 622-630 [PMID:19015351]
ChEMBL	Antimalarial malarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human A positive erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 24 hrs	F	8.07	pIC50	8.5	nM	IC50	Bioorg Med Chem Lett (2011) 21: 3644-3647 [PMID:21570837]
ChEMBL	Growth inhibitory concentration against Plasmodium falciparum NF54	F	8.07	pIC50	8.5	nM	IC50	J Med Chem (2003) 46: 3166-3169 [PMID:12825955]
ChEMBL	Antimalarial activity as 3rd generation ring-stage chloroquine-sensitive Plasmodium falciparum 3D7 after 48 hrs dose then 48 hrs drug-free	F	8.07	pIC50	8.49	nM	IC50	Antimicrob Agents Chemother (2007) 51: 3485-3490 [PMID:17698630]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum HB3 assessed as SYBR Green 1 fluorescence emission after 72 hrs	F	8.08	pIC50	8.4	nM	IC50	Bioorg Med Chem (2009) 17: 6560-6566 [PMID:19703776]
ChEMBL	Antimalarial activity against erythrocyte stage Plasmodium falciparum 3D7	F	8.08	pIC50	8.3	nM	IC50	J Nat Prod (2013) 76: 311-315 [PMID:23167812]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 assessed as [3H]hypoxanthine incorporation	F	8.09	pIC50	8.2	nM	IC50	Antimicrob Agents Chemother (2009) 53: 1320-1324 [PMID:19171802]
ChEMBL	Antimalarial activity against synchronized ring stage Plasmodium falciparum 3D7 transfected with nano-luciferase assessed as parasite growth inhibition after 72 hrs by Nano-Glo luciferase assay	F	8.09	pIC50	8.15	nM	IC50	Medchemcomm (2019) 10: 1599-1605 [PMID:31803400]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum 3D7 infected in erythrocytes after 72 hrs by syber green 1 assay	F	8.09	pIC50	8.15	nM	IC50	Eur J Med Chem (2011) 46: 676-690 [PMID:21194812]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs	F	8.09	pIC50	8.15	nM	IC50	Bioorg Med Chem Lett (2009) 19: 6996-6999 [PMID:19879137]
ChEMBL	Antimalarial activity against Plasmodium falciparum GC03	F	8.09	pIC50	8.1	nM	IC50	J Med Chem (2008) 51: 2170-2177 [PMID:18341274]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by 96-well format based SYBR green assay	F	8.1	pIC50	8	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiprotozoal activity against chloroquine-sensitive Plasmodium falciparum NF54	F	8.1	pIC50	8	nM	IC50	J Nat Prod (2019) 82: 3150-3164 [PMID:31630523]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7 in human erythrocytes after 48hrs by [3H]hypoxanthine uptake	F	8.1	pIC50	8	nM	IC50	J Med Chem (2008) 51: 4870-4873 [PMID:18680278]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 3D7 after 3 days by SYBR green1 dye based assay	F	8.1	pIC50	8	nM	IC50	Medchemcomm (2017) 8: 1069-1092 [PMID:29308121]
ChEMBL	Antiplasmodial activity against multidrug-sensitive asexual blood stage Plasmodium falciparum NF54 strain assessed as reduction in parasite growth after 72 hrs by NBT reagent based LDH assay	F	8.1	pIC50	8	nM	IC50	J Med Chem (2020) 63: 13013-13030 [PMID:33103428]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 assessed as reduction in [3H]-hypoxanthine incorporation pretreated for 48 hrs followed by [3H]-hypoxanthine addition measured after 24 hrs by liquid scintillation counting method	F	8.1	pIC50	8	nM	IC50	J Nat Prod (2018) 81: 918-933 [PMID:29560715]
ChEMBL	Antimalarial activity against CQ-sensitive Plasmodium falciparum NF54 infected in human type O+ erythrocytes assessed as growth inhibition incubated for 48 hrs by LDH assay	F	8.1	pIC50	8	nM	IC50	J Med Chem (2016) 59: 6512-6530 [PMID:27299916]
ChEMBL	Antimalarial activity against erythrocytic stage of Plasmodium falciparum 3D7 incubated for 50 hrs	F	8.1	pIC50	8	nM	IC50	Bioorg Med Chem Lett (2020) 30: 127037-127037 [PMID:32081449]
ChEMBL	Antimalarial activity against Plasmodium falciparum D6 in MSF assay	F	8.11	pIC50	7.8	nM	IC50	Bioorg Med Chem (2008) 16: 1174-1183 [PMID:18023189]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54 infected in normal type A human erythrocytes incubated for 72 hrs by spectrophotometry based parasite lactate dehydrogenase assay	F	8.11	pIC50	7.8	nM	IC50	Bioorg Med Chem Lett (2018) 28: 1287-1291 [PMID:29559277]
ChEMBL	Antimalarial activity against chloroquine-susceptible Plasmodium falciparum 3D7 assessed as inhibition of parasite growth after 48 hrs by [3H]hypoxanthine reuptake assay	F	8.11	pIC50	7.75	nM	IC50	Eur J Med Chem (2009) 44: 5071-5079 [PMID:19811859]
ChEMBL	Antimalarial activity against chloroquine sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR green 1 dye based fluorescence assay	F	8.11	pIC50	7.68	nM	IC50	Eur J Med Chem (2017) 135: 382-391 [PMID:28460312]
ChEMBL	Antimalarial activity against chloroquine-susceptible Plasmodium falciparum 3D7 after 72 hrs by SYBR Green-I based fluorescence assay	F	8.11	pIC50	7.68	nM	IC50	Bioorg Med Chem Lett (2012) 22: 5455-5459 [PMID:22850213]
ChEMBL	Antiprotozoal activity against erythrocytic stage of Plasmodium falciparum 3D7 incubated for 72 hrs by lactate dehydrogenase assay	F	8.12	pIC50	7.6	nM	IC50	J Nat Prod (2019) 82: 2907-2915 [PMID:31549837]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 3D7 axenic culture after 72 hrs by NBT dye based LDH assay	F	8.12	pIC50	7.6	nM	IC50	J Nat Prod (2018) 81: 2545-2552 [PMID:30387355]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 3D7 by SYBR Green 1-based fluorescence assay	F	8.14	pIC50	7.2	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3597-3604 [PMID:20547797]
ChEMBL	In vitro antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum Haiti 135	F	8.15	pIC50	7	nM	IC50	J Med Chem (1998) 41: 4918-4926 [PMID:9836608]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes measured after 72 hrs by SYBR green 1 dye based fluorescence assay	F	8.15	pIC50	7	nM	IC50	Eur J Med Chem (2017) 131: 171-184 [PMID:28319782]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum Haiti 135 by [3H]hypoxanthine uptake	F	8.15	pIC50	7	nM	IC50	J Med Chem (2008) 51: 3466-3479 [PMID:18512900]
ChEMBL	Antiplasmodial activity against drug-sensitive asexual intraerythrocytic stage of Plasmodium falciparum 3D7 infected in human O+ erythrocytes assessed as inhibition of parasite growth incubated for 48 hrs followed by addition of [3H]hypoxanthine for 24 hrs by [3H]hypoxanthine incorporation assay	F	8.15	pIC50	7	nM	IC50	Eur J Med Chem (2021) 211: 113065-113065 [PMID:33360801]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 incubated for 72 hrs by DAPI-staining based imaging analysis	F	8.15	pIC50	7	nM	IC50	J Nat Prod (2020) 83: 422-428 [PMID:31961680]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum D6	F	8.15	pIC50	7	nM	IC50	Bioorg Med Chem Lett (2013) 23: 3088-3095 [PMID:23562058]
ChEMBL	Antimalarial activity after 48 hrs against chloroquine-sensitive Plasmodium falciparum NF54 infected human A+ erythrocytes by [3H]hypoxanthine uptake	F	8.15	pIC50	7	nM	IC50	J Med Chem (2009) 52: 502-513 [PMID:19113955]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum NF54 erythrocytic stages assessed as reduction in [3H]hypoxanthine incorporation measured after 48 hrs by liquid scintillation counting method	F	8.15	pIC50	7	nM	IC50	Eur J Med Chem (2021) 210: 112969-112969 [PMID:33148495]
ChEMBL	Antiapicomplexan activity against chloroquine-sensitive Plasmodium falciparum D6 assessed as growth inhibition after 72 hrs by MSF assay	F	8.15	pIC50	7	nM	IC50	J Med Chem (2012) 55: 8375-8391 [PMID:22970937]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 asynchronous cultures infected in human erythrocytes after 72 hrs by SYBR green1 staining based fluorescence assay	F	8.15	pIC50	7	nM	IC50	Eur J Med Chem (2019) 162: 448-454 [PMID:30469040]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes after 72 hrs by SYBR Green 1 staining based fluorescence assay	F	8.15	pIC50	7	nM	IC50	Eur J Med Chem (2018) 155: 764-771 [PMID:29940466]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation incubated for 48 hrs prior to [3H]hypoxanthine addition measured after 48 hrs by liquid scintillation counting	F	8.15	pIC50	7	nM	IC50	J Med Chem (2012) 55: 6948-6967 [PMID:22783984]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 after 72 hrs by fluorescence based method	F	8.15	pIC50	7	nM	IC50	J Med Chem (2010) 53: 916-919 [PMID:20088608]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D6 after 72 hrs by SYBR green 1 fluorescence-based method	F	8.16	pIC50	6.9	nM	IC50	J Med Chem (2010) 53: 6477-6489 [PMID:20684562]
ChEMBL	Antiplasmodial activity against asexual erythrocytic stage of Plasmodium falciparum 3D7 assessed as reduction in parasite growth after 72 hrs by LDH assay	F	8.16	pIC50	6.9	nM	IC50	J Nat Prod (2020) 83: 481-488 [PMID:32040324]
ChEMBL	Antimalarial activity against Plasmodium falciparum HB3	F	8.18	pIC50	6.6	nM	IC50	J Med Chem (2008) 51: 2170-2177 [PMID:18341274]
ChEMBL	Antiplasmodial activity against multidrug-sensitive Plasmodium falciparum 3D7 after 18 hrs by [3H]hypoxanthine incorporation assay	F	8.19	pIC50	6.5	nM	IC50	Antimicrob Agents Chemother (2009) 53: 5069-5073 [PMID:19770282]
ChEMBL	Antimalarial activity against Plasmodium falciparum D6 in vitro.	F	8.19	pIC50	6.5	nM	IC50	J Med Chem (1998) 41: 4360-4364 [PMID:9784111]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum D6 infected in erythrocytes by [3H]-hypoxanthine incorporation assay	F	8.19	pIC50	6.5	nM	IC50	Eur J Med Chem (2017) 139: 22-47 [PMID:28800458]
ChEMBL	Antimicrobial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as inhibition of [3H] hypoxanthine incorporation after 24 hrs by scintillation counting	F	8.19	pIC50	6.5	nM	IC50	Eur J Med Chem (2011) 46: 1897-1905 [PMID:21377771]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6	F	8.19	pIC50	6.5	nM	IC50	J Med Chem (2006) 49: 5623-5625 [PMID:16942036]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 by SYBR green I-based assay	F	8.2	pIC50	6.3	nM	IC50	J Nat Prod (2012) 75: 1299-1304 [PMID:22709138]
ChEMBL	OSM: CSIR assay 3D7: Compounds were tested for inhibition of Plasmodium falciparum growth using a SYBR green I fluorescence based assay.	F	8.2	pIC50	6.3	nM	IC50	Open Source Malaria Deposition 1. http://malaria.ourexperiment.org
ChEMBL	Antimalarial activity against Plasmodium falciparum NF54 assessed as inhibition of parasite growth incubated for 48 hrs by [3H]hypoxanthine incorporation assay based liquid scintillation counting method	F	8.2	pIC50	6.25	nM	IC50	Bioorg Med Chem (2021) 33: 116018-116018 [PMID:33524940]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D6 infected human erythrocytes as [3H]hypoxanthine uptake after 24 hrs	F	8.21	pIC50	6.18	nM	IC50	J Nat Prod (1999) 62: 59-66 [PMID:9917283]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive IEF stage of Plasmodium falciparum NF54 infected in human RBC assessed as reduction in [3H]hypoxanthine incorporation preincubated for 48 hrs followed by [3H]hypoxanthine addition measured after 24 hrs by liquid scintillation counting method	F	8.22	pIC50	6	nM	IC50	Bioorg Med Chem (2017) 25: 4433-4443 [PMID:28666857]
ChEMBL	Antiprotozoal activity against erythrocytic stage of Plasmodium falciparum NF54 after 48 hrs by [3H]- hypoxanthine incorporation assay	F	8.22	pIC50	6	nM	IC50	J Nat Prod (2017) 80: 459-470 [PMID:28116906]
ChEMBL	In vitro antiparasitic activity against chloroquine-sensitive Plasmodium falciparum Haiti 135	F	8.22	pIC50	6	nM	IC50	J Med Chem (2004) 47: 2700-2705 [PMID:15115412]
ChEMBL	Antiplasmodial activity against chloroquine sensitive Plasmodium falciparum NF54 assessed as reduction in [3H]-hypoxanthine incorporation incubated for 48 hrs by liquid scintillation counting method	F	8.22	pIC50	6	nM	IC50	Eur J Med Chem (2017) 140: 595-603 [PMID:28988153]
ChEMBL	Antimalarial activity against transgenic Plasmodium falciparum 3D7 infected in human A positive erythrocytes after 72 hrs by luciferase reporter gene assay	F	8.22	pIC50	6	nM	IC50	Bioorg Med Chem (2011) 19: 5756-5762 [PMID:21907583]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum NF54 erythrocytic stage assessed as reduction in [3H]hypoxanthine incorporation preincubated for 48 hrs followed by [3H]hypoxanthine addition and measured after 24 hrs by liquid scintillation counting method	F	8.22	pIC50	6	nM	IC50	J Nat Prod (2018) 81: 2292-2295 [PMID:30302998]
ChEMBL	Antimalarial activity against Plasmodium falciparum NF54	F	8.22	pIC50	6	nM	IC50	J Med Chem (2011) 54: 4581-4589 [PMID:21644541]
ChEMBL	Antispasmodial activity against chloroquine-sensitive asexual blood stages of Plasmodium falciparum 3D7 after 72 hrs by HRP2-based ELISA	F	8.24	pIC50	5.7	nM	IC50	J Med Chem (2017) 60: 6036-6044 [PMID:28653845]
ChEMBL	Antimalarial activity as 2nd generation ring-stage chloroquine-sensitive Plasmodium falciparum 3D7 after 48 hrs by flow cytometry	F	8.25	pIC50	5.64	nM	IC50	Antimicrob Agents Chemother (2007) 51: 3485-3490 [PMID:17698630]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 assessed as inhibition of [3H]hypoxanthine incorporation after 96 hrs by microtiter plate scintillation counting	F	8.25	pIC50	5.6	nM	IC50	Bioorg Med Chem (2011) 19: 1692-1701 [PMID:21316974]
ChEMBL	Antiplasmodial activity against chloroquine and pyrimethamine-resistant ring stage Plasmodium falciparum V1/S infected in human red blood cells after 48 hrs	F	8.26	pIC50	5.5	nM	IC50	J Med Chem (2011) 54: 734-750 [PMID:21207937]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by MSF assay	F	8.27	pIC50	5.4	nM	IC50	Eur J Med Chem (2013) 66: 69-81 [PMID:23792317]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7 assessed as parasite growth inhibition after 72 hrs by MSF assay	F	8.27	pIC50	5.4	nM	IC50	Eur J Med Chem (2013) 62: 693-704 [PMID:23454512]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by DAPI staining based fluorescence assay	F	8.28	pIC50	5.3	nM	IC50	J Nat Prod (2018) 81: 1079-1083 [PMID:29533611]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7 after 72 hrs by DAPI staining-based fluorescence microscopic analysis	F	8.28	pIC50	5.3	nM	IC50	Bioorg Med Chem Lett (2017) 27: 4091-4095 [PMID:28774427]
