cerlapirdine [Ligand Id: 7356] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2103880 (Cerlapirdine, PF-05212365, Sam-531, SAM-531, SAM-531 FREE BASE, WAY-262,531, WAY-262531)
  • 5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406]
ChEMBL Antagonist activity at human recombinant 5HT6 receptor expressed in CHO cells B 8.89 pKi 1.3 nM Ki J Med Chem (2014) 57: 7160-7181 [PMID:24850589]
ChEMBL Antagonist activity at 5-HT6 receptor (unknown origin) B 8.89 pKi 1.3 nM Ki J Med Chem (2017) 60: 1843-1859 [PMID:28212021]
GtoPdb - - 8.89 pKi 1.3 nM Ki Alzheimers Dement (2010) 6: S548-S549

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]