ChEMBL ligand: CHEMBL76 (Aralen, Chlorochine, Chloroquine, NSC-187208)
α2A-adrenoceptor/Alpha-2a adrenergic receptor in Human [ChEMBL: CHEMBL1867] [GtoPdb: 25] [UniProtKB: P08913] There should be some charts here, you may need to enable JavaScript!
α2B-adrenoceptor/Alpha-2b adrenergic receptor in Human [ChEMBL: CHEMBL1942] [GtoPdb: 26] [UniProtKB: P18089] There should be some charts here, you may need to enable JavaScript!
α2C-adrenoceptor/Alpha-2c adrenergic receptor in Human [ChEMBL: CHEMBL1916] [GtoPdb: 27] [UniProtKB: P18825] There should be some charts here, you may need to enable JavaScript!
Amyloid-beta A4 protein in Human [ChEMBL: CHEMBL2487] [UniProtKB: P05067] There should be some charts here, you may need to enable JavaScript!
Angiotensin-converting enzyme 2 in Human [ChEMBL: CHEMBL3736] [GtoPdb: 1614] [UniProtKB: Q9BYF1] There should be some charts here, you may need to enable JavaScript!
beta-secretase 1/Beta-secretase 1 in Human [ChEMBL: CHEMBL4822] [GtoPdb: 2330] [UniProtKB: P56817] There should be some charts here, you may need to enable JavaScript!
CXCR4/C-X-C chemokine receptor type 4 in Human [ChEMBL: CHEMBL2107] [GtoPdb: 71] [UniProtKB: P61073] There should be some charts here, you may need to enable JavaScript!
Dihydrofolate reductase in Bovine [ChEMBL: CHEMBL1075051] [UniProtKB: P00376] There should be some charts here, you may need to enable JavaScript!
Falcipain 2 in Plasmodium falciparum [ChEMBL: CHEMBL1697672] [UniProtKB: Q9NAW2] There should be some charts here, you may need to enable JavaScript!
Hemozoin in Plasmodium falciparum [ChEMBL: CHEMBL613898] There should be some charts here, you may need to enable JavaScript!
Kv11.1/HERG in Human [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] There should be some charts here, you may need to enable JavaScript!
Histidine-rich protein in Plasmodium falciparum [ChEMBL: CHEMBL1923] [UniProtKB: P05227] There should be some charts here, you may need to enable JavaScript!
M1 receptor/Muscarinic acetylcholine receptor M1 in Human [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229] There should be some charts here, you may need to enable JavaScript!
M2 receptor/Muscarinic acetylcholine receptor M2 in Human [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172] There should be some charts here, you may need to enable JavaScript!
M3 receptor/Muscarinic acetylcholine receptor M3 in Human [ChEMBL: CHEMBL245] [GtoPdb: 15] [UniProtKB: P20309] There should be some charts here, you may need to enable JavaScript!
M4 receptor/Muscarinic acetylcholine receptor M4 in Human [ChEMBL: CHEMBL1821] [GtoPdb: 16] [UniProtKB: P08173] There should be some charts here, you may need to enable JavaScript!
M5 receptor/Muscarinic acetylcholine receptor M5 in Human [ChEMBL: CHEMBL2035] [GtoPdb: 17] [UniProtKB: P08912] There should be some charts here, you may need to enable JavaScript!
Nuclear receptor related 1/Nuclear receptor subfamily 4 group A member 2 in Human [ChEMBL: CHEMBL5002] [GtoPdb: 630] [UniProtKB: P43354] There should be some charts here, you may need to enable JavaScript!
Plasmodium berghei [ChEMBL: CHEMBL612653] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum K1 [ChEMBL: CHEMBL612856] There should be some charts here, you may need to enable JavaScript!
Plasmodium knowlesi [ChEMBL: CHEMBL613011] There should be some charts here, you may need to enable JavaScript!
Plasmodium malariae [ChEMBL: CHEMBL613257] There should be some charts here, you may need to enable JavaScript!
