carboxylesterase 1 | Hydrolases | IUPHAR/BPS Guide to PHARMACOLOGY

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carboxylesterase 1

Target not currently curated in GtoImmuPdb

Target id: 2592

Nomenclature: carboxylesterase 1

Abbreviated Name: CES1

Family: Hydrolases

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 567 16q22.2 CES1 carboxylesterase 1
Mouse - 565 8 C5 Ces1g carboxylesterase 1G
Rat - 565 19p11 Ces1d carboxylesterase 1D
Previous and Unofficial Names
CEH | HMSE1 | monocyte/macrophage serine esterase 1 | SES1
Database Links
Specialist databases
MEROPS S09.982 (Hs)
Other databases
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
GR148672X Hs Inhibition 8.4 pIC50 1
pIC50 8.4 (IC50 4x10-9 M) [1]


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1. Borg-Capra Catherine Sylvia et al.. (2001) Method of screening for triacyglycerol hydrolase inhibitors. Patent number: WO2001016358. Assignee: Glaxo (now GSK). Priority date: 23/08/1999. Publication date: 08/03/2001.

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