ChEMBL	Antiplasmodial activity chloroquine-sensitive Plasmodium falciparum 3D7 infected in human A+ erythrocytes assessed as reduction of [3H]hypoxanthine incorporation after 24 hrs by scintillation counting	F	8.3	pIC50	5	nM	IC50	Bioorg Med Chem (2013) 21: 4904-4913 [PMID:23896611]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 measured after 72 hrs by SYBR green 1 dye based fluorescence assay	F	8.3	pIC50	5	nM	IC50	Eur J Med Chem (2017) 138: 1089-1105 [PMID:28763644]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes by lactate dehydrogenase assay	F	8.3	pIC50	5	nM	IC50	J Nat Prod (2012) 75: 1228-1230 [PMID:22694295]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 asynchronous cultures infected in human erythrocytes measured after 72 hrs by SYBR Green1 dye based fluorescence assay	F	8.31	pIC50	4.9	nM	IC50	Medchemcomm (2018) 9: 1232-1238 [PMID:30109012]
ChEMBL	Antimalarial activity after 48 hrs against Plasmodium falciparum GCO3 by [3H]hypoxanthine uptake	F	8.31	pIC50	4.9	nM	IC50	J Biol Chem (2007) 282: 2494-2504 [PMID:17110371]
ChEMBL	Inhibition of Plasmodium falciparum FCK2 growth as [3H]hypoxanthine uptake after 48 hrs	F	8.32	pIC50	4.8	nM	IC50	Antimicrob Agents Chemother (2007) 51: 307-316 [PMID:17060533]
ChEMBL	Antimalarial activity after 96 hrs against Plasmodium falciparum GCO3 by [3H]hypoxanthine uptake	F	8.32	pIC50	4.8	nM	IC50	J Biol Chem (2007) 282: 2494-2504 [PMID:17110371]
ChEMBL	Inhibitory concentration against Plasmodium falciparum D6 infected erythrocytes	F	8.32	pIC50	4.8	nM	IC50	J Med Chem (1994) 37: 1486-1494 [PMID:8182707]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 by [3H]hypoxanthine incorporation assay	F	8.33	pIC50	4.7	nM	IC50	J Nat Prod (2008) 71: 1887-1890 [PMID:18950229]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes assessed as inhibition of parasite growth incubated for 72 hrs by DAPI staining based fluorescence analysis	F	8.33	pIC50	4.7	nM	IC50	J Nat Prod (2020) 83: 2390-2398 [PMID:32790306]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7 asexual forms incubated for 72 hrs by luminescence method	F	8.33	pIC50	4.69	nM	IC50	Eur J Med Chem (2020) 188: 111983-111983 [PMID:31911292]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7 infected in human erythrocytes after 48 hrs by flow-cytometry	F	8.34	pIC50	4.6	nM	IC50	J Med Chem (2010) 53: 3552-3557 [PMID:20349996]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as reduction in parasite rowth incubated for 72 hrs by DAPI staining based fluorescence assay	F	8.35	pIC50	4.5	nM	IC50	J Nat Prod (2020) 83: 316-322 [PMID:32067457]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human RBC after 72 hrs by DAPI staining based confocal microscopic method	F	8.35	pIC50	4.5	nM	IC50	J Nat Prod (2017) 80: 114-125 [PMID:28001067]
ChEMBL	Antiprotozoal activity against Plasmodium falciparum NF54 assessed as reduction in [3H]hypoxanthine incorporation preincubated for 48 hrs followed by [3H]hypoxanthine addition and measured after 24 hrs by liquid scintillation counting method	F	8.38	pIC50	4.2	nM	IC50	Bioorg Med Chem Lett (2020) 30: 126778-126778 [PMID:31706668]
ChEMBL	Inhibition of Plasmodium falciparum FCK2 growth as [3H]hypoxanthine uptake after 96 hrs	F	8.38	pIC50	4.2	nM	IC50	Antimicrob Agents Chemother (2007) 51: 307-316 [PMID:17060533]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum K1 after 48 hrs by lactate dehydrogenase assay	F	8.4	pIC50	4	nM	IC50	J Med Chem (2018) 61: 9371-9385 [PMID:30256636]
ChEMBL	Antimalarial activity against erythrocytic stage of Plasmodium falciparum NF54 assessed as inhibition of [3H]-hypoxanthine incorporation after 48 hrs by liquid scintillation counting analysis	F	8.4	pIC50	4	nM	IC50	Eur J Med Chem (2018) 143: 97-106 [PMID:29172086]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive synchronized Plasmodium falciparum NF54 late trophozoite stage assessed as reduction in parasite survival incubated for 72 hrs under hypoxic condition by parasite lactate dehydrogenase based NBT microplate reader assay	F	8.4	pIC50	4	nM	IC50	ACS Med Chem Lett (2021) 12: 1333-1341 [PMID:34413963]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7 infected in human red blood cells after 72 hrs by DAPI-staining based assay	F	8.4	pIC50	4	nM	IC50	J Med Chem (2021) 64: 4150-4162 [PMID:33759519]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7 infected HEK293 cells by DAPI-staining based assay	F	8.4	pIC50	4	nM	IC50	J Med Chem (2019) 62: 2485-2498 [PMID:30715882]
ChEMBL	Antimalarial activity against Plasmodium falciparum K1 infected in human erythrocytes preincubated for 48 hrs followed by [3H]-hypoxanthine addition and measured after 24 hrs by liquid scintillation counting	F	8.4	pIC50	4	nM	IC50	J Med Chem (2018) 61: 9371-9385 [PMID:30256636]
ChEMBL	Antimalarial activity against synchronized ring stage CQ-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes incubated for 24 hrs followed by compound washout and subsequent compound addition and measured after 48 hrs by YOYO-1 probe-based flow cytometry	F	8.4	pIC50	4	nM	IC50	J Med Chem (2019) 62: 5562-5578 [PMID:31062592]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum NF54 infected in human erythrocytes assessed as reduction in [3H]-hypoxanthine incorporation pretreated for 48 hrs followed by [3H]-hypoxanthine addition measured after 24 hrs by liquid scintillation counting method	F	8.4	pIC50	4	nM	IC50	J Nat Prod (2019) 82: 958-969 [PMID:30916554]
ChEMBL	Antimalarial activity against erythrocytic stage of Plasmodium falciparum NF54 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counting analysis	F	8.41	pIC50	3.9	nM	IC50	J Med Chem (2013) 56: 700-711 [PMID:23301592]
ChEMBL	Antiplasmodial activity against erythrocytic stage of chloroquine-sensitive Plasmodium falciparum NF54 assessed as reduction in [3H]hypoxanthine incorporation after 48 hrs by liquid scintillation counting method	F	8.41	pIC50	3.9	nM	IC50	Bioorg Med Chem (2017) 25: 2251-2259 [PMID:28279559]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum NF54 erythrocytic stages assessed as parasite growth inhibition preincubated overnight followed by [G-3H]hypoxanthine addition and measured after 24 hrs by liquid scintillation counting method	F	8.52	pIC50	3.02	nM	IC50	Eur J Med Chem (2020) 207: 112837-112837 [PMID:33002847]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive erythrocytic stage Plasmodium falciparum 3D7 assessed as inhibition of parasite growth incubated for 3 days by HRP2-ELISA	F	8.52	pIC50	3	nM	IC50	Eur J Med Chem (2021) 224: 113687-113687 [PMID:34274829]
ChEMBL	Antiparasitic activity against Plasmodium falciparum	F	8.52	pIC50	3	nM	IC50	J Med Chem (2001) 44: 909-916 [PMID:11300872]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum assessed as growth inhibition	F	8.52	pIC50	3	nM	IC50	Bioorg Med Chem Lett (2015) 25: 462-465 [PMID:25547934]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 erythrocytic stage measured after 3 days by HRP2 assay	F	8.52	pIC50	3	nM	IC50	Eur J Med Chem (2020) 187: 111927-111927 [PMID:31812035]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum NF54 erythrocytic stages assessed as parasite growth inhibition preincubated overnight followed by [G-3H]hypoxanthine addition and measured after 24 hrs by liquid scintillation counting method	F	8.52	pIC50	3	nM	IC50	Eur J Med Chem (2020) 207: 112837-112837 [PMID:33002847]
ChEMBL	Antimalarial activity against drug-sensitive Plasmodium falciparum 3D7 after 24 hrs	F	8.62	pIC50	2.4	nM	IC50	Bioorg Med Chem (2007) 15: 5551-5562 [PMID:17548196]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum NF54 after 48 hrs by [3H]-hypoxanthine incorporation assay	F	8.7	pIC50	2	nM	IC50	J Nat Prod (2013) 76: 97-102 [PMID:23320609]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7	F	8.7	pIC50	2	nM	IC50	Bioorg Med Chem Lett (2011) 21: 4561-4563 [PMID:21705220]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D10	F	8.7	pIC50	2	nM	IC50	Bioorg Med Chem Lett (2011) 21: 4561-4563 [PMID:21705220]
ChEMBL	Antiplasmodial activity chloroquine-sensitive Plasmodium falciparum 3D7 infected in human A+ erythrocytes assessed as inhibition of [3H]-hypoxanthine incorporation after 24 hrs by scintillation counting	F	8.85	pIC50	1.4	nM	IC50	Eur J Med Chem (2012) 52: 82-97 [PMID:22459876]
ChEMBL	Intrinsic equimolar activity against Plasmodium falciparum D6 (Sierra Leone) relative to QHS	F	9.01	pIC50	0.97	nM	IC50	J Med Chem (1988) 31: 645-650 [PMID:3279208]
ChEMBL	Intrinsic equimolar activity against Plasmodium falciparum W2 Indochina relative to QHS	F	10.22	pIC50	0.06	nM	IC50	J Med Chem (1988) 31: 645-650 [PMID:3279208]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D10	F	10.4	pIC50	0.04	nM	IC50	J Nat Prod (2009) 72: 1265-1268 [PMID:19572738]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in type B+ human erythrocytes assessed as inhibition of parasitemia after 48 hrs by Giemsa staining	F	10.52	pIC50	0.03	nM	IC50	Eur J Med Chem (2009) 44: 3388-3393 [PMID:19269069]
ChEMBL	Antimalarial activity against chloroquine, mefloquine, pyrimethamine and atovaquone-resistant Plasmodium falciparum TM90-C2B infected in human A+ erythrocytes after 72 hrs by SYBR Green I assay	F	4.32	pEC50	48200	nM	EC50	J Med Chem (2010) 53: 7076-7094 [PMID:20828199]
ChEMBL	Antimalarial activity against Plasmodium falciparum NF54 harboring pfs16-LUC-GFP late stage 4 to 5 gametocytes after 48 hrs by MitoTracker Red staining based confocal microscopy	F	4.4	pEC50	>40000	nM	EC50	J Med Chem (2017) 60: 1171-1188 [PMID:28080063]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7 incubated for 72 hrs by LDH assay	F	4.68	pEC50	21000	nM	EC50	Eur J Med Chem (2021) 214: 113253-113253 [PMID:33610028]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum RKL9 infected in red blood cells assessed as reduction in mature schizonts formation after 24 hrs by Giemsa-staining based assay	F	4.95	pEC50	11250	nM	EC50	Eur J Med Chem (2018) 149: 139-147 [PMID:29499486]
ChEMBL	Antimalarial activity against Plasmodium falciparum NF54 late stage (1 to 3) expressing Pfs16-LUC-GFP assessed as growth inhibition by high content imaging assay	F	5	pEC50	>10000	nM	EC50	Eur J Med Chem (2021) 214: 113253-113253 [PMID:33610028]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in red blood cells assessed as reduction in mature schizonts formation after 24 hrs by Giemsa-staining based assay	F	5.53	pEC50	2970	nM	EC50	Eur J Med Chem (2018) 149: 139-147 [PMID:29499486]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 after 48 hrs	F	5.82	pEC50	1500	nM	EC50	J Med Chem (2007) 50: 2281-2284 [PMID:17441706]
ChEMBL	Antiplasmodial activity against multidrug-resistant Plasmodium falciparum K1 infected in human erythrocytes assessed as reduction in parasite growth incubated for 72 hrs by SYBR green I fluorescence based assay	F	6.1	pEC50	800	nM	EC50	Eur J Med Chem (2021) 224: 113722-113722 [PMID:34364164]
ChEMBL	Antimalarial activity against synchronous culture of Plasmodium falciparum 3D7 ring stage parasite infected in human erythrocytes incubated for 6 hrs followed by compound wash out and measured after 24 hrs by NanoGlo-reagent based bioluminescence assay	F	6.19	pEC50	643	nM	EC50	J Med Chem (2017) 60: 1171-1188 [PMID:28080063]
ChEMBL	Antimalarial activity against synchronous culture of Plasmodium falciparum 3D7 ring stage parasite infected in human erythrocytes incubated for 3 hrs followed by compound wash out and measured after 24 hrs by NanoGlo-reagent based bioluminescence assay	F	6.22	pEC50	608	nM	EC50	J Med Chem (2017) 60: 1171-1188 [PMID:28080063]
ChEMBL	Antimalarial activity against asexual blood stage of chloroquine-resistant Plasmodium falciparum Dd2 assessed as reduction in cell viability after 72 hrs by EtBr staining based flow cytometric analysis	F	6.24	pEC50	580	nM	EC50	Eur J Med Chem (2021) 214: 113253-113253 [PMID:33610028]
ChEMBL	Antimalarial activity against asexual blood stage of artemisinin-resistant Plasmodium falciparum Cam3.12539T cambodian isolate assessed as reduction in cell viability after 72 hrs by EtBr staining based flow cytometric analysis	F	6.25	pEC50	560	nM	EC50	Eur J Med Chem (2021) 214: 113253-113253 [PMID:33610028]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human erythrocytes assessed as reduction in [3H]hypoxanthine incorporation pretreated for 24 hrs followed by [3H]hypoxanthine addition and measured after 24 hrs by liquid scintillation counting method	F	6.33	pEC50	470	nM	EC50	ACS Med Chem Lett (2019) 10: 137-141 [PMID:30655961]
ChEMBL	Antimalarial activity against multi-drug-resistant Plasmodium falciparum W2 infected in human type A+ erythrocytes assessed as growth inhibition after 72 hrs by SYBR Green I assay	F	6.38	pEC50	421	nM	EC50	J Med Chem (2014) 57: 8860-8879 [PMID:25148516]
ChEMBL	Antimalarial activity against Plasmodium falciparum W2	F	6.38	pEC50	421	nM	EC50	J Med Chem (2016) 59: 6943-6960 [PMID:27291102]
ChEMBL	Antimalarial activity against pyrimethamine/chloroquine-resistant Plasmodium falciparum W2 infected in human type A-positive erythrocytes after 48 hrs by [3H]-hypoxanthine incorporation assay	F	6.38	pEC50	420	nM	EC50	J Med Chem (2018) 61: 1450-1473 [PMID:29215279]
ChEMBL	Antimalarial activity against Plasmodium falciparum W2 after 72 hr by LDH assay	F	6.44	pEC50	359	nM	EC50	Med Chem Res (2005) 14: 74-105
ChEMBL	Antimalarial activity against asexual blood stage of chloroquine-resistant Plasmodium falciparum 7G8 assessed as reduction in cell viability after 72 hrs by EtBr staining based flow cytometric analysis	F	6.49	pEC50	320	nM	EC50	Eur J Med Chem (2021) 214: 113253-113253 [PMID:33610028]
