ChEMBL ligand: CHEMBL168 (NSC-114945)
acetyl-CoA acetyltransferase 1/Acetyl-CoA acetyltransferase, mitochondrial in Rat [ChEMBL: CHEMBL3393] [GtoPdb: 2435] [UniProtKB: P17764] There should be some charts here, you may need to enable JavaScript!
carboxylesterase 1/Acyl coenzyme A:cholesterol acyltransferase in Human [ChEMBL: CHEMBL2265] [GtoPdb: 2592] [UniProtKB: P23141] There should be some charts here, you may need to enable JavaScript!
Aldo-keto reductase family 1 member B10 in Human [ChEMBL: CHEMBL5983] [UniProtKB: O60218] There should be some charts here, you may need to enable JavaScript!
coagulation factor III, tissue factor/Coagulation factor III in Human [ChEMBL: CHEMBL4081] [GtoPdb: 3192] [UniProtKB: P13726] There should be some charts here, you may need to enable JavaScript!
Cyclooxygenase-1 in Sheep [ChEMBL: CHEMBL2949] [UniProtKB: P05979] There should be some charts here, you may need to enable JavaScript!
COX-2 /Cyclooxygenase-2 in Human [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354] There should be some charts here, you may need to enable JavaScript!
DNA polymerase beta in Human [ChEMBL: CHEMBL2392] [GtoPdb: 3231] [UniProtKB: P06746] DNA polymerase beta in Rat [ChEMBL: CHEMBL4343] [GtoPdb: 3231] [UniProtKB: P06766] There should be some charts here, you may need to enable JavaScript!
Dual specificity phosphatase Cdc25B in Human [ChEMBL: CHEMBL4804] [UniProtKB: P30305] There should be some charts here, you may need to enable JavaScript!
Dual specificity protein phosphatase 3 in Human [ChEMBL: CHEMBL2635] [UniProtKB: P51452] There should be some charts here, you may need to enable JavaScript!
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533] There should be some charts here, you may need to enable JavaScript!
Glycogen phosphorylase, muscle form in Rabbit [ChEMBL: CHEMBL4696] [UniProtKB: P00489] There should be some charts here, you may need to enable JavaScript!
GP41 in Human immunodeficiency virus 1 [ChEMBL: CHEMBL3559676] [UniProtKB: Q76270] There should be some charts here, you may need to enable JavaScript!
GPBA receptor/G-protein coupled bile acid receptor 1 in Human [ChEMBL: CHEMBL5409] [GtoPdb: 37] [UniProtKB: Q8TDU6] There should be some charts here, you may need to enable JavaScript!
Hemagglutinin in Influenza A virus [ChEMBL: CHEMBL3559640] [UniProtKB: B4URE7] There should be some charts here, you may need to enable JavaScript!
RTP Type C/Leukocyte common antigen in Human [ChEMBL: CHEMBL3243] [GtoPdb: 1852] [UniProtKB: P08575] There should be some charts here, you may need to enable JavaScript!
Low molecular weight phosphotyrosine protein phosphatase in Human [ChEMBL: CHEMBL4903] [UniProtKB: P24666] There should be some charts here, you may need to enable JavaScript!
sirtuin 5/NAD-dependent protein deacylase sirtuin-5, mitochondrial in Human [ChEMBL: CHEMBL2163183] [GtoPdb: 2711] [UniProtKB: Q9NXA8] There should be some charts here, you may need to enable JavaScript!
Inducible NOS/Nitric oxide synthase, inducible in Human [ChEMBL: CHEMBL4481] [GtoPdb: 1250] [UniProtKB: P35228] There should be some charts here, you may need to enable JavaScript!
nuclear factor, erythroid 2 like 2/Nuclear factor erythroid 2-related factor 2 in Human [ChEMBL: CHEMBL1075094] [GtoPdb: 3057] [UniProtKB: Q16236] There should be some charts here, you may need to enable JavaScript!
RELA proto-oncogene, NF-kB subunit/Nuclear factor NF-kappa-B p65 subunit in Human [ChEMBL: CHEMBL5533] [GtoPdb: 3280] [UniProtKB: Q04206] There should be some charts here, you may need to enable JavaScript!
Pancreatic alpha-amylase in Pig [ChEMBL: CHEMBL5730] [UniProtKB: P00690] There should be some charts here, you may need to enable JavaScript!
sPLA2-1B/Phospholipase A2 group 1B in Human [ChEMBL: CHEMBL4426] [GtoPdb: 1416] [UniProtKB: P04054] There should be some charts here, you may need to enable JavaScript!
