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Hydrolases C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Listed in this section are hydrolases not accumulated in other parts of the Concise Guide, such as monoacylglycerol lipase and acetylcholinesterase. Pancreatic lipase is the predominant mechanism of fat digestion in the alimentary system; its inhibition is associated with decreased fat absorption. CES1 is present at lower levels in the gut than CES2 (P23141), but predominates in the liver, where it is responsible for the hydrolysis of many aliphatic, aromatic and steroid esters. Hormone-sensitive lipase is also a relatively non-selective esterase associated with steroid ester hydrolysis and triglyceride metabolism, particularly in adipose tissue. Endothelial lipase is secreted from endothelial cells and regulates circulating cholesterol in high density lipoproteins.

Enzymes

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AChE (acetylcholinesterase (Cartwright blood group)) C Show summary » More detailed page go icon to follow link

BChE (butyrylcholinesterase) C Show summary » More detailed page go icon to follow link

DAGLα (Diacylglycerol lipase α) C Show summary » More detailed page go icon to follow link

DAGLβ (Diacylglycerol lipase β) C Show summary » More detailed page go icon to follow link

CES1 (carboxylesterase 1) C Show summary » More detailed page go icon to follow link

NTPDase-1 (ectonucleoside triphosphate diphosphohydrolase 1 / CD39) C Show summary » More detailed page go icon to follow link

NTPDase-2 (ectonucleoside triphosphate diphosphohydrolase 2 / CD39L1) C Show summary » More detailed page go icon to follow link

epoxide hydrolase 2 Show summary » More detailed page go icon to follow link

FAAH (Fatty acid amide hydrolase) C Show summary » More detailed page go icon to follow link

Leukotriene A4 hydrolase C Show summary » More detailed page go icon to follow link

LIPE (lipase E, hormone sensitive type) C Show summary » More detailed page go icon to follow link

LIPG (lipase G, endothelial type) C Show summary » More detailed page go icon to follow link

MAGL (Monoacylglycerol lipase) C Show summary » More detailed page go icon to follow link

nudix hydrolase 7 Show summary » More detailed page go icon to follow link

O-GlcNAcase Show summary » More detailed page go icon to follow link

PNLIP (pancreatic lipase) C Show summary » More detailed page go icon to follow link

PLA2-G7 Show summary » More detailed page go icon to follow link

sPLA2-2A Show summary » More detailed page go icon to follow link

PLD2 Show summary » More detailed page go icon to follow link

vanin 1 Show summary » More detailed page go icon to follow link

Further reading

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.