modithromycin   Click here for help

GtoPdb Ligand ID: 13000

Synonyms: EDP-420 | EP-013420 | S-013420
Compound class: Synthetic organic
Comment: Modithromycin is a is a ketolide (macrolide) antibacterial. Ketolides are erythromycin derivatives with a broad-spectrum of antibacterial activity.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 15
Hydrogen bond donors 2
Rotatable bonds 9
Topological polar surface area 202.97
Molecular weight 841
XLogP 1.24
No. Lipinski's rules broken 2
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES CC[C@@H]1[C@](C)([C@H]2[C@@H](C)/C(=N/C(=O)C)/[C@H](C)C[C@](C)([C@@H]([C@@H](C)C(=O)[C@@H](C)C(=O)O1)O[C@H]3[C@@H]([C@H](C[C@@H](C)O3)N(C)C)O)OC/C(=N/OCC4=CC=C(N=C4)N5C=CC=N5)/CO2)O
Isomeric SMILES CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@]3(C)C[C@@H](C)/C(=N\C(C)=O)/[C@H](C)[C@@H](OC/C(=N\OCC4=CC=C(N5C=CC=N5)N=C4)/CO3)[C@]1(C)O
InChI InChI=1S/C43H64N6O11/c1-12-33-43(9,54)39-26(4)35(46-29(7)50)24(2)19-42(8,56-23-31(22-55-39)47-57-21-30-14-15-34(44-20-30)49-17-13-16-45-49)38(27(5)36(51)28(6)40(53)59-33)60-41-37(52)32(48(10)11)18-25(3)58-41/h13-17,20,24-28,32-33,37-39,41,52,54H,12,18-19,21-23H2,1-11H3/b46-35+,47-31+/t24-,25-,26+,27+,28-,32+,33-,37-,38-,39-,41+,42-,43-/m1/s1
InChI Key WLGSYOKBEDVHQB-XSKCQLPHSA-N
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
N-[(1R,2R,3R,5R,8R,9R,10R,13E,17R,19S)-2-[(2S,3R,4S,6R)-4-dimethylamino-3-hydroxy-6-methyloxan-2-yl]oxy-8-ethyl-9-hydroxy-1,3,5,9,17,19-hexamethyl-4,6-dioxo-13-[(6-pyrazol-1-ylpyridin-3-yl)methoxyimino]-7,11,15-trioxabicyclo[8.5.4]nonadecan-18-ylidene]acetamide
International Nonproprietary Names Click here for help
INN number INN
9171 modithromycin
Synonyms Click here for help
EDP-420 | EP-013420 | S-013420
Database Links Click here for help
Specialist databases
Antibiotic DB Antibiotic DB Database logo Modithromycin, EDP-420, EP-013420, S-013420
Other databases
CAS Registry No. 736992-12-4 (source: Scifinder)
ChEMBL Ligand CHEMBL263886
DrugBank Ligand DB16238
GtoPdb PubChem SID 485206121
PubChem CID 139032949
Search Google for chemical match using the InChIKey WLGSYOKBEDVHQB-XSKCQLPHSA-N
Search Google for chemicals with the same backbone WLGSYOKBEDVHQB
Search PubMed clinical trials modithromycin
Search PubMed titles modithromycin
Search PubMed titles/abstracts modithromycin
UniChem Compound Search for chemical match using the InChIKey WLGSYOKBEDVHQB-XSKCQLPHSA-N
UniChem Connectivity Search for chemical match using the InChIKey WLGSYOKBEDVHQB-XSKCQLPHSA-N