oleanolic acid [Ligand Id: 3306] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL168 (NSC-114945)
  • acetyl-CoA acetyltransferase 1/Acetyl-CoA acetyltransferase, mitochondrial in Rat [ChEMBL: CHEMBL3393] [GtoPdb: 2435] [UniProtKB: P17764]
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  • carboxylesterase 1/Acyl coenzyme A:cholesterol acyltransferase in Human [ChEMBL: CHEMBL2265] [GtoPdb: 2592] [UniProtKB: P23141]
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  • Aldo-keto reductase family 1 member B10 in Human [ChEMBL: CHEMBL5983] [UniProtKB: O60218]
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  • coagulation factor III, tissue factor/Coagulation factor III in Human [ChEMBL: CHEMBL4081] [GtoPdb: 3192] [UniProtKB: P13726]
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  • Dual specificity phosphatase Cdc25B in Human [ChEMBL: CHEMBL4804] [UniProtKB: P30305]
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  • Dual specificity protein phosphatase 3 in Human [ChEMBL: CHEMBL2635] [UniProtKB: P51452]
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  • epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
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  • Glycogen phosphorylase, muscle form in Rabbit [ChEMBL: CHEMBL4696] [UniProtKB: P00489]
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  • GPBA receptor/G-protein coupled bile acid receptor 1 in Human [ChEMBL: CHEMBL5409] [GtoPdb: 37] [UniProtKB: Q8TDU6]
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  • RTP Type C/Leukocyte common antigen in Human [ChEMBL: CHEMBL3243] [GtoPdb: 1852] [UniProtKB: P08575]
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  • Low molecular weight phosphotyrosine protein phosphatase in Human [ChEMBL: CHEMBL4903] [UniProtKB: P24666]
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  • Inducible NOS/Nitric oxide synthase, inducible in Human [ChEMBL: CHEMBL4481] [GtoPdb: 1250] [UniProtKB: P35228]
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  • nuclear factor, erythroid 2 like 2/Nuclear factor erythroid 2-related factor 2 in Human [ChEMBL: CHEMBL1075094] [GtoPdb: 3057] [UniProtKB: Q16236]
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  • Nuclear factor NF-kappa-B p65 subunit in Human [ChEMBL: CHEMBL5533] [UniProtKB: Q04206]
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  • sPLA2-1B/Phospholipase A2 group 1B in Human [ChEMBL: CHEMBL4426] [GtoPdb: 1416] [UniProtKB: P04054]
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  • Phosphotyrosine protein phosphatase in Mycobacterium tuberculosis [ChEMBL: CHEMBL4295521] [UniProtKB: A0A045ISB3]
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  • protein tyrosine phosphatase non-receptor type 1/Protein-tyrosine phosphatase 1B in Human [ChEMBL: CHEMBL335] [GtoPdb: 2976] [UniProtKB: P18031]
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  • Protein-tyrosine phosphatase 1C in Human [ChEMBL: CHEMBL3166] [UniProtKB: P29350]
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  • protein tyrosine phosphatase non-receptor type 11/Protein-tyrosine phosphatase 2C in Human [ChEMBL: CHEMBL3864] [GtoPdb: 3203] [UniProtKB: Q06124]
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  • RTP Type A/Receptor-type tyrosine-protein phosphatase alpha in Human [ChEMBL: CHEMBL3918] [GtoPdb: 1850] [UniProtKB: P18433]
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  • RTP Type E/Receptor-type tyrosine-protein phosphatase epsilon in Human [ChEMBL: CHEMBL4850] [GtoPdb: 1854] [UniProtKB: P23469]
