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Target not currently curated in GtoImmuPdb
Target id: 1397
Nomenclature: diacylglycerol lipase β
Abbreviated Name: DAGLβ
Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | 4 | 672 | 7p22.1 | DAGLB | diacylglycerol lipase beta | |
Mouse | 4 | 669 | 5 G2 | Daglb | diacylglycerol lipase, beta | |
Rat | 4 | 668 | 12p11 | Daglb | diacylglycerol lipase, beta |
Previous and Unofficial Names ![]() |
diacylglycerol lipase | diacylglycerol lipase, beta | KCCR13L | neural stem cell-derived dendrite regulator | NSDDR |
Database Links ![]() |
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Alphafold | Q8NCG7 (Hs), Q91WC9 (Mm), P0C1S9 (Rn) |
BRENDA | 3.1.1.- |
CATH/Gene3D | 3.40.50.1820 |
ChEMBL Target | CHEMBL5521 (Hs), CHEMBL5656 (Mm) |
Ensembl Gene | ENSG00000164535 (Hs), ENSMUSG00000039206 (Mm), ENSRNOG00000001079 (Rn) |
Entrez Gene | 221955 (Hs), 231871 (Mm), 304289 (Rn) |
Human Protein Atlas | ENSG00000164535 (Hs) |
KEGG Enzyme | 3.1.1.- |
KEGG Gene | hsa:221955 (Hs), mmu:231871 (Mm), rno:304289 (Rn) |
OMIM | 614016 (Hs) |
Pharos | Q8NCG7 (Hs) |
RefSeq Nucleotide | NM_001142936 (Hs), NM_144915 (Mm), NM_001107120 (Rn) |
RefSeq Protein | NP_001136408 (Hs), NP_659164 (Mm), NP_001100590 (Rn) |
UniProtKB | Q8NCG7 (Hs), Q91WC9 (Mm), P0C1S9 (Rn) |
Wikipedia | DAGLB (Hs) |
Enzyme Reaction ![]() |
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Endogenous substrates |
diacylglycerol |
Download all structure-activity data for this target as a CSV file
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Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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1. Baggelaar MP, Chameau PJ, Kantae V, Hummel J, Hsu KL, Janssen F, van der Wel T, Soethoudt M, Deng H, den Dulk H et al.. (2015) Highly Selective, Reversible Inhibitor Identified by Comparative Chemoproteomics Modulates Diacylglycerol Lipase Activity in Neurons. J Am Chem Soc, 137 (27): 8851-7. [PMID:26083464]
2. Bisogno T, Howell F, Williams G, Minassi A, Cascio MG, Ligresti A, Matias I, Schiano-Moriello A, Paul P, Williams EJ et al.. (2003) Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain. J Cell Biol, 163 (3): 463-8. [PMID:14610053]
3. Hsu KL, Tsuboi K, Adibekian A, Pugh H, Masuda K, Cravatt BF. (2012) DAGLβ inhibition perturbs a lipid network involved in macrophage inflammatory responses. Nat Chem Biol, 8 (12): 999-1007. [PMID:23103940]
4. Ogasawara D, Deng H, Viader A, Baggelaar MP, Breman A, den Dulk H, van den Nieuwendijk AM, van den Nieuwendijk AM, Soethoudt M, van der Wel T et al.. (2016) Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition. Proc Natl Acad Sci USA, 113 (1): 26-33. [PMID:26668358]