donepezil   Click here for help

GtoPdb Ligand ID: 6599

Synonyms: Aricept® | E-2020
Approved drug
donepezil is an approved drug (FDA (1996))
Compound class: Synthetic organic
Comment: May be refered to as donepezil hydrochloride (PubChem CID 5741). In addition to the original brand, Aricept, generic donepezil formulations are now approved by the US FDA.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 6
Topological polar surface area 38.77
Molecular weight 379.21
XLogP 3.67
No. Lipinski's rules broken 0
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Canonical SMILES COc1cc2c(cc1OC)CC(C2=O)CC1CCN(CC1)Cc1ccccc1
Isomeric SMILES COc1cc2c(cc1OC)CC(C2=O)CC1CCN(CC1)Cc1ccccc1
InChI InChI=1S/C24H29NO3/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18/h3-7,14-15,17,20H,8-13,16H2,1-2H3
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA (1996))
IUPAC Name Click here for help
International Nonproprietary Names Click here for help
INN number INN
7517 donepezil
Synonyms Click here for help
Aricept® | E-2020
Database Links Click here for help
Specialist databases
Reactome Drug Reactome logo R-ALL-9635088
Reactome Reaction Reactome logo R-HSA-9634834
Other databases
CAS Registry No. 120014-06-4
DrugBank Ligand DB00843
DrugCentral Ligand 946
GtoPdb PubChem SID 178103212
PubChem CID 3152
Search Google for chemical match using the InChIKey ADEBPBSSDYVVLD-UHFFFAOYSA-N
Search Google for chemicals with the same backbone ADEBPBSSDYVVLD
Search PubMed clinical trials donepezil
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SynPHARM 78555 (in complex with acetylcholinesterase (Cartwright blood group))
UniChem Compound Search for chemical match using the InChIKey ADEBPBSSDYVVLD-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey ADEBPBSSDYVVLD-UHFFFAOYSA-N
Wikipedia Donepezil