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  • RTP Type F/Receptor-type tyrosine-protein phosphatase F (LAR) in Human [ChEMBL: CHEMBL3521] [GtoPdb: 1855] [UniProtKB: P10586]
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  • signal transducer and activator of transcription 3/Signal transducer and activator of transcription 3 in Human [ChEMBL: CHEMBL4026] [GtoPdb: 2994] [UniProtKB: P40763]
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  • protein tyrosine phosphatase non-receptor type 2/T-cell protein-tyrosine phosphatase in Human [ChEMBL: CHEMBL3807] [GtoPdb: 3255] [UniProtKB: P17706]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
acetyl-CoA acetyltransferase 1/Acetyl-CoA acetyltransferase, mitochondrial in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3393] [GtoPdb: 2435] [UniProtKB: P17764]
ChEMBL Inhibition of rat liver microsomal ACAT B 4.11 pIC50 77900 nM IC50 Eur J Med Chem (2017) 139: 201-213 [PMID:28802120]
carboxylesterase 1/Acyl coenzyme A:cholesterol acyltransferase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2265] [GtoPdb: 2592] [UniProtKB: P23141]
ChEMBL Inhibition of CES1A1 in human liver microsomes using D-luciferin methyl ester as substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins by fluorescence assay B 7 pIC50 100 nM IC50 J Nat Prod (2020) 83: 2940-2949 [PMID:32951423]
Aldo-keto reductase family 1 member B10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5983] [UniProtKB: O60218]
ChEMBL Competitive inhibition of dehydrogenase activity of N-terminal 6His-tagged human AKR1B10 W220Y mutant expressed in Escherichia coli BL21(DE3) assessed as NADP+-linked geraniol oxidation B 5.45 pKi 3560 nM Ki J Nat Prod (2011) 74: 1201-1206 [PMID:21561086]
ChEMBL Competitive inhibition of dehydrogenase activity of N-terminal 6His-tagged human AKR1B10 V301L mutant expressed in Escherichia coli BL21(DE3) assessed as NADP+-linked geraniol oxidation B 6.03 pKi 940 nM Ki J Nat Prod (2011) 74: 1201-1206 [PMID:21561086]
ChEMBL Competitive inhibition of dehydrogenase activity of N-terminal 6His-tagged human AKR1B10 Q303S mutant expressed in Escherichia coli BL21(DE3) assessed as NADP+-linked geraniol oxidation B 6.18 pKi 660 nM Ki J Nat Prod (2011) 74: 1201-1206 [PMID:21561086]
ChEMBL Competitive inhibition of dehydrogenase activity of N-terminal 6His-tagged human AKR1B10 K125L mutant expressed in Escherichia coli BL21(DE3) assessed as NADP+-linked geraniol oxidation B 6.8 pKi 160 nM Ki J Nat Prod (2011) 74: 1201-1206 [PMID:21561086]
ChEMBL Competitive inhibition of dehydrogenase activity of N-terminal 6His-tagged human AKR1B10 expressed in Escherichia coli BL21(DE3) assessed as NADP+-linked geraniol oxidation B 7.14 pKi 72 nM Ki J Nat Prod (2011) 74: 1201-1206 [PMID:21561086]
ChEMBL Inhibition of N-terminal 6His-tagged human AKR1B10 overexpressed in human HeLa cells assessed as inhibition of [1-14C]farnesol reduction pretreated for 2 hrs before [1-14C]farnesol challenge measured after 6 hrs B 5.4 pIC50 4000 nM IC50 J Nat Prod (2011) 74: 1201-1206 [PMID:21561086]
ChEMBL Inhibition of reductase activity of N-terminal 6His-tagged human AKR1B10 expressed in Escherichia coli BL21(DE3) assessed as pyridine-3-aldehyde reduction B 7.05 pIC50 90 nM IC50 J Nat Prod (2011) 74: 1201-1206 [PMID:21561086]
coagulation factor III, tissue factor/Coagulation factor III in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4081] [GtoPdb: 3192] [UniProtKB: P13726]