Plasmodium vivax [ChEMBL: CHEMBL613013] There should be some charts here, you may need to enable JavaScript!
Plasmodium yoelii [ChEMBL: CHEMBL612889] There should be some charts here, you may need to enable JavaScript!
Prion protein in Human [ChEMBL: CHEMBL4869] [UniProtKB: P04156] There should be some charts here, you may need to enable JavaScript!
Quinone reductase 2 in Human [ChEMBL: CHEMBL3959] [UniProtKB: P16083] There should be some charts here, you may need to enable JavaScript!
CoV Replicase polyprotein 1ab/CoV RNA-dependent RNA polymerase/CoV Non-structural protein 15/CoV Non-structural protein 13/Replicase polyprotein 1ab in Severe acute respiratory syndrome coronavirus 2 [ChEMBL: CHEMBL4523582] [GtoPdb: 3125, 3139, 3206, 3261] [UniProtKB: P0DTD1] There should be some charts here, you may need to enable JavaScript!
Riboflavin-binding protein in Chicken [ChEMBL: CHEMBL1944489] [UniProtKB: P02752] There should be some charts here, you may need to enable JavaScript!
mechanistic target of rapamycin kinase/Serine/threonine-protein kinase mTOR in Human [ChEMBL: CHEMBL2842] [GtoPdb: 2109] [UniProtKB: P42345] There should be some charts here, you may need to enable JavaScript!
σ2/Sigma intracellular receptor 2 in Human [ChEMBL: CHEMBL4105907] [GtoPdb: 2553] [UniProtKB: Q5BJF2] There should be some charts here, you may need to enable JavaScript!
sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720] There should be some charts here, you may need to enable JavaScript!
CoV Spike glycoprotein/Spike glycoprotein in Severe acute respiratory syndrome coronavirus 2 [ChEMBL: CHEMBL4662936] [GtoPdb: 3114] [UniProtKB: P0DTC2] There should be some charts here, you may need to enable JavaScript!
MRGPRX1 in Human [GtoPdb: 156] [UniProtKB: Q96LB2] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
α2A-adrenoceptor/Alpha-2a adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1867] [GtoPdb: 25] [UniProtKB: P08913]
ChEMBL	Activity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscine	B	5.36	pKi	4365.16	nM	Ki	A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
α2B-adrenoceptor/Alpha-2b adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1942] [GtoPdb: 26] [UniProtKB: P18089]
ChEMBL	Activity of compound against Alpha 2B (ADRA2B) adrenergic receptor by displacement of [3H]-rauwolscine	B	4.5	pKi	31622.78	nM	Ki	A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
α2C-adrenoceptor/Alpha-2c adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1916] [GtoPdb: 27] [UniProtKB: P18825]
ChEMBL	Activity of compound against Alpha 2C (ADRA2C) adrenergic receptor by displacement of [3H]-rauwolscine	B	5	pKi	10000	nM	Ki	A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
Amyloid-beta A4 protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2487] [UniProtKB: P05067]
ChEMBL	Modulation of human wild-type APP695 expressed in SH-SY5Y cells assessed as inhibition of amyloid beta (1 to 42 residues) production measured after 24 hrs by ELISA	B	4.89	pIC50	12800	nM	IC50	Bioorg Med Chem (2018) 26: 2151-2164 [PMID:29559198]
ChEMBL	Modulation of human wild-type APP695 expressed in SH-SY5Y cells assessed as inhibition of amyloid beta (1 to 40 residues) production measured after 24 hrs	B	5.15	pIC50	7000	nM	IC50	Bioorg Med Chem (2018) 26: 2151-2164 [PMID:29559198]