Phosphotyrosine protein phosphatase in Mycobacterium tuberculosis [ChEMBL: CHEMBL4295521] [UniProtKB: A0A045ISB3] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
Protease in Human immunodeficiency virus 1 [ChEMBL: CHEMBL2366517] [UniProtKB: Q9YQ12] There should be some charts here, you may need to enable JavaScript!
protein tyrosine phosphatase non-receptor type 1/Protein-tyrosine phosphatase 1B in Human [ChEMBL: CHEMBL335] [GtoPdb: 2976] [UniProtKB: P18031] There should be some charts here, you may need to enable JavaScript!
Protein-tyrosine phosphatase 1C in Human [ChEMBL: CHEMBL3166] [UniProtKB: P29350] There should be some charts here, you may need to enable JavaScript!
protein tyrosine phosphatase non-receptor type 11/Protein-tyrosine phosphatase 2C in Human [ChEMBL: CHEMBL3864] [GtoPdb: 3203] [UniProtKB: Q06124] There should be some charts here, you may need to enable JavaScript!
RTP Type A/Receptor-type tyrosine-protein phosphatase alpha in Human [ChEMBL: CHEMBL3918] [GtoPdb: 1850] [UniProtKB: P18433] There should be some charts here, you may need to enable JavaScript!
RTP Type E/Receptor-type tyrosine-protein phosphatase epsilon in Human [ChEMBL: CHEMBL4850] [GtoPdb: 1854] [UniProtKB: P23469] There should be some charts here, you may need to enable JavaScript!
RTP Type F/Receptor-type tyrosine-protein phosphatase F (LAR) in Human [ChEMBL: CHEMBL3521] [GtoPdb: 1855] [UniProtKB: P10586] There should be some charts here, you may need to enable JavaScript!
signal transducer and activator of transcription 3/Signal transducer and activator of transcription 3 in Human [ChEMBL: CHEMBL4026] [GtoPdb: 2994] [UniProtKB: P40763] There should be some charts here, you may need to enable JavaScript!
protein tyrosine phosphatase non-receptor type 2/T-cell protein-tyrosine phosphatase in Human [ChEMBL: CHEMBL3807] [GtoPdb: 3255] [UniProtKB: P17706] There should be some charts here, you may need to enable JavaScript!
Ubiquitin carboxyl-terminal hydrolase 7 in Human [ChEMBL: CHEMBL2157850] [UniProtKB: Q93009] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
acetyl-CoA acetyltransferase 1/Acetyl-CoA acetyltransferase, mitochondrial in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3393] [GtoPdb: 2435] [UniProtKB: P17764]
ChEMBL	Inhibition of rat liver microsomal ACAT	B	4.11	pIC50	77900	nM	IC50	Eur J Med Chem (2017) 139: 201-213 [PMID:28802120]
carboxylesterase 1/Acyl coenzyme A:cholesterol acyltransferase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2265] [GtoPdb: 2592] [UniProtKB: P23141]
ChEMBL	Inhibition of CES1A1 in human liver microsomes using D-luciferin methyl ester as substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins by fluorescence assay	B	7	pIC50	100	nM	IC50	J Nat Prod (2020) 83: 2940-2949 [PMID:32951423]
Aldo-keto reductase family 1 member B10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5983] [UniProtKB: O60218]
ChEMBL	Competitive inhibition of dehydrogenase activity of N-terminal 6His-tagged human AKR1B10 W220Y mutant expressed in Escherichia coli BL21(DE3) assessed as NADP+-linked geraniol oxidation	B	5.45	pKi	3560	nM	Ki	J Nat Prod (2011) 74: 1201-1206 [PMID:21561086]
ChEMBL	Competitive inhibition of dehydrogenase activity of N-terminal 6His-tagged human AKR1B10 V301L mutant expressed in Escherichia coli BL21(DE3) assessed as NADP+-linked geraniol oxidation	B	6.03	pKi	940	nM	Ki	J Nat Prod (2011) 74: 1201-1206 [PMID:21561086]
ChEMBL	Competitive inhibition of dehydrogenase activity of N-terminal 6His-tagged human AKR1B10 Q303S mutant expressed in Escherichia coli BL21(DE3) assessed as NADP+-linked geraniol oxidation	B	6.18	pKi	660	nM	Ki	J Nat Prod (2011) 74: 1201-1206 [PMID:21561086]