ChEMBL	Antiplasmodial activity against chloroquine, pyrimethamine and mefloquine-resistant asexual blood stage of Plasmodium falciparum Dd2 assessed as reduction in parasite growth after 72 hrs by SYBR green I staining based fluorescence assay	F	6.5	pEC50	319	nM	EC50	ACS Med Chem Lett (2022) 13: 371-376 [PMID:35300082]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 IndoChina after 48 hr by parasite LDH assay	F	6.51	pEC50	310	nM	EC50	Med Chem Res (2005) 14: 332-346
ChEMBL	Antiparasitic activity against chloroquine-resistant Plasmodium falciparum W2	F	6.51	pEC50	310	nM	EC50	Bioorg Med Chem Lett (2004) 14: 615-619 [PMID:14741254]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human erythrocytes incubated for 72 hrs by SYBR green staining based fluorescence assay	F	6.52	pEC50	302.8	nM	EC50	Bioorg Med Chem Lett (2020) 30: 127514-127514 [PMID:32860980]
ChEMBL	Antimicrobial activity against chloroquine-resistant Plasmodium falciparum W2 after 72 hrs	F	6.53	pEC50	293	nM	EC50	Antimicrob Agents Chemother (2007) 51: 2164-2172 [PMID:17371810]
ChEMBL	Antimalarial activity against synchronous culture of Plasmodium falciparum 3D7 ring stage parasite infected in human erythrocytes incubated for 24 hrs followed by compound wash out and measured after 24 hrs by NanoGlo-reagent based bioluminescence assay	F	6.54	pEC50	286	nM	EC50	J Med Chem (2017) 60: 1171-1188 [PMID:28080063]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 infected in human erythrocyte assessed as growth inhibition by SYBR Green-1 assay	F	6.55	pEC50	285	nM	EC50	Eur J Med Chem (2015) 102: 320-333 [PMID:26295174]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 as LDH activity after 48 hrs	F	6.55	pEC50	280	nM	EC50	J Med Chem (2004) 47: 6609-6615 [PMID:15588096]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2	F	6.59	pEC50	260	nM	EC50	J Med Chem (2013) 56: 2975-2990 [PMID:23517371]
ChEMBL	Antimalarial activity against chloroquine and mefloquine resistant Plasmodium falciparum W2mef infected in human erythrocytes incubated for 72 hrs by LDH assay	F	6.6	pEC50	250	nM	EC50	J Med Chem (2017) 60: 1171-1188 [PMID:28080063]
ChEMBL	Antimalarial activity against atovaquone-resistant Plasmodium falciparum TM90C2B	F	6.6	pEC50	250	nM	EC50	J Med Chem (2013) 56: 2975-2990 [PMID:23517371]
ChEMBL	Antimalarial activity against asexual blood stage of Mefloquine-resistant Plasmodium falciparum W2mef assessed as reduction in cell viability after 72 hrs by EtBr staining based flow cytometric analysis	F	6.6	pEC50	250	nM	EC50	Eur J Med Chem (2021) 214: 113253-113253 [PMID:33610028]
ChEMBL	Antimalarial activity against mefloquine/chloroquine/atovaquone/pyrimethamine-resistant Plasmodium falciparum TM90-C2B infected in human type A-positive erythrocytes after 48 hrs by [3H]-hypoxanthine incorporation assay	F	6.64	pEC50	230	nM	EC50	J Med Chem (2018) 61: 1450-1473 [PMID:29215279]
ChEMBL	Antimalarial activity against chloroquine, pyrimethamine, mefloquine and atovaquone- resistant Plasmodium falciparum TM90-C2B infected in human erythrocytes assessed as reduction in parasite growth incubated for 48 hrs followed by addition of [3H]-hypoxanthine and measured after 24 hrs by Topcount liquid scintillation counting method	F	6.64	pEC50	229.09	nM	EC50	J Med Chem (2021) 64: 6581-6595 [PMID:33979164]
ChEMBL	Antimalarial activity against Plasmodium falciparum TM90-C2B	F	6.64	pEC50	229	nM	EC50	J Med Chem (2016) 59: 6943-6960 [PMID:27291102]
ChEMBL	Antimalarial activity against multi-drug-resistant Plasmodium falciparum TM90-C2B infected in human type A+ erythrocytes assessed as growth inhibition after 72 hrs by SYBR Green I assay	F	6.64	pEC50	229	nM	EC50	J Med Chem (2014) 57: 8860-8879 [PMID:25148516]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 infected in human erythrocytes assessed as reduction in microbial growth after 72 hrs by SYBR green I staining based fluorescence assay	F	6.76	pEC50	174	nM	EC50	J Med Chem (2020) 63: 11756-11785 [PMID:32959656]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 infected in human erythrocytes incubated for 72 hrs by SYBR green staining based fluorescence assay	F	6.78	pEC50	165.3	nM	EC50	Bioorg Med Chem Lett (2020) 30: 127514-127514 [PMID:32860980]
ChEMBL	Antimalarial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum W2 infected in human A+ erythrocytes after 72 hrs by SYBR Green I assay	F	6.79	pEC50	163.9	nM	EC50	J Med Chem (2010) 53: 7076-7094 [PMID:20828199]
ChEMBL	Antimalarial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum W2 infected in human A positive erythrocytes after 72 hrs by SYBR Green I assay	F	6.79	pEC50	162	nM	EC50	J Med Chem (2011) 54: 4399-4426 [PMID:21630666]
ChEMBL	Antimalarial activity against chloroquine-, mefloquine-, pyrimethamine-,atovaquone-resistant ring stage Plasmodium falciparum TM90-C2B infected in human A positive erythrocytes after 72 hrs by SYBR green 1-based fluorescence assay	F	6.79	pEC50	162	nM	EC50	J Med Chem (2011) 54: 8321-8327 [PMID:22111907]
ChEMBL	Antimalarial activity against chloroquine and pyrimethamine resistant Plasmodium falciparum W2 infected in human erythrocytes assessed as reduction in parasite growth incubated for 48 hrs followed by addition of [3H]-hypoxanthine and measured after 24 hrs by Topcount liquid scintillation counting method	F	6.8	pEC50	158.49	nM	EC50	J Med Chem (2021) 64: 6581-6595 [PMID:33979164]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1	F	6.82	pEC50	150	nM	EC50	J Med Chem (2006) 49: 4795-4798 [PMID:16854088]
ChEMBL	Antimalarial activity against multidrug-resistant and atovaquone-sensitive Plasmodium falciparum TM91C235	F	6.85	pEC50	140	nM	EC50	J Med Chem (2013) 56: 2975-2990 [PMID:23517371]
ChEMBL	Antimalarial activity against chloroquine-, pyrimethamine-resistant ring stage Plasmodium falciparum W2 infected in human A positive erythrocytes after 72 hrs by SYBR green 1-based fluorescence assay	F	6.88	pEC50	131	nM	EC50	J Med Chem (2011) 54: 8321-8327 [PMID:22111907]
ChEMBL	Antimalarial activity against chloroquine, mefloquine, pyrimethamine and atovaquone-resistant Plasmodium falciparum TM90-C2B infected in human A positive erythrocytes after 72 hrs by SYBR Green I assay	F	6.88	pEC50	131	nM	EC50	J Med Chem (2011) 54: 4399-4426 [PMID:21630666]
ChEMBL	In vitro antimalarial activity against chloroquine-resistant Plasmodium falciparum K1	F	6.89	pEC50	130	nM	EC50	J Med Chem (1999) 42: 3163-3166 [PMID:10447961]
ChEMBL	Antimalarial activity against Plasmodium falciparum Dd2 after 3 days by SYBR green I assay	F	6.92	pEC50	120	nM	EC50	ACS Med Chem Lett (2013) 4: 278-282 [PMID:23795240]
ChEMBL	Antimalarial activity against Plasmodium falciparum NF54 early stage (1 to 3) expressing Pfs16-LUC-GFP assessed as growth inhibition by high content imaging assay	F	7.01	pEC50	97	nM	EC50	Eur J Med Chem (2021) 214: 113253-113253 [PMID:33610028]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected human erythrocytes after 72 hrs by MSF assay	F	7.05	pEC50	90	nM	EC50	Bioorg Med Chem (2010) 18: 2756-2766 [PMID:20206533]
ChEMBL	NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay	F	7.08	pEC50	83.7	nM	EC50	Proc Natl Acad Sci U S A (2008) 105: 9059-9064 [PMID:18579783]
ChEMBL	Antimalarial activity as reduced parasitaemia after 72 hrs against chloroquine-resistant Plasmodium falciparum Dd2 in human erythrocytes by DAPI stain	F	7.18	pEC50	66	nM	EC50	Bioorg Med Chem Lett (2008) 18: 6521-6524 [PMID:18993067]
ChEMBL	Antimalarial activity against Plasmodium falciparum NF54 harboring pfs16-LUC-GFP early stage 1 to 3 gametocytes after 48 hrs by MitoTracker Red staining based confocal microscopy	F	7.23	pEC50	59	nM	EC50	J Med Chem (2017) 60: 1171-1188 [PMID:28080063]
ChEMBL	Antiparasitic activity against Plasmodium falciparum W2 after 48 hrs by YOYO-1 probe-based flow cytometry	F	7.24	pEC50	57	nM	EC50	J Med Chem (2017) 60: 6911-6923 [PMID:28763614]
ChEMBL	Antimalarial activity against Plasmodium falciparum Dd2	F	7.26	pEC50	55	nM	EC50	Antimicrob Agents Chemother (2007) 51: 759-762 [PMID:17088482]
ChEMBL	Antimalarial activity as reduced parasitaemia after 72 hrs against chloroquine-resistant Plasmodium falciparum FCB in human erythrocytes by DAPI stain	F	7.28	pEC50	52	nM	EC50	Bioorg Med Chem Lett (2008) 18: 6521-6524 [PMID:18993067]
ChEMBL	Antiplasmodial activity against multidrug-resistant Plasmodium falciparum W2 infected in human erythrocytes after 24 hrs by [3H]-hypoxanthine incorporation assay	F	7.31	pEC50	49	nM	EC50	Bioorg Med Chem Lett (2013) 23: 2829-2843 [PMID:23587422]
ChEMBL	Antimalarial activity as reduced parasitaemia after 72 hrs against chloroquine-resistant Plasmodium falciparum 7G8 in human erythrocytes by DAPI stain	F	7.34	pEC50	46	nM	EC50	Bioorg Med Chem Lett (2008) 18: 6521-6524 [PMID:18993067]
ChEMBL	Antimalarial activity against Plasmodium falciparum W2 by automated image mining based cytological profiling assay	F	7.48	pEC50	33	nM	EC50	J Med Chem (2014) 57: 7425-7434 [PMID:25137549]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes assessed as reduction in parasitemia after 72 hrs by spectrophotometry	F	7.52	pEC50	30	nM	EC50	J Med Chem (2011) 54: 7084-7093 [PMID:21910466]
ChEMBL	Antiplasmodial activity against erythrocytic stages of Plasmodium falciparum 3D7 after 48 hrs by SYBR green assay	F	7.52	pEC50	30	nM	EC50	Eur J Med Chem (2010) 45: 5140-5149 [PMID:20817362]
ChEMBL	Antimicrobial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 48 hrs	F	7.6	pEC50	25	nM	EC50	Antimicrob Agents Chemother (2010) 54: 1334-1337 [PMID:20028821]
ChEMBL	Antimicrobial activity against chloroquine-sensitive Plasmodium falciparum D10 after 48 hrs	F	7.64	pEC50	23	nM	EC50	Antimicrob Agents Chemother (2010) 54: 1334-1337 [PMID:20028821]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7 asexual blood stage infected in human erythrocytes incubated for 72 hrs by LDH assay	F	7.64	pEC50	23	nM	EC50	J Med Chem (2017) 60: 1171-1188 [PMID:28080063]
ChEMBL	Antimicrobial activity against Plasmodium falciparum harboring HFP-tagged Pfs16 protein after 48 hrs	F	7.64	pEC50	23	nM	EC50	Antimicrob Agents Chemother (2010) 54: 1334-1337 [PMID:20028821]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7 after 3 days by SYBR green I assay	F	7.68	pEC50	21	nM	EC50	ACS Med Chem Lett (2013) 4: 278-282 [PMID:23795240]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum D6 infected in human erythrocytes by SYBR green I fluorescence assay	F	7.7	pEC50	20	nM	EC50	Bioorg Med Chem Lett (2010) 20: 4836-4839 [PMID:20634066]
ChEMBL	Antimalarial activity against Plasmodium falciparum NF54 harboring pfs16-LUC-GFP ring stage gametocytes after 24 hrs by MitoTracker Red staining based confocal microscopy	F	7.7	pEC50	20	nM	EC50	J Med Chem (2017) 60: 1171-1188 [PMID:28080063]
ChEMBL	In vitro antimalarial activity against Plasmodium falciparum FCR3	F	7.74	pEC50	18	nM	EC50	J Med Chem (2003) 46: 4351-4359 [PMID:13678413]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum FCR-3 assessed as growth inhibition	F	7.74	pEC50	18	nM	EC50	Bioorg Med Chem (2014) 22: 1993-2004 [PMID:24650700]
ChEMBL	Antimalarial activity as reduced parasitaemia after 72 hrs against chloroquine-sensitive Plasmodium falciparum FCR3 in human erythrocytes by Diff-Quick stain	F	7.74	pEC50	18	nM	EC50	Bioorg Med Chem (2008) 16: 6027-6033 [PMID:18479926]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum FCR3	F	7.74	pEC50	18	nM	EC50	Bioorg Med Chem Lett (2006) 16: 2758-2760 [PMID:16524728]
ChEMBL	In vitro antimalarial activity against chloroquine-sensitive Plasmodium falciparum FCR3	F	7.74	pEC50	18	nM	EC50	J Med Chem (2002) 45: 995-998 [PMID:11855978]
ChEMBL	In vitro antimalarial activity against Plasmodium falciparum	F	7.74	pEC50	18	nM	EC50	J Med Chem (2003) 46: 638-641 [PMID:12570385]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum FCR3	F	7.74	pEC50	18	nM	EC50	J Med Chem (2000) 43: 3274-3282 [PMID:10966746]
ChEMBL	In vitro antimalarial activity against chloroquine-sensitive Plasmodium falciparum FCR3	F	7.74	pEC50	18	nM	EC50	J Med Chem (1999) 42: 3163-3166 [PMID:10447961]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes assessed as reduction in microbial growth after 72 hrs by SYBR green I staining based fluorescence assay	F	7.75	pEC50	17.8	nM	EC50	J Med Chem (2020) 63: 11756-11785 [PMID:32959656]
ChEMBL	Antimalarial activity against Plasmodium falciparum clinical isolate measured after 72 hrs by SYBR green dye based fluorescence assay	F	7.77	pEC50	16.9	nM	EC50	J Med Chem (2019) 62: 6137-6145 [PMID:31177777]
ChEMBL	Antimalarial activity as reduced parasitaemia after 72 hrs against chloroquine-resistant Plasmodium falciparum 106/1 in human erythrocytes by DAPI stain	F	7.85	pEC50	14	nM	EC50	Bioorg Med Chem Lett (2008) 18: 6521-6524 [PMID:18993067]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6	F	7.85	pEC50	14	nM	EC50	J Med Chem (2013) 56: 2975-2990 [PMID:23517371]
ChEMBL	Antiparasitic activity against Plasmodium falciparum D6	F	7.85	pEC50	14	nM	EC50	Bioorg Med Chem Lett (2004) 14: 615-619 [PMID:14741254]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54	F	7.89	pEC50	13	nM	EC50	Bioorg Med Chem (2018) 26: 5730-5741 [PMID:30391094]
ChEMBL	Antimicrobial activity against blood-stage Plasmodium falciparum NF54 assessed as inhibition of [3H]hypoxanthine incorporation after 48 hrs by liquid scintillation counting	F	7.89	pEC50	13	nM	EC50	J Med Chem (2014) 57: 2773-2788 [PMID:24641010]
ChEMBL	Antimicrobial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs	F	8	pEC50	10	nM	EC50	Antimicrob Agents Chemother (2007) 51: 2164-2172 [PMID:17371810]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 3D7 by [3H]hypoxanthine incorporation assay	F	8	pEC50	>10	nM	EC50	Nat Chem Biol (2008) 4: 347-356 [PMID:18454143]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7 infected in human erythrocytes after 72 hrs by SYBR green dye fluorescence assay	F	8.01	pEC50	9.8	nM	EC50	Bioorg Med Chem (2018) 26: 3610-3618 [PMID:29887512]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7 infected in human erythrocytes after 72 hrs by SYBR Green1 dye based fluorescence assay relative to control	F	8.01	pEC50	9.8	nM	EC50	Eur J Med Chem (2019) 170: 55-72 [PMID:30878832]