ChEMBL Inhibition of LPS-induced tissue factor procoagulant activity in human THP1 cells preincubated for 1 hr followed by LPS addition measured after 5 hrs using factor 10a chromogenic substrate in presence of prothrombin complex B 8.3 pIC50 4.97 nM IC50 Bioorg Med Chem Lett (2017) 27: 1026-1030 [PMID:28109788]
Cyclooxygenase-1 in Sheep (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2949] [UniProtKB: P05979]
ChEMBL Inhibition of ovine recombinant COX1 assessed as decrease in formation of PGE2 using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition measured after 45 mins by LC-MS analysis B 4.38 pIC50 42000 nM IC50 J Nat Prod (2019) 82: 3311-3320 [PMID:31774676]
COX-2 /Cyclooxygenase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354]
ChEMBL Inhibition of COX2 by scintillation proximity assay B 4.06 pIC50 87000 nM IC50 J Nat Prod (2002) 65: 1517-1521 [PMID:12444669]
ChEMBL Inhibition of human recombinant COX2 expressed in baculovirus infected sf21 cells assessed as decrease in PGE2 formation using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition measured after 45 mins by LC-MS analysis B 4.4 pIC50 >40000 nM IC50 J Nat Prod (2019) 82: 3311-3320 [PMID:31774676]
DNA polymerase beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2392] [GtoPdb: 3231] [UniProtKB: P06746]
ChEMBL Inhibition of lyase activity of DNA polymerase beta B 4.58 pIC50 26250 nM IC50 Bioorg Med Chem (2008) 16: 4331-4340 [PMID:18343122]
ChEMBL Inhibition of polymerase activity of DNA polymerase beta B 4.6 pIC50 24980 nM IC50 Bioorg Med Chem (2008) 16: 4331-4340 [PMID:18343122]
ChEMBL Inhibition of DNA polymerase beta lyase activity B 5.06 pIC50 8800 nM IC50 J Nat Prod (2004) 67: 964-967 [PMID:15217274]
ChEMBL Inhibition of DNA polymerase beta lyase activity by deoxyribose phosphate excision assay B 5.06 pIC50 8800 nM IC50 J Nat Prod (2003) 66: 1463-1465 [PMID:14640519]
ChEMBL Inhibition of DNA polymerase beta B 5.52 pIC50 3000 nM IC50 J Nat Prod (2011) 74: 1201-1206 [PMID:21561086]
GtoPdb Inhibition of POLB polymerase activity - 5.6 pIC50 2498 nM IC50 Bioorg Med Chem (2008) 16: 4331-40 [PMID:18343122]
DNA polymerase beta in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4343] [GtoPdb: 3231] [UniProtKB: P06766]
ChEMBL Inhibition of rat DNA polymerase beta in presence of BSA B 5.12 pIC50 7500 nM IC50 J Nat Prod (1999) 62: 1624-1626 [PMID:10654412]
ChEMBL Inhibition of rat DNA polymerase beta in absence of BSA B 5.43 pIC50 3700 nM IC50 J Nat Prod (1999) 62: 1624-1626 [PMID:10654412]
Dual specificity phosphatase Cdc25B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4804] [UniProtKB: P30305]
ChEMBL Inhibition of CDC25B (unknown origin) using pNPP as substrate by spectrophotometry B 6.01 pIC50 980 nM IC50 Bioorg Med Chem (2015) 23: 38-45 [PMID:25497963]
Dual specificity protein phosphatase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2635] [UniProtKB: P51452]
ChEMBL Inhibition of human VHR expressed in Escherichia coli using pNPP as substrate preincubated for 10 mins followed by substrate addition measured after 30 mins B 5.27 pIC50 5400 nM IC50 Bioorg Med Chem Lett (2017) 27: 1159-1161 [PMID:28189419]
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
ChEMBL Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR (668 to 1210 residues) expressed in a Baculovirus infected Sf9 cell expression system using poly-EY as substrate incubated for 30 mins by ADP-Glo kinase assay B 4.7 pIC50 >20000 nM IC50 J Nat Prod (2019) 82: 3065-3073 [PMID:31718182]
ChEMBL Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR L858R/T790M double mutant (668 to 1210 residues) expressed in a Baculovirus infected Sf9 cell expression system using poly-EY as substrate incubated for 30 mins by ADP-Glo kinase assay B 4.7 pIC50 >20000 nM IC50 J Nat Prod (2019) 82: 3065-3073 [PMID:31718182]
