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Compound class:
Endogenous peptide in human, mouse or rat
Comment: The pigment epithelium-derived factor (PEDF) encoded by SERPINF1 is an endogenous ligand of PNPLA2 (a.k.a.adipose triglyceride lipase, ATGL) [7]. PEDF a non-inhibitory member of the serine protease inhibitor (SERPIN) superfamily that is expressed on the surface of retinal epithelial cells [2], and appears to be required for photoreceptor and retinal neuron cell survival [4,8]. Age-related loss of PEDF in the retina is associated with retinal damage and conditions like AMD.
Peptide fragment derivatives of PEDF have demonstrated protective effects in experimental models of degenerative retinal diseases [3,5].
Species: Human
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
Classification  |
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| Compound class | Endogenous peptide in human, mouse or rat |
| Gene/Precursor |
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| Database Links |
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| GtoPdb PubChem SID | 513757516 |