ChEMBL	Antiparasitic activity against Plasmodium falciparum 3D7 at erythrocytic stage	F	8.03	pEC50	9.4	nM	EC50	Bioorg Med Chem Lett (2010) 20: 1816-1818 [PMID:20185305]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D6 after 48 hrs as LDH reporter activity	F	8.05	pEC50	9	nM	EC50	J Med Chem (2004) 47: 6609-6615 [PMID:15588096]
ChEMBL	Antimalarial activity against Plasmodium falciparum D6 trophozoites after 72 hrs by SYBR Green I dye-based fluorescence assay	F	8.05	pEC50	8.9	nM	EC50	ACS Med Chem Lett (2018) 9: 996-1001 [PMID:30344906]
ChEMBL	Antiprotozoal activity against Plasmodium falciparum	F	8.1	pEC50	8	nM	EC50	Bioorg Med Chem Lett (2008) 18: 2455-2458 [PMID:18313921]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7 infected in human A positive erythrocytes by [3H]hypoxanthine uptake assay in presence of serum in medium	F	8.15	pEC50	7.1	nM	EC50	J Med Chem (2011) 54: 3935-3949 [PMID:21517059]
ChEMBL	Antimalarial activity against erythrocytic stages of Plasmodium falciparum 3D7 infected in human O positive RBC after 48 hrs by SYBR-green assay	F	8.15	pEC50	7	nM	EC50	J Med Chem (2012) 55: 10948-10957 [PMID:23240776]
ChEMBL	Antimalarial activity as reduced parasitaemia after 72 hrs against chloroquine-sensitive Plasmodium falciparum 3D7 in human erythrocytes by DAPI stain	F	8.15	pEC50	7	nM	EC50	Bioorg Med Chem Lett (2008) 18: 6521-6524 [PMID:18993067]
ChEMBL	Antiplasmodial activity against ring-stage Plasmodium falciparum 3D7 assessed as reduction in parasite viability after 72 hrs by LDH assay	F	8.22	pEC50	6	nM	EC50	Eur J Med Chem (2018) 154: 182-198 [PMID:29800827]
ChEMBL	Antimicrobial activity against Plasmodium falciparum NF54 infected in human RBC after 48 hrs by [3H]hypoxanthine incorporation assay	F	8.22	pEC50	6	nM	EC50	Eur J Med Chem (2013) 66: 450-465 [PMID:23831695]
ChEMBL	Antimalarial activity against asexual blood stage of Plasmodium falciparum 3D7 assessed as reduction in cell viability after 72 hrs by EtBr staining based flow cytometric analysis	F	8.4	pEC50	4	nM	EC50	Eur J Med Chem (2021) 214: 113253-113253 [PMID:33610028]
ChEMBL	NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay	F	8.62	pEC50	2.43	nM	EC50	Proc Natl Acad Sci U S A (2008) 105: 9059-9064 [PMID:18579783]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 3D7 assessed as inhibition of [3H]hypoxanthine incorporation after 18 hrs by liquid scintillation counting	F	9.17	pEC50	0.67	nM	EC50	ACS Med Chem Lett (2011) 2: 901-906 [PMID:24900279]
Plasmodium falciparum 3D7 (target type: ORGANISM) [ChEMBL: CHEMBL2366922]
ChEMBL	Antimicrobial activity against chloroquine and mefloquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes after 48 hrs by SYBR Green I assay	F	7.09	pIC50	82	nM	IC50	Eur J Med Chem (2014) 81: 378-393 [PMID:24858543]
ChEMBL	Antimalarial activity against ring-stage Plasmodium falciparum 3D7 assessed as schizonticidal activity after 42 hrs	F	7.11	pIC50	78	nM	IC50	Eur J Med Chem (2013) 70: 607-612 [PMID:24211636]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs by LDH colorimetric assay	F	7.3	pIC50	50	nM	IC50	Bioorg Med Chem (2014) 22: 1128-1138 [PMID:24411478]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 72 hrs by SYBR Green I dye-based fluorescence assay	F	7.4	pIC50	40	nM	IC50	Eur J Med Chem (2015) 95: 16-28 [PMID:25791675]
ChEMBL	Antimicrobial activity against chloroquine-sensitive Plasmodium falciparum 3D7	F	7.52	pIC50	30	nM	IC50	Eur J Med Chem (2015) 90: 280-295 [PMID:25461328]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as inhibition of parasite growth after 48 hrs by parasite lactate dehydrogenase assay	F	7.64	pIC50	23	nM	IC50	Eur J Med Chem (2016) 114: 79-88 [PMID:26974377]
ChEMBL	Antimalarial activity against ring stage Plasmodium falciparum 3D7 infected with human red blood cells incubated for 48 hrs by SYBR Green method	F	7.64	pIC50	23	nM	IC50	Bioorg Med Chem (2015) 23: 1530-1539 [PMID:25725608]
ChEMBL	Antimalarial activity against chloroquine-sensitive ring-stage Plasmodium falciparum 3D7 assessed as parasite viability after 72 hrs by malstat assay	F	7.7	pIC50	20	nM	IC50	Bioorg Med Chem (2016) 24: 3636-3642 [PMID:27316542]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7	F	7.74	pIC50	18	nM	IC50	Eur J Med Chem (2015) 94: 56-62 [PMID:25747499]
ChEMBL	Antimalarial activity against schizont stage of chloroquine-susceptible Plasmodium falciparum 3D7 infected in erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 48 hrs by scintillation counting analysis	F	7.74	pIC50	18	nM	IC50	Medchemcomm (2011) 2: 430-435
ChEMBL	Antimalarial activity against schizont stage of chloroquine-susceptible Plasmodium falciparum 3D7 infected in erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 96 hrs by scintillation counting analysis	F	7.74	pIC50	18	nM	IC50	Medchemcomm (2011) 2: 430-435
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes by [3H]-hypoxanthine incorporation assay	F	7.76	pIC50	17.3	nM	IC50	J Med Chem (2014) 57: 10557-10563 [PMID:25412465]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 3D7 infected in erythrocytes assessed as [3H]hypoxanthine incorporation after 24 hrs by microbeta scintillation counting analysis	F	7.8	pIC50	16	nM	IC50	Bioorg Med Chem Lett (2014) 24: 3263-3267 [PMID:24974345]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs by parasite lactate dehydrogenase assay	F	7.8	pIC50	16	nM	IC50	Eur J Med Chem (2014) 87: 197-202 [PMID:25255435]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as [3H]-hypoxanthine incorporation after 48 hrs by liquid scintillation counting analysis	F	7.82	pIC50	15	nM	IC50	ACS Med Chem Lett (2014) 5: 178-182 [PMID:24900794]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as incorporation of [3H]hypoxanthine after 48 hr microdilution method	F	7.85	pIC50	14	nM	IC50	Med Chem Res (2007) 16: 213-229
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as [3H]hypoxanthine incorporation after 48 hrs by betaplate liquid scintillation counting analysis	F	7.9	pIC50	12.52	nM	IC50	Medchemcomm (2011) 2: 661-665
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human type A-positive red blood cells assessed as growth inhibition after 72 hrs by spectrophotometrically	F	7.92	pIC50	12	nM	IC50	Bioorg Med Chem (2014) 22: 5757-5765 [PMID:25311562]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7 incubated for 72 hours by DAPI-staining based confocal imaging analysis	F	7.95	pIC50	11.35	nM	IC50	Bioorg Med Chem Lett (2016) 26: 3326-3329 [PMID:27212070]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR Green fluorescence assay	F	7.96	pIC50	11	nM	IC50	ACS Med Chem Lett (2014) 5: 878-883 [PMID:25147607]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human RBCs after 72 hrs by SYBR Green based parasite proliferation assay	F	7.96	pIC50	10.9	nM	IC50	Bioorg Med Chem Lett (2016) 26: 854-857 [PMID:26748697]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as parasite growth inhibition after 48 hrs by SYBR green-1 dye-based fluorescence assay	F	7.99	pIC50	10.2	nM	IC50	Bioorg Med Chem (2013) 21: 7392-7397 [PMID:24148834]
ChEMBL	Antimalarial activity against asexual blood stage of Plasmodium falciparum 3D7 infected in human serum assessed as [3H]hypoxanthine incorporation incubated for 48 hrs prior to 3H]hypoxanthine addition measured after 24 hrs by liquid scintillation counting analysis	F	8	pIC50	10	nM	IC50	Eur J Med Chem (2014) 82: 204-213 [PMID:24904967]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 72 hrs by SYBR Green I dye based fluorescence assay	F	8	pIC50	10	nM	IC50	Eur J Med Chem (2014) 85: 289-292 [PMID:25089811]
ChEMBL	Antiplasmodial activity against CQ-sensitive Plasmodium falciparum 3D7	F	8	pIC50	10	nM	IC50	Bioorg Med Chem (2015) 23: 5098-5119 [PMID:25593097]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 72 hrs by SYBR Green I assay	F	8.01	pIC50	9.8	nM	IC50	Bioorg Med Chem (2015) 23: 5452-5458 [PMID:26260339]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 48 hrs by FACS analysis	F	8.03	pIC50	9.25	nM	IC50	J Med Chem (2014) 57: 4916-4923 [PMID:24824551]
ChEMBL	Antiplasmodial activity against asexual intraerythrocytic ring stage of chloroquine-sensitive Plasmodium falciparum 3D7 infected in human O+ erythrocytes assessed as inhibition of parasitic proliferation after 96 hrs by SYBR Green-1 based fluorescence assay	F	8.05	pIC50	9	nM	IC50	Bioorg Med Chem (2015) 23: 5131-5143 [PMID:25684422]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as inhibition of parasite proliferation after 96 hrs by SYBR Green I-based fluorescence method	F	8.07	pIC50	8.6	nM	IC50	Eur J Med Chem (2015) 90: 33-44 [PMID:25461309]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 3D7 asexual blood stages after 3 days by HRP2 detection based ELISA method	F	8.17	pIC50	6.8	nM	IC50	J Med Chem (2014) 57: 7971-7976 [PMID:25195945]
ChEMBL	Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum 3D7 infected in human O+ erythrocytes after 72 hrs by SYBR Green based parasite proliferation assay	F	8.18	pIC50	6.6	nM	IC50	Bioorg Med Chem Lett (2015) 25: 5339-5343 [PMID:26421992]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected after 72 hrs by Malaria SYBR Green I-staining based fluorescence assay	F	8.18	pIC50	6.57	nM	IC50	Bioorg Med Chem Lett (2014) 24: 1719-1723 [PMID:24630564]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 3D7 late ring stages and early trophozoites forms infected in human erythrocytes assessed as parasite growth inhibition by LDH release assay	F	8.26	pIC50	5.5	nM	IC50	J Nat Prod (2014) 77: 2118-2123 [PMID:25215605]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green-1 staining-based fluorescence assay	F	8.27	pIC50	5.4	nM	IC50	Bioorg Med Chem (2014) 22: 3573-3586 [PMID:24906512]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 24 hrs by [3H]hypoxanthine incorporation assay	F	8.28	pIC50	5.2	nM	IC50	ACS Med Chem Lett (2013) 4: 1198-1202 [PMID:24900630]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as growth inhibition	F	8.3	pIC50	5	nM	IC50	Eur J Med Chem (2014) 82: 459-465 [PMID:24929343]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 incubated for 72 hrs by SYBR Green 1 assay	F	8.3	pIC50	5	nM	IC50	Bioorg Med Chem Lett (2015) 25: 4657-4663 [PMID:26338359]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 by Malaria SYBR Green I-nucleic acid staining based fluorescence assay	F	8.32	pIC50	4.75	nM	IC50	Bioorg Med Chem (2014) 22: 5950-5960 [PMID:25284252]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as inhibition of parasite growth after 72 hrs by DAPI staining-based confocal microscopic analysis	F	8.37	pIC50	4.3	nM	IC50	J Nat Prod (2015) 78: 2932-2939 [PMID:26651537]
ChEMBL	Antiplasmodium activity against blood stage Plasmodium falciparum 3D7 assessed as reduction in parasite growth after 72 hrs by SYBR green assay	F	8.52	pIC50	3	nM	IC50	J Med Chem (2014) 57: 4521-4531 [PMID:24786226]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocyte assessed as growth inhibition by SYBR Green-1 assay	F	7.64	pEC50	23	nM	EC50	Eur J Med Chem (2015) 102: 320-333 [PMID:26295174]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as inhibition of parasite growth after 72 hrs by cell based assay	F	7.64	pEC50	23	nM	EC50	Bioorg Med Chem Lett (2014) 24: 5234-5237 [PMID:25316317]
ChEMBL	Antimalarial activity against ring-stage Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite viability after 72 hrs by LDH assay	F	7.92	pEC50	12	nM	EC50	Bioorg Med Chem (2016) 24: 1993-2010 [PMID:27021426]
ChEMBL	Antiparasitic activity against early ring-stage of Plasmodium falciparum 3D7 infected in human erythrocytes assessed as inhibition of parasite viability after 72 hrs by flow cytometric analysis	F	8	pEC50	10	nM	EC50	Medchemcomm (2015) 6: 437-443
ChEMBL	Antiplasmodial activity against chloroquine, pyrimethamine and mefloquine-sensitive asexual blood stage of Plasmodium falciparum 3D7 assessed as reduction in parasite growth after 72 hrs by SYBR green I staining based fluorescence assay	F	8.15	pEC50	7	nM	EC50	ACS Med Chem Lett (2022) 13: 371-376 [PMID:35300082]
ChEMBL	Antimicrobial activity against blood-stage Plasmodium falciparum 3D7 assessed as inhibition of [3H]hypoxanthine incorporation after 48 hrs by liquid scintillation counting	F	8.22	pEC50	6	nM	EC50	J Med Chem (2014) 57: 2773-2788 [PMID:24641010]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human O positive erythrocyte after 72 hrs	F	8.52	pEC50	3	nM	EC50	J Med Chem (2014) 57: 7644-7662 [PMID:25167370]
Plasmodium falciparum D6 (target type: ORGANISM) [ChEMBL: CHEMBL2367107]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 after 72 hr by LDJH assay	F	6.4	pIC50	400	nM	IC50	Med Chem Res (2011) 20: 401-407
ChEMBL	Antiplasmodial activity against mefloquine-resistant Plasmodium falciparum D6 assessed as inhibition of [3H]-hypoxanthine uptake after 48 hrs by liquid scintillation counting analysis	F	6.62	pIC50	240	nM	IC50	Bioorg Med Chem Lett (2016) 26: 1048-1051 [PMID:26750257]
ChEMBL	Antimicrobial activity against Plasmodium falciparum D6 after 72 hrs by LDH activity assay	F	7.1	pIC50	<80	nM	IC50	Medchemcomm (2013) 4: 1042-1048
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 assessed as inhibition of parasite growth after 72 hrs by parasite LDH release assay	F	7.46	pIC50	35	nM	IC50	Eur J Med Chem (2015) 89: 490-502 [PMID:25462261]