ChEMBL Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR L858R/T790M/C797S mutant (668 to 1210 residues) expressed in a Baculovirus infected Sf9 cell expression system using poly-EY as substrate incubated for 30 mins by ADP-Glo kinase assay B 4.7 pIC50 >20000 nM IC50 J Nat Prod (2019) 82: 3065-3073 [PMID:31718182]
Glycogen phosphorylase, muscle form in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4696] [UniProtKB: P00489]
ChEMBL Inhibition of rabbit muscle glycogen phosphorylase a assessed as release of phosphate from glucose-1-phosphate after 25 mins using malachite green staining B 4.64 pIC50 22900 nM IC50 Bioorg Med Chem Lett (2012) 22: 1036-1039 [PMID:22204907]
ChEMBL Inhibition of rabbit muscle glycogen phosphorylase assessed as release of phosphate from glucose-1-phosphate after 25 mins B 4.66 pIC50 22100 nM IC50 J Nat Prod (2009) 72: 1414-1418 [PMID:19642687]
ChEMBL Inhibition of rabbit muscle glycogen phosphorylase A assessed as release of phosphate from glucose-1-phosphate after 25 mins by microplate reader based method B 4.85 pIC50 14125.38 nM IC50 Eur J Med Chem (2011) 46: 2011-2021 [PMID:21439694]
ChEMBL Inhibition of rabbit muscle GPa B 4.85 pIC50 14000 nM IC50 Bioorg Med Chem Lett (2006) 16: 2915-2919 [PMID:16546381]
ChEMBL Inhibition of rabbit muscle glycogen phosphorylase A assessed as phosphate release from glucose-1-phosphate B 4.85 pIC50 14000 nM IC50 J Med Chem (2008) 51: 3540-3554 [PMID:18517260]
ChEMBL Inhibition of rabbit muscle glycogen phosphorylase A assessed as release of phosphate from glucose-1-phosphate after 25 mins by microplate reader based method B 4.85 pIC50 14000 nM IC50 Eur J Med Chem (2011) 46: 2011-2021 [PMID:21439694]
GP41 in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3559676] [UniProtKB: Q76270]
ChEMBL Inhibition of HIV1 gp41-induced cell-cell fusion between viral envelope expressing human HL2/3 cells to CD4/CCR5 receptor expressing TZM-bl cells after 6 to 8 hrs by luciferase assay B 4 pEC50 >100000 nM EC50 J Med Chem (2014) 57: 7342-7354 [PMID:25156906]
GPBA receptor/G-protein coupled bile acid receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5409] [GtoPdb: 37] [UniProtKB: Q8TDU6]
ChEMBL Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay F 5.65 pEC50 2250 nM EC50 J Med Chem (2010) 53: 178-190 [PMID:19911773]
GtoPdb - - 5.65 pEC50 2250 nM EC50 Biochem Biophys Res Commun (2007) 362: 793-8 [PMID:17825251]
RTP Type C/Leukocyte common antigen in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3243] [GtoPdb: 1852] [UniProtKB: P08575]
ChEMBL Inhibition of human CD45 cytoplasmic domain (584 to 1281 residues) expressed in yeast using pNPP as substrate preincubated for 10 mins followed by substrate addition measured after 30 mins B 6 pIC50 1000 nM IC50 Bioorg Med Chem Lett (2017) 27: 1159-1161 [PMID:28189419]
Low molecular weight phosphotyrosine protein phosphatase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4903] [UniProtKB: P24666]
ChEMBL Inhibition of human recombinant LMW-PTP2 expressed in Escherichia coli TB1 using p-nitrophenyl phosphate as substrate after 1 hr B 4.64 pIC50 22900 nM IC50 Eur J Med Chem (2011) 46: 2243-2251 [PMID:21453996]
ChEMBL Inhibition of human LMW-PTP IF2 using p-nitrophenylphosphate as substrate by spectrophotometry B 4.64 pIC50 22900 nM IC50 Eur J Med Chem (2014) 87: 316-327 [PMID:25264584]