ChEMBL	Competitive inhibition of dehydrogenase activity of N-terminal 6His-tagged human AKR1B10 K125L mutant expressed in Escherichia coli BL21(DE3) assessed as NADP+-linked geraniol oxidation	B	6.8	pKi	160	nM	Ki	J Nat Prod (2011) 74: 1201-1206 [PMID:21561086]
ChEMBL	Competitive inhibition of dehydrogenase activity of N-terminal 6His-tagged human AKR1B10 expressed in Escherichia coli BL21(DE3) assessed as NADP+-linked geraniol oxidation	B	7.14	pKi	72	nM	Ki	J Nat Prod (2011) 74: 1201-1206 [PMID:21561086]
ChEMBL	Inhibition of N-terminal 6His-tagged human AKR1B10 overexpressed in human HeLa cells assessed as inhibition of [1-14C]farnesol reduction pretreated for 2 hrs before [1-14C]farnesol challenge measured after 6 hrs	B	5.4	pIC50	4000	nM	IC50	J Nat Prod (2011) 74: 1201-1206 [PMID:21561086]
ChEMBL	Inhibition of reductase activity of N-terminal 6His-tagged human AKR1B10 expressed in Escherichia coli BL21(DE3) assessed as pyridine-3-aldehyde reduction	B	7.05	pIC50	90	nM	IC50	J Nat Prod (2011) 74: 1201-1206 [PMID:21561086]
coagulation factor III, tissue factor/Coagulation factor III in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4081] [GtoPdb: 3192] [UniProtKB: P13726]
ChEMBL	Inhibition of LPS-induced tissue factor procoagulant activity in human THP1 cells preincubated for 1 hr followed by LPS addition measured after 5 hrs using factor 10a chromogenic substrate in presence of prothrombin complex	B	8.3	pIC50	4.97	nM	IC50	Bioorg Med Chem Lett (2017) 27: 1026-1030 [PMID:28109788]
Cyclooxygenase-1 in Sheep (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2949] [UniProtKB: P05979]
ChEMBL	Inhibition of ovine recombinant COX1 assessed as decrease in formation of PGE2 using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition measured after 45 mins by LC-MS analysis	B	4.38	pIC50	42000	nM	IC50	J Nat Prod (2019) 82: 3311-3320 [PMID:31774676]
COX-2 /Cyclooxygenase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354]
ChEMBL	Inhibition of COX2 by scintillation proximity assay	B	4.06	pIC50	87000	nM	IC50	J Nat Prod (2002) 65: 1517-1521 [PMID:12444669]
ChEMBL	Inhibition of human recombinant COX2 expressed in baculovirus infected sf21 cells assessed as decrease in PGE2 formation using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition measured after 45 mins by LC-MS analysis	B	4.4	pIC50	>40000	nM	IC50	J Nat Prod (2019) 82: 3311-3320 [PMID:31774676]
DNA polymerase beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2392] [GtoPdb: 3231] [UniProtKB: P06746]
ChEMBL	Inhibition of lyase activity of DNA polymerase beta	B	4.58	pIC50	26250	nM	IC50	Bioorg Med Chem (2008) 16: 4331-4340 [PMID:18343122]
ChEMBL	Inhibition of polymerase activity of DNA polymerase beta	B	4.6	pIC50	24980	nM	IC50	Bioorg Med Chem (2008) 16: 4331-4340 [PMID:18343122]
ChEMBL	Inhibition of DNA polymerase beta lyase activity	B	5.06	pIC50	8800	nM	IC50	J Nat Prod (2004) 67: 964-967 [PMID:15217274]
ChEMBL	Inhibition of DNA polymerase beta lyase activity by deoxyribose phosphate excision assay	B	5.06	pIC50	8800	nM	IC50	J Nat Prod (2003) 66: 1463-1465 [PMID:14640519]
ChEMBL	Inhibition of DNA polymerase beta	B	5.52	pIC50	3000	nM	IC50	J Nat Prod (2011) 74: 1201-1206 [PMID:21561086]
GtoPdb	Inhibition of POLB polymerase activity	-	5.6	pIC50	2498	nM	IC50	Bioorg Med Chem (2008) 16: 4331-40 [PMID:18343122]
DNA polymerase beta in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4343] [GtoPdb: 3231] [UniProtKB: P06766]