ChEMBL	Antimalarial activity against chloroquine-susceptible Plasmodium falciparum african D6 assessed as [3H]-hypoxanthine incorporation by liquid scintillation counting analysis	F	7.82	pIC50	15	nM	IC50	Bioorg Med Chem (2015) 23: 2176-2186 [PMID:25801154]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 assessed as growth inhibition after 18 hrs by [3H]-hypoxanthine uptake assay	F	7.82	pIC50	15	nM	IC50	J Med Chem (2015) 58: 3411-3431 [PMID:25654185]
ChEMBL	Antimalarial activity against chloroquine-sensitive/mefloquine-resistant Plasmodium falciparum D6 by malaria SYBR green 1-based fluorescence (MSF) assay	F	7.85	pIC50	14	nM	IC50	Bioorg Med Chem Lett (2015) 25: 327-332 [PMID:25488841]
ChEMBL	Antimalarial activity against CQ, MFQ-susceptible Plasmodium falciparum D6 clone Sierra 1/UNC isolate assessed as inhibition of parasite proliferation by MSF assay	F	7.91	pIC50	12.27	nM	IC50	J Med Chem (2014) 57: 4134-4153 [PMID:24742203]
ChEMBL	Antimalarial activity against chloroquine-susceptible Plasmodium falciparum D6 after 48 hrs by [3H]hypoxanthine incorporation assay	F	7.92	pIC50	12	nM	IC50	J Med Chem (2016) 59: 264-281 [PMID:26640981]
ChEMBL	Antimicrobial activity against Plasmodium falciparum D6 infected in human erythrocytes after 72 hrs by SYBR green I fluorescence-based method	F	8.16	pIC50	6.9	nM	IC50	Eur J Med Chem (2015) 90: 280-295 [PMID:25461328]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D6 in human erythrocyte after 72 hrs by SYBR Green I assay	F	8.3	pIC50	5	nM	IC50	J Nat Prod (2015) 78: 413-420 [PMID:25562664]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum D6	F	8.42	pIC50	3.8	nM	IC50	Eur J Med Chem (2015) 93: 373-380 [PMID:25721025]
ChEMBL	Antimalarial activity against Plasmodium falciparum D6 after 72 hr by LDH assay	F	7.23	pEC50	59	nM	EC50	Med Chem Res (2005) 14: 74-105
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 SierraLeone after 48 hr by parasite LDH assay	F	7.85	pEC50	14	nM	EC50	Med Chem Res (2005) 14: 332-346
ChEMBL	Antiparasite activity against Plasmodium falciparum D6 assessed as growth inhibition incubated for 72 hrs by SYBR green fluorescence assay	F	7.89	pEC50	13	nM	EC50	J Med Chem (2015) 58: 5522-5537 [PMID:26087257]
Plasmodium falciparum (isolate FcB1 / Columbia) in Plasmodium falciparum FcB1/Columbia (target type: ORGANISM) [ChEMBL: CHEMBL612608]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FcB1/Columbia assessed as [3H]hypoxanthine incorporation after 48 hrs	F	6.77	pIC50	170	nM	IC50	Bioorg Med Chem (2012) 20: 4856-4861 [PMID:22766218]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum FcB1/Columbia assessed as suppression of parasitemia after 4 hrs by Giemsa staining	F	6.78	pIC50	167	nM	IC50	Antimicrob Agents Chemother (2009) 53: 4393-4398 [PMID:19667291]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FcB1/Columbia infected in erythrocytes assessed as inhibition of parasite growth after 48 hrs by 3H-hypoxanthine incorporation assay	F	6.8	pIC50	160	nM	IC50	J Nat Prod (2016) 79: 607-610 [PMID:26670413]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FcB1/Columbia after 48 hrs	F	6.81	pIC50	155	nM	IC50	Eur J Med Chem (2010) 45: 2854-2859 [PMID:20362359]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FcB1 infected in RBC assessed as inhibition of [3H]-hypoxanthine incorporation after 48 hrs by beta-counting	F	6.82	pIC50	151	nM	IC50	Eur J Med Chem (2014) 78: 269-274 [PMID:24686013]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum FcB1 assessed as [3H]hypoxanthine incorporation after 48 hrs by beta-counter	F	6.82	pIC50	151	nM	IC50	J Med Chem (2010) 53: 699-714 [PMID:20014857]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FcB1 after 48 hrs	F	6.82	pIC50	150	nM	IC50	Bioorg Med Chem (2010) 18: 6006-6011 [PMID:20634081]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FcB1 by [3H]hypoxanthine uptake	F	6.84	pIC50	145	nM	IC50	J Nat Prod (2008) 71: 1451-1454 [PMID:18572964]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum FcB1	F	6.92	pIC50	120	nM	IC50	Antimicrob Agents Chemother (2009) 53: 1100-1106 [PMID:19015354]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FcB1/Columbia infected in human erythrocytes assessed as parasite growth inhibition after 24 hrs by [3H]-hypoxanthine incorporation assay	F	6.95	pIC50	111	nM	IC50	Eur J Med Chem (2013) 65: 284-294 [PMID:23727538]
ChEMBL	Antimalarial activity against Plasmodium falciparum FcB1 infected in human O positive erythrocytes under low oxygen atmosphere after 72 hrs by spectrophotometric analysis	F	6.96	pIC50	110	nM	IC50	J Med Chem (2012) 55: 10909-10917 [PMID:23176597]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum FcB1/Columbia infected human erythrocytes after 24 hrs by [3H]hypoxanthine uptake	F	6.98	pIC50	105.3	nM	IC50	Bioorg Med Chem (2008) 16: 9133-9144 [PMID:18819813]
ChEMBL	Antiparasitic activity against chloroquine-resistant Plasmodium falciparum FcB1/Columbia after 24 hrs by [3H]hypoxanthine incorporation assay	F	7.14	pIC50	72	nM	IC50	Medchemcomm (2013) 4: 1034-1041
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FcB1/Columbia assessed as parasite growth inhibition in human erythrocytes after 24 hrs by [3H]hypoxanthine incorporation assay	F	7.14	pIC50	72	nM	IC50	Medchemcomm (2012) 3: 1512-1517
ChEMBL	Antiplasmodial activity against erythrocytic stages of chloroquine-resistant Plasmodium falciparum FcB1/Columbia incubated for 24 hrs followed by [3H]-hypoxanthine addition measured after 24 hrs by liquid scintillation spectrometry	F	7.14	pIC50	72	nM	IC50	Bioorg Med Chem (2013) 21: 4885-4892 [PMID:23902828]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FcB1/Columbia infected in human erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay	F	7.14	pIC50	72	nM	IC50	Eur J Med Chem (2016) 109: 173-186 [PMID:26774924]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum FcB1/Columbia infected in human red blood cells assessed as parasite growth inhibition after 48 hrs by [3H]-hypoxanthine incorporation assay	F	9.96	pIC50	0.11	nM	IC50	Eur J Med Chem (2015) 93: 93-100 [PMID:25659770]
Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 (target type: ORGANISM) [ChEMBL: CHEMBL612856]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human O positive erythrocyte assessed as reduction in parasitemia after 72 hrs	F	4.19	pIC50	>64000	nM	IC50	Bioorg Med Chem (2014) 22: 5241-5248 [PMID:25199582]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human RBC	F	4.49	pIC50	32000	nM	IC50	ACS Med Chem Lett (2013) 4: 1037-1041 [PMID:24900603]
ChEMBL	Antimalarial activity against Plasmodium falciparum K1 after 72 hrs by SYBR Green fluorescence assay	F	5.94	pIC50	1160	nM	IC50	ACS Med Chem Lett (2014) 5: 878-883 [PMID:25147607]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human A+ erythrocytes assessed as inhibition of parasite growth after 48 hrs by LDH assay	F	6.03	pIC50	930	nM	IC50	Bioorg Med Chem (2015) 23: 5156-5167 [PMID:25678015]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum K1 as [3H]hypoxanthine uptake	F	6.05	pIC50	900	nM	IC50	Bioorg Med Chem (2009) 17: 1428-1436 [PMID:19196516]
ChEMBL	Antimalarial activity against Plasmodium falciparum K1 assessed as [3H]hypoxanthine incorporation by scintillation counting	F	6.07	pIC50	850	nM	IC50	J Med Chem (2010) 53: 699-714 [PMID:20014857]
ChEMBL	Antimalarial activity against multidrug-resistant Plasmodium falciparum K1 by [3H]hypoxanthine uptake	F	6.1	pIC50	800	nM	IC50	Bioorg Med Chem Lett (2008) 18: 5294-5298 [PMID:18774709]
ChEMBL	Antimalarial activity after 48 hrs against chloroquine-resistant Plasmodium falciparum K1 by [3H]hypoxanthine uptake	F	6.17	pIC50	682	nM	IC50	Eur J Med Chem (2008) 43: 1903-1910 [PMID:18215443]
ChEMBL	Antiplasmodial activity against chloroquine-, pyrimethamine- and proguanil-resistant Plasmodium falciparum K1 infected in human erythrocytes after 72 hrs by SYBR Green I fluorescence-based method	F	6.22	pIC50	600	nM	IC50	Eur J Med Chem (2014) 83: 26-35 [PMID:24946216]
ChEMBL	Antiplasmodial activity against chloroquine/purimethamine/proguanil-resistant Plasmodium falciparum K1 infected in human A+ erythrocytes assessed as reduction in parasitaemia measured after 72 hrs by SYBR Green I fluorescence-based assay	F	6.22	pIC50	600	nM	IC50	Eur J Med Chem (2016) 119: 34-44 [PMID:27155463]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1	F	6.25	pIC50	560	nM	IC50	Bioorg Med Chem Lett (2004) 14: 3901-3905 [PMID:15225694]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1	F	6.27	pIC50	540	nM	IC50	Eur J Med Chem (2010) 45: 3245-3264 [PMID:20466465]
ChEMBL	Antiplasmodial activity against chloroquine, pyrimethamine and proguanil-resistant Plasmodium falciparum K1 infected in human erythrocytes assessed as reduction in Parasitemia incubated for 72 hrs by SYBR Green I fluorescence-based method	F	6.3	pIC50	500	nM	IC50	Eur J Med Chem (2014) 87: 440-453 [PMID:25282267]
ChEMBL	Antiplasmodial activity against multi-drug resistant Plasmodium falciparum K1 infected in human erythrocytes assessed as parasite growth inhibition after 72 hrs by SYBR Green I dye-based fluorescence assay	F	6.3	pIC50	500	nM	IC50	Eur J Med Chem (2015) 95: 16-28 [PMID:25791675]
ChEMBL	Antiplasmodial activity against multidrug-resistant Plasmodium falciparum K1 ring stage after 72 hrs by SYBP Green fluorescence-based assay	F	6.3	pIC50	500	nM	IC50	Eur J Med Chem (2012) 55: 315-324 [PMID:22889559]
ChEMBL	Antiplasmodial activity against chloroquine-, pyrimethamine-, proguanil-resistant Plasmodium falciparum K1 infected in A-positive human erythrocytes after 72 hrs by SYBR green 1 fluorescence-based method	F	6.3	pIC50	500	nM	IC50	Eur J Med Chem (2012) 54: 75-86 [PMID:22608675]
ChEMBL	Antiplasmodial activity against chloroquine, pyrimethamine, and proguanil-resistant Plasmodium falciparum K1 infected in human A+ erythrocytes after 72 hrs by SYBR Green-I fluorescence-based method	F	6.3	pIC50	500	nM	IC50	Bioorg Med Chem Lett (2011) 21: 6003-6006 [PMID:21852132]
ChEMBL	Antimalarial activity against Plasmodium falciparum K1 infected in human erythrocytes assessed as reduction in [3H]-hypoxanthine incorporation preincubated for 24 hrs followed by [3H]-hypoxanthine addition measured after 24 hrs by scintillation counting method	F	6.32	pIC50	480	nM	IC50	J Med Chem (2017) 60: 5889-5908 [PMID:28635296]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 after 72 hrs by SYBR Green-I based fluorescence assay	F	6.33	pIC50	>463	nM	IC50	Bioorg Med Chem Lett (2012) 22: 5455-5459 [PMID:22850213]
ChEMBL	Antimalarial activity against chloroquine resistant Plasmodium falciparum K1 after 72 hrs by SYBR green 1 dye based fluorescence assay	F	6.33	pIC50	463	nM	IC50	Eur J Med Chem (2017) 135: 382-391 [PMID:28460312]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1	F	6.34	pIC50	460	nM	IC50	J Nat Prod (2017) 80: 134-140 [PMID:28055207]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 after 72 hrs by SYBR Green I-based fluorescence assay	F	6.35	pIC50	443.57	nM	IC50	J Med Chem (2013) 56: 31-45 [PMID:23270565]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 assessed as parasite growth inhibition after 24 hrs by [3H]-hypoxathine incorporation assay	F	6.36	pIC50	440	nM	IC50	ACS Med Chem Lett (2013) 4: 642-646 [PMID:24900724]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human erythrocytes measured after 72 hrs by SYBR green 1 dye based fluorescence assay	F	6.36	pIC50	440	nM	IC50	Eur J Med Chem (2017) 131: 171-184 [PMID:28319782]
ChEMBL	Antimalarial malarial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human A positive erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 24 hrs	F	6.37	pIC50	430	nM	IC50	Bioorg Med Chem Lett (2011) 21: 3644-3647 [PMID:21570837]
ChEMBL	Antimalarial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 infected in human O positive red blood cells assessed as inhibition of [3H]-hypoxanthine uptake after 48 hrs	F	6.4	pIC50	400	nM	IC50	J Nat Prod (2011) 74: 74-78 [PMID:21155593]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 by microculture radioisotope technique	F	6.43	pIC50	370	nM	IC50	J Nat Prod (2015) 78: 2364-2371 [PMID:26398312]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 after 48 hrs	F	6.45	pIC50	354.7	nM	IC50	Eur J Med Chem (2013) 69: 338-347 [PMID:24077524]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human O+ erythrocytes by parasite LDH assay	F	6.45	pIC50	352.3	nM	IC50	Bioorg Med Chem Lett (2010) 20: 1078-1080 [PMID:20034790]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 infected after 72 hrs by Malaria SYBR Green I-staining based fluorescence assay	F	6.45	pIC50	352.3	nM	IC50	Bioorg Med Chem Lett (2014) 24: 1719-1723 [PMID:24630564]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum K1 by SYBR-green based assay	F	6.46	pIC50	347.3	nM	IC50	J Med Chem (2014) 57: 6642-6652 [PMID:25007124]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 after 72 hrs by SYBR I method	F	6.46	pIC50	347.29	nM	IC50	J Med Chem (2014) 57: 5702-5713 [PMID:24914738]
ChEMBL	Antimalarial activity against multidrug-resistant Plasmodium falciparum K1 by SYBR green-based assay	F	6.46	pIC50	347	nM	IC50	Bioorg Med Chem Lett (2015) 25: 1100-1103 [PMID:25650255]
ChEMBL	Antiplasmodial activity against multidrug-resistant Plasmodium falciparum K1 by SYBR Green-based method	F	6.46	pIC50	347	nM	IC50	Bioorg Med Chem Lett (2015) 25: 952-955 [PMID:25599834]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 assessed as [3H]hypoxanthine incorporation after 24 hrs by scintillation counting	F	6.46	pIC50	344	nM	IC50	Bioorg Med Chem Lett (2012) 22: 5046-5050 [PMID:22749280]
ChEMBL	Antiplasmodial activity against multidrug-resistant Plasmodium falciparum K1 infected in human erythrocytes after 48 hrs by [3H]-hypoxanthine incorporation assay	F	6.46	pIC50	344	nM	IC50	Bioorg Med Chem (2015) 23: 5419-5432 [PMID:26264839]