ChEMBL Inhibition of human recombinant LMW-PTP1 expressed in Escherichia coli TB1 using p-nitrophenyl phosphate as substrate after 1 hr B 4.67 pIC50 21200 nM IC50 Eur J Med Chem (2011) 46: 2243-2251 [PMID:21453996]
ChEMBL Inhibition of human LMW-PTP IF1 using p-nitrophenylphosphate as substrate by spectrophotometry B 4.67 pIC50 21200 nM IC50 Eur J Med Chem (2014) 87: 316-327 [PMID:25264584]
Inducible NOS/Nitric oxide synthase, inducible in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4481] [GtoPdb: 1250] [UniProtKB: P35228]
ChEMBL Inhibition of inducible nitric oxide synthase in activated macrophages B 4.4 pIC50 >40000 nM IC50 Bioorg Med Chem Lett (2005) 15: 2215-2219 [PMID:15837296]
nuclear factor, erythroid 2 like 2/Nuclear factor erythroid 2-related factor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075094] [GtoPdb: 3057] [UniProtKB: Q16236]
ChEMBL Activation of Nrf2 (unknown origin) expressed in human HaCaT-ARE-luc cells after 6 hrs by luciferase reporter gene assay B 4.72 pEC50 >=18900 nM EC50 J Nat Prod (2017) 80: 2276-2283 [PMID:28753294]
Nuclear factor NF-kappa-B p65 subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5533] [UniProtKB: Q04206]
ChEMBL Inhibition of biotinylated consensus sequence binding to NF-kB p65 in human HeLa nuclear extracts after 3 hrs by ELISA B 5.62 pIC50 2400 nM IC50 Bioorg Med Chem (2018) 26: 4452-4460 [PMID:30057155]
Pancreatic alpha-amylase in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5730] [UniProtKB: P00690]
ChEMBL Non-competitive inhibition of porcine pancreatic alpha-amylase assessed as inhibitor-enzyme complex using starch as substrate by Lineweaver-Burk plot analysis B 4.02 pKi 95.8 uM Kii Bioorg Med Chem Lett (2017) 27: 5065-5070 [PMID:28964635]
ChEMBL Inhibition of porcine pancreatic alpha-amylase using starch as substrate preincubated for 15 mins followed by substrate addition measured after 10 mins by dinitrosalicylic acid reagent based assay B 4.03 pIC50 94100 nM IC50 Bioorg Med Chem Lett (2017) 27: 5065-5070 [PMID:28964635]
sPLA2-1B/Phospholipase A2 group 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4426] [GtoPdb: 1416] [UniProtKB: P04054]
ChEMBL Inhibition of phospholipase A2 B 5.52 pIC50 3000 nM IC50 J Nat Prod (2011) 74: 1201-1206 [PMID:21561086]
Phosphotyrosine protein phosphatase in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4295521] [UniProtKB: A0A045ISB3]
ChEMBL Inhibition of Mycobacterium tuberculosis H37Ra PTPB expressed in Escherichia coli BL21 (DE3) using p-nitrophenyl phosphate as substrate preincubated for 10 mins followed by substrate addition measured for 5 mins by spectrophotometric analysis B 4.66 pIC50 22100 nM IC50 J Nat Prod (2018) 81: 1376-1383 [PMID:29792702]
ChEMBL Inhibition of Mycobacterium tuberculosis H37Ra PTPB expressed in Escherichia coli BL21 (DE3) using p-nitrophenyl phosphate as substrate preincubated for 10 mins followed by substrate addition and measured for 5 mins by spectrophotometric analysis B 4.66 pIC50 22000 nM IC50 J Nat Prod (2019) 82: 2268-2278 [PMID:31365251]
ChEMBL Inhibition of Mycobacterium tuberculosis H37Rv ptpB expressed in Escherichia coli BL21 (DH3) cells using 6,8-difluoromethylumbelliferyl phosphate as substrate incubated for 30 mins by fluorescence based assay B 4.85 pIC50 14000 nM IC50 J Nat Prod (2019) 82: 3440-3449 [PMID:31799843]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antiplasmodial activity against Plasmodium falciparum W2 F 4.58 pIC50 26240 nM IC50 Bioorg Med Chem Lett (2013) 23: 3088-3095 [PMID:23562058]
ChEMBL Antiplasmodial activity against Plasmodium falciparum D6 F 4.62 pIC50 23810 nM IC50 Bioorg Med Chem Lett (2013) 23: 3088-3095 [PMID:23562058]