Angiotensin-converting enzyme 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3736] [GtoPdb: 1614] [UniProtKB: Q9BYF1]
ChEMBL	Inhibition of human recombinant ACE2 at 50 uM using (7Mca-Y-V-A- D -A-P- K(Knp) as a flurogenic substrate measured after 10 mins by fluorescence based analysis	B	5.95	pIC50	1130	nM	IC50	J Med Chem (2020) 63: 12256-12274 [PMID:32539378]
beta-secretase 1/Beta-secretase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4822] [GtoPdb: 2330] [UniProtKB: P56817]
ChEMBL	Inhibition of BACE1 in human SH-SY5Y cells harboring wild type APP695 assessed as reduction in amyloid beta (1 to 42) level after 24 hrs by ELISA method	B	4.9	pIC50	12700	nM	IC50	Eur J Med Chem (2018) 159: 104-125 [PMID:30268822]
ChEMBL	Inhibition of BACE1 in human SH-SY5Y cells harboring wild type APP695 assessed as reduction in amyloid beta (1 to 40) level after 24 hrs by ELISA method	B	5.15	pIC50	7000	nM	IC50	Eur J Med Chem (2018) 159: 104-125 [PMID:30268822]
CXCR4/C-X-C chemokine receptor type 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2107] [GtoPdb: 71] [UniProtKB: P61073]
ChEMBL	Antagonist activity at CXCR4 receptor in human MIA PaCa-2 cells assessed as reduction in forskolin-stimulated inhibition of cAMP production	B	5.19	pEC50	6500	nM	EC50	Eur J Med Chem (2018) 157: 582-598 [PMID:30125720]
Dihydrofolate reductase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075051] [UniProtKB: P00376]
ChEMBL	Inhibition of bovine liver DHFR	B	7.52	pIC50	30.1	nM	IC50	Bioorg Med Chem (2017) 25: 5396-5406 [PMID:28789907]
ChEMBL	Inhibition of bovine liver DHFR pre-incubated 2 mins before dihydrofolic acid substrate addition and measured over 10 mins in presence of NADPH	B	7.52	pIC50	30.1	nM	IC50	Bioorg Med Chem (2017) 25: 4064-4075 [PMID:28634040]
Falcipain 2 in Plasmodium falciparum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1697672] [UniProtKB: Q9NAW2]
ChEMBL	Inhibition of falcipain-2 in chloroquine resistant Plasmodium falciparum RKL9 schizont stage infected in human erythrocytes assessed as reduction in bacterial growth after 24 hrs by Giemsa staining based assay	B	6.7	pIC50	200	nM	IC50	Bioorg Med Chem Lett (2018) 28: 1566-1569 [PMID:29602682]
Hemozoin in Plasmodium falciparum (target type: MACROMOLECULE) [ChEMBL: CHEMBL613898]
ChEMBL	Inhibition of beta-hematin formation assessed as reduction in hemozoin formation incubated for 16 hrs by NP40 detergent-mediated assay	B	4.13	pIC50	74000	nM	IC50	Eur J Med Chem (2019) 180: 121-133 [PMID:31301563]
ChEMBL	Inhibition of beta-hematin	B	4.28	pIC50	53000	nM	IC50	J Med Chem (2016) 59: 6512-6530 [PMID:27299916]
ChEMBL	Inhibition of beta-hematin formation assessed as reduction in hemozoin formation incubated for 5 hrs by NP40 detergent-based assay	B	4.28	pIC50	53000	nM	IC50	Medchemcomm (2019) 10: 450-455 [PMID:31015908]
ChEMBL	Inhibition of beta-hematin in water/NP40/DMSO solution incubated for 5 to 6hrs by detergent-mediated pyridine-ferrichrome method	B	4.5	pIC50	31500	nM	IC50	J Med Chem (2016) 59: 6512-6530 [PMID:27299916]
ChEMBL	Inhibition of Beta-hematin in Plasmodium falciparum NF54 assessed as hemozoin formation after 36 hrs by flow cytometry analysis	B	4.66	pIC50	22000	nM	IC50	J Med Chem (2022) 65: 16695-16715 [PMID:36507890]