ChEMBL	Antiplasmodial activity against erythrocytic stage of multidrug-resistant Plasmodium falciparum Thailand K1 infected in human A positive RBC after 48 hrs by [3H]hypoxanthine incorporation assay	F	6.47	pIC50	340	nM	IC50	ACS Med Chem Lett (2013) 4: 637-641 [PMID:24900723]
ChEMBL	Antiplasmodial activity against erythrocytic stage of Plasmodium falciparum K1 after 48 hrs by [3H]-hypoxanthine incorporation assay	F	6.48	pIC50	328	nM	IC50	ACS Med Chem Lett (2013) 4: 538-541 [PMID:24900706]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human erythrocytes assessed as [3H]hypoxanthine incorporation after 48 hrs by betaplate liquid scintillation counting analysis	F	6.49	pIC50	325	nM	IC50	Medchemcomm (2011) 2: 661-665
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1	F	6.49	pIC50	320	nM	IC50	J Nat Prod (2002) 65: 85-88 [PMID:11809075]
ChEMBL	Antiplasmodial activity against chloroquine, pyrimethamine, cycloguanil-resistant Plasmodium falciparum K1 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs	F	6.5	pIC50	316.3	nM	IC50	J Med Chem (2010) 53: 3214-3226 [PMID:20329733]
ChEMBL	Antimalarial activity against Plasmodium falciparum K1 infected in RBC assessed as growth inhibition after 48 hrs by SYBR Green-I fluorescence assay	F	6.52	pIC50	300	nM	IC50	J Med Chem (2013) 56: 6200-6215 [PMID:23837878]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human O+erythrocytes after 72 hrs by lactate dehydrogenase assay	F	6.52	pIC50	300	nM	IC50	J Nat Prod (2016) 79: 2865-2872 [PMID:27933893]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 infected in erythrocytes assessed as [3H]hypoxanthine incorporation	F	6.53	pIC50	293.3	nM	IC50	Antimicrob Agents Chemother (2009) 53: 1362-1366 [PMID:19188388]
ChEMBL	Antiprotozoal activity against erythrocytic stage of chloroquine and pyrimethamine resistant Plasmodium falciparum K1 after 48 hrs by [3H]- hypoxanthine incorporation assay	F	6.54	pIC50	291	nM	IC50	J Nat Prod (2017) 80: 443-458 [PMID:28121440]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 by Malaria SYBR Green I-nucleic acid staining based fluorescence assay	F	6.54	pIC50	287.89	nM	IC50	Bioorg Med Chem (2014) 22: 5950-5960 [PMID:25284252]
ChEMBL	Antiparasitic activity against Plasmodium falciparum K1 amastigotes IEF stage forms incubated for 72 hrs by Alamar Blue staining based fluorometric assay	F	6.55	pIC50	280	nM	IC50	J Nat Prod (2011) 74: 1972-1979 [PMID:21846091]
ChEMBL	Antiprotozoal activity against erythrocytic stages of Plasmodium falciparum K1 by [3H]hypoxanthine incorporation assay	F	6.55	pIC50	280	nM	IC50	Bioorg Med Chem Lett (2013) 23: 452-454 [PMID:23265884]
ChEMBL	Inhibition of Plasmodium falciparum K1	F	6.57	pIC50	267	nM	IC50	J Med Chem (2000) 43: 2646-2654 [PMID:10893302]
ChEMBL	OSM: Inhibition of Plasmodium falciparum K1 growth. IC50 values determined from 21 point dose response curves. Avery Group Griffith.	F	6.58	pIC50	266	nM	IC50	Open Source Malaria Deposition 1. http://malaria.ourexperiment.org
ChEMBL	Antimalarial activity after 24 hrs against chloroquine-resistant synchronous Plasmodium falciparum K1 infected human A+ erythrocytes by [3H]hypoxanthine uptake	F	6.59	pIC50	260	nM	IC50	J Med Chem (2009) 52: 502-513 [PMID:19113955]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum K1	F	6.59	pIC50	259	nM	IC50	Eur J Med Chem (2010) 45: 5370-5383 [PMID:20850207]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 after 72 hrs by SYBR Green-1 staining-based fluorescence assay	F	6.59	pIC50	255	nM	IC50	Bioorg Med Chem (2014) 22: 3573-3586 [PMID:24906512]
ChEMBL	Antimalarial activity against Plasmodium falciparum K1 assessed as parasite growth inhibition after 72 hrs by MSF assay	F	6.6	pIC50	254.05	nM	IC50	Eur J Med Chem (2013) 62: 693-704 [PMID:23454512]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 incubated for 72 hrs by SYBR Green 1 assay	F	6.6	pIC50	254	nM	IC50	Bioorg Med Chem Lett (2015) 25: 4657-4663 [PMID:26338359]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 after 72 hrs by MSF assay	F	6.6	pIC50	254	nM	IC50	Eur J Med Chem (2013) 66: 69-81 [PMID:23792317]
ChEMBL	Antiparasitic activity against intraerythrocytic form of chloroquine/pyrimethamine-resistant Plasmodium falciparum K1 infected in human RBC preincubated for 48 hrs followed by [3H]-hypoxanthine addition measured after 24 hrs by liquid scintillation counting analysis	F	6.6	pIC50	250	nM	IC50	Bioorg Med Chem Lett (2017) 27: 3945-3949 [PMID:28789893]
ChEMBL	Antiplasmodial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 infected in rat L6 cells	F	6.6	pIC50	250	nM	IC50	Bioorg Med Chem (2010) 18: 142-150 [PMID:19942439]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1	F	6.6	pIC50	250	nM	IC50	Bioorg Med Chem Lett (2009) 19: 401-405 [PMID:19091562]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2	F	6.62	pIC50	240	nM	IC50	Bioorg Med Chem Lett (2004) 14: 3901-3905 [PMID:15225694]
ChEMBL	Antimalarial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 by [3H]hypoxanthine incorporation assay	F	6.62	pIC50	240	nM	IC50	Bioorg Med Chem (2009) 17: 7209-7217 [PMID:19781948]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 assessed as inhibition of [3H]hypoxanthine incorporation	F	6.62	pIC50	240	nM	IC50	Antimicrob Agents Chemother (2011) 55: 961-966 [PMID:21135175]
ChEMBL	OSM: CSIR assay K1: Compounds were tested for inhibition of Plasmodium falciparum growth using a SYBR green I fluorescence based assay.	F	6.63	pIC50	235	nM	IC50	Open Source Malaria Deposition 1. http://malaria.ourexperiment.org
ChEMBL	Antiplasmodial activity chloroquinone-resistant Plasmodium falciparum K1 by parasite lactate dehydrogenase assay	F	6.64	pIC50	230	nM	IC50	J Nat Prod (2015) 78: 1848-1858 [PMID:26235033]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1	F	6.64	pIC50	230	nM	IC50	Bioorg Med Chem Lett (2009) 19: 481-484 [PMID:19054674]
ChEMBL	Antiplasmodial activity against chloroquine/pyrimethamine-resistant Plasmodium falciparum K1 assessed as growth inhibition after 24 hrs by [3H]-hypoxanthine incorporation assay	F	6.64	pIC50	230	nM	IC50	J Med Chem (2013) 56: 7516-7526 [PMID:24063369]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 after 24 hrs by [3H]hypoxanthine incorporation assay	F	6.66	pIC50	220	nM	IC50	ACS Med Chem Lett (2013) 4: 1198-1202 [PMID:24900630]
ChEMBL	Antiplasmodial activity against chloroquine- and pyrimethamine-resistant Plasmodium falciparum K1 infected in human red blood cells assessed as [3H]hypoxanthine incorporation after 48 hrs by liquid scintillation counting	F	6.66	pIC50	220	nM	IC50	J Nat Prod (2011) 74: 559-566 [PMID:21438586]
ChEMBL	Antiplasmodial activity against CQ-resistant Plasmodium falciparum K1	F	6.66	pIC50	219	nM	IC50	Bioorg Med Chem (2015) 23: 5098-5119 [PMID:25593097]
ChEMBL	Antimalarial activity against Plasmodium falciparum K1 assessed as inhibition of [3H] hypoxanthine uptake by liquid scintillation counting	F	6.67	pIC50	213	nM	IC50	ACS Med Chem Lett (2013) 4: 128-131 [PMID:24900574]
ChEMBL	Antimalarial activity against chloroquine-resistant erythrocytic stage of Plasmodium falciparum K1 infected in human red blood cells assessed as growth inhibition after 48 hrs by [3H]-hypoxanthine incorporation assay	F	6.68	pIC50	210	nM	IC50	Eur J Med Chem (2013) 64: 498-511 [PMID:23685569]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1	F	6.68	pIC50	209.5	nM	IC50	Medchemcomm (2014) 5: 927-931
ChEMBL	Antimalarial activity against erythrocytic stage of chloroquine/pyrimethamine-resistant Plasmodium falciparum K1 after 48 hrs by [3H]-hypoxanthine incorporation assay	F	6.68	pIC50	209.5	nM	IC50	Bioorg Med Chem (2014) 22: 2629-2642 [PMID:24721829]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 after 72 hrs by [3H]hypoxanthine incorporation assay	F	6.68	pIC50	209.5	nM	IC50	J Med Chem (2013) 56: 1431-1442 [PMID:23360309]
ChEMBL	Antiplasmodial activity chloroquine-resistant Plasmodium falciparum K1 infected in human A+ erythrocytes assessed as inhibition of [3H]-hypoxanthine incorporation after 24 hrs by scintillation counting	F	6.7	pIC50	201.8	nM	IC50	Eur J Med Chem (2012) 52: 82-97 [PMID:22459876]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1	F	6.7	pIC50	201	nM	IC50	Eur J Med Chem (2013) 67: 310-324 [PMID:23871911]
ChEMBL	In vitro inhibition of Plasmodium falciparum K1 (0.0638 ug/mL)	F	6.7	pIC50	200	nM	IC50	Bioorg Med Chem Lett (2005) 15: 595-597 [PMID:15664819]
ChEMBL	Antimalarial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 assessed as inhibition of [3H]hypoxanthine incorporation after 48 hrs by scintillation counting	F	6.7	pIC50	200	nM	IC50	J Nat Prod (2010) 73: 1404-1410 [PMID:20614907]
ChEMBL	Antiplasmodial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 infected mice (Mus musculus) macrophage by reporter dye assay	F	6.7	pIC50	200	nM	IC50	Antimicrob Agents Chemother (2007) 51: 3796-3802 [PMID:17698622]
ChEMBL	Antiprotozoal activity against erythrocytic stages chloroquine- and pyrimethamine-resistant Plasmodium falciparum K1 assessed as inhibition of [3H]hypoxanthine incorporation pre-incubated for 48 hrs prior [3H]hypoxanthine addition measured after 24 hrs by liquid scintillation counting	F	6.7	pIC50	200	nM	IC50	Bioorg Med Chem (2012) 20: 1482-1493 [PMID:22285027]
ChEMBL	Antimalarial activity against chloroquine- and pyrimethamine-resistant Plasmodium falciparum K1 assessed as [3H]-hypoxanthine incorporation after 48 hrs by liquid scintillation counting	F	6.7	pIC50	200	nM	IC50	J Nat Prod (2011) 74: 888-892 [PMID:21348447]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum K1 infected in erythrocytes assessed as [3H]hypoxanthine incorporation after 24 hrs by microbeta scintillation counting analysis	F	6.7	pIC50	200	nM	IC50	Bioorg Med Chem Lett (2014) 24: 3263-3267 [PMID:24974345]
ChEMBL	Antimalarial activity against Plasmodium falciparum K1 assessed as inhibition of [3H]hypoxanthine incorporation preincubated for 48 hrs measured 24 hrs post [3H]hypoxanthine addition by liquid scintillation counting	F	6.7	pIC50	198	nM	IC50	Bioorg Med Chem (2014) 22: 3749-3752 [PMID:24856305]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum K1	F	6.71	pIC50	194	nM	IC50	J Med Chem (2011) 54: 7713-7719 [PMID:21966980]
ChEMBL	Antimalarial activity against multidrug-resistant Plasmodium falciparum K1	F	6.71	pIC50	194	nM	IC50	J Med Chem (2014) 57: 2789-2798 [PMID:24568587]
ChEMBL	Antiplasmodial activity against multidrug-resistant Plasmodium falciparum K1 by [3H]-hypoxanthine incorporation assay	F	6.71	pIC50	194	nM	IC50	J Med Chem (2015) 58: 7572-7579 [PMID:26322748]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1	F	6.72	pIC50	190	nM	IC50	Eur J Med Chem (2009) 44: 3091-3113 [PMID:19361896]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 after 48 hrs by [G-3H]hypoxanthine uptake	F	6.72	pIC50	190	nM	IC50	Eur J Med Chem (2008) 43: 2840-2852 [PMID:18395298]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 assessed as incorporation of [3H]hypoxanthine after 48 hr microdilution method	F	6.72	pIC50	190	nM	IC50	Med Chem Res (2007) 16: 213-229
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 infected type A+ human erythrocytes after 24 hrs by [G-3H]hypoxanthine uptake	F	6.73	pIC50	187.34	nM	IC50	Bioorg Med Chem Lett (2009) 19: 2038-2043 [PMID:19251414]
ChEMBL	Antiplasmodial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 assessed as inhibition of [3H]hypoxanthine incorporation incubated for 48 hrs prior to [3H] hypoxanthine addition measured after 24 hrs by liquid scintillation counting	F	6.74	pIC50	184	nM	IC50	Bioorg Med Chem (2011) 19: 7493-7500 [PMID:22061825]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 in human erythrocytes after 48 hrs by [3H]hypoxanthine uptake	F	6.74	pIC50	183.2	nM	IC50	J Med Chem (2009) 52: 1408-1415 [PMID:19222165]
ChEMBL	Antiparasitic activity against Plasmodium falciparum K1 infected in rat L6 cells assessed as inhibition of parasite growth preincubated for 48 hrs before [3H]hypoxanthine addition measured after 24 hrs by [3H]hypoxanthine incorporation assay	F	6.75	pIC50	178	nM	IC50	Bioorg Med Chem Lett (2011) 21: 6319-6321 [PMID:21937228]
ChEMBL	Antiplasmodial activity against erythrocytic stage of chloroquine - and pyrimethamine-resistant Plasmodium falciparum K1 assessed as [3H]hypoxanthine incorporation after 48 hrs	F	6.76	pIC50	172	nM	IC50	Antimicrob Agents Chemother (2009) 53: 3815-3821 [PMID:19564359]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum K1	F	6.77	pIC50	170.6	nM	IC50	J Med Chem (2009) 52: 1828-1844 [PMID:19284751]
ChEMBL	Antimalarial activity against multidrug-resistant Plasmodium falciparum K1 infected in human red blood cells assessed as 3H-hypoxanthine incorporation after 48 hrs by liquid scintillation counting	F	6.77	pIC50	170	nM	IC50	J Med Chem (2011) 54: 4581-4589 [PMID:21644541]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human A positive erythrocytes assessed as inhibition of [G-3H]-hypoxanthine uptake after 24 hrs by liquid scintillation counting	F	6.78	pIC50	165.6	nM	IC50	Bioorg Med Chem (2012) 20: 927-932 [PMID:22182577]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1	F	6.79	pIC50	163	nM	IC50	Antimicrob Agents Chemother (2009) 53: 622-630 [PMID:19015351]
ChEMBL	Antimalarial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1	F	6.8	pIC50	160	nM	IC50	Eur J Med Chem (2009) 44: 736-744 [PMID:18571774]
ChEMBL	Antimalarial activity against multidrug resistant Plasmodium falciparum K1 infected in human erythrocytes assessed as inhibition of parasite proliferation after 96 hrs by SYBR Green I fluorescence based assay	F	6.81	pIC50	154.73	nM	IC50	Bioorg Med Chem Lett (2016) 26: 3006-3009 [PMID:27210430]
