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2-Acylglycerol ester turnover C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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ABHD12 is a 398-aa protein, with serine hydrolase activity. It has a molecular weight of ~45 kDa. A single TM is predicted at 75-95, with an extracellular catalytic domain. ABHD12 is a monoacylglycerol hydrolase [12], but may also regulate lysophosphatidylserine levels [8]. Loss-of-function mutations in ABHD12 are associated with a disorder known as PHARC (polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataracts) [5].


DAGLα (Diacylglycerol lipase α) C Show summary » More detailed page

DAGLβ (Diacylglycerol lipase β) C Show summary » More detailed page

MAGL (Monoacylglycerol lipase) C Show summary » More detailed page

ABHD2 (αβ-Hydrolase 2) Show summary »

ABHD6 (αβ-Hydrolase 6) C Show summary » More detailed page

αβ-Hydrolase 12 C Show summary » More detailed page


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How to cite this family page

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Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.