ChEMBL	Inhibition of rat DNA polymerase beta in presence of BSA	B	5.12	pIC50	7500	nM	IC50	J Nat Prod (1999) 62: 1624-1626 [PMID:10654412]
ChEMBL	Inhibition of rat DNA polymerase beta in absence of BSA	B	5.43	pIC50	3700	nM	IC50	J Nat Prod (1999) 62: 1624-1626 [PMID:10654412]
Dual specificity phosphatase Cdc25B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4804] [UniProtKB: P30305]
ChEMBL	Inhibition of CDC25B (unknown origin) using pNPP as substrate by spectrophotometry	B	6.01	pIC50	980	nM	IC50	Bioorg Med Chem (2015) 23: 38-45 [PMID:25497963]
Dual specificity protein phosphatase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2635] [UniProtKB: P51452]
ChEMBL	Inhibition of human VHR expressed in Escherichia coli using pNPP as substrate preincubated for 10 mins followed by substrate addition measured after 30 mins	B	5.27	pIC50	5400	nM	IC50	Bioorg Med Chem Lett (2017) 27: 1159-1161 [PMID:28189419]
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
ChEMBL	Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR (668 to 1210 residues) expressed in a Baculovirus infected Sf9 cell expression system using poly-EY as substrate incubated for 30 mins by ADP-Glo kinase assay	B	4.7	pIC50	>20000	nM	IC50	J Nat Prod (2019) 82: 3065-3073 [PMID:31718182]
ChEMBL	Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR L858R/T790M double mutant (668 to 1210 residues) expressed in a Baculovirus infected Sf9 cell expression system using poly-EY as substrate incubated for 30 mins by ADP-Glo kinase assay	B	4.7	pIC50	>20000	nM	IC50	J Nat Prod (2019) 82: 3065-3073 [PMID:31718182]
ChEMBL	Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR L858R/T790M/C797S mutant (668 to 1210 residues) expressed in a Baculovirus infected Sf9 cell expression system using poly-EY as substrate incubated for 30 mins by ADP-Glo kinase assay	B	4.7	pIC50	>20000	nM	IC50	J Nat Prod (2019) 82: 3065-3073 [PMID:31718182]
Glycogen phosphorylase, muscle form in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4696] [UniProtKB: P00489]
ChEMBL	Inhibition of rabbit muscle glycogen phosphorylase a assessed as release of phosphate from glucose-1-phosphate after 25 mins using malachite green staining	B	4.64	pIC50	22900	nM	IC50	Bioorg Med Chem Lett (2012) 22: 1036-1039 [PMID:22204907]
ChEMBL	Inhibition of rabbit muscle glycogen phosphorylase assessed as release of phosphate from glucose-1-phosphate after 25 mins	B	4.66	pIC50	22100	nM	IC50	J Nat Prod (2009) 72: 1414-1418 [PMID:19642687]
ChEMBL	Inhibition of rabbit muscle glycogen phosphorylase A assessed as release of phosphate from glucose-1-phosphate after 25 mins by microplate reader based method	B	4.85	pIC50	14125.38	nM	IC50	Eur J Med Chem (2011) 46: 2011-2021 [PMID:21439694]
ChEMBL	Inhibition of rabbit muscle GPa	B	4.85	pIC50	14000	nM	IC50	Bioorg Med Chem Lett (2006) 16: 2915-2919 [PMID:16546381]
ChEMBL	Inhibition of rabbit muscle glycogen phosphorylase A assessed as phosphate release from glucose-1-phosphate	B	4.85	pIC50	14000	nM	IC50	J Med Chem (2008) 51: 3540-3554 [PMID:18517260]
ChEMBL	Inhibition of rabbit muscle glycogen phosphorylase A assessed as release of phosphate from glucose-1-phosphate after 25 mins by microplate reader based method	B	4.85	pIC50	14000	nM	IC50	Eur J Med Chem (2011) 46: 2011-2021 [PMID:21439694]
GP41 in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3559676] [UniProtKB: Q76270]
ChEMBL	Inhibition of HIV1 gp41-induced cell-cell fusion between viral envelope expressing human HL2/3 cells to CD4/CCR5 receptor expressing TZM-bl cells after 6 to 8 hrs by luciferase assay	B	4	pEC50	>100000	nM	EC50	J Med Chem (2014) 57: 7342-7354 [PMID:25156906]
