carboxylesterase 1 | Hydrolases | IUPHAR/BPS Guide to PHARMACOLOGY

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carboxylesterase 1

Target not currently curated in GtoImmuPdb

Target id: 2592

Nomenclature: carboxylesterase 1

Abbreviated Name: CES1

Family: Hydrolases

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 567 16q22.2 CES1 carboxylesterase 1
Mouse - 565 8 C5 Ces1g carboxylesterase 1G
Rat - 565 19p11 Ces1d carboxylesterase 1D
Previous and Unofficial Names
CEH | HMSE1 | monocyte/macrophage serine esterase 1 | SES1
Database Links
Specialist databases
MEROPS S09.982 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.1.1.1

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
GR148672X Hs Inhibition 8.4 pIC50 1
pIC50 8.4 (IC50 4x10-9 M) [1]

References

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1. Borg-Capra Catherine Sylvia et al.. (2001) Method of screening for triacyglycerol hydrolase inhibitors. Patent number: WO2001016358. Assignee: Glaxo (now GSK). Priority date: 23/08/1999. Publication date: 08/03/2001.

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