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ChEMBL ligand: CHEMBL1403981 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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RTP Type C/Leukocyte common antigen in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3243] [GtoPdb: 1852] [UniProtKB: P08575] | ||||||||
ChEMBL | Inhibition of CD45 expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincubated for 20 mins by FRET assay | B | 4.1 | pIC50 | 79000 | nM | IC50 | J Med Chem (2011) 54: 6548-6562 [PMID:21882820] |
protein tyrosine phosphatase non-receptor type 1/Protein-tyrosine phosphatase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL335] [GtoPdb: 2976] [UniProtKB: P18031] | ||||||||
ChEMBL | Inhibition of PTP1B expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincubated for 20 mins by FRET assay | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2011) 54: 6548-6562 [PMID:21882820] |
RTP Type G/Receptor-type tyrosine-protein phosphatase gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4905] [GtoPdb: 1856] [UniProtKB: P23470] | ||||||||
GtoPdb | - | - | 5.6 | pKi | 2500 | nM | Ki | J Med Chem (2011) 54: 6548-62 [PMID:21882820] |
ChEMBL | Inhibition of RPTPgamma expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincubated for 20 mins by Lineweaver-Burk plot | B | 5.6 | pKi | 2500 | nM | Ki | J Med Chem (2011) 54: 6548-6562 [PMID:21882820] |
ChEMBL | Inhibition of RPTPgamma expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide by FRET assay | B | 4.89 | pIC50 | 12800 | nM | IC50 | J Med Chem (2011) 54: 6548-6562 [PMID:21882820] |
ChEMBL | Inhibition of RPTPgamma expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincubated for 20 mins by FRET assay | B | 5.59 | pIC50 | 2600 | nM | IC50 | J Med Chem (2011) 54: 6548-6562 [PMID:21882820] |
ChEMBL | Inhibition of RPTPgamma expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincubated for 40 mins by FRET assay | B | 5.6 | pIC50 | 2500 | nM | IC50 | J Med Chem (2011) 54: 6548-6562 [PMID:21882820] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]