Protease in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2366517] [UniProtKB: Q9YQ12]
ChEMBL Inhibition of HIV1 recombinant protease expressed in Escherichia coli using Abz-Ala-Arg-Val-Nle-Tyr(NO2)-Glu-Ala-Nle-NH2 as substrate by FRET assay B 4.24 pIC50 57700 nM IC50 Eur J Med Chem (2014) 74: 278-301 [PMID:24480359]
ChEMBL Inhibition of HIV1 protease expressed in Escherichia coli using Abz-Ala-Arg-Val-Nle-Tyr(NO2)-Glu-Ala-Nle-NH2 peptide as substrate by FRET assay B 4.24 pIC50 57700 nM IC50 J Nat Prod (2019) 82: 2886-2896 [PMID:31617361]
ChEMBL Inhibition of HIV1 protease activity B 5.1 pIC50 8000 nM IC50 Bioorg Med Chem (2009) 17: 5238-5246 [PMID:19515569]
protein tyrosine phosphatase non-receptor type 1/Protein-tyrosine phosphatase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL335] [GtoPdb: 2976] [UniProtKB: P18031]
ChEMBL Mixed type inhibition of human recombinant PTP-1B expressed in Escherichia coli TB1 using p-nitrophenyl phosphate as substrate B 5.22 pKi 6000 nM Ki Eur J Med Chem (2011) 46: 2243-2251 [PMID:21453996]
ChEMBL Mixed-type inhibition of purified human GST-tagged PTP-1B using p-nitrophenylphosphate as substrate by double-reciprocal plot method B 5.22 pKi 6000 nM Ki Eur J Med Chem (2014) 87: 316-327 [PMID:25264584]
ChEMBL Inhibition of PTP1B (unknown origin) using pNPP as substrate incubated for 30 mins by ELISA B 4.39 pIC50 40700 nM IC50 J Nat Prod (2019) 82: 3267-3278 [PMID:31738062]
ChEMBL Inhibition of purified human GST-tagged PTP-1B using p-nitrophenylphosphate as substrate by spectrophotometry B 5.02 pIC50 9500 nM IC50 Eur J Med Chem (2014) 87: 316-327 [PMID:25264584]
ChEMBL Inhibition of human recombinant PTP-1B expressed in Escherichia coli TB1 using p-nitrophenyl phosphate as substrate after 1 hr B 5.02 pIC50 9500 nM IC50 Eur J Med Chem (2011) 46: 2243-2251 [PMID:21453996]
ChEMBL Inhibition of human recombinant PTP1B after 30 mins B 5.12 pIC50 7600 nM IC50 J Nat Prod (2008) 71: 1775-1778 [PMID:18798681]
ChEMBL Inhibition of GST-tagged human recombinant PTP1B using para-nitrophenyl phosphate as substrate by spectrophotometric analysis B 5.25 pIC50 5600 nM IC50 J Nat Prod (2012) 75: 1160-1166 [PMID:22690646]
ChEMBL Inhibition of PTP1B (unknown origin) B 5.3 pIC50 5050.1 nM IC50 Med Chem Res (2012) 21: 351-361
ChEMBL Inhibition of N-terminal GST tagged recombinant human PTP1B catalytic domain (1 to 321 residues) expressed in Escherichia coli using pNPP as substrate preincubated for 10 mins followed by substrate addition and measured every 5 mins for 30 mins B 5.37 pIC50 4300 nM IC50 J Nat Prod (2019) 82: 2916-2924 [PMID:31618031]
ChEMBL Inhibition of GST-tagged human PTP1B B 5.38 pIC50 4200 nM IC50 J Nat Prod (2009) 72: 1620-1626 [PMID:19702283]
ChEMBL Inhibition of human recombinant PTP1B B 5.41 pIC50 3900 nM IC50 Bioorg Med Chem Lett (2006) 16: 3273-3276 [PMID:16580200]
ChEMBL Inhibition of GST-tagged human recombinant PTP1B assessed as dephosphorylation of para-nitrophenyl phosphate after 10 mins by spectrophotometric analysis B 5.42 pIC50 3840 nM IC50 J Nat Prod (2011) 74: 2431-2437 [PMID:22044245]
ChEMBL Inhibition of recombinant human PTP1B catalytic domain expressed in Escherichia coli BL21-CodonPlus (DE3) using pNPP as substrate measured for 2 mins B 5.46 pIC50 3480 nM IC50 Bioorg Med Chem Lett (2017) 27: 1105-1108 [PMID:28111140]
ChEMBL Inhibition of PTP1B by pNPP assay B 5.47 pIC50 3370 nM IC50 Bioorg Med Chem (2008) 16: 8697-8705 [PMID:18707891]
ChEMBL Inhibition of PTP1B (unknown origin) B