ChEMBL	Inhibition of beta-hematin formation assessed as reduction in hemozoin formation incubated for 5 hrs by NP40 detergent-mediated assay	B	4.68	pIC50	21000	nM	IC50	J Med Chem (2020) 63: 13013-13030 [PMID:33103428]
ChEMBL	Inhibition of Beta-hematin assessed as bis-pyridyl-Fe(III)PPIX complex formation incubated for 5 hrs by NP40 detergent-mediated colorimetric assay	B	4.72	pIC50	19000	nM	IC50	J Med Chem (2021) 64: 2739-2761 [PMID:33620219]
ChEMBL	Inhibition of beta hematin formation after 5 hrs by NP40 detergent-based assay	B	4.74	pIC50	18000	nM	IC50	J Med Chem (2019) 62: 1022-1035 [PMID:30562027]
ChEMBL	Inhibition of beta-hematin formation assessed as reduction in hemozoin formation incubated for 20 hrs by NP40 detergent-mediated assay	B	4.77	pIC50	16900	nM	IC50	RSC Med Chem (2020) 11: 85-91 [PMID:33479606]
ChEMBL	Inhibition of Beta-hematin in Plasmodium falciparum cells assessed as hemozoin formation after 32 hrs by NP40 detergent-mediated assay	B	4.77	pIC50	16800	nM	IC50	Bioorg Med Chem Lett (2021) 54: 128442-128442 [PMID:34763083]
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL	Inhibition of human ERG expressed in CHO cells	B	5.12	pKi	7500	nM	Ki	ACS Med Chem Lett (2013) 4: 1037-1041 [PMID:24900603]
ChEMBL	Inhibition of human ERG	B	5.6	pIC50	2511.89	nM	IC50	Eur J Med Chem (2011) 46: 618-630 [PMID:21185626]
ChEMBL	Inhibitory concentration against IKr potassium channel	B	5.6	pIC50	2500	nM	IC50	Bioorg Med Chem Lett (2004) 14: 4771-4777 [PMID:15324906]
ChEMBL	Inhibition of human cloned ERG	B	5.6	pIC50	2500	nM	IC50	J Med Chem (2009) 52: 1408-1415 [PMID:19222165]
ChEMBL	Inhibition of human ERG expressed in HEK293 cells assessed as reduction in tail current at membrane potential of +20 mV	B	5.6	pIC50	2500	nM	IC50	Bioorg Med Chem Lett (2015) 25: 1390-1393 [PMID:25746816]
Histidine-rich protein in Plasmodium falciparum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1923] [UniProtKB: P05227]
ChEMBL	Inhibition of 1-monooleoyl glycerol (MOG) induced beta-hematin formation	F	4.12	pIC50	76500	nM	IC50	Bioorg Med Chem Lett (2003) 13: 3783-3787 [PMID:14552779]
ChEMBL	Inhibition of beta-hematin formation in Plasmodium falciparum	F	4.12	pIC50	75000	nM	IC50	Bioorg Med Chem Lett (2001) 11: 2075-2077 [PMID:11514142]
ChEMBL	Inhibition of 1-monooleoyl glycerol induced beta-hematin formation	F	4.22	pIC50	60000	nM	IC50	Bioorg Med Chem Lett (2006) 16: 31-35 [PMID:16263280]
ChEMBL	Inhibition of lipid-induced beta-hematin formation	F	4.33	pIC50	46300	nM	IC50	J Med Chem (2006) 49: 4707-4714 [PMID:16854077]
ChEMBL	Inhibition of beta-hematin formation	F	4.42	pIC50	38000	nM	IC50	J Med Chem (2002) 45: 4975-4983 [PMID:12408708]
ChEMBL	Inhibition of beta-hematin formation after 16 hrs	F	4.81	pIC50	15400	nM	IC50	Antimicrob Agents Chemother (2007) 51: 2842-2847 [PMID:17562796]
ChEMBL	Inhibition of hematin polymerization	F	4.82	pIC50	15000	nM	IC50	J Med Chem (1999) 42: 4630-4639 [PMID:10579825]
ChEMBL	Inhibition of beta-hematin polymerization	B	6.4	pIC50	400	nM	IC50	J Med Chem (2007) 50: 394-398 [PMID:17228883]
ChEMBL	Inhibitory activity against beta-hematin formation	F	7.12	pIC50	76.5	nM	IC50	J Med Chem (2003) 46: 542-557 [PMID:12570376]
M1 receptor/Muscarinic acetylcholine receptor M1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229]
