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ChEMBL ligand: CHEMBL539 (Acetasol, Acetic, Acetic acid, Acetic Acid, Acetic acid, diluted, Acetic acid glacial, Acetic acid,glacial, Acetic acid, glacial, Acetic Acid, Glacial, Aceticum acidum, Acetopyrine, Acidum aceticum, Acidum aceticum glaciale, Aci-jel, Acopyrine, Antipyrine acetylsalicylate, Distilled vinegar, E260, E-260, Earcalm, FEMA NO. 2006, Glacial acetic acid, INS-260, INS NO.260, NSC-111201, NSC-112209, NSC-115870, NSC-127175, NSC-132953, NSC-406306, Orlex, Orthoacetic acid, Pyrosal, Vinegar, Vinegar acid, Vosol) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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FFA3 receptor/Free fatty acid receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5201] [GtoPdb: 227] [UniProtKB: O14843] | ||||||||
GtoPdb | - | - | 3.9 | pEC50 | - | - | - |
J Biol Chem (2003) 278: 11312-9 [PMID:12496283]; J Biol Chem (2003) 278: 25481-9 [PMID:12711604]; Proc Natl Acad Sci USA (2004) 101: 1045-50 [PMID:14722361]; J Biol Chem (2011) 286: 10628-40 [PMID:21220428] |
ChEMBL | Agonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting method | F | 4.92 | pEC50 | 12000 | nM | EC50 | J Med Chem (2018) 61: 47-61 [PMID:28745893] |
FYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase FYN in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1841] [GtoPdb: 2026] [UniProtKB: P06241] | ||||||||
ChEMBL | Dissociation constant for binding to SH2 domain of Fyn protein kinase | B | 6.05 | pKd | 900 | nM | Kd | J Med Chem (1999) 42: 784-787 [PMID:10072676] |
LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239] | ||||||||
ChEMBL | Dissociation constant for binding to SH2 domain of p56 lck tyrosine kinase | B | 5.89 | pKd | 1300 | nM | Kd | J Med Chem (1999) 42: 784-787 [PMID:10072676] |
ChEMBL | Dissociation constant for binding to SH2 domain of p56 lck tyrosine kinase | B | 6.19 | pKd | 640 | nM | Kd | J Med Chem (1999) 42: 784-787 [PMID:10072676] |
FFA2 receptor in Human [GtoPdb: 226] [UniProtKB: O15552] | ||||||||
GtoPdb | - | - | 4.6 | pEC50 | - | - | - |
J Biol Chem (2003) 278: 11312-9 [PMID:12496283]; Biochem Biophys Res Commun (2003) 303: 1047-52 [PMID:12684041]; J Biol Chem (2003) 278: 25481-9 [PMID:12711604]; J Biol Chem (2011) 286: 10628-40 [PMID:21220428] |
ChEMBL data shown on this page come from version 32:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]