Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	500	18q21.1	LIPG	lipase G, endothelial type
Mouse	-	500	18 E2	Lipg	lipase, endothelial
Rat	-	493	18q12.2	Lipg	lipase G, endothelial type

Previous and Unofficial Names

EDL | EL | endothelial cell-derived lipase|lipase G | lipase, endothelial | lipase

Database Links
Alphafold	Q9Y5X9 (Hs), Q9WVG5 (Mm), Q8VBX1 (Rn)
BRENDA	3.1.1.3
CATH/Gene3D	3.40.50.1820, 2.60.60.20
ChEMBL Target	CHEMBL5080 (Hs), CHEMBL2380190 (Mm), CHEMBL3638354 (Rn)
Ensembl Gene	ENSG00000101670 (Hs), ENSMUSG00000053846 (Mm), ENSRNOG00000018694 (Rn)
Entrez Gene	9388 (Hs), 16891 (Mm), 291437 (Rn)
Human Protein Atlas	ENSG00000101670 (Hs)
KEGG Enzyme	3.1.1.3
KEGG Gene	hsa:9388 (Hs), mmu:16891 (Mm), rno:291437 (Rn)
OMIM	603684 (Hs)
Pharos	Q9Y5X9 (Hs)
RefSeq Nucleotide	NM_006033 (Hs), NM_010720 (Mm), NM_001012741 (Rn)
RefSeq Protein	NP_006024 (Hs), NP_034850 (Mm), NP_001012759 (Rn)
UniProtKB	Q9Y5X9 (Hs), Q9WVG5 (Mm), Q8VBX1 (Rn)
Wikipedia	LIPG (Hs)

Enzyme Reaction
EC Number: 3.1.1.3

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference GSK-264220A Hs Irreversible inhibition 8.9 pIC50 1 ⤷ pIC50 8.9 (IC50 1.3x10-7 M) [1] compound 12 [PMID: 31990537] Hs Inhibition 8.3 pIC50 2 ⤷ pIC50 8.3 (IC50 5x10-9 M) [2] Description: Determined in a fluorogenic substrate assay using recombinant human EL.