compound 1 [PMID: 24900526] [Ligand Id: 7870] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1335679 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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| MMP1/Matrix metalloproteinase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL332] [GtoPdb: 1628] [UniProtKB: P03956] | ||||||||
| ChEMBL | Inhibition of MMP1 (unknown origin)-mediated Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorimetric assay | B | 4.54 | pKi | 29000 | nM | Ki | ACS Med Chem Lett (2013) 4: 565-569 [PMID:24900710] |
| MMP12/Matrix metalloproteinase 12 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4393] [GtoPdb: 1636] [UniProtKB: P39900] | ||||||||
| ChEMBL | Inhibition of MMP12 (unknown origin)-mediated Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorimetric assay | B | 4.74 | pKi | 18000 | nM | Ki | ACS Med Chem Lett (2013) 4: 565-569 [PMID:24900710] |
| ChEMBL | Inhibition of human MMP12 by FRET reporter assay | B | 6.54 | pIC50 | 290 | nM | IC50 | ACS Med Chem Lett (2012) 3: 653-657 [PMID:24900526] |
| GtoPdb | - | - | 6.54 | pIC50 | 290 | nM | IC50 | ACS Med Chem Lett (2012) 3: 653-7 [PMID:24900526] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
