acetic acid [Ligand Id: 1058] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL539 (Orlex, NSC-111201, NSC-127175, Glacial acetic acid, E260, Acetic Acid, Glacial, Acetic acid, glacial, Aci-jel, NSC-115870, Vosol, Acetasol, INS NO.260, Acetic Acid, INS-260, NSC-406306, Earcalm, Acetic acid, FEMA NO. 2006, NSC-112209, NSC-132953, E-260)
  • FFA3 receptor/Free fatty acid receptor 3 in Human [ChEMBL: CHEMBL5201] [GtoPdb: 227] [UniProtKB: O14843]
  • This target only has 0 pki data point
  • 0
1 CHEMBL539_lig_chart_1 Free fatty acid receptor 3 Human
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  • FYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase FYN in Human [ChEMBL: CHEMBL1841] [GtoPdb: 2026] [UniProtKB: P06241]
  • This target only has 0 pki data point
  • 0
2 CHEMBL539_lig_chart_2 Tyrosine-protein kinase FYN Human
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  • LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Human [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239]
  • This target only has 0 pki data point
  • 0
3 CHEMBL539_lig_chart_3 Tyrosine-protein kinase LCK Human
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  • FFA2 receptor in Human [GtoPdb: 226] [UniProtKB: O15552]
  • This target only has 0 pki data point
  • 0
4 CHEMBL539_lig_chart_4 FFA2 receptor Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
FFA3 receptor/Free fatty acid receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5201] [GtoPdb: 227] [UniProtKB: O14843]
GtoPdb - - 3.9 pEC50 - - - J Biol Chem (2003) 278: 11312-9 [PMID:12496283];
J Biol Chem (2003) 278: 25481-9 [PMID:12711604];
Proc Natl Acad Sci USA (2004) 101: 1045-50 [PMID:14722361];
J Biol Chem (2011) 286: 10628-40 [PMID:21220428]
ChEMBL Agonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting method B 4.92 pEC50 12000 nM EC50 J Med Chem (2018) 61: 47-61 [PMID:28745893]
FYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase FYN in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1841] [GtoPdb: 2026] [UniProtKB: P06241]
ChEMBL Dissociation constant for binding to SH2 domain of Fyn protein kinase B 6.05 pKd 900 nM Kd J. Med. Chem. (1999) 42: 784-787 [PMID:10072676]
LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239]
ChEMBL Dissociation constant for binding to SH2 domain of p56 lck tyrosine kinase B 5.89 pKd 1300 nM Kd J. Med. Chem. (1999) 42: 784-787 [PMID:10072676]
ChEMBL Dissociation constant for binding to SH2 domain of p56 lck tyrosine kinase B 6.19 pKd 640 nM Kd J. Med. Chem. (1999) 42: 784-787 [PMID:10072676]
FFA2 receptor in Human [GtoPdb: 226] [UniProtKB: O15552]
GtoPdb - - 4.6 pEC50 - - - J Biol Chem (2003) 278: 11312-9 [PMID:12496283];
Biochem Biophys Res Commun (2003) 303: 1047-52 [PMID:12684041];
J Biol Chem (2003) 278: 25481-9 [PMID:12711604];
J Biol Chem (2011) 286: 10628-40 [PMID:21220428]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]