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Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
ABHD12 is a 398-aa protein, with serine hydrolase activity. It has a molecular weight of ~45 kDa. A single TM is predicted at 75-95, with an extracellular catalytic domain. ABHD12 is a monoacylglycerol hydrolase [12], but may also regulate lysophosphatidylserine levels [8]. Loss-of-function mutations in ABHD12 are associated with a disorder known as PHARC (polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataracts) [5].
DAGLα (Diacylglycerol lipase α)
C
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DAGLβ (Diacylglycerol lipase β)
C
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MAGL (Monoacylglycerol lipase)
C
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ABHD2 (αβ-Hydrolase 2) Show summary » |
ABHD6 (αβ-Hydrolase 6)
C
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αβ-Hydrolase 12
C
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Database page citation (select format):
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.