ChEMBL	Activity of compound against Muscarinic acetylcholine receptor M1 (CHRM1) by displacement of 3H-QNB	B	5.04	pKi	9120.11	nM	Ki	A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
M2 receptor/Muscarinic acetylcholine receptor M2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172]
ChEMBL	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	B	5.33	pKi	4677.35	nM	Ki	A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
M3 receptor/Muscarinic acetylcholine receptor M3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL245] [GtoPdb: 15] [UniProtKB: P20309]
ChEMBL	Activity of compound against Muscarinic acetylcholine receptor M3 (CHRM3) by displacement of 3H-QNB	B	5.48	pKi	3311.31	nM	Ki	A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
M4 receptor/Muscarinic acetylcholine receptor M4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1821] [GtoPdb: 16] [UniProtKB: P08173]
ChEMBL	Activity of compound against Muscarinic acetylcholine receptor M4 (CHRM4) by displacement of 3H-QNB	B	5.24	pKi	5754.4	nM	Ki	A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
M5 receptor/Muscarinic acetylcholine receptor M5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2035] [GtoPdb: 17] [UniProtKB: P08912]
ChEMBL	Activity of compound against Muscarinic acetylcholine receptor M5 (CHRM5) by displacement of 3H-QNB	B	4.66	pKi	21877.62	nM	Ki	A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
Nuclear receptor related 1/Nuclear receptor subfamily 4 group A member 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5002] [GtoPdb: 630] [UniProtKB: P43354]
ChEMBL	Agonist activity at Nurr1 ligand binding domain (unknown origin) measured by Gal4-based reporter gene assay	B	4.3	pEC50	50000	nM	EC50	J Med Chem (2022) 65: 9548-9563 [PMID:35797147]
ChEMBL	Agonist activity at Gal4-fused human Nurr1 LBD expressed in HEK293T cells co-expressing firefly luciferase assessed as luciferase activity incubated for 12 to 14 hrs by hybrid reporter gene assay	B	4.33	pEC50	47000	nM	EC50	J Med Chem (2021) 64: 2659-2668 [PMID:33629841]
Plasmodium berghei (target type: ORGANISM) [ChEMBL: CHEMBL612653]
ChEMBL	Antimalarial activity against luciferase-expressing Plasmodium berghei ANKA 676m1cl1 sporozoites infected in human HepG2A16 cells measured after 45 hrs by luciferase-luciferin based reporter gene assay	F	4.5	pIC50	>31262	nM	IC50	J Med Chem (2020) 63: 6179-6202 [PMID:32390431]
ChEMBL	Antimalarial activity against luciferase-expressing Plasmodium berghei ANKA 676m1cl1 sporozoites infected in human HepG2A16 cells measured after 45 hrs by luciferase-luciferin based reporter assay	F	4.5	pIC50	>31262	nM	IC50	J Med Chem (2019) 62: 3475-3502 [PMID:30852885]
ChEMBL	Antiplasmodial activity against Plasmodium berghei liver stage form transfected in human Huh-7 cells assessed as cell viability after 48 hrs by luciferase reporter gene assay	F	4.8	pIC50	15900	nM	IC50	J Med Chem (2013) 56: 556-567 [PMID:23273038]
ChEMBL	Antiplasmodial activity against liver stage of Plasmodium berghei expressing GFP-Luc infected in HuH7 cells incubated at 1 hr prior to infection followed by compound replenisment at 24 hrs post-infection measured after 48 hrs by Alamar blue assay	F	4.82	pIC50	>15000	nM	IC50	Bioorg Med Chem Lett (2013) 23: 610-613 [PMID:23290049]