GPBA receptor/G-protein coupled bile acid receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5409] [GtoPdb: 37] [UniProtKB: Q8TDU6]
ChEMBL	Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay	F	5.65	pEC50	2250	nM	EC50	J Med Chem (2010) 53: 178-190 [PMID:19911773]
GtoPdb	-	-	5.65	pEC50	2250	nM	EC50	Biochem Biophys Res Commun (2007) 362: 793-8 [PMID:17825251]
Hemagglutinin in Influenza A virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3559640] [UniProtKB: B4URE7]
ChEMBL	Binding affinity to recombinant influenza A hemagglutinin assessed as dissociation constant by SPR assay	B	4.96	pKd	10900	nM	Kd	J Med Chem (2022) 65: 7154-7169 [PMID:35579113]
RTP Type C/Leukocyte common antigen in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3243] [GtoPdb: 1852] [UniProtKB: P08575]
ChEMBL	Inhibition of human CD45 cytoplasmic domain (584 to 1281 residues) expressed in yeast using pNPP as substrate preincubated for 10 mins followed by substrate addition measured after 30 mins	B	6	pIC50	1000	nM	IC50	Bioorg Med Chem Lett (2017) 27: 1159-1161 [PMID:28189419]
Low molecular weight phosphotyrosine protein phosphatase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4903] [UniProtKB: P24666]
ChEMBL	Inhibition of human recombinant LMW-PTP2 expressed in Escherichia coli TB1 using p-nitrophenyl phosphate as substrate after 1 hr	B	4.64	pIC50	22900	nM	IC50	Eur J Med Chem (2011) 46: 2243-2251 [PMID:21453996]
ChEMBL	Inhibition of human LMW-PTP IF2 using p-nitrophenylphosphate as substrate by spectrophotometry	B	4.64	pIC50	22900	nM	IC50	Eur J Med Chem (2014) 87: 316-327 [PMID:25264584]
ChEMBL	Inhibition of human recombinant LMW-PTP1 expressed in Escherichia coli TB1 using p-nitrophenyl phosphate as substrate after 1 hr	B	4.67	pIC50	21200	nM	IC50	Eur J Med Chem (2011) 46: 2243-2251 [PMID:21453996]
ChEMBL	Inhibition of human LMW-PTP IF1 using p-nitrophenylphosphate as substrate by spectrophotometry	B	4.67	pIC50	21200	nM	IC50	Eur J Med Chem (2014) 87: 316-327 [PMID:25264584]
sirtuin 5/NAD-dependent protein deacylase sirtuin-5, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2163183] [GtoPdb: 2711] [UniProtKB: Q9NXA8]
ChEMBL	Inhibition of SIRT5 (unknown origin)	B	4.15	pIC50	70000	nM	IC50	Eur J Med Chem (2022) 236: 114363-114363 [PMID:35436671]
Inducible NOS/Nitric oxide synthase, inducible in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4481] [GtoPdb: 1250] [UniProtKB: P35228]
ChEMBL	Inhibition of inducible nitric oxide synthase in activated macrophages	B	4.4	pIC50	>40000	nM	IC50	Bioorg Med Chem Lett (2005) 15: 2215-2219 [PMID:15837296]
nuclear factor, erythroid 2 like 2/Nuclear factor erythroid 2-related factor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075094] [GtoPdb: 3057] [UniProtKB: Q16236]
ChEMBL	Activation of Nrf2 (unknown origin) expressed in human HaCaT-ARE-luc cells after 6 hrs by luciferase reporter gene assay	B	4.72	pEC50	>=18900	nM	EC50	J Nat Prod (2017) 80: 2276-2283 [PMID:28753294]
RELA proto-oncogene, NF-kB subunit/Nuclear factor NF-kappa-B p65 subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5533] [GtoPdb: 3280] [UniProtKB: Q04206]
ChEMBL	Inhibition of biotinylated consensus sequence binding to NF-kB p65 in human HeLa nuclear extracts after 3 hrs by ELISA	B	5.62	pIC50	2400	nM	IC50	Bioorg Med Chem (2018) 26: 4452-4460 [PMID:30057155]
Pancreatic alpha-amylase in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5730] [UniProtKB: P00690]
