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Target not currently curated in GtoImmuPdb
Target id: 2591
Nomenclature: lipase G, endothelial type
Abbreviated Name: LIPG
Family: Hydrolases & Lipases
Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 500 | 18q21.1 | LIPG | lipase G, endothelial type | |
Mouse | - | 500 | 18 E2 | Lipg | lipase, endothelial | |
Rat | - | 493 | 18q12.2 | Lipg | lipase G, endothelial type |
Previous and Unofficial Names ![]() |
EDL | EL | endothelial cell-derived lipase|lipase G | lipase, endothelial | lipase |
Database Links ![]() |
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Alphafold | Q9Y5X9 (Hs), Q9WVG5 (Mm), Q8VBX1 (Rn) |
BRENDA | 3.1.1.3 |
CATH/Gene3D | 3.40.50.1820, 2.60.60.20 |
ChEMBL Target | CHEMBL5080 (Hs), CHEMBL2380190 (Mm), CHEMBL3638354 (Rn) |
Ensembl Gene | ENSG00000101670 (Hs), ENSMUSG00000053846 (Mm), ENSRNOG00000018694 (Rn) |
Entrez Gene | 9388 (Hs), 16891 (Mm), 291437 (Rn) |
Human Protein Atlas | ENSG00000101670 (Hs) |
KEGG Enzyme | 3.1.1.3 |
KEGG Gene | hsa:9388 (Hs), mmu:16891 (Mm), rno:291437 (Rn) |
OMIM | 603684 (Hs) |
Pharos | Q9Y5X9 (Hs) |
RefSeq Nucleotide | NM_006033 (Hs), NM_010720 (Mm), NM_001012741 (Rn) |
RefSeq Protein | NP_006024 (Hs), NP_034850 (Mm), NP_001012759 (Rn) |
UniProtKB | Q9Y5X9 (Hs), Q9WVG5 (Mm), Q8VBX1 (Rn) |
Wikipedia | LIPG (Hs) |
Enzyme Reaction ![]() |
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Download all structure-activity data for this target as a CSV file
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Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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1. Goodman KB, Bury MJ, Cheung M, Cichy-Knight MA, Dowdell SE, Dunn AK, Lee D, Lieby JA, Moore ML, Scherzer DA et al.. (2009) Discovery of potent, selective sulfonylfuran urea endothelial lipase inhibitors. Bioorg Med Chem Lett, 19 (1): 27-30. [PMID:19058966]
2. Tora G, Kim SH, Pi Z, Johnson JA, Jiang J, Phillips M, Lloyd J, Abell LM, Lu H, Locke G et al.. (2020) Identification of Reversible Small Molecule Inhibitors of Endothelial Lipase (EL) That Demonstrate HDL-C Increase In Vivo. J Med Chem, 63 (4): 1660-1670. DOI: 10.1021/acs.jmedchem.9b01831 [PMID:31990537]