Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	465	10q25.3	PNLIP	pancreatic lipase
Mouse	-	465	19 54.46 cM	Pnlip	pancreatic lipase
Rat	-	465	1q55	Pnlip	pancreatic lipase

Previous and Unofficial Names

PANLI | PL | pancreatic triacylglycerol lipase | pancreatic triglyceride lipase

Database Links
Alphafold	P16233 (Hs), Q6P8U6 (Mm), P27657 (Rn)
BRENDA	3.1.1.3
CATH/Gene3D	2.60.60.20, 3.40.50.1820
ChEMBL Target	CHEMBL1812 (Hs)
DrugBank Target	P16233 (Hs)
Ensembl Gene	ENSG00000175535 (Hs), ENSMUSG00000046008 (Mm), ENSRNOG00000017725 (Rn)
Entrez Gene	5406 (Hs), 69060 (Mm), 25702 (Rn)
Human Protein Atlas	ENSG00000175535 (Hs)
KEGG Enzyme	3.1.1.3
KEGG Gene	hsa:5406 (Hs), mmu:69060 (Mm), rno:25702 (Rn)
OMIM	246600 (Hs)
Pharos	P16233 (Hs)
RefSeq Nucleotide	NM_000936 (Hs), NM_026925 (Mm), NM_013161 (Rn)
RefSeq Protein	NP_000927 (Hs), NP_081201 (Mm), NP_037293 (Rn)
UniProtKB	P16233 (Hs), Q6P8U6 (Mm), P27657 (Rn)
Wikipedia	PNLIP (Hs)

Enzyme Reaction
EC Number: 3.1.1.3

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference orlistat Hs Inhibition 8.9 pIC50 1 ⤷ pIC50 8.9 (IC50 1.3x10-9 M) [1] cetilistat Hs Inhibition 8.2 pIC50 2 ⤷ pIC50 8.2 (IC50 5.95x10-9 M) [2] cetilistat Rn Inhibition 7.3 pIC50 2 ⤷ pIC50 7.3 (IC50 5.48x10-8 M) [2]
View species-specific inhibitor tables