ChEMBL	Non-competitive inhibition of porcine pancreatic alpha-amylase assessed as inhibitor-enzyme complex using starch as substrate by Lineweaver-Burk plot analysis	B	4.02	pKi	95.8	uM	Kii	Bioorg Med Chem Lett (2017) 27: 5065-5070 [PMID:28964635]
ChEMBL	Inhibition of porcine pancreatic alpha-amylase using starch as substrate preincubated for 15 mins followed by substrate addition measured after 10 mins by dinitrosalicylic acid reagent based assay	B	4.03	pIC50	94100	nM	IC50	Bioorg Med Chem Lett (2017) 27: 5065-5070 [PMID:28964635]
sPLA2-1B/Phospholipase A2 group 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4426] [GtoPdb: 1416] [UniProtKB: P04054]
ChEMBL	Inhibition of phospholipase A2	B	5.52	pIC50	3000	nM	IC50	J Nat Prod (2011) 74: 1201-1206 [PMID:21561086]
Phosphotyrosine protein phosphatase in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4295521] [UniProtKB: A0A045ISB3]
ChEMBL	Inhibition of Mycobacterium tuberculosis H37Ra PTPB expressed in Escherichia coli BL21 (DE3) using p-nitrophenyl phosphate as substrate preincubated for 10 mins followed by substrate addition measured for 5 mins by spectrophotometric analysis	B	4.66	pIC50	22100	nM	IC50	J Nat Prod (2018) 81: 1376-1383 [PMID:29792702]
ChEMBL	Inhibition of Mycobacterium tuberculosis H37Ra PTPB expressed in Escherichia coli BL21 (DE3) using p-nitrophenyl phosphate as substrate preincubated for 10 mins followed by substrate addition and measured for 5 mins by spectrophotometric analysis	B	4.66	pIC50	22000	nM	IC50	J Nat Prod (2019) 82: 2268-2278 [PMID:31365251]
ChEMBL	Inhibition of Mycobacterium tuberculosis H37Rv ptpB expressed in Escherichia coli BL21 (DH3) cells using 6,8-difluoromethylumbelliferyl phosphate as substrate incubated for 30 mins by fluorescence based assay	B	4.85	pIC50	14000	nM	IC50	J Nat Prod (2019) 82: 3440-3449 [PMID:31799843]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum W2	F	4.58	pIC50	26240	nM	IC50	Bioorg Med Chem Lett (2013) 23: 3088-3095 [PMID:23562058]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum D6	F	4.62	pIC50	23810	nM	IC50	Bioorg Med Chem Lett (2013) 23: 3088-3095 [PMID:23562058]
Protease in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2366517] [UniProtKB: Q9YQ12]
ChEMBL	Inhibition of HIV1 recombinant protease expressed in Escherichia coli using Abz-Ala-Arg-Val-Nle-Tyr(NO2)-Glu-Ala-Nle-NH2 as substrate by FRET assay	B	4.24	pIC50	57700	nM	IC50	Eur J Med Chem (2014) 74: 278-301 [PMID:24480359]
ChEMBL	Inhibition of HIV1 protease expressed in Escherichia coli using Abz-Ala-Arg-Val-Nle-Tyr(NO2)-Glu-Ala-Nle-NH2 peptide as substrate by FRET assay	B	4.24	pIC50	57700	nM	IC50	J Nat Prod (2019) 82: 2886-2896 [PMID:31617361]
ChEMBL	Inhibition of HIV1 protease activity	B	5.1	pIC50	8000	nM	IC50	Bioorg Med Chem (2009) 17: 5238-5246 [PMID:19515569]
protein tyrosine phosphatase non-receptor type 1/Protein-tyrosine phosphatase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL335] [GtoPdb: 2976] [UniProtKB: P18031]
ChEMBL	Mixed type inhibition of human recombinant PTP-1B expressed in Escherichia coli TB1 using p-nitrophenyl phosphate as substrate	B	5.22	pKi	6000	nM	Ki	Eur J Med Chem (2011) 46: 2243-2251 [PMID:21453996]
ChEMBL	Mixed-type inhibition of purified human GST-tagged PTP-1B using p-nitrophenylphosphate as substrate by double-reciprocal plot method	B	5.22	pKi	6000	nM	Ki	Eur J Med Chem (2014) 87: 316-327 [PMID:25264584]
ChEMBL	Inhibition of PTP1B (unknown origin) using pNPP as substrate incubated for 30 mins by ELISA	B	4.39	pIC50	40700	nM	IC50	J Nat Prod (2019) 82: 3267-3278 [PMID:31738062]
ChEMBL	Inhibition of purified human GST-tagged PTP-1B using p-nitrophenylphosphate as substrate by spectrophotometry	B