ChEMBL	Antimalarial activity after 48 hrs against chloroquine-resistant asynchronous Plasmodium falciparum K1 infected human A+ erythrocytes by [3H]hypoxanthine uptake	F	6.81	pIC50	154	nM	IC50	J Med Chem (2009) 52: 502-513 [PMID:19113955]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation incubated for 48 hrs prior to [3H]hypoxanthine addition measured after 48 hrs by liquid scintillation counting	F	6.81	pIC50	154	nM	IC50	J Med Chem (2012) 55: 6948-6967 [PMID:22783984]
ChEMBL	Antimalarial activity against Plasmodium falciparum K1 infected in human O positive erythrocytes under low oxygen atmosphere after 72 hrs by spectrophotometric analysis	F	6.81	pIC50	154	nM	IC50	J Med Chem (2012) 55: 10909-10917 [PMID:23176597]
ChEMBL	Antimalarial activity against Plasmodium falciparum K1	F	6.82	pIC50	151	nM	IC50	J Med Chem (2011) 54: 4581-4589 [PMID:21644541]
ChEMBL	Antiprotozoal activity against chloroquine- and pyrimethamine-resistant Plasmodium falciparum K1 after 48 hrs by [3H]-hypoxanthine incorporation assay	F	6.82	pIC50	150	nM	IC50	Bioorg Med Chem (2013) 21: 4988-4996 [PMID:23880082]
ChEMBL	Antiplasmodial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 assessed as [3H]hypoxanthine incorporation after 48 hrs by liquid scintillation counter	F	6.82	pIC50	150	nM	IC50	Eur J Med Chem (2012) 47: 510-519 [PMID:22136906]
ChEMBL	Growth inhibitory concentration against Plasmodium falciparum K1	F	6.82	pIC50	150	nM	IC50	J Med Chem (2003) 46: 3166-3169 [PMID:12825955]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum K1 infected in human blood by [3H]hypoxanthine incorporation assay	F	6.82	pIC50	150	nM	IC50	Bioorg Med Chem (2010) 18: 6796-6804 [PMID:20709557]
ChEMBL	Antiplasmodial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 by microplate assay	F	6.82	pIC50	150	nM	IC50	Eur J Med Chem (2010) 45: 179-185 [PMID:19879671]
ChEMBL	Antimalarial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 after 48 hrs as [3H]hypoxanthine uptake	F	6.82	pIC50	150	nM	IC50	Bioorg Med Chem (2009) 17: 3595-3603 [PMID:19395265]
ChEMBL	Antiplasmodial activity against chloroquine/pyrimethamine resistant Plasmodium falciparum K1 infected in human red blood cells after 48 hrs by [3H]hypoxanthine incorporation assay	F	6.82	pIC50	150	nM	IC50	Bioorg Med Chem (2016) 24: 3781-3789 [PMID:27344215]
ChEMBL	Antiplasmodial activity against erythrocytic stage of chloroquine/pyrimethamine-resistant Plasmodium falciparum K1 assessed as reduction in [3H]hypoxanthine incorporation after 48 hrs by liquid scintillation counting method	F	6.82	pIC50	150	nM	IC50	Bioorg Med Chem (2017) 25: 2251-2259 [PMID:28279559]
ChEMBL	Antimalarial activity against Plasmodium falciparum K1 at pH 7.4 by microplate assay	F	6.83	pIC50	148	nM	IC50	Bioorg Med Chem Lett (2011) 21: 5804-5807 [PMID:21868222]
ChEMBL	Antiprotozoal activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1	F	6.83	pIC50	148	nM	IC50	Medchemcomm (2012) 3: 1435-1442
ChEMBL	Antimalarial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1	F	6.83	pIC50	147.72	nM	IC50	Bioorg Med Chem (2009) 17: 1481-1485 [PMID:19181530]
ChEMBL	Antimalarial activity against erythrocyte stages of chloroquine-resistant Plasmodium falciparum K1 infected in human erythrocytes by lactate dehydrogenase assay	F	6.84	pIC50	144	nM	IC50	J Med Chem (2011) 54: 6956-6968 [PMID:21875063]
ChEMBL	Antimalarial activity against Plasmodium falciparum K1 intra-erythrocytic form	F	6.85	pIC50	141	nM	IC50	J Nat Prod (2011) 74: 603-608 [PMID:21456549]
ChEMBL	Antiplasmodial activity against chloroquine resistant Plasmodium falciparum K1 erythrocytic stage assessed as reduction in [3H]hypoxanthine incorporation after 48 hrs by liquid scintillation counting assay	F	6.85	pIC50	140	nM	IC50	Bioorg Med Chem (2017) 25: 2091-2104 [PMID:28284860]
ChEMBL	Antiparasitic activity against chloroquine-resistant erythrocytic stage of Plasmodium falciparum K1 infected in human RPMI1640 cells after 72 hrs by NBT staining based spectroscopic analysis	F	6.85	pIC50	140	nM	IC50	Eur J Med Chem (2016) 113: 28-33 [PMID:26922226]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1	F	6.88	pIC50	131	nM	IC50	Eur J Med Chem (2015) 94: 56-62 [PMID:25747499]
ChEMBL	In vitro antiplasmodial activity for chloroquine-resistant Plasmodium falciparum FcB1	F	6.89	pIC50	130	nM	IC50	Bioorg Med Chem Lett (2005) 15: 2637-2640 [PMID:15863333]
ChEMBL	Antiprotozoal activity against intraerythrocytic stage of chloroquine/pyrimethamine-resistant Plasmodium falciparum K1 by [3H]hypoxanthine incorporation assay	F	6.89	pIC50	130	nM	IC50	J Med Chem (2015) 58: 1940-1949 [PMID:25642604]
ChEMBL	Growth inhibitory concentration against chloroquine-resistant Plasmodium falciparum	F	6.9	pIC50	126	nM	IC50	Bioorg Med Chem Lett (2004) 14: 4439-4443 [PMID:15357968]
ChEMBL	Antiplasmodial activity against chloroquine/pyrimethamine-resistant Plasmodium falciparum K1 infected in human red blood cells assessed as [3H]-hypoxanthine incorporation incubated for 48 hrs prior to [3H]-hypoxanthine addition measured after 24 hrs by liquid scintillation counting analysis	F	6.9	pIC50	125	nM	IC50	Bioorg Med Chem (2014) 22: 559-576 [PMID:24268543]
ChEMBL	Antiprotozoal activity against chloroquine-resistant Plasmodium falciparum K1 after 48 hrs by [3H]-hypoxanthine incorporation assay	F	6.9	pIC50	125	nM	IC50	J Med Chem (2013) 56: 5473-5494 [PMID:23795673]
ChEMBL	Antiparasitic activity against chloroquine-resistant Plasmodium falciparum K1 after 3 days by [3H]-hypoxanthine incorporation assay	F	6.9	pIC50	125	nM	IC50	Eur J Med Chem (2014) 83: 167-173 [PMID:24956553]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1	F	6.91	pIC50	124	nM	IC50	J Med Chem (2008) 51: 6927-6944 [PMID:18841956]
ChEMBL	Antiplasmodial activity after 48 hrs against chloroquine-resistant Plasmodium falciparum K1 infected human erythrocytes by [3H]hypoxanthine uptake	F	6.91	pIC50	124	nM	IC50	J Med Chem (2009) 52: 4657-4667 [PMID:19606902]
ChEMBL	Antiprotozoal activity after 48 hrs against chloroquine-resistant Plasmodium falciparum K1 infected erythrocytes by [3H]hypoxanthine uptake	F	6.91	pIC50	124	nM	IC50	J Med Chem (2009) 52: 2016-2035 [PMID:19267462]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human erythrocytes after 48 hrs assessed as [3H]hypoxanthine incorporation by liquid scintillation counting	F	6.91	pIC50	124	nM	IC50	J Med Chem (2010) 53: 254-272 [PMID:19928900]
ChEMBL	Antiplasmodial activity against chloroquine and pyrimethamine resistant Plasmodium falciparum K1 infected in human red blood cells assessed as reduction in parasite viability after 48 hrs by [3H]-hypoxanthine incorporation assay	F	6.92	pIC50	120	nM	IC50	Bioorg Med Chem Lett (2015) 25: 1390-1393 [PMID:25746816]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1	F	6.92	pIC50	120	nM	IC50	J Med Chem (2013) 56: 2547-2555 [PMID:23489135]
ChEMBL	In vitro antimalarial activity against Plasmodium falciparum resistant W-2	F	6.96	pIC50	110	nM	IC50	Bioorg Med Chem Lett (2005) 15: 2629-2631 [PMID:15863331]
ChEMBL	Antimalarial activity against erythrocytic stage of Plasmodium falciparum K1 after 18 hrs by [3H]-hypoxanthine incorporation assay	F	7.15	pIC50	71	nM	IC50	Bioorg Med Chem Lett (2016) 26: 2861-2865 [PMID:27156774]
ChEMBL	Inhibitory concentration against Plasmodium falciparum in FACS	F	7.23	pIC50	59	nM	IC50	J Med Chem (2005) 48: 3654-3658 [PMID:15887974]
ChEMBL	Antimicrobial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 in erythrocytes	F	7.28	pIC50	53	nM	IC50	J Med Chem (2009) 52: 6757-6767 [PMID:19817445]
ChEMBL	Antiplasmodial activity chloroquine-resistant Plasmodium falciparum K1 infected in human A+ erythrocytes assessed as reduction of [3H]hypoxanthine incorporation after 24 hrs by scintillation counting	F	7.44	pIC50	36	nM	IC50	Bioorg Med Chem (2013) 21: 4904-4913 [PMID:23896611]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 by [3H]hypoxanthine incorporation assay	F	7.44	pIC50	36	nM	IC50	Bioorg Med Chem Lett (2017) 27: 658-661 [PMID:28012840]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1	F	7.44	pIC50	36	nM	IC50	ACS Med Chem Lett (2013) 4: 1198-1202 [PMID:24900630]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D10	F	7.52	pIC50	30	nM	IC50	Bioorg Med Chem Lett (2004) 14: 3901-3905 [PMID:15225694]
ChEMBL	In vitro antimalarial activity as schizont maturation in chemo-resistant Plasmodium falciparum	F	7.52	pIC50	30	nM	IC50	Bioorg Med Chem Lett (2005) 15: 1371-1373 [PMID:15713389]
ChEMBL	Antimicrobial activity against chloroquine-resistant Plasmodium falciparum K1	F	7.52	pIC50	30	nM	IC50	Eur J Med Chem (2015) 90: 280-295 [PMID:25461328]
ChEMBL	In vitro antimalarial activity as schizont maturation in chemo-sensitive Plasmodium falciparum	F	7.7	pIC50	20	nM	IC50	Bioorg Med Chem Lett (2005) 15: 1371-1373 [PMID:15713389]
ChEMBL	In vitro inhibition of Plasmodium falciparum	F	7.7	pIC50	20	nM	IC50	J Med Chem (2005) 48: 3639-3643 [PMID:15887971]
ChEMBL	Antimalarial activity against chloroquine and pyrimethamine resistant Plasmodium falciparum K1	F	7.72	pIC50	19	nM	IC50	ACS Med Chem Lett (2010) 1: 360-364 [PMID:24900219]
ChEMBL	In vitro antimalarial activity against Plasmodium falciparum (Ghana)	F	7.74	pIC50	18	nM	IC50	Bioorg Med Chem Lett (2005) 15: 2629-2631 [PMID:15863331]
ChEMBL	Antiplasmodial activity against multidrug resistant Plasmodium falciparum K1 infected in human erythrocytes after 48 hrs by [3H]-hypoxanthine incorporation assay	F	7.8	pIC50	16	nM	IC50	J Med Chem (2015) 58: 8713-8722 [PMID:26502160]
ChEMBL	Antiplasmodial activity against chloroquine and pyrimethamine resistant Plasmodium falciparum K1 infected in human erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay	F	7.9	pIC50	12.5	nM	IC50	Bioorg Med Chem (2016) 24: 4038-4044 [PMID:27387356]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1	F	7.92	pIC50	12	nM	IC50	Bioorg Med Chem Lett (2011) 21: 4561-4563 [PMID:21705220]
ChEMBL	Inhibitory concentration against chloroquine-sensitive Plasmodium falciparum	F	8.22	pIC50	6	nM	IC50	Bioorg Med Chem Lett (2005) 15: 345-348 [PMID:15603951]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 infected human erythrocytes after 72 hrs by MSF assay	F	5.79	pEC50	1610	nM	EC50	Bioorg Med Chem (2010) 18: 2756-2766 [PMID:20206533]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human erythrocytes assessed as reduction in parasitemia after 72 hrs by spectrophotometry	F	6	pEC50	1000	nM	EC50	J Med Chem (2011) 54: 7084-7093 [PMID:21910466]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 assessed as inhibition of parasite growth after 72 hrs by cell based assay	F	6.16	pEC50	690	nM	EC50	Bioorg Med Chem Lett (2014) 24: 5234-5237 [PMID:25316317]
ChEMBL	Effective concentration for Plasmodium falciparum W2	F	6.42	pEC50	382	nM	EC50	Bioorg Med Chem Lett (2005) 15: 1015-1018 [PMID:15686903]
ChEMBL	Antimicrobial activity against blood-stage Plasmodium falciparum K1 assessed as inhibition of [3H]hypoxanthine incorporation after 48 hrs by liquid scintillation counting	F	6.59	pEC50	255	nM	EC50	J Med Chem (2014) 57: 2773-2788 [PMID:24641010]
ChEMBL	Antimalarial activity against Plasmodium falciparum K1 by automated image mining based cytological profiling assay	F	6.68	pEC50	208	nM	EC50	J Med Chem (2014) 57: 7425-7434 [PMID:25137549]
ChEMBL	Antimalarial activity against chloroquine-resistant erythrocytic stage of Plasmodium falciparum K1 assessed as inhibition of [3H}hypoxanthine incorporation after 24 hrs by liquid scintillation counter	F	7	pEC50	100	nM	EC50	Bioorg Med Chem (2011) 19: 2378-2391 [PMID:21411327]
ChEMBL	Antiparasitic activity against chloroquine/pyrimethamine-resistant Plasmodium falciparum K1 infected in erythrocytes assessed as parasite growth inhibition after 48 hrs by [3H]-hypoxanthine incorporation assay	F	7	pEC50	100	nM	EC50	Bioorg Med Chem (2013) 21: 5876-5885 [PMID:23916149]
ChEMBL	Effective concentration for Plasmodium falciparum 3D7	F	7.77	pEC50	17	nM	EC50	Bioorg Med Chem Lett (2005) 15: 1015-1018 [PMID:15686903]
ChEMBL	Antimalarial activity against erythrocytic stage of chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 assessed as inhibition of [3H]-hypoxanthine incorporation incubated for 48 hrs prior to [3H]-hypoxanthine addition measured after 24 hrs by liquid scintillation counting	F	10.02	pEC50	0.1	nM	EC50	J Med Chem (2013) 56: 2975-2990 [PMID:23517371]
Plasmodium falciparum NF54 (target type: ORGANISM) [ChEMBL: CHEMBL2367131]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54	F	4.9	pIC50	12500	nM	IC50	Bioorg Med Chem Lett (2014) 24: 5466-5469 [PMID:25455485]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive asexual erythrocytic stage of Plasmodium falciparum NF54 assessed as parasite growth inhibition by parasite lactate dehydrogenase assay	F	6.61	pIC50	245	nM	IC50	Bioorg Med Chem (2015) 23: 4163-4171 [PMID:26174655]
ChEMBL	Antiplasmodial activity against drug sensitive Plasmodium falciparum NF54 infected in human erythrocytes after 48 hrs by [3H]-hypoxanthine incorporation assay	F	6.71	pIC50	194	nM	IC50	J Med Chem (2015) 58: 8713-8722 [PMID:26502160]
ChEMBL	Antigametocytocidal activity against Plasmodium falciparum NF54-pfs16-GPF early (1 to 3) gametocyte assessed as viability after 72 hrs by MitoTracker Red CM-H2XRos/micro-plate confocal imaging system	F	6.9	pIC50	126	nM	IC50	Bioorg Med Chem Lett (2015) 25: 327-332 [PMID:25488841]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 by LDH assay	F	7.52	pIC50	30	nM	IC50	Medchemcomm (2013) 4: 724-730
ChEMBL	Antiplasmodial activity against chloroquine-sensitive asexual erythrocytic stage of Plasmodium falciparum NF54 assessed as [3H]-hypoxanthine incorporation by lactate dehydrogenase assay	F	7.68	pIC50	21	nM	IC50	Eur J Med Chem (2015) 92: 91-102 [PMID:25544689]
