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lipase G, endothelial type

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Target not currently curated in GtoImmuPdb

Target id: 2591

Nomenclature: lipase G, endothelial type

Abbreviated Name: LIPG

Family: Hydrolases

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 500 18q21.1 LIPG lipase G, endothelial type
Mouse - 500 18 E2 Lipg lipase, endothelial
Rat - 493 18q12.2 Lipg lipase G, endothelial type
Previous and Unofficial Names Click here for help
EDL | EL | endothelial cell-derived lipase|lipase G | lipase, endothelial | lipase
Database Links Click here for help
Alphafold
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 3.1.1.3

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
GSK-264220A Small molecule or natural product Hs Irreversible inhibition 8.9 pIC50 1
pIC50 8.9 (IC50 1.3x10-7 M) [1]
compound 12 [PMID: 31990537] Small molecule or natural product Hs Inhibition 8.3 pIC50 2
pIC50 8.3 (IC50 5x10-9 M) [2]
Description: Determined in a fluorogenic substrate assay using recombinant human EL.

References

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1. Goodman KB, Bury MJ, Cheung M, Cichy-Knight MA, Dowdell SE, Dunn AK, Lee D, Lieby JA, Moore ML, Scherzer DA et al.. (2009) Discovery of potent, selective sulfonylfuran urea endothelial lipase inhibitors. Bioorg Med Chem Lett, 19 (1): 27-30. [PMID:19058966]

2. Tora G, Kim SH, Pi Z, Johnson JA, Jiang J, Phillips M, Lloyd J, Abell LM, Lu H, Locke G et al.. (2020) Identification of Reversible Small Molecule Inhibitors of Endothelial Lipase (EL) That Demonstrate HDL-C Increase In Vivo. J Med Chem, 63 (4): 1660-1670. DOI: 10.1021/acs.jmedchem.9b01831 [PMID:31990537]

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