ChEMBL	Antimalarial activity against exo-erythrocytic form of Plasmodium berghei infected in human HepG2 cells after 48 hrs	F	5	pIC50	>10000	nM	IC50	Eur J Med Chem (2014) 82: 204-213 [PMID:24904967]
ChEMBL	Antimalarial activity against sporozoite stage of Plasmodium berghei yoelii infected in human HepG2 cells	F	5.05	pIC50	9000	nM	IC50	J Med Chem (2016) 59: 264-281 [PMID:26640981]
ChEMBL	Antimalarial activity against schizonts of chloroquine-sensitive Plasmodium berghei ANKA 2.34 after 16 hrs	F	7.22	pIC50	60	nM	IC50	Bioorg Med Chem Lett (2012) 22: 7048-7051 [PMID:23084276]
ChEMBL	Antiplasmodial activity against liver stage Plasmodium berghei ANKA infected in human HepG2 cells measured after 44 hrs	F	8.92	pIC50	>1.2	nM	IC50	Eur J Med Chem (2018) 146: 1-14 [PMID:29360043]
ChEMBL	Antimicrobial activity against Plasmodium berghei sporozoites infected in 12 hrs compound pretreated human HepG2 cells assessed as reduction in viability of exoerythrocytic forms measured after 48 hrs of incubation by luciferase bioluminescence assay	F	5	pEC50	>10000	nM	EC50	J Med Chem (2014) 57: 2773-2788 [PMID:24641010]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Inhibition of hematin polymerization in Plasmodium falciparum	F	4.1	pIC50	80000	nM	IC50	J Med Chem (1998) 41: 4360-4364 [PMID:9784111]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human O positive erythrocyte assessed as reduction in parasitemia after 72 hrs	F	4.19	pIC50	>64000	nM	IC50	Bioorg Med Chem (2014) 22: 5241-5248 [PMID:25199582]
ChEMBL	Gametocytocidal activity against synchronous stage 4 to 5 of transgenic Plasmodium falciparum NF54 gametocyte harboring pfs16 promoter assessed as parasite viability after 72 hrs by MitoTracker Red CMXRos-based assay	F	4.22	pIC50	60000	nM	IC50	J Med Chem (2013) 56: 6200-6215 [PMID:23837878]
ChEMBL	Inhibition of hydrogen peroxide-mediated haem detoxification in Plasmodium falciparum	F	4.43	pIC50	37000	nM	IC50	Bioorg Med Chem Lett (2001) 11: 2075-2077 [PMID:11514142]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human RBC	F	4.49	pIC50	32000	nM	IC50	ACS Med Chem Lett (2013) 4: 1037-1041 [PMID:24900603]
ChEMBL	Antimalarial activity after 72 hrs against chloroquine-sensitive Plasmodium falciparum D6 infected in erythrocytes by LDH assay	F	4.53	pIC50	29700	nM	IC50	Bioorg Med Chem (2009) 17: 741-751 [PMID:19084416]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum	F	4.53	pIC50	29640	nM	IC50	Eur J Med Chem (2019) 166: 206-223 [PMID:30711831]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in erythrocytes after 96 hrs by [3H]hypoxanthine incorporation assay	F	4.68	pIC50	21000	nM	IC50	J Med Chem (2009) 52: 7954-7957 [PMID:19908867]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay	F	4.72	pIC50	19000	nM	IC50	J Med Chem (2009) 52: 7954-7957 [PMID:19908867]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 by lactate dehydrogenase assay	F	4.79	pIC50	16300	nM	IC50	J Nat Prod (2018) 81: 41-48 [PMID:29309141]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7 infected in human O positive erythrocytes assessed as reduction of parasite growth after 24 to 44 hrs by Giemsa staining	F	4.82	pIC50	15000	nM	IC50	Eur J Med Chem (2013) 67: 158-165 [PMID:23851117]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54	F	4.9	pIC50