ChEMBL	Antiplasmodial activity chloroquinone-sensitive Plasmodium falciparum NF54 by parasite lactate dehydrogenase assay	F	7.7	pIC50	20	nM	IC50	J Nat Prod (2015) 78: 1848-1858 [PMID:26235033]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum NF54 by SYBR-green based assay	F	7.77	pIC50	17.1	nM	IC50	J Med Chem (2014) 57: 6642-6652 [PMID:25007124]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 after 72 hrs by SYBR I method	F	7.77	pIC50	17.09	nM	IC50	J Med Chem (2014) 57: 5702-5713 [PMID:24914738]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum NF54 by SYBR Green-based method	F	7.77	pIC50	17	nM	IC50	Bioorg Med Chem Lett (2015) 25: 952-955 [PMID:25599834]
ChEMBL	Antimalarial activity against drug-sensitive Plasmodium falciparum NF54 by SYBR green-based assay	F	7.77	pIC50	17	nM	IC50	Bioorg Med Chem Lett (2015) 25: 1100-1103 [PMID:25650255]
ChEMBL	Antiplasmodial activity chloroquine-sensitive Plasmodium falciparum NF54 by lactate dehydrogenase assay	F	7.8	pIC50	16	nM	IC50	Bioorg Med Chem Lett (2014) 24: 1214-1217 [PMID:24468411]
ChEMBL	Antimalarial activity against drug-sensitive Plasmodium falciparum NF54	F	7.8	pIC50	16	nM	IC50	J Med Chem (2014) 57: 2789-2798 [PMID:24568587]
ChEMBL	Antiplasmodial activity against multidrug-sensitive Plasmodium falciparum NF54 by [3H]-hypoxanthine incorporation assay	F	7.8	pIC50	16	nM	IC50	J Med Chem (2015) 58: 7572-7579 [PMID:26322748]
ChEMBL	Antiplasmodial activity against chloroquine sensitive Plasmodium falciparum NF54 infected in human RBC after 48 hrs by [3H]hypoxanthine incorporation assay	F	7.8	pIC50	16	nM	IC50	Medchemcomm (2015) 6: 2023-2028
ChEMBL	Antiparasitic activity against erythrocytic stage of Plasmodium falciparum NF54 assessed as growth inhibition after 48 hrs by [3H]-hypoxanthine incorporation assay	F	7.89	pIC50	13	nM	IC50	Medchemcomm (2015) 6: 403-406
ChEMBL	Antiplasmodial activity against blood stage of chloroquine-sensitive Plasmodium falciparum NF54 by parasite lactate dehydrogenase assay	F	7.9	pIC50	12.5	nM	IC50	Eur J Med Chem (2015) 101: 266-273 [PMID:26142491]
ChEMBL	Antiprotozoal activity against intraerythrocytic stage of chloroquine-sensitive Plasmodium falciparum NF54 by [3H]hypoxanthine incorporation assay	F	7.92	pIC50	12	nM	IC50	J Med Chem (2015) 58: 1940-1949 [PMID:25642604]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 asexual erythrocyte stages by parasite lactate dehydrogenase assay	F	7.97	pIC50	10.6	nM	IC50	Bioorg Med Chem Lett (2014) 24: 5207-5211 [PMID:25316314]
ChEMBL	Antimalarial activity against chloroquine-sensitive asexual Plasmodium falciparum NF54 infected in human erythrocytes assessed as inhibition of parasite proliferation after 96 hrs by SYBR Green I fluorescence based assay	F	8	pIC50	10	nM	IC50	Bioorg Med Chem Lett (2016) 26: 3006-3009 [PMID:27210430]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 infected in human erythrocytes after 48 hrs by [3H]-hypoxanthine incorporation assay	F	8	pIC50	10	nM	IC50	Bioorg Med Chem (2015) 23: 5419-5432 [PMID:26264839]
ChEMBL	Antimalarial activity against erythrocytic stage of chloroquine-sensitive Plasmodium falciparum NF54 after 48 hrs by [3H]-hypoxanthine incorporation assay	F	8.03	pIC50	9.4	nM	IC50	Bioorg Med Chem (2014) 22: 2629-2642 [PMID:24721829]
ChEMBL	Antiplasmodial activity against chloroquine sensitive Plasmodium falciparum NF54 by spectroscopic method	F	8.05	pIC50	9	nM	IC50	Bioorg Med Chem Lett (2016) 26: 1151-1155 [PMID:26832222]
ChEMBL	Antiparasitic activity against Plasmodium falciparum NF54	F	8.22	pIC50	6	nM	IC50	J Nat Prod (2014) 77: 1976-1980 [PMID:25080196]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive erythrocytic stage Plasmodium falciparum NF54 assessed as [3H]hypoxanthine incorporation after 48 to 72 hrs by Betaplate liquid scintillation counting	F	8.22	pIC50	6	nM	IC50	J Nat Prod (2015) 78: 604-614 [PMID:25871440]
ChEMBL	Antimicrobial activity against intraerythrocytic stage of Plasmodium falciparum NF54 infected in human erythrocytes by [3H]hypoxanthine incorporation assay	F	8.22	pIC50	6	nM	IC50	Eur J Med Chem (2014) 81: 481-491 [PMID:24865793]
ChEMBL	Antiplasmodial activity against erythrocytic stages of Plasmodium falciparum NF54	F	8.22	pIC50	6	nM	IC50	J Nat Prod (2014) 77: 779-783 [PMID:24673206]
ChEMBL	Antiprotozoan activity against Plasmodium falciparum NF54 IEF forms	F	8.22	pIC50	6	nM	IC50	Bioorg Med Chem Lett (2015) 25: 459-461 [PMID:25563890]
Plasmodium knowlesi (target type: ORGANISM) [ChEMBL: CHEMBL613011]
ChEMBL	Antimalarial activity against Plasmodium knowlesi infected in rhesus monkey RBC assessed as [3H]-hypoxanthine incorporation after 12 hrs by scintillation counting	F	8	pIC50	10	nM	IC50	ACS Med Chem Lett (2012) 3: 43-47 [PMID:24900369]
ChEMBL	Antimalarial activity against asexual blood stage of Plasmodium knowlesi YHI assessed as reduction in cell viability after 48 hrs by EtBr staining based flow cytometric analysis	F	8	pEC50	10	nM	EC50	Eur J Med Chem (2021) 214: 113253-113253 [PMID:33610028]
Plasmodium malariae (target type: ORGANISM) [ChEMBL: CHEMBL613257]
ChEMBL	Antimalarial activity against Plasmodium malariae trophozoite stage infected in red blood cells in presence of AB+ human serum by drug susceptibility assay	F	6.89	pIC50	127.9	nM	IC50	Antimicrob Agents Chemother (2011) 55: 197-202 [PMID:20937779]
ChEMBL	Antimalarial activity against Plasmodium malariae ring stage infected in red blood cells in presence of AB+ human serum by drug susceptibility assay	F	7.85	pIC50	14	nM	IC50	Antimicrob Agents Chemother (2011) 55: 197-202 [PMID:20937779]
Plasmodium vivax (target type: ORGANISM) [ChEMBL: CHEMBL613013]
ChEMBL	Antimicrobial activity against Plasmodium vivax at the trophozoites by microscopy treated during ring stage	F	5.55	pIC50	2812	nM	IC50	Antimicrob Agents Chemother (2008) 52: 1040-1045 [PMID:18180357]
ChEMBL	Antimalarial activity against Plasmodium vivax trophozoites infected in human erythrocytes assessed as growth inhibition by microscopic analysis using giemsa staining	F	5.61	pIC50	2427	nM	IC50	Antimicrob Agents Chemother (2010) 54: 5146-5150 [PMID:20876370]
ChEMBL	Antimalarial activity against trophozoites stage of Plasmodium vivax assessed as parasites growth inhibition using giemsa staining after 24 to 56 hrs by microscopic analysis in presence of 20% human serum	F	6.07	pIC50	841.4	nM	IC50	Antimicrob Agents Chemother (2011) 55: 961-966 [PMID:21135175]
ChEMBL	Antimicrobial activity against Plasmodium vivax trophozoites measured within 30 hrs by microscopy	F	6.27	pIC50	539	nM	IC50	Antimicrob Agents Chemother (2008) 52: 1040-1045 [PMID:18180357]
ChEMBL	Antimicrobial activity against Plasmodium vivax trophozoites by microscopy	F	6.32	pIC50	478	nM	IC50	Antimicrob Agents Chemother (2008) 52: 1040-1045 [PMID:18180357]
ChEMBL	Antimicrobial activity against Plasmodium vivax at the ring stage measured within 30 hrs by microscopy	F	6.32	pIC50	475	nM	IC50	Antimicrob Agents Chemother (2008) 52: 1040-1045 [PMID:18180357]
ChEMBL	Antimicrobial activity against Plasmodium vivax at ring stage	F	6.35	pIC50	442	nM	IC50	Antimicrob Agents Chemother (2008) 52: 2435-2441 [PMID:18443130]
ChEMBL	Antimicrobial activity against fast-growing synchronous Plasmodium vivax by microscopy	F	6.36	pIC50	435	nM	IC50	Antimicrob Agents Chemother (2008) 52: 1040-1045 [PMID:18180357]
ChEMBL	Antimicrobial activity against Plasmodium vivax trophozoites measured after 30 hrs by microscopy	F	6.53	pIC50	298	nM	IC50	Antimicrob Agents Chemother (2008) 52: 1040-1045 [PMID:18180357]
ChEMBL	Growth inhibition of Plasmodium vivax isolate 4 assessed as parasite LDH synthesis after 48 hrs by double-site Plasmodium LDH antigen capture enzyme-linked immunosorbent assay	F	6.74	pIC50	180	nM	IC50	Antimicrob Agents Chemother (2007) 51: 2112-2116 [PMID:17387158]
ChEMBL	Antimalarial activity against Plasmodium vivax infected in human erythrocytes assessed as growth inhibition by microscopic analysis using giemsa staining	F	6.85	pIC50	141.5	nM	IC50	Antimicrob Agents Chemother (2010) 54: 5146-5150 [PMID:20876370]
ChEMBL	Growth inhibition of Plasmodium vivax isolate 3 assessed as parasite LDH synthesis after 48 hrs by double-site Plasmodium LDH antigen capture enzyme-linked immunosorbent assay	F	7.05	pIC50	89.9	nM	IC50	Antimicrob Agents Chemother (2007) 51: 2112-2116 [PMID:17387158]
ChEMBL	Antimicrobial activity against Plasmodium vivax at the ring stage measured after 30 hrs by microscopy	F	7.22	pIC50	59.8	nM	IC50	Antimicrob Agents Chemother (2008) 52: 1040-1045 [PMID:18180357]
ChEMBL	Antimalarial activity against Plasmodium vivax with >50% parasites at ring stage infected in human erythrocytes assessed as growth inhibition after 30 to 50 hrs by microscopic analysis using giemsa staining	F	7.26	pIC50	55.3	nM	IC50	Antimicrob Agents Chemother (2010) 54: 5146-5150 [PMID:20876370]
ChEMBL	Antimicrobial activity against Plasmodium vivax at the ring stage by microscopy	F	7.26	pIC50	55.2	nM	IC50	Antimicrob Agents Chemother (2008) 52: 1040-1045 [PMID:18180357]
ChEMBL	Antimalarial activity against ring stage of Plasmodium vivax assessed as parasites growth inhibition using giemsa staining after 24 to 56 hrs by microscopic analysis in presence of 20% human serum	F	7.28	pIC50	53	nM	IC50	Antimicrob Agents Chemother (2011) 55: 961-966 [PMID:21135175]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium vivax by Giemsa staining	F	7.28	pIC50	52.7	nM	IC50	Antimicrob Agents Chemother (2009) 53: 1094-1099 [PMID:19104023]
ChEMBL	Antimalarial activity against Plasmodium vivax at the ring stage infected in human erythrocytes assessed as growth inhibition by microscopic analysis using giemsa staining	F	7.31	pIC50	49.2	nM	IC50	Antimicrob Agents Chemother (2010) 54: 5146-5150 [PMID:20876370]
ChEMBL	Antimalarial activity against multidrug-resistant Plasmodium vivax clinical isolates assessed as reduction in parasite growth after 35 to 56 hrs by nucleic acid staining based flow cytometry	F	7.32	pIC50	48.4	nM	IC50	J Med Chem (2019) 62: 2485-2498 [PMID:30715882]
ChEMBL	Antimalarial activity against Plasmodium vivax assessed as parasites growth inhibition using giemsa staining after 24 to 56 hrs by microscopic analysis in presence of 20% human serum	F	7.39	pIC50	40.4	nM	IC50	Antimicrob Agents Chemother (2011) 55: 961-966 [PMID:21135175]
ChEMBL	Antimicrobial activity against slow-growing synchronous Plasmodium vivax by microscopy	F	7.4	pIC50	39.9	nM	IC50	Antimicrob Agents Chemother (2008) 52: 1040-1045 [PMID:18180357]
ChEMBL	Antimicrobial activity against Plasmodium vivax at trophozoite stage	F	7.42	pIC50	38	nM	IC50	Antimicrob Agents Chemother (2008) 52: 2435-2441 [PMID:18443130]
ChEMBL	Growth inhibition of Plasmodium vivax isolate 2 assessed as parasite LDH synthesis after 48 hrs by double-site Plasmodium LDH antigen capture enzyme-linked immunosorbent assay	F	7.92	pIC50	11.9	nM	IC50	Antimicrob Agents Chemother (2007) 51: 2112-2116 [PMID:17387158]
ChEMBL	Growth inhibition of Plasmodium vivax isolate 1 assessed as parasite LDH synthesis after 48 hrs by double-site Plasmodium LDH antigen capture enzyme-linked immunosorbent assay	F	8.26	pIC50	5.5	nM	IC50	Antimicrob Agents Chemother (2007) 51: 2112-2116 [PMID:17387158]
Plasmodium yoelii (target type: ORGANISM) [ChEMBL: CHEMBL612889]
ChEMBL	Antimalarial activity against Plasmodium yoelii infected in Swiss mouse assessed as inhibition of beta-hematin formation in plasma after 16 hrs by spectrophotometric analysis	F	5.11	pIC50	7700	nM	IC50	Eur J Med Chem (2013) 60: 497-502 [PMID:23354072]
ChEMBL	Antiplasmodial activity against liver stage of Plasmodium yoelii 17X NL sporozoites infected in human HepG2 cells expressing CD81 after 48 hrs by DAPI staining-based immunofluorescence analysis	F	5.78	pIC50	1650	nM	IC50	Eur J Med Chem (2015) 95: 16-28 [PMID:25791675]
ChEMBL	Antimalarial activity against Plasmodium yoelii N67	F	6.97	pIC50	106	nM	IC50	Eur J Med Chem (2009) 44: 3091-3113 [PMID:19361896]
Prion protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4869] [UniProtKB: P04156]
ChEMBL	Half maximal inhibition of Prion protein PrPsc formation was assayed in ScN2a cells	B	5.4	pEC50	4000	nM	EC50	J Med Chem (2003) 46: 3563-3564 [PMID:12904059]
Quinone reductase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3959] [UniProtKB: P16083]
ChEMBL	Inhibition of human recombinant NQO2	B	5.82	pIC50	1500	nM	IC50	Bioorg Med Chem Lett (2010) 20: 7331-7336 [PMID:21074425]
Riboflavin-binding protein in Chicken (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1944489] [UniProtKB: P02752]
ChEMBL	Binding affinity to chicken riboflavin binding protein assessed as dissociation constant at pH 7.4 in phosphate buffer by isothermal titration calorimetric assay	B	5.68	pKd	2100	nM	Kd	ACS Med Chem Lett (2011) 2: 363-367 [PMID:21686082]
σ2/Sigma intracellular receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105907] [GtoPdb: 2553] [UniProtKB: Q5BJF2]
ChEMBL	Displacement of [3H]-DTG from the Sigma2 receptor	B	6.3	pKi	501.19	nM	Ki	A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720]
ChEMBL	Displacement of [3H]-pentazocin from the Sigma1 receptor	B	7.1	pKi	79.43	nM	Ki	A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
CoV Spike glycoprotein/Spike glycoprotein in Severe acute respiratory syndrome coronavirus 2 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4662936] [GtoPdb: 3114] [UniProtKB: P0DTC2]
ChEMBL	Inhibition of spike glycoprotein S in SARS-CoV-2 pseudovirus infected in human 293T/ACE2 cells assessed as inhibition of viral infection pretreated the virus for 30 mins followed by viral infection measured after 48 hrs by by luciferase reporter gene assay	B	6.8	pIC50	160	nM	IC50	J Nat Prod (2021) 84: 436-443 [PMID:33560122]
MRGPRX1 in Human [GtoPdb: 156] [UniProtKB: Q96LB2]
GtoPdb	-	-	3.53	pEC50	297000	nM	EC50	Cell (2009) 139: 1353-65 [